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The map label for this gene is lytS [H]

Identifier: 119870155

GI number: 119870155

Start: 4356572

End: 4357783

Strand: Direct

Name: lytS [H]

Synonym: Mkms_4125

Alternate gene names: 119870155

Gene position: 4356572-4357783 (Clockwise)

Preceding gene: 119870152

Following gene: 119870156

Centisome position: 75.94

GC content: 72.61

Gene sequence:

>1212_bases
ATGTCCGGCGAGCTCGCGATAGTCCTGGCGGCGGTGCTGATCGTGACAGCCGTGGCCGCCGCGGTCGTCGTGCGCACCCG
CCGGGTGGTGGCGACCCCCACCGAACGCGCCGTCCACGCCGCGCTGCACACCGCATCGCTGGCCGCGCGCGCGTTGCGCC
AGGGTCTCGACACCACCTCGGCCGAATCGGCGGCGCCGTTCCTGCGCGAGCTCACCGGCACCGACGGGATCGCGCTGTTC
GACGGCGAAGGCCGGCTGCTCGCCCGCGAACCGGAGGACGACGCGATCTGGACGTCCGACGTGGTCGACGACGCGGCACG
CACCGTCCGCGAGTCGATCGCCGGGGAGCGCCGCGTGCTCACGTCCGTGCGCGCGGCCACGGTCATCGCCCAACCCCTGC
TGACCGATGCCGGGGACCTACTCGGGGTGCTCGCCGTCGTCACCACCCGCGATCCGGGGCCGGGCATGCTCGGCGCGGTC
GGCGAGGTCGCGCGCTACGCCGCAGGCCAACTCGAACTCGCCGAACTCGACGCCTCCCGCGCCCGCCTGGACCGGGCCGA
AGTGCTCGCCCTGCGCGCGCAGATCAGCCCGCACTTCATCTACAACGCGCTCAACACCATCGCCTCGTTCGTGCGCACCG
ATCCCGACCGGGCCCGCGAACTCATCCTGGAGTTCGCCGATTTCACCCGCTATTCGTTCCGCGCCGCCGGGCAGTACACG
ACCCTGGCCGAGGAGTTGCGCAACATCGACCGCTACCTGACGCTCGAGCGAGCCCGTTTCGGGACGTCGCTGGACGTACG
CCTGCAGGTGGCCCCCGAGGTGCTCGGGGTCGTGGTGCCGTTCCTGGCGCTGCAACCGCTCGTCGAGAACGCCGTGCGGC
ACGGGCTGGCCGGGCGCGGCGGCGGGTCCATCGAGATCATCGCCCGCGACGAGGGTTCCGACTGCGTCATCACCGTCGAG
GACGACGGTGTCGGGATGGACCCCGCCGCCCTGCGCACCGGGCCGGGTGACGCGCTGGGCGGTGACGGCTCCCCCGCCCC
CGGCGACGGCGCGCACGTCGGCCTGACGAATGTCGACCATCGCCTGCGCGCGGCGTTCGGCAACGATTACGGTCTGGTGG
TCGAGACGGCGATCGGGGCGGGCACGAAGGTCATCATGCGGGTACCCAAGTTCCGGTCCGGCGTGCGGGCCGGCGGAGGT
GCATACGGGTGA

Upstream 100 bases:

>100_bases
GGCCGCCGGATCCTGGACAAGCTGCAGTTTCGCCACCCCGCCAGTTTAAGGTGGCCGAAAACCCGTGAGGTGACGCGGAC
GCGAGGAGCACCTACAGCAG

Downstream 100 bases:

>100_bases
ACAGGTCCGGCCTGACCGTGCTCGCCGTCGACGACGAGATGCCCGCACTCGACGAGCTGGCGTACCTGCTGGGCCGCCAT
CCCGACATCGGCGAGGTGCT

Product: signal transduction histidine kinase, LytS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSGELAIVLAAVLIVTAVAAAVVVRTRRVVATPTERAVHAALHTASLAARALRQGLDTTSAESAAPFLRELTGTDGIALF
DGEGRLLAREPEDDAIWTSDVVDDAARTVRESIAGERRVLTSVRAATVIAQPLLTDAGDLLGVLAVVTTRDPGPGMLGAV
GEVARYAAGQLELAELDASRARLDRAEVLALRAQISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYT
TLAEELRNIDRYLTLERARFGTSLDVRLQVAPEVLGVVVPFLALQPLVENAVRHGLAGRGGGSIEIIARDEGSDCVITVE
DDGVGMDPAALRTGPGDALGGDGSPAPGDGAHVGLTNVDHRLRAAFGNDYGLVVETAIGAGTKVIMRVPKFRSGVRAGGG
AYG

Sequences:

>Translated_403_residues
MSGELAIVLAAVLIVTAVAAAVVVRTRRVVATPTERAVHAALHTASLAARALRQGLDTTSAESAAPFLRELTGTDGIALF
DGEGRLLAREPEDDAIWTSDVVDDAARTVRESIAGERRVLTSVRAATVIAQPLLTDAGDLLGVLAVVTTRDPGPGMLGAV
GEVARYAAGQLELAELDASRARLDRAEVLALRAQISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYT
TLAEELRNIDRYLTLERARFGTSLDVRLQVAPEVLGVVVPFLALQPLVENAVRHGLAGRGGGSIEIIARDEGSDCVITVE
DDGVGMDPAALRTGPGDALGGDGSPAPGDGAHVGLTNVDHRLRAAFGNDYGLVVETAIGAGTKVIMRVPKFRSGVRAGGG
AYG
>Mature_402_residues
SGELAIVLAAVLIVTAVAAAVVVRTRRVVATPTERAVHAALHTASLAARALRQGLDTTSAESAAPFLRELTGTDGIALFD
GEGRLLAREPEDDAIWTSDVVDDAARTVRESIAGERRVLTSVRAATVIAQPLLTDAGDLLGVLAVVTTRDPGPGMLGAVG
EVARYAAGQLELAELDASRARLDRAEVLALRAQISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYTT
LAEELRNIDRYLTLERARFGTSLDVRLQVAPEVLGVVVPFLALQPLVENAVRHGLAGRGGGSIEIIARDEGSDCVITVED
DGVGMDPAALRTGPGDALGGDGSPAPGDGAHVGLTNVDHRLRAAFGNDYGLVVETAIGAGTKVIMRVPKFRSGVRAGGGA
YG

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=404, Percent_Identity=25.990099009901, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788723, Length=239, Percent_Identity=33.4728033472803, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42286; Mature: 42155

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGELAIVLAAVLIVTAVAAAVVVRTRRVVATPTERAVHAALHTASLAARALRQGLDTTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCCC
AESAAPFLRELTGTDGIALFDGEGRLLAREPEDDAIWTSDVVDDAARTVRESIAGERRVL
CHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCHHHHH
TSVRAATVIAQPLLTDAGDLLGVLAVVTTRDPGPGMLGAVGEVARYAAGQLELAELDASR
HHHHHHHHHHHHHHHCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCEEHHHHCHHH
ARLDRAEVLALRAQISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHH
TLAEELRNIDRYLTLERARFGTSLDVRLQVAPEVLGVVVPFLALQPLVENAVRHGLAGRG
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGSIEIIARDEGSDCVITVEDDGVGMDPAALRTGPGDALGGDGSPAPGDGAHVGLTNVDH
CCEEEEEEECCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHH
RLRAAFGNDYGLVVETAIGAGTKVIMRVPKFRSGVRAGGGAYG
HHHHHHCCCCCEEEEECCCCCCCEEHCCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SGELAIVLAAVLIVTAVAAAVVVRTRRVVATPTERAVHAALHTASLAARALRQGLDTTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCCC
AESAAPFLRELTGTDGIALFDGEGRLLAREPEDDAIWTSDVVDDAARTVRESIAGERRVL
CHHHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCHHHHH
TSVRAATVIAQPLLTDAGDLLGVLAVVTTRDPGPGMLGAVGEVARYAAGQLELAELDASR
HHHHHHHHHHHHHHHCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCEEHHHHCHHH
ARLDRAEVLALRAQISPHFIYNALNTIASFVRTDPDRARELILEFADFTRYSFRAAGQYT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHH
TLAEELRNIDRYLTLERARFGTSLDVRLQVAPEVLGVVVPFLALQPLVENAVRHGLAGRG
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGSIEIIARDEGSDCVITVEDDGVGMDPAALRTGPGDALGGDGSPAPGDGAHVGLTNVDH
CCEEEEEEECCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHH
RLRAAFGNDYGLVVETAIGAGTKVIMRVPKFRSGVRAGGGAYG
HHHHHHCCCCCEEEEECCCCCCCEEHCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]