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The map label for this gene is corA [H]

Identifier: 119870082

GI number: 119870082

Start: 4278956

End: 4280017

Strand: Direct

Name: corA [H]

Synonym: Mkms_4052

Alternate gene names: 119870082

Gene position: 4278956-4280017 (Clockwise)

Preceding gene: 119870079

Following gene: 119870089

Centisome position: 74.58

GC content: 66.1

Gene sequence:

>1062_bases
GTGGCCGGGCCGGACGCGTACCATTTCCGGATGCCGTCCTTCCACGTCCCGGTGGCCCGGGCGGTCGTGGACTGCGCCGT
GTACTGCGACGGGGAGCGCGTGGCCGGCAGGTTCACCCACGCGTCGGCGCTGCAGCAGGCCCGCGAGTTGGGCAACGAGG
GGCGCGCGGCGTTCGTGTGGATCGGGTTGCACGAACCCGACGATCACCAGATGCAGACCGTCGCCGAGGTGTTCGGCCTG
CACGAACTCGCGGTCGAAGACGCGGTGCACGCCCATCAGCGGCCCAAGGTCGAACGCTACGACGACACCCTGTTCCTGGT
GCTCAAGACGGTGAAGTACGTCGAACACGAGTCGATGGCCAAGGCGCGCGAGATCGTCGAGACCGGCGAGATCATGGTGT
TCGTCGGATCCGACTTCGTCGTCACGGTCCGCCACGGTGACCACAGCGGGCTGACCGGCGTGCGCAGACGCCTCGAAGCA
TCCCCCGCGGCCCTCGCCCTCGGCCCGTACGCGGTCATGCACGCGATCGCCGACCAGGTGGTGGACAGCTACCTCGAGGT
CACCGAGATGGTGGAGACCGACATCGACGCGATCGAGGAGGACATCTTCTCCCCGCGGTCGCGCACGAACATCGAGAACA
TCTACCTGCTCAAGCGCGAGGTGGTGGAACTTCGCCGTTCGGTCTCACCCCTGACGCCGGCGCTGCAGCGGATCAGCGAC
TACGACGACCTCATCTCCATCGAGATCCGCCGGTACATGTCCGATGTCCTCGACCACAACATCCGCGCCTCCGACCGCAT
CAGCAGCTACGACGACCTGCTCAGTTCGCTGGTGCAGGCCGCGCTGGGCAAGGTGGCGATGCAGCAGAACGTCGACATCC
GCAAGATCTCGGCATGGGTGGCGATCGCCGCGGTGCCGACCGCACTGGCTGGCATCTACGGGATGAACTTCGACCACATG
CCCGAATTGCATTCGCCGTGGGGCTATCCCGCGGTCCTGCTGGTGATGTTGACCATCTGTTCGCTGCTCTACCGCACCCT
GCGCCGCAACCACTGGCTCTAG

Upstream 100 bases:

>100_bases
TGATGACGACCTGTGAGGAACCAACAACAGTTTCAGCCACGAGTGAACACTATCGGACCCCGCGTTCTCACCGACCGGGC
TCACCCCTCGGTGAGGTCCG

Downstream 100 bases:

>100_bases
GAGGGGCTGGCGGCCCTTCGGTGGGGATCCAGCACGTCGACACCGTCGGCCGTCCACGCCTCGCGCATCGCGTCGGCGCC
CTTGAGGCGCACCCACGCCG

Product: magnesium and cobalt transport protein CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MAGPDAYHFRMPSFHVPVARAVVDCAVYCDGERVAGRFTHASALQQARELGNEGRAAFVWIGLHEPDDHQMQTVAEVFGL
HELAVEDAVHAHQRPKVERYDDTLFLVLKTVKYVEHESMAKAREIVETGEIMVFVGSDFVVTVRHGDHSGLTGVRRRLEA
SPAALALGPYAVMHAIADQVVDSYLEVTEMVETDIDAIEEDIFSPRSRTNIENIYLLKREVVELRRSVSPLTPALQRISD
YDDLISIEIRRYMSDVLDHNIRASDRISSYDDLLSSLVQAALGKVAMQQNVDIRKISAWVAIAAVPTALAGIYGMNFDHM
PELHSPWGYPAVLLVMLTICSLLYRTLRRNHWL

Sequences:

>Translated_353_residues
MAGPDAYHFRMPSFHVPVARAVVDCAVYCDGERVAGRFTHASALQQARELGNEGRAAFVWIGLHEPDDHQMQTVAEVFGL
HELAVEDAVHAHQRPKVERYDDTLFLVLKTVKYVEHESMAKAREIVETGEIMVFVGSDFVVTVRHGDHSGLTGVRRRLEA
SPAALALGPYAVMHAIADQVVDSYLEVTEMVETDIDAIEEDIFSPRSRTNIENIYLLKREVVELRRSVSPLTPALQRISD
YDDLISIEIRRYMSDVLDHNIRASDRISSYDDLLSSLVQAALGKVAMQQNVDIRKISAWVAIAAVPTALAGIYGMNFDHM
PELHSPWGYPAVLLVMLTICSLLYRTLRRNHWL
>Mature_352_residues
AGPDAYHFRMPSFHVPVARAVVDCAVYCDGERVAGRFTHASALQQARELGNEGRAAFVWIGLHEPDDHQMQTVAEVFGLH
ELAVEDAVHAHQRPKVERYDDTLFLVLKTVKYVEHESMAKAREIVETGEIMVFVGSDFVVTVRHGDHSGLTGVRRRLEAS
PAALALGPYAVMHAIADQVVDSYLEVTEMVETDIDAIEEDIFSPRSRTNIENIYLLKREVVELRRSVSPLTPALQRISDY
DDLISIEIRRYMSDVLDHNIRASDRISSYDDLLSSLVQAALGKVAMQQNVDIRKISAWVAIAAVPTALAGIYGMNFDHMP
ELHSPWGYPAVLLVMLTICSLLYRTLRRNHWL

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=106, Percent_Identity=33.0188679245283, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324442, Length=192, Percent_Identity=26.0416666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 39660; Mature: 39529

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPDAYHFRMPSFHVPVARAVVDCAVYCDGERVAGRFTHASALQQARELGNEGRAAFVW
CCCCCCEEEECCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
IGLHEPDDHQMQTVAEVFGLHELAVEDAVHAHQRPKVERYDDTLFLVLKTVKYVEHESMA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHH
KAREIVETGEIMVFVGSDFVVTVRHGDHSGLTGVRRRLEASPAALALGPYAVMHAIADQV
HHHHHHHCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VDSYLEVTEMVETDIDAIEEDIFSPRSRTNIENIYLLKREVVELRRSVSPLTPALQRISD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
YDDLISIEIRRYMSDVLDHNIRASDRISSYDDLLSSLVQAALGKVAMQQNVDIRKISAWV
HHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AIAAVPTALAGIYGMNFDHMPELHSPWGYPAVLLVMLTICSLLYRTLRRNHWL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AGPDAYHFRMPSFHVPVARAVVDCAVYCDGERVAGRFTHASALQQARELGNEGRAAFVW
CCCCCEEEECCCCCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
IGLHEPDDHQMQTVAEVFGLHELAVEDAVHAHQRPKVERYDDTLFLVLKTVKYVEHESMA
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHH
KAREIVETGEIMVFVGSDFVVTVRHGDHSGLTGVRRRLEASPAALALGPYAVMHAIADQV
HHHHHHHCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VDSYLEVTEMVETDIDAIEEDIFSPRSRTNIENIYLLKREVVELRRSVSPLTPALQRISD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
YDDLISIEIRRYMSDVLDHNIRASDRISSYDDLLSSLVQAALGKVAMQQNVDIRKISAWV
HHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AIAAVPTALAGIYGMNFDHMPELHSPWGYPAVLLVMLTICSLLYRTLRRNHWL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]