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The map label for this gene is mmgC [H]

Identifier: 119870252

GI number: 119870252

Start: 4448215

End: 4449384

Strand: Direct

Name: mmgC [H]

Synonym: Mkms_4222

Alternate gene names: 119870252

Gene position: 4448215-4449384 (Clockwise)

Preceding gene: 119870250

Following gene: 119870256

Centisome position: 77.53

GC content: 68.97

Gene sequence:

>1170_bases
ATGACGGTACGTATCGACGATCTGCTGGACACCGACGCCATGCTCGCCCCCGAGGAACGCGAGCTGCGTCAGACCGTGCG
CCGCTTCGGTGAGCAGCGCCTGCGCCCCCACGTCGGCGAGTGGTTCGAGGCCGGTGAGGTGCCGGTGCGCGAGCTGGCCT
CCGAGTTCGGCAAGCTCGGTCTGCTCGGCATGCACCTCGAGGGGTACGGCTGCGGTGGGTCGACGGCCACGGCCTACGGG
TTGGTGTGCCAGGAACTCGAGGCCGTCGACAGCGGGCTGCGCAGCATGGTCTCGGTGCAGGGTTCGCTGGCGATGTTCGC
GATCCACAAACACGGAAGCGAGGAGCAGCGCAAGCAGTGGCTGCCCGCGATGGCCACCGGCGACGTGATCGGTTGCTTCG
GCCTCACCGAACCCGATTTCGGATCGAATCCCGCGGGGATGCGCACCACCGCGCGCCGCGACGGATCCGACTGGATCCTC
AACGGGTCGAAGATGTGGATCACCAACGGTTCGGTCGCCGACGTCGCGGTGGTCTGGGCGCGAGCCGAGGAGGGCATCCT
GGGGTTCGTCGTCCCCGCCGGCACCGAGGGCTTCTCGGGGCGGGAGATGAAGCACAAACTGTCCCTGCGGGCGTCGAACA
CCTCGGAACTGCACCTCGACGACGTCCGGCTGCCCGCCGAGGCCCAGCTCCCCGACGCGCGCGGGCTGTCCGGCCCGTTG
GCGTGTCTGTCGGAGGCGCGGTTCGGCATCGTGTTCGGCAGCGTGGGCGCGGCCCGGGACTGTCTGGAGACGACGCTGGA
CTACGTCGGCAGCCGCGAGGTGTTCGACAAACCGCTGGCGGCCTACCAGCTGACCCAGGCCAAGATCGCCGACATGGCCG
TCGAACTGGGTAAGGCGCAACTGCTCGCGCTGCACCTGGGCCGGCTCAAGGACGAGGGGCGGATCCGTCCCGACCAGGTC
AGCTTCGGCAAGCTCAACAACGTCCGCGAGGCGCTGGCGATCGCACGCCAGTGCCGCACCCTGCTGGGCGCCAACGGGAT
CACGCTCGAGTATCCGGTGCTGCGCCACGCCAACAACCTGGAGTCGGTGCTGACCTACGAGGGCACCTCGGAGGTGCACC
AGATGGTCATCGGGGAGGCGCTGACCGGGGTCAGCGCCTTCCGCGGATGA

Upstream 100 bases:

>100_bases
TGGCGAGTCCAGTGGCGAGTCCGTGGGCGGGTCCGTGGGCGCTGCGCTGTTCAGTCATAACACCGTCGAGCCTATCGAAG
CGCCGTGTAGACATGGGTTC

Downstream 100 bases:

>100_bases
CGTGGGCTACTGCTTGGGTGCGACCTGACCGCCGGTGAGGACGCGGTAGGTGTAGACGAGGATCAGCGTGGCGACGGGGG
CGGCCACCAGTAGGCCGACA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTVRIDDLLDTDAMLAPEERELRQTVRRFGEQRLRPHVGEWFEAGEVPVRELASEFGKLGLLGMHLEGYGCGGSTATAYG
LVCQELEAVDSGLRSMVSVQGSLAMFAIHKHGSEEQRKQWLPAMATGDVIGCFGLTEPDFGSNPAGMRTTARRDGSDWIL
NGSKMWITNGSVADVAVVWARAEEGILGFVVPAGTEGFSGREMKHKLSLRASNTSELHLDDVRLPAEAQLPDARGLSGPL
ACLSEARFGIVFGSVGAARDCLETTLDYVGSREVFDKPLAAYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPDQV
SFGKLNNVREALAIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQMVIGEALTGVSAFRG

Sequences:

