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The map label for this gene is pth

Identifier: 119870369

GI number: 119870369

Start: 4558620

End: 4559198

Strand: Direct

Name: pth

Synonym: Mkms_4340

Alternate gene names: 119870369

Gene position: 4558620-4559198 (Clockwise)

Preceding gene: 119870368

Following gene: 119870370

Centisome position: 79.46

GC content: 68.57

Gene sequence:

>579_bases
ATGGCCGAGCCGTTGCTGGTGGTGGGCCTGGGCAACCCCGGGCCCAACTACGCCAAAACCCGCCACAACGTCGGCTTCGT
CGTCGCGGATCTGCTGGCCGGGCGGATCGGTTCGGGATTCAAGGCGCACCGGAAGTCCGGCGCCGACATCGCGACCGGTC
GCCTGGCGGGCAGAGCCGTCGTGCTGGCCAAGCCACGCACGTACATGAACGAGTCGGGCCGCAACGTCGGGCCGCTGGCG
AAGTTCTACTCCGTGGCGCCCGCCGACGTGATCGTCATCCACGACGAACTCGACATCGACTTCGGCCGCATCCGTCTGAA
GTTCGGCGGCGGCGTCGCGGGCCACAACGGCCTCAAGTCGGTGGCGGCGGCGTTGGGCACCAAGGATTTCCAGCGCGTCC
GGGTCGGGGTCGGTCGCCCGCCCGGGCGTAAGGACGCGGCGACGTACGTGCTGGAACCGTTCACGTCCGTTGAACGCCCC
GAGGTGCCGACCATCTGTGAACAGGCCGCCGACGCCACCGAACTGCTGATCGCCCAGGGTTTGGAGCCGGCTCAGAATCT
CGTTCACGCCTGGGCGTGA

Upstream 100 bases:

>100_bases
CGGCGGCGCGTCGCTCGAGGAGCAGGCCGCCGAGGTCGCCGAAGCCGAGGCCTCGGAGGAGGCTGCCGAGGCCGGCGAGG
AATCGGCCGAGTAAGTCGAC

Downstream 100 bases:

>100_bases
CTCCCCCGCTTCCCCGCGCGAGCAGACACAGAATCGCCCAAATCCTGGTGGATTCGGGCGATTCTGTGTCTGGTGGCGAA
AGGTGGTGGGCATGCTGTTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MAEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAVVLAKPRTYMNESGRNVGPLA
KFYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKSVAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERP
EVPTICEQAADATELLIAQGLEPAQNLVHAWA

Sequences:

>Translated_192_residues
MAEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAVVLAKPRTYMNESGRNVGPLA
KFYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKSVAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERP
EVPTICEQAADATELLIAQGLEPAQNLVHAWA
>Mature_191_residues
AEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAVVLAKPRTYMNESGRNVGPLAK
FYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKSVAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERPE
VPTICEQAADATELLIAQGLEPAQNLVHAWA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=38.0952380952381, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=38.5026737967914, Blast_Score=113, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321983, Length=184, Percent_Identity=32.6086956521739, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_MYCSJ (A3Q5H1)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001072889.1
- ProteinModelPortal:   A3Q5H1
- SMR:   A3Q5H1
- STRING:   A3Q5H1
- EnsemblBacteria:   EBMYCT00000050102
- GeneID:   4880332
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_4633
- eggNOG:   COG0193
- GeneTree:   EBGT00050000017462
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A3Q5H1
- ProtClustDB:   PRK05426
- BioCyc:   MSP164757:MJLS_4633-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20257; Mature: 20125

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAV
CCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCEE
VLAKPRTYMNESGRNVGPLAKFYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKS
EEECCHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHHH
VAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERPEVPTICEQAADATELLIAQG
HHHHHCCHHHHHHHHCCCCCCCCCCHHHHEECCCCCCCCCCCCHHHHHHCCHHHHHHHCC
LEPAQNLVHAWA
CCHHHHHHHHCC
>Mature Secondary Structure 
AEPLLVVGLGNPGPNYAKTRHNVGFVVADLLAGRIGSGFKAHRKSGADIATGRLAGRAV
CCCEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCEE
VLAKPRTYMNESGRNVGPLAKFYSVAPADVIVIHDELDIDFGRIRLKFGGGVAGHNGLKS
EEECCHHHHCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHHH
VAAALGTKDFQRVRVGVGRPPGRKDAATYVLEPFTSVERPEVPTICEQAADATELLIAQG
HHHHHCCHHHHHHHHCCCCCCCCCCHHHHEECCCCCCCCCCCCHHHHHHCCHHHHHHHCC
LEPAQNLVHAWA
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA