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The map label for this gene is cysM [C]

Identifier: 119870941

GI number: 119870941

Start: 5147922

End: 5149028

Strand: Direct

Name: cysM [C]

Synonym: Mkms_4913

Alternate gene names: 119870941

Gene position: 5147922-5149028 (Clockwise)

Preceding gene: 119870940

Following gene: 119870942

Centisome position: 89.73

GC content: 68.2

Gene sequence:

>1107_bases
GTGACGGGGCGGTCCTCGATCGCCACTCACAGTCAGCCCCGCGCGTGGGTCGACAACGCCGTGCGCCTGATCGAGGCCGA
TGCCCGGCGCAGCGCCGACACCCACCTGCTGCGCTATCCGCTGCCGTCCGCCTGGGGTGAGGACTGCGATGTCGCGCTGT
ACCTCAAGGACGAGTCGACCCACATCACCGGCAGCCTCAAGCACCGGTTGGCGCGCTCGCTGTTCCTCTACGGGTTGTGC
AACGGGTGGATCTGCGAGGGCACGACGGTCATCGAGGCCTCCAGCGGGTCGACCGCGGTGTCCGAGGCGTATTTCGCGGC
GCTGCTCGGCCTGCCGTTCATCGCGGTGATGACGTCGTCGACCAGCGCGAGTAAGGTCGCACTGATCGAATCACAAGGTG
GCCGTTGCCATTTCGTCGAGGAATCGTCCCAGGTGTACGCCGAGGCCGAACGCCTGGCCCAGGAGACCGGCGGGCACTAT
CTCGATCAGTTCACCAACGCCGAACGGGCCACCGACTGGCGCGGCAACAACAACATCGCCGAATCGATCTATCACCAGAT
GGCCGCCGAGCAGCATCCGATTCCGGAGTGGATCGTCGTGGGTGCGGGCACCGGCGGGACGAGCGCGACCATCGGCCGCT
ACATCCGCTACCGGCGATACGCCACCAGACTGTGCGTGGTCGATCCGGAGAACTCGGCGTTCTTCCCCGCCTACGCCCAG
CAGGATCCGACCATCGTCACCGGCGCGTCGTCGCGGATCGAGGGGATCGGCCGTCCGCGGGTGGAACCGTCGTTTCTGCC
CGAGGTGGTGGACCGCATGGTCGCCGTCCTCGACGGGGCATCGGTGGCGGCCGCCCGGCATGCGAGCCGGGTGCTGGGCC
GGCGGGTCGGCCCGTCGACCGGAACGAATCTGTGGGGTGCCTTCGGGCTGCTCGCGGAGATGAAGGCGCAGGGGCGGAGC
GGATCGGTGGTGACGTTGATCGCCGACAGCGGCGACCGCTACGCCGACACCTACTTCTGCGACGAGTGGCTCAGCAGCCA
GGGCATCGATCCGTCCGAATCGGCCGAGGTGCTGGCCGACTTCGAGCGGTCCGGCGTCTGGCGCTGA

Upstream 100 bases:

>100_bases
GCCACACTGCTGACGCTGGTCGCCGCGCCGACCGGCGGCCGGGACGCCGACGTGCAGGCTGGACAGTCGCCGTCGACCGT
CTCGGCACGGTGACGGGGCG

Downstream 100 bases:

>100_bases
TCCTCGGAGCCGCCGGACAGCGGCCCGTCGGCGGTCAGGAAGAGCCAGATCGCCGCCAGAGCGAAGAACCCCAGGTAGAT
GGAAGCTCCCAACCCGGTCA

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTGRSSIATHSQPRAWVDNAVRLIEADARRSADTHLLRYPLPSAWGEDCDVALYLKDESTHITGSLKHRLARSLFLYGLC
NGWICEGTTVIEASSGSTAVSEAYFAALLGLPFIAVMTSSTSASKVALIESQGGRCHFVEESSQVYAEAERLAQETGGHY
LDQFTNAERATDWRGNNNIAESIYHQMAAEQHPIPEWIVVGAGTGGTSATIGRYIRYRRYATRLCVVDPENSAFFPAYAQ
QDPTIVTGASSRIEGIGRPRVEPSFLPEVVDRMVAVLDGASVAAARHASRVLGRRVGPSTGTNLWGAFGLLAEMKAQGRS
GSVVTLIADSGDRYADTYFCDEWLSSQGIDPSESAEVLADFERSGVWR

Sequences:

>Translated_368_residues
MTGRSSIATHSQPRAWVDNAVRLIEADARRSADTHLLRYPLPSAWGEDCDVALYLKDESTHITGSLKHRLARSLFLYGLC
NGWICEGTTVIEASSGSTAVSEAYFAALLGLPFIAVMTSSTSASKVALIESQGGRCHFVEESSQVYAEAERLAQETGGHY
LDQFTNAERATDWRGNNNIAESIYHQMAAEQHPIPEWIVVGAGTGGTSATIGRYIRYRRYATRLCVVDPENSAFFPAYAQ
QDPTIVTGASSRIEGIGRPRVEPSFLPEVVDRMVAVLDGASVAAARHASRVLGRRVGPSTGTNLWGAFGLLAEMKAQGRS
GSVVTLIADSGDRYADTYFCDEWLSSQGIDPSESAEVLADFERSGVWR
>Mature_367_residues
TGRSSIATHSQPRAWVDNAVRLIEADARRSADTHLLRYPLPSAWGEDCDVALYLKDESTHITGSLKHRLARSLFLYGLCN
GWICEGTTVIEASSGSTAVSEAYFAALLGLPFIAVMTSSTSASKVALIESQGGRCHFVEESSQVYAEAERLAQETGGHYL
DQFTNAERATDWRGNNNIAESIYHQMAAEQHPIPEWIVVGAGTGGTSATIGRYIRYRRYATRLCVVDPENSAFFPAYAQQ
DPTIVTGASSRIEGIGRPRVEPSFLPEVVDRMVAVLDGASVAAARHASRVLGRRVGPSTGTNLWGAFGLLAEMKAQGRSG
SVVTLIADSGDRYADTYFCDEWLSSQGIDPSESAEVLADFERSGVWR

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=336, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI295821200, Length=336, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4557415, Length=336, Percent_Identity=26.7857142857143, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI2367138, Length=307, Percent_Identity=26.3843648208469, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71996324, Length=363, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539800, Length=356, Percent_Identity=29.4943820224719, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17539640, Length=360, Percent_Identity=25.2777777777778, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39935; Mature: 39804

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRSSIATHSQPRAWVDNAVRLIEADARRSADTHLLRYPLPSAWGEDCDVALYLKDEST
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
HITGSLKHRLARSLFLYGLCNGWICEGTTVIEASSGSTAVSEAYFAALLGLPFIAVMTSS
EEHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEECC
TSASKVALIESQGGRCHFVEESSQVYAEAERLAQETGGHYLDQFTNAERATDWRGNNNIA
CCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHH
ESIYHQMAAEQHPIPEWIVVGAGTGGTSATIGRYIRYRRYATRLCVVDPENSAFFPAYAQ
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCEEEEECCCCCEECCCCCC
QDPTIVTGASSRIEGIGRPRVEPSFLPEVVDRMVAVLDGASVAAARHASRVLGRRVGPST
CCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
GTNLWGAFGLLAEMKAQGRSGSVVTLIADSGDRYADTYFCDEWLSSQGIDPSESAEVLAD
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
FERSGVWR
HHHCCCCC
>Mature Secondary Structure 
TGRSSIATHSQPRAWVDNAVRLIEADARRSADTHLLRYPLPSAWGEDCDVALYLKDEST
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
HITGSLKHRLARSLFLYGLCNGWICEGTTVIEASSGSTAVSEAYFAALLGLPFIAVMTSS
EEHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHEEEEECC
TSASKVALIESQGGRCHFVEESSQVYAEAERLAQETGGHYLDQFTNAERATDWRGNNNIA
CCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCHHH
ESIYHQMAAEQHPIPEWIVVGAGTGGTSATIGRYIRYRRYATRLCVVDPENSAFFPAYAQ
HHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCEEEEECCCCCEECCCCCC
QDPTIVTGASSRIEGIGRPRVEPSFLPEVVDRMVAVLDGASVAAARHASRVLGRRVGPST
CCCCEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
GTNLWGAFGLLAEMKAQGRSGSVVTLIADSGDRYADTYFCDEWLSSQGIDPSESAEVLAD
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
FERSGVWR
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]