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The map label for this gene is 119869972

Identifier: 119869972

GI number: 119869972

Start: 4148991

End: 4150613

Strand: Direct

Name: 119869972

Synonym: Mkms_3942

Alternate gene names: NA

Gene position: 4148991-4150613 (Clockwise)

Preceding gene: 119869969

Following gene: 119869974

Centisome position: 72.32

GC content: 68.33

Gene sequence:

>1623_bases
ATGGACGCCACGACGACCGCCAAGAAAAGCGTTCCACAACGCCTGGGCCTGCTCCTGGAGAAGGTGACCAGGCAGAGCGG
GCGGCTGCCGGACACCCCGCATTACGGCTCGTGGCTGCTGGGCAAGCCGGAGGAGAACCAGCAGCGCCGGCGCATCCGCA
TCCAGATCATCCTGACCTTCTTGATCCTCGTCACGAACATCCTGGGCATCGGGGTGTCGTTGCTGCTCAACGCCGTCGCC
ATCCCGGTGCCGAGCGTCTTCTCCGACGCGCCGGCCTGGCTGACCTGGGGTGTGGTCCCCGCGTACATGCTGGTCGCGCT
GCTGTTCGGCACGGCGTGGATCACCTCGCACATCGTCCGATCGTTGCGATGGGCGATCGAGGAGCGCACGCCCACCCGCG
CCGACCAGTACAACGTGTTCCGGGCGCCGTGGCAGGTGGCGCGGATGCTGCTGCTCTTCTGGGGGGTCGGTACCGCGCTC
CTGACGCTGCTGTACGGCCTGCAGGATTCGGCGTTCATCCCCCGGTTCTTGTTCGCGGTGGGCTTCCCCGGCATCGTCGT
GGCCACCGCCTGCTACCTCGTCACCGAGTTCGCGCTGCGGCCGATCGCCGCCCAGGCGCTCGAAGCCGGCCGCCCACCAC
GCCGGCTCGCACAGGGGGTCATGGGCCGCACCATGACGGTCTGGCTGCTCAGCTCGGGTGTGCCCGTGCTCGGCATCCTC
CTGCTCGCCGTGTTCTCGCTCTCGATGCAGAATCTGAGCGCCACGCAGTTCGGGATCGCCGTGATGATCATCGCGGTGGT
CGCGCTGCTGTTCGGGTTGATCCTGATGTGGCTGCTGTCGTGGCTCATCGCCACCCCGGTGCGCGTGGTGCGCGCCGCGC
TCAAGAACGTCGAACGGGGCGACTTCGACTGTCAGCTGGTCGTTTTCGACGGCACCGAACTTGGTGAGCTGCAACGGGGT
TTCAACAAGATGGTGGAGGGGCTGCGCGAACGCGAACGGGTGCGCGACCTGTTCGGCCGCCACGTCGGCCGTGAGGTCGC
CCTGGCGGCGGAGAAGGAGCAGATCGAGCTGGGCGGCGAGGAACGCCACGCCGCGGTGATCTTCGTCGACATCATCGGAT
CGACGCAGATGGTCACCAGCAGGCCTGCGTCGGAGATCGTCGAACTGCTCAACCGGTTCTTCGCCGTGATCGTCGACGAG
GTGGACCGCCACCACGGCCTGGTCAACAAGTTCGAAGGCGATGCGGTGCTGGCCGTGTTCGGCGCCCCGGTCGCGCTCGA
CAACGCCGCGGCCGAGGCGCTGGCCGCCGCCCGTGCCATCGCCGAGCGGCTCACCTCCGAGGTGCCCGACTGTGAGGCGG
GGATCGGGGTGGCGGCGGGTCAGGTGGTCGCGGGCAACGTGGGCGCCAAGGAGCGTTTCGAGTACACCGTGATCGGCGAA
CCGGTCAACGAGGCCGCCCGGCTGTGCGAACTCGCGAAATCGGTGCCGAACCGGTTGGTCGCGTCCTCCGACACCGTCAA