>Translated_389_residues
MTVRIDDLLDTDAMLAPEERELRQTVRRFGEQRLRPHVGEWFEAGEVPVRELASEFGKLGLLGMHLEGYGCGGSTATAYG
LVCQELEAVDSGLRSMVSVQGSLAMFAIHKHGSEEQRKQWLPAMATGDVIGCFGLTEPDFGSNPAGMRTTARRDGSDWIL
NGSKMWITNGSVADVAVVWARAEEGILGFVVPAGTEGFSGREMKHKLSLRASNTSELHLDDVRLPAEAQLPDARGLSGPL
ACLSEARFGIVFGSVGAARDCLETTLDYVGSREVFDKPLAAYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPDQV
SFGKLNNVREALAIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQMVIGEALTGVSAFRG
>Mature_388_residues
TVRIDDLLDTDAMLAPEERELRQTVRRFGEQRLRPHVGEWFEAGEVPVRELASEFGKLGLLGMHLEGYGCGGSTATAYGL
VCQELEAVDSGLRSMVSVQGSLAMFAIHKHGSEEQRKQWLPAMATGDVIGCFGLTEPDFGSNPAGMRTTARRDGSDWILN
GSKMWITNGSVADVAVVWARAEEGILGFVVPAGTEGFSGREMKHKLSLRASNTSELHLDDVRLPAEAQLPDARGLSGPLA
CLSEARFGIVFGSVGAARDCLETTLDYVGSREVFDKPLAAYQLTQAKIADMAVELGKAQLLALHLGRLKDEGRIRPDQVS
FGKLNNVREALAIARQCRTLLGANGITLEYPVLRHANNLESVLTYEGTSEVHQMVIGEALTGVSAFRG

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=47.9166666666667, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=48.0769230769231, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI4557233, Length=370, Percent_Identity=34.8648648648649, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=33.1578947368421, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI226958412, Length=388, Percent_Identity=30.4123711340206, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=29.6495956873315, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=30.1169590643275, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4557231, Length=371, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI187960098, Length=371, Percent_Identity=28.5714285714286, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21361497, Length=400, Percent_Identity=30, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI7656849, Length=384, Percent_Identity=26.3020833333333, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI76496475, Length=391, Percent_Identity=26.8542199488491, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=27.3458445040214, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI38505218, Length=293, Percent_Identity=25.5972696245734, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI48976061, Length=404, Percent_Identity=24.009900990099, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI211971008, Length=404, Percent_Identity=24.009900990099, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786223, Length=278, Percent_Identity=24.1007194244604, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081958, Length=283, Percent_Identity=24.3816254416961, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534353, Length=386, Percent_Identity=44.559585492228, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=33.0645161290323, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=30.6666666666667, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=29.7082228116711, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=29.6587926509186, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=35.2490421455939, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=29.5514511873351, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=359, Percent_Identity=28.6908077994429, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=24.8677248677249, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=26.6490765171504, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=287, Percent_Identity=29.616724738676, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=33.0434782608696, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=28.494623655914, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=365, Percent_Identity=26.3013698630137, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=29.1044776119403, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=292, Percent_Identity=23.2876712328767, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=47.4093264248705, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=30.2702702702703, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=29.973474801061, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=31.3829787234043, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=29.1666666666667, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=28.042328042328, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=27.2988505747126, Blast_Score=138, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42110; Mature: 41979

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRIDDLLDTDAMLAPEERELRQTVRRFGEQRLRPHVGEWFEAGEVPVRELASEFGKLG
CEEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCC
LLGMHLEGYGCGGSTATAYGLVCQELEAVDSGLRSMVSVQGSLAMFAIHKHGSEEQRKQW
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHC
LPAMATGDVIGCFGLTEPDFGSNPAGMRTTARRDGSDWILNGSKMWITNGSVADVAVVWA
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHEEEE
RAEEGILGFVVPAGTEGFSGREMKHKLSLRASNTSELHLDDVRLPAEAQLPDARGLSGPL
ECCCCCEEEEEECCCCCCCCCHHHHHEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHH
ACLSEARFGIVFGSVGAARDCLETTLDYVGSREVFDKPLAAYQLTQAKIADMAVELGKAQ
HHHHCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LLALHLGRLKDEGRIRPDQVSFGKLNNVREALAIARQCRTLLGANGITLEYPVLRHANNL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCCCCH
ESVLTYEGTSEVHQMVIGEALTGVSAFRG
HHHEEECCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVRIDDLLDTDAMLAPEERELRQTVRRFGEQRLRPHVGEWFEAGEVPVRELASEFGKLG
EEEECCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHCCCC
LLGMHLEGYGCGGSTATAYGLVCQELEAVDSGLRSMVSVQGSLAMFAIHKHGSEEQRKQW
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHC
LPAMATGDVIGCFGLTEPDFGSNPAGMRTTARRDGSDWILNGSKMWITNGSVADVAVVWA
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCHHHHHEEEE
RAEEGILGFVVPAGTEGFSGREMKHKLSLRASNTSELHLDDVRLPAEAQLPDARGLSGPL
ECCCCCEEEEEECCCCCCCCCHHHHHEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCHH
ACLSEARFGIVFGSVGAARDCLETTLDYVGSREVFDKPLAAYQLTQAKIADMAVELGKAQ
HHHHCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LLALHLGRLKDEGRIRPDQVSFGKLNNVREALAIARQCRTLLGANGITLEYPVLRHANNL
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCCCCH
ESVLTYEGTSEVHQMVIGEALTGVSAFRG
HHHEEECCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]