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The map label for this gene is moaA

Identifier: 119870593

GI number: 119870593

Start: 4795141

End: 4796193

Strand: Direct

Name: moaA

Synonym: Mkms_4564

Alternate gene names: 119870593

Gene position: 4795141-4796193 (Clockwise)

Preceding gene: 119870592

Following gene: 119870594

Centisome position: 83.58

GC content: 71.7

Gene sequence:

>1053_bases
ATGACGGTGACCCCACTCGGTGTCCCCACCATCTCGCGTCCGGCGGCAGGCATGCCCACCACCGGACCGCTGGTCGACAC
CTTCGGCCGCATCGCCACCGACCTGCGGGTGTCGCTGACCGACCGCTGCAATCTGCGCTGCACCTACTGCATGCCCGCCG
AAGGCCTCGACTGGCTGCCGGGTGAGCAGCTGCTGAGCGCCGACGAACTGATCCGGCTGCTGCGTATCGCGGTCACCCGC
CTCGGCATCACCAACGTGCGCTTCACCGGCGGTGAACCGCTGGTGGTGCGGCACCTCGAGGACGTGGTGGCGGCCACGGG
CGCGCTGCGCCCCCGCCCGGAGATGGCGATGACCACCAACGGGATCGGGCTGGCCAAGCGGGCGCGGGCCCTCAAGGCCG
CCGGGCTCGACCGGGTCAACGTCTCGCTCGACAGCGTCGACGCCGCCCACTTCGCGCGCATCACCCGCCGCGACCGGCTG
GGTGACGTGCTCGCCGGGCTGGCCGCCGCCAAGGAGGCCGGGCTGACGCCGGTCAAGGTCAACGCCGTCCTCGATCCCGA
CACCGGTCTCGACGACGCGGTCTCGCTGCTGCGGTACTGCCTCGACCACGGCTATCAGCTGCGCATCATCGAGCAGATGC
CGCTCGACGCCGAACACCAGTGGCAGCGCGGCCGCTCACTCGAGGCCGCCGGCATCCTCGCCGCCCTGCGCGCGCACTTC
ACCCTGGTCCCCGACTCCAAACCGCGGGGTTCGGCTCCGGCACAGCTGTGGCGGGTCGACGGCGGGACGGCGACGGTCGG
GGTGATCGCGTCGGTCTCCGAGGCGTTCTGCGCGGCGTGTGACCGCACCCGGCTCACCGCCGACGGTCAGGTGCGTAACT
GTCTGTTCGCCCGCGAGGAGAGCGATCTGCGCCGGCTGCTGCGTGGCGGCGCCGACGACGACGCGATCGAGCAGGCCTGG
CGCGCCGCGATGTGGACGAAGGCTGCAGGTCACGGCATCAACGATCCAGGCTTCGAACAGCCGTCGCGGCCGATGAGTGC
GATCGGGGGCTGA

Upstream 100 bases:

>100_bases
TCGCGCTGGCCAACCTCAAGCTCATCCCGGTCTCGCTGGTGCCGCTCGGCAAAGAGATCGTGCCGGTCGACCCGCCCGTA
CCCGCCATGCGAGCCGCCGC

Downstream 100 bases:

>100_bases
CGTGTCGACCACCACGACGGTGCGCGTCGCGGTCCGGTACTTCGCCGCCGCCCGGGCCGCCGCCGGCACCGAATCAGAGG
ATCTGACCGTCCCCGCGGGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLPGEQLLSADELIRLLRIAVTR
LGITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTNGIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRL
GDVLAGLAAAKEAGLTPVKVNAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHF
TLVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREESDLRRLLRGGADDDAIEQAW
RAAMWTKAAGHGINDPGFEQPSRPMSAIGG

Sequences:

>Translated_350_residues
MTVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLPGEQLLSADELIRLLRIAVTR
LGITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTNGIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRL
GDVLAGLAAAKEAGLTPVKVNAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHF
TLVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREESDLRRLLRGGADDDAIEQAW
RAAMWTKAAGHGINDPGFEQPSRPMSAIGG
>Mature_349_residues
TVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLPGEQLLSADELIRLLRIAVTRL
GITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTNGIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRLG
DVLAGLAAAKEAGLTPVKVNAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHFT
LVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREESDLRRLLRGGADDDAIEQAWR
AAMWTKAAGHGINDPGFEQPSRPMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=336, Percent_Identity=37.202380952381, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI22027536, Length=336, Percent_Identity=37.202380952381, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=34.7432024169184, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=337, Percent_Identity=33.2344213649852, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=339, Percent_Identity=33.9233038348083, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32566331, Length=331, Percent_Identity=32.3262839879154, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574488, Length=334, Percent_Identity=37.7245508982036, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574490, Length=330, Percent_Identity=37.2727272727273, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_MYCSJ (A3Q648)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001073116.1
- ProteinModelPortal:   A3Q648
- SMR:   A3Q648
- STRING:   A3Q648
- EnsemblBacteria:   EBMYCT00000047912
- GeneID:   4880559
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_4860
- eggNOG:   COG2896
- GeneTree:   EBGT00050000014611
- HOGENOM:   HBG529885
- OMA:   RDEMITA
- ProtClustDB:   PRK00164
- BioCyc:   MSP164757:MJLS_4860-MONOMER
- HAMAP:   MF_01225_B
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02666

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 37511; Mature: 37380

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 36-36 BINDING 49-49 BINDING 87-87 BINDING 91-91 BINDING 118-118 BINDING 142-142 BINDING 179-179 BINDING 213-213

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCC
GEQLLSADELIRLLRIAVTRLGITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTN
HHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEECC
GIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRLGDVLAGLAAAKEAGLTPVKV
CCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHF
EEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHE
TLVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREE
EECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCH
SDLRRLLRGGADDDAIEQAWRAAMWTKAAGHGINDPGFEQPSRPMSAIGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TVTPLGVPTISRPAAGMPTTGPLVDTFGRIATDLRVSLTDRCNLRCTYCMPAEGLDWLP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCC
GEQLLSADELIRLLRIAVTRLGITNVRFTGGEPLVVRHLEDVVAATGALRPRPEMAMTTN
HHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEECC
GIGLAKRARALKAAGLDRVNVSLDSVDAAHFARITRRDRLGDVLAGLAAAKEAGLTPVKV
CCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NAVLDPDTGLDDAVSLLRYCLDHGYQLRIIEQMPLDAEHQWQRGRSLEAAGILAALRAHF
EEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHE
TLVPDSKPRGSAPAQLWRVDGGTATVGVIASVSEAFCAACDRTRLTADGQVRNCLFAREE
EECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCH
SDLRRLLRGGADDDAIEQAWRAAMWTKAAGHGINDPGFEQPSRPMSAIGG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA