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The map label for this gene is tesB [H]

Identifier: 119870965

GI number: 119870965

Start: 5175978

End: 5176796

Strand: Direct

Name: tesB [H]

Synonym: Mkms_4938

Alternate gene names: 119870965

Gene position: 5175978-5176796 (Clockwise)

Preceding gene: 119870964

Following gene: 119870966

Centisome position: 90.22

GC content: 70.09

Gene sequence:

>819_bases
ATGATGACCGCCCTTCGAGACACCTCCTGGCCGCACGACGCGAGCTGGATCGCGCGGCTGCTCGAATTCGACCGTGACGG
CGACACGTTCCTCGCACCGCAGGTGACGAGCGGTCCGGCGCACCGACTGTTCGGCGGTCTGATCGCGGCGCAGGCGTTGG
GCGCGGCGGGAGCGACGGTCGATCCCGATAAGCGGGCGCAGTCACTGCACGCCTACTTCGTGCGCGGCGGCAAATACGGG
ATCGACGTCGAACTCGAGGTGGAACGCACCCGCGACGGACGTTCGTTCGACACGCGCCGCGTCACCGCGATCCAGGAGGG
TAAGGCCATCCTCGAGATGATCGCGTCATTCCACCGTCCAGAGGACAGTGCCGACTGGCACCCGGCGCGACCGCCGGCCC
TCGCGTTCGAGGATGCGGTGCCGAAGGCCCCGGACCTCGAGGCGGTGGACCGCCTGGAGGTCCGCTGCCACCCGGACGAT
CTGTCGCCGTTCGCGATCCCGCCGTTCTGGATCCGCAGCCGAGACGTCATCGAGGACGATCCGCTGATCCGTGCGTGCAT
GCTGACCTACATGTCCGACCTCGGGCCGGTGCCCGCCGCCCGGCCGGCCGGCGCCCCCGACGAGCCGGGCGCCGGGATGG
CGGCATCGCTGGATCACTCGGTGTGGTTCCATCGGCCGTTCGACCCGCACCGCTGGCACCGGTACGAGGTGACCGGCGTG
AACAACAGCGACGCCCGCGGCCTGGCGGTCGGTTCGCTGTACGACGACGCCGGCGCGCTGATCGCCAGCACCACGCAGGA
AGCGCTCTGGCGGTTCTGA

Upstream 100 bases:

>100_bases
ACGCTGTGGCTGATCACCGGGAACGGTGCGGCCGAGATCGCTCGCGCACGCACGCCTCACCCCTGACAATGCTCCCAACC
AGTTGGTCGATAGTCTGGCT

Downstream 100 bases:

>100_bases
CCGACCGATTCGTCCGGCCCGGGGCGATTGGACAGACCAAGTAGCGGGTAGTTCACCCGGCGTGACATCCGCGCCGATCA
TGGTTGAACCGACGTTGCCC

Product: acyl-CoA thioesterase

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MMTALRDTSWPHDASWIARLLEFDRDGDTFLAPQVTSGPAHRLFGGLIAAQALGAAGATVDPDKRAQSLHAYFVRGGKYG
IDVELEVERTRDGRSFDTRRVTAIQEGKAILEMIASFHRPEDSADWHPARPPALAFEDAVPKAPDLEAVDRLEVRCHPDD
LSPFAIPPFWIRSRDVIEDDPLIRACMLTYMSDLGPVPAARPAGAPDEPGAGMAASLDHSVWFHRPFDPHRWHRYEVTGV
NNSDARGLAVGSLYDDAGALIASTTQEALWRF

Sequences:

>Translated_272_residues
MMTALRDTSWPHDASWIARLLEFDRDGDTFLAPQVTSGPAHRLFGGLIAAQALGAAGATVDPDKRAQSLHAYFVRGGKYG
IDVELEVERTRDGRSFDTRRVTAIQEGKAILEMIASFHRPEDSADWHPARPPALAFEDAVPKAPDLEAVDRLEVRCHPDD
LSPFAIPPFWIRSRDVIEDDPLIRACMLTYMSDLGPVPAARPAGAPDEPGAGMAASLDHSVWFHRPFDPHRWHRYEVTGV
NNSDARGLAVGSLYDDAGALIASTTQEALWRF
>Mature_272_residues
MMTALRDTSWPHDASWIARLLEFDRDGDTFLAPQVTSGPAHRLFGGLIAAQALGAAGATVDPDKRAQSLHAYFVRGGKYG
IDVELEVERTRDGRSFDTRRVTAIQEGKAILEMIASFHRPEDSADWHPARPPALAFEDAVPKAPDLEAVDRLEVRCHPDD
LSPFAIPPFWIRSRDVIEDDPLIRACMLTYMSDLGPVPAARPAGAPDEPGAGMAASLDHSVWFHRPFDPHRWHRYEVTGV
NNSDARGLAVGSLYDDAGALIASTTQEALWRF

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=261, Percent_Identity=34.8659003831418, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1786657, Length=252, Percent_Identity=38.4920634920635, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71988741, Length=298, Percent_Identity=30.8724832214765, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI212645202, Length=278, Percent_Identity=32.3741007194245, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115532456, Length=288, Percent_Identity=30.5555555555556, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17531889, Length=269, Percent_Identity=30.8550185873606, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17531885, Length=286, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17558508, Length=305, Percent_Identity=29.8360655737705, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982224, Length=284, Percent_Identity=27.8169014084507, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 29976; Mature: 29976

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTALRDTSWPHDASWIARLLEFDRDGDTFLAPQVTSGPAHRLFGGLIAAQALGAAGATV
CCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DPDKRAQSLHAYFVRGGKYGIDVELEVERTRDGRSFDTRRVTAIQEGKAILEMIASFHRP
CHHHHHHHHHHHEEECCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EDSADWHPARPPALAFEDAVPKAPDLEAVDRLEVRCHPDDLSPFAIPPFWIRSRDVIEDD
CCCCCCCCCCCCCCCHHHCCCCCCCHHHHHCEEEEECCCCCCCCCCCCHHCCCCCCCCCC
PLIRACMLTYMSDLGPVPAARPAGAPDEPGAGMAASLDHSVWFHRPFDPHRWHRYEVTGV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCEEEEEECC
NNSDARGLAVGSLYDDAGALIASTTQEALWRF
CCCCCCCEEEECHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMTALRDTSWPHDASWIARLLEFDRDGDTFLAPQVTSGPAHRLFGGLIAAQALGAAGATV
CCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DPDKRAQSLHAYFVRGGKYGIDVELEVERTRDGRSFDTRRVTAIQEGKAILEMIASFHRP
CHHHHHHHHHHHEEECCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
EDSADWHPARPPALAFEDAVPKAPDLEAVDRLEVRCHPDDLSPFAIPPFWIRSRDVIEDD
CCCCCCCCCCCCCCCHHHCCCCCCCHHHHHCEEEEECCCCCCCCCCCCHHCCCCCCCCCC
PLIRACMLTYMSDLGPVPAARPAGAPDEPGAGMAASLDHSVWFHRPFDPHRWHRYEVTGV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCEEEEEECC
NNSDARGLAVGSLYDDAGALIASTTQEALWRF
CCCCCCCEEEECHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]