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The map label for this gene is adhB [H]

Identifier: 119870702

GI number: 119870702

Start: 4900094

End: 4901221

Strand: Direct

Name: adhB [H]

Synonym: Mkms_4673

Alternate gene names: 119870702

Gene position: 4900094-4901221 (Clockwise)

Preceding gene: 119870701

Following gene: 119870703

Centisome position: 85.41

GC content: 66.67

Gene sequence:

>1128_bases
ATGAAGACCAAGGGCGCCCTCATCTGGGAGTTCAACCAACCGTGGTCGATCGAGGAGATCGAGATCGGTGACCCGGTCAA
GGACGAAGTCAAGATCCGGATGGAAGCGTCGGGGATGTGCCACTCCGACCATCACCTGGTCACCGGCGGTATCCCGATGG
CCGGCTTCCCGGTGCTCGGCGGGCACGAGGGTGCCGGCGTGGTCACCGAGGTCGGACCGGGCGTCGAGGACCTCGCGCCC
GGCGACCACGTCGTGCTCTCGTTCATCCCGTCCTGCGGGCGCTGCCCGTCGTGTCAGGCCGGGCTGCGCAACCTGTGCGA
CCTGGGCGCCGGCCTGCTGGGCGGCACCGCGGTGTCCGACGGCACCCACCGCATCCATGCCAAGGGTCAGCCCGTCTTCC
CGATGACCCTGCTGGGCACGTTCAGCCCGTACATGGTCGTGCACAAGAGCTCGGTCGTGAAGATCGACCCGTCGGTTCCG
TTCGAGGTCGCCTGCCTGGTCGGCTGCGGCGTCACCACCGGTTACGGCTCGGCCGTGCGCGCCGGTGACATCCGGCCCGG
GGACGACGTCGCGGTCGTCGGCGTCGGCGGTGTCGGCATGTCGGCGCTGCAGGGCGCGGTCAACGCCGGTGCGCGCAACA
TCTTCGTCATCGAGCCCGTGGAGTGGAAGCGTGACGCCGCGCTGAAGTTCGGCGGCACCCACGCCTACCCCGACCTGGAA
TCGGCGTTCGCCGGGATCGCCGAGGTCACCCAGGGACTGATGGCCAAGAAGGTCATCGTCACCGTCGGCGAACTGCACGG
CAACGACGTCGACAACTACGTCAACCTCACGTCCAAGGGCGGCACCTGCGTGCTGACCGCCATCGGCAGCATGCTCGACA
CGCAGGTGACCCTGAACCTCGCCATGCTGACCCTGTTGCAGAAGAACCTGCAGGGCACCATCTTCGGCGGCGGCAACCCC
CACTTCGACATCCCGCAGCTGCTGTCGATGTACAAGGCGGGCAAGCTCAACCTCGACGACATGATCACCCGGCAGTACAA
GCTGGAGCAGATCAACGAGGGCTACTCGGACATGTTGGAGGGCAAGAACATCCGCGGCGTCATCCGCTACACCGACAACG
ACTGGTGA

Upstream 100 bases:

>100_bases
CGCGGCGTCGGGTGTGTAGTTTGACACCCGTCGAGAAATCCGCTGAGACCCACGTCACTAGGCTGGTGGCCGAGACGTTC
TCCGAAGGAAAGCAGGCAAT

Downstream 100 bases:

>100_bases
GCCAGTGACCCAGGAGGCGGTCGAGCAGTCACCGGTGGTCGCGGCGTCACGCGCGTCGTGGCGCTGCGTCCAATCGGCTG
ACAAAGAGGGCTGGCTGGCC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIRMEASGMCHSDHHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVEDLAP
GDHVVLSFIPSCGRCPSCQAGLRNLCDLGAGLLGGTAVSDGTHRIHAKGQPVFPMTLLGTFSPYMVVHKSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRAGDIRPGDDVAVVGVGGVGMSALQGAVNAGARNIFVIEPVEWKRDAALKFGGTHAYPDLE
SAFAGIAEVTQGLMAKKVIVTVGELHGNDVDNYVNLTSKGGTCVLTAIGSMLDTQVTLNLAMLTLLQKNLQGTIFGGGNP
HFDIPQLLSMYKAGKLNLDDMITRQYKLEQINEGYSDMLEGKNIRGVIRYTDNDW

Sequences:

>Translated_375_residues
MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIRMEASGMCHSDHHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVEDLAP
GDHVVLSFIPSCGRCPSCQAGLRNLCDLGAGLLGGTAVSDGTHRIHAKGQPVFPMTLLGTFSPYMVVHKSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRAGDIRPGDDVAVVGVGGVGMSALQGAVNAGARNIFVIEPVEWKRDAALKFGGTHAYPDLE
SAFAGIAEVTQGLMAKKVIVTVGELHGNDVDNYVNLTSKGGTCVLTAIGSMLDTQVTLNLAMLTLLQKNLQGTIFGGGNP
HFDIPQLLSMYKAGKLNLDDMITRQYKLEQINEGYSDMLEGKNIRGVIRYTDNDW
>Mature_375_residues
MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIRMEASGMCHSDHHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVEDLAP
GDHVVLSFIPSCGRCPSCQAGLRNLCDLGAGLLGGTAVSDGTHRIHAKGQPVFPMTLLGTFSPYMVVHKSSVVKIDPSVP
FEVACLVGCGVTTGYGSAVRAGDIRPGDDVAVVGVGGVGMSALQGAVNAGARNIFVIEPVEWKRDAALKFGGTHAYPDLE
SAFAGIAEVTQGLMAKKVIVTVGELHGNDVDNYVNLTSKGGTCVLTAIGSMLDTQVTLNLAMLTLLQKNLQGTIFGGGNP
HFDIPQLLSMYKAGKLNLDDMITRQYKLEQINEGYSDMLEGKNIRGVIRYTDNDW

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=35.9249329758713, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=35.9249329758713, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501933, Length=376, Percent_Identity=37.2340425531915, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=36.6310160427808, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=35.3887399463807, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=34.7708894878706, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=33.8624338624339, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=33.5120643431635, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=33.5149863760218, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI156627571, Length=365, Percent_Identity=25.4794520547945, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=34.3163538873995, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=25.5208333333333, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI226510992, Length=374, Percent_Identity=25.9358288770053, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=30.188679245283, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=24.8618784530387, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786825, Length=378, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=27.4336283185841, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790045, Length=367, Percent_Identity=23.433242506812, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=31.5649867374005, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=31.3984168865435, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17565904, Length=353, Percent_Identity=31.1614730878187, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=28.2666666666667, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=382, Percent_Identity=25.130890052356, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=193, Percent_Identity=29.0155440414508, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=26.1111111111111, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=382, Percent_Identity=24.869109947644, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=379, Percent_Identity=33.509234828496, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6319621, Length=362, Percent_Identity=24.8618784530387, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=363, Percent_Identity=24.5179063360882, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=349, Percent_Identity=27.7936962750716, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=349, Percent_Identity=27.7936962750716, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=24.7761194029851, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=335, Percent_Identity=24.7761194029851, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=35.3887399463807, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39632; Mature: 39632

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIRMEASGMCHSDHHLVTGGIPMAGFPVLG
CCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEC
GHEGAGVVTEVGPGVEDLAPGDHVVLSFIPSCGRCPSCQAGLRNLCDLGAGLLGGTAVSD
CCCCCCEEEECCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCEECC
GTHRIHAKGQPVFPMTLLGTFSPYMVVHKSSVVKIDPSVPFEVACLVGCGVTTGYGSAVR
CCEEEECCCCCCCCHHHHHCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCCEE
AGDIRPGDDVAVVGVGGVGMSALQGAVNAGARNIFVIEPVEWKRDAALKFGGTHAYPDLE
CCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCHH
SAFAGIAEVTQGLMAKKVIVTVGELHGNDVDNYVNLTSKGGTCVLTAIGSMLDTQVTLNL
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEHEEHHHHHHHHHHHHH
AMLTLLQKNLQGTIFGGGNPHFDIPQLLSMYKAGKLNLDDMITRQYKLEQINEGYSDMLE
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHC
GKNIRGVIRYTDNDW
CCCCEEEEEECCCCC
>Mature Secondary Structure
MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIRMEASGMCHSDHHLVTGGIPMAGFPVLG
CCCCCCEEEECCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEC
GHEGAGVVTEVGPGVEDLAPGDHVVLSFIPSCGRCPSCQAGLRNLCDLGAGLLGGTAVSD
CCCCCCEEEECCCCHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCEECC
GTHRIHAKGQPVFPMTLLGTFSPYMVVHKSSVVKIDPSVPFEVACLVGCGVTTGYGSAVR
CCEEEECCCCCCCCHHHHHCCCCEEEEECCEEEEECCCCCEEEEEEEECCCCCCCCCCEE
AGDIRPGDDVAVVGVGGVGMSALQGAVNAGARNIFVIEPVEWKRDAALKFGGTHAYPDLE
CCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCHH
SAFAGIAEVTQGLMAKKVIVTVGELHGNDVDNYVNLTSKGGTCVLTAIGSMLDTQVTLNL
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEHEEHHHHHHHHHHHHH
AMLTLLQKNLQGTIFGGGNPHFDIPQLLSMYKAGKLNLDDMITRQYKLEQINEGYSDMLE
HHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHC
GKNIRGVIRYTDNDW
CCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]