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The map label for this gene is fadA [H]

Identifier: 119870792

GI number: 119870792

Start: 4997080

End: 4998243

Strand: Direct

Name: fadA [H]

Synonym: Mkms_4764

Alternate gene names: 119870792

Gene position: 4997080-4998243 (Clockwise)

Preceding gene: 119870783

Following gene: 119870794

Centisome position: 87.1

GC content: 67.27

Gene sequence:

>1164_bases
ATGGGCAACCCTGTCATCGTCGAAGCCACCCGCAGTCCGATCGGAAAGCGCAACGGATGGCTGTCCGGACTCCACGCGAC
CGAACTGTTGGGTGCGGTGCAGAAGGCTCTGGTCGAGAAGGCCGGGATCGATCCGGGCGATGTCGAGCAGCTCATCGGCG
GCTGCGTCACCCAGTACGGCGAGCAGTCCAACAACATCACCCGCGTGAGCTGGCTGACCGCGGGGTTGCCCGAGCATGTC
GGCGCCACCACGATCGACTGCCAGTGCGGGAGCGCCCAGCAGGCCAACCACCTGGTCGCCGGCCTGATCGCCACCGGCGC
CATCGACATCGGTATCGCCTGCGGTATCGAGGCGATGAGCCGGGTCGGGCTCGGCGCGAACGCCGGACCCGACCGCTCGA
AGATCCGCGCGGAGTCGTGGGACATCGACATGCCCAACCAGTTCGAGGCCGCCGAACGCATCGCCAAGCGCCGCGGTATC
ACGCGCGAGGACATCGACCAGCTCGGCTTCGCGTCACAGGCCAAGGCCAAGCAGGCGTGGGCCGAGAACCGCTTCGACCG
GGAGATCTCGCCGATCGTGGCGCCGGTGCTCGACGAGAACAAGCAGCCGACCTCCGAGCGCGCACCGGTGTCCAAGGATC
AGGGTCTGCGCGACACCACCCTCGAGGGGCTGGCCCAACTGAAGCCGGTCATGGAAGGCGGAATCCACACCGCGGGCACC
TCCTCGCAGATCTCGGACGGCGCCGCCGCGGTTCTGTGGATGGATGAGGACAAGGCGAAGGCGCTGGGATTGAAGCCGCG
TGCCCGGATCGTGGCGCAGGCCAACGTCGGCGCGGAGACCTATTACCACCTCGACGGACCCGTCCAGTCGACTGCCAAGG
TGCTGGAGAAGGCCGGGATGAAGCTCGGCGACATCGACTTGGTCGAGATCAACGAGGCGTTCGCGTCGGTGGTGTTGTCG
TGGGCGCAGGTACACGGCGCCGATATGGACAAGGTCAACGTCAACGGCGGCGCGATCGCCCTCGGACATCCGGTGGGCTC
CACCGGTGCCCGGTTGATCACCACCGCGCTGCACGAACTCGAACGCACCGGTAAGGGCACCGCGCTGATCACGATGTGCG
CGGGCGGCGCCCTGTCGACGGGCACCATCATCGAGCGGATCTGA

Upstream 100 bases:

>100_bases
AACGTGTTCTAGTGTCAGTAAAACATGCCTCCACCGCAGATGAAAGGCACGGTGGCATCGCTGCTTGTCAGACGAATGAA
ACGTGTTCTAGCCTGACGCA

Downstream 100 bases:

>100_bases
AGCGCTAGGCCGGCACGATCGCAGGGCGGATCCTCGCCCGGATGTGGTGGATCAGACCATCGGACGCCGGGATCAGAAAT
GTCTCGTCGACATGGGCGAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MGNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIDPGDVEQLIGGCVTQYGEQSNNITRVSWLTAGLPEHV
GATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMSRVGLGANAGPDRSKIRAESWDIDMPNQFEAAERIAKRRGI
TREDIDQLGFASQAKAKQAWAENRFDREISPIVAPVLDENKQPTSERAPVSKDQGLRDTTLEGLAQLKPVMEGGIHTAGT
SSQISDGAAAVLWMDEDKAKALGLKPRARIVAQANVGAETYYHLDGPVQSTAKVLEKAGMKLGDIDLVEINEAFASVVLS
WAQVHGADMDKVNVNGGAIALGHPVGSTGARLITTALHELERTGKGTALITMCAGGALSTGTIIERI

Sequences:

>Translated_387_residues
MGNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIDPGDVEQLIGGCVTQYGEQSNNITRVSWLTAGLPEHV
GATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMSRVGLGANAGPDRSKIRAESWDIDMPNQFEAAERIAKRRGI
TREDIDQLGFASQAKAKQAWAENRFDREISPIVAPVLDENKQPTSERAPVSKDQGLRDTTLEGLAQLKPVMEGGIHTAGT
SSQISDGAAAVLWMDEDKAKALGLKPRARIVAQANVGAETYYHLDGPVQSTAKVLEKAGMKLGDIDLVEINEAFASVVLS
WAQVHGADMDKVNVNGGAIALGHPVGSTGARLITTALHELERTGKGTALITMCAGGALSTGTIIERI
>Mature_386_residues
GNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIDPGDVEQLIGGCVTQYGEQSNNITRVSWLTAGLPEHVG
ATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMSRVGLGANAGPDRSKIRAESWDIDMPNQFEAAERIAKRRGIT
REDIDQLGFASQAKAKQAWAENRFDREISPIVAPVLDENKQPTSERAPVSKDQGLRDTTLEGLAQLKPVMEGGIHTAGTS
SQISDGAAAVLWMDEDKAKALGLKPRARIVAQANVGAETYYHLDGPVQSTAKVLEKAGMKLGDIDLVEINEAFASVVLSW
AQVHGADMDKVNVNGGAIALGHPVGSTGARLITTALHELERTGKGTALITMCAGGALSTGTIIERI

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=387, Percent_Identity=37.2093023255814, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI148539872, Length=396, Percent_Identity=34.8484848484849, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=35.0253807106599, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=33.7531486146096, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=30.2325581395349, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI194353979, Length=384, Percent_Identity=29.1666666666667, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=38.8206388206388, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=38.9162561576355, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788554, Length=402, Percent_Identity=38.5572139303483, Blast_Score=208, Evalue=4e-55,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=36.8421052631579, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1788683, Length=428, Percent_Identity=32.2429906542056, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=34.5959595959596, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI25147385, Length=397, Percent_Identity=32.7455919395466, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=31.9444444444444, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=31.6455696202532, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=27.5, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=32.512315270936, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24655093, Length=399, Percent_Identity=36.3408521303258, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=33.5858585858586, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=29.9303944315545, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40616; Mature: 40484

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIDPGDVEQLIGGCVTQYG
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EQSNNITRVSWLTAGLPEHVGATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMS
CCCCCEEEEEEECCCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RVGLGANAGPDRSKIRAESWDIDMPNQFEAAERIAKRRGITREDIDQLGFASQAKAKQAW
HCCCCCCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
AENRFDREISPIVAPVLDENKQPTSERAPVSKDQGLRDTTLEGLAQLKPVMEGGIHTAGT
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SSQISDGAAAVLWMDEDKAKALGLKPRARIVAQANVGAETYYHLDGPVQSTAKVLEKAGM
CCCCCCCCEEEEEECCCCHHHCCCCCHHEEEEEECCCCCEEEECCCCHHHHHHHHHHCCC
KLGDIDLVEINEAFASVVLSWAQVHGADMDKVNVNGGAIALGHPVGSTGARLITTALHEL
CCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHH
ERTGKGTALITMCAGGALSTGTIIERI
HHCCCCCEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure 
GNPVIVEATRSPIGKRNGWLSGLHATELLGAVQKALVEKAGIDPGDVEQLIGGCVTQYG
CCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EQSNNITRVSWLTAGLPEHVGATTIDCQCGSAQQANHLVAGLIATGAIDIGIACGIEAMS
CCCCCEEEEEEECCCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHH
RVGLGANAGPDRSKIRAESWDIDMPNQFEAAERIAKRRGITREDIDQLGFASQAKAKQAW
HCCCCCCCCCCHHHEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHH
AENRFDREISPIVAPVLDENKQPTSERAPVSKDQGLRDTTLEGLAQLKPVMEGGIHTAGT
HHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SSQISDGAAAVLWMDEDKAKALGLKPRARIVAQANVGAETYYHLDGPVQSTAKVLEKAGM
CCCCCCCCEEEEEECCCCHHHCCCCCHHEEEEEECCCCCEEEECCCCHHHHHHHHHHCCC
KLGDIDLVEINEAFASVVLSWAQVHGADMDKVNVNGGAIALGHPVGSTGARLITTALHEL
CCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHH
ERTGKGTALITMCAGGALSTGTIIERI
HHCCCCCEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA