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The map label for this gene is mntH [H]

Identifier: 119870482

GI number: 119870482

Start: 4684902

End: 4686128

Strand: Direct

Name: mntH [H]

Synonym: Mkms_4453

Alternate gene names: 119870482

Gene position: 4684902-4686128 (Clockwise)

Preceding gene: 119870480

Following gene: 119870483

Centisome position: 81.66

GC content: 69.36

Gene sequence:

>1227_bases
GTGCTGCCGGACACCGACCGTCGGACCAGATCGACGTGGCTGCTCCTGGGCCCGGCGTTCGTCGCCGCGATCGCCTACGT
CGATCCGGGCAACGTCGCGGCCAACGTCAGCGCGGGCGCCCAGTTCGGCTTCCTGCTCGTCTGGGTCATCGTGCTGGCCA
ATGTGATGGCCGGACTGGTGCAGTACCTGTCGGCGAAGCTGGGTCTGGTCACCGGCCGATCGCTGCCCGAATCCGTCGCG
GGCCGCACCCGCACGCCGACCCGCATCGCCTACTGGCTACAGGCCGAATTGGTCGCCATGGCAACGGATCTCGCGGAGGT
GGTGGGCGGCGCGATCGCGCTGTACCTGTTGTTCGACCTGCCGCTGCTGATCGGCGGCGTGATCACGGGCGCGGTGTCGC
TGGCCCTGCTGGCGGTGCAGAACCGCCGCGGTCAACGGCACTTCGAGCGGGTGATCAGCAGTCTGCTGCTGATCATCGCC
ATCGGCTTCCTGACGAGCGTGTTCGTCGAACCGCCGCCCGTCGCCGACGTCGCCGGCGGCCTCATCCCGCTCTTCGAAGG
CACCGACAGCGTCCTGCTGGCGACCGCGATGCTGGGCGCGACCGTGATGCCGCACGCGGTCTACCTGCACTCCGGGCTGG
CCCGCGACCGCCACGGCCACGCCGAACCCGGCGCCCGGCGGCGCCTGCTGCTCAAGGCCACCCGCATCGATGTGGGCCTG
GCGATGCTGATCGCCGGGGCGGTGAACATGTCGATGCTGCTGGTCGCCGCCACCAACCTGCAGGGCATGTCCGATACCGA
CACCCTCGAGGGCGCGCATGCCGCGGTGCAGCAGACGCTCGGCCCGGCCGTCGCACTGTGCTTCGCGATCGGCCTGCTGG
CATCCGGTCTGGCGTCGACGTCGGTGGGCGCCTACGCCGGCGCGATGATCATGGGCGGACTGCTGCGCCGCACCTACCCG
CTGCTGGTGCGCCGCCTCGTCACGCTGGTGCCTGCCCTGGCGATCCTCGCGATCGGCGTGGACCCCACCCGCGCCCTGGT
GCTGTCGCAGGTGGTGCTGTCGTTCGGGATCCCGTTCGCGCTGATCCCGCTCATCCGGCTGACCAGCGATCGGGCCGTGA
TGGGTGACGACGTCAACCACCGCATCACCACCACACTGGGCTGGGTTGTCGCGGGTTTGATTAGTCTTTTGAACGTGGTG
CTCATCTATCTGACCGTGACAGGCTGA

Upstream 100 bases:

>100_bases
GATCATCGGCTTCGGCATCTGAGCCGGTACCCACCTACGCCTGACGGGAGTTTTCGGCTAACCTAACTTTTCTATTCGCT
GCTCCGCAGGAAGGAAAAGG

Downstream 100 bases:

>100_bases
ATGCTGCGCCCTGGTCGACACGCCTACTTCGCGTACGGGTCCAACCTGTGCGTGCAGCAGATGGCGCAGCGCTGCCCCGA
CGCCGCCGACCCGCGTCCGG

Product: Mn2+/Fe2+ transporter

Products: NA

Alternate protein names: BRAMP [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLPDTDRRTRSTWLLLGPAFVAAIAYVDPGNVAANVSAGAQFGFLLVWVIVLANVMAGLVQYLSAKLGLVTGRSLPESVA
GRTRTPTRIAYWLQAELVAMATDLAEVVGGAIALYLLFDLPLLIGGVITGAVSLALLAVQNRRGQRHFERVISSLLLIIA
IGFLTSVFVEPPPVADVAGGLIPLFEGTDSVLLATAMLGATVMPHAVYLHSGLARDRHGHAEPGARRRLLLKATRIDVGL
AMLIAGAVNMSMLLVAATNLQGMSDTDTLEGAHAAVQQTLGPAVALCFAIGLLASGLASTSVGAYAGAMIMGGLLRRTYP
LLVRRLVTLVPALAILAIGVDPTRALVLSQVVLSFGIPFALIPLIRLTSDRAVMGDDVNHRITTTLGWVVAGLISLLNVV
LIYLTVTG

Sequences:

>Translated_408_residues
MLPDTDRRTRSTWLLLGPAFVAAIAYVDPGNVAANVSAGAQFGFLLVWVIVLANVMAGLVQYLSAKLGLVTGRSLPESVA
GRTRTPTRIAYWLQAELVAMATDLAEVVGGAIALYLLFDLPLLIGGVITGAVSLALLAVQNRRGQRHFERVISSLLLIIA
IGFLTSVFVEPPPVADVAGGLIPLFEGTDSVLLATAMLGATVMPHAVYLHSGLARDRHGHAEPGARRRLLLKATRIDVGL
AMLIAGAVNMSMLLVAATNLQGMSDTDTLEGAHAAVQQTLGPAVALCFAIGLLASGLASTSVGAYAGAMIMGGLLRRTYP
LLVRRLVTLVPALAILAIGVDPTRALVLSQVVLSFGIPFALIPLIRLTSDRAVMGDDVNHRITTTLGWVVAGLISLLNVV
LIYLTVTG
>Mature_408_residues
MLPDTDRRTRSTWLLLGPAFVAAIAYVDPGNVAANVSAGAQFGFLLVWVIVLANVMAGLVQYLSAKLGLVTGRSLPESVA
GRTRTPTRIAYWLQAELVAMATDLAEVVGGAIALYLLFDLPLLIGGVITGAVSLALLAVQNRRGQRHFERVISSLLLIIA
IGFLTSVFVEPPPVADVAGGLIPLFEGTDSVLLATAMLGATVMPHAVYLHSGLARDRHGHAEPGARRRLLLKATRIDVGL
AMLIAGAVNMSMLLVAATNLQGMSDTDTLEGAHAAVQQTLGPAVALCFAIGLLASGLASTSVGAYAGAMIMGGLLRRTYP
LLVRRLVTLVPALAILAIGVDPTRALVLSQVVLSFGIPFALIPLIRLTSDRAVMGDDVNHRITTTLGWVVAGLISLLNVV
LIYLTVTG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI295293167, Length=430, Percent_Identity=31.6279069767442, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI295293178, Length=441, Percent_Identity=31.0657596371882, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI295293175, Length=447, Percent_Identity=30.6487695749441, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI295293173, Length=447, Percent_Identity=30.6487695749441, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI10835169, Length=447, Percent_Identity=30.6487695749441, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI295293171, Length=436, Percent_Identity=31.1926605504587, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI295293169, Length=436, Percent_Identity=31.1926605504587, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI109255241, Length=445, Percent_Identity=30.7865168539326, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788736, Length=397, Percent_Identity=45.3400503778337, Blast_Score=320, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17569473, Length=398, Percent_Identity=30.9045226130653, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71999499, Length=444, Percent_Identity=28.8288288288288, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193210616, Length=441, Percent_Identity=28.7981859410431, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71993856, Length=212, Percent_Identity=34.9056603773585, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323062, Length=392, Percent_Identity=34.1836734693878, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6321841, Length=408, Percent_Identity=32.3529411764706, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324450, Length=419, Percent_Identity=29.8329355608592, Blast_Score=142, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24648607, Length=431, Percent_Identity=29.4663573085847, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281362176, Length=431, Percent_Identity=29.4663573085847, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24648609, Length=431, Percent_Identity=29.4663573085847, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45553443, Length=431, Percent_Identity=29.4663573085847, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005025
- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF03358 FMN_red; PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 42709; Mature: 42709

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDTDRRTRSTWLLLGPAFVAAIAYVDPGNVAANVSAGAQFGFLLVWVIVLANVMAGLV
CCCCCCCCCCCCEEEECHHHHHHHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
QYLSAKLGLVTGRSLPESVAGRTRTPTRIAYWLQAELVAMATDLAEVVGGAIALYLLFDL
HHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLIGGVITGAVSLALLAVQNRRGQRHFERVISSLLLIIAIGFLTSVFVEPPPVADVAGG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LIPLFEGTDSVLLATAMLGATVMPHAVYLHSGLARDRHGHAEPGARRRLLLKATRIDVGL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AMLIAGAVNMSMLLVAATNLQGMSDTDTLEGAHAAVQQTLGPAVALCFAIGLLASGLAST
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGAYAGAMIMGGLLRRTYPLLVRRLVTLVPALAILAIGVDPTRALVLSQVVLSFGIPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
LIPLIRLTSDRAVMGDDVNHRITTTLGWVVAGLISLLNVVLIYLTVTG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MLPDTDRRTRSTWLLLGPAFVAAIAYVDPGNVAANVSAGAQFGFLLVWVIVLANVMAGLV
CCCCCCCCCCCCEEEECHHHHHHHHEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
QYLSAKLGLVTGRSLPESVAGRTRTPTRIAYWLQAELVAMATDLAEVVGGAIALYLLFDL
HHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLIGGVITGAVSLALLAVQNRRGQRHFERVISSLLLIIAIGFLTSVFVEPPPVADVAGG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
LIPLFEGTDSVLLATAMLGATVMPHAVYLHSGLARDRHGHAEPGARRRLLLKATRIDVGL
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AMLIAGAVNMSMLLVAATNLQGMSDTDTLEGAHAAVQQTLGPAVALCFAIGLLASGLAST
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SVGAYAGAMIMGGLLRRTYPLLVRRLVTLVPALAILAIGVDPTRALVLSQVVLSFGIPFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHH
LIPLIRLTSDRAVMGDDVNHRITTTLGWVVAGLISLLNVVLIYLTVTG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972; 9632246 [H]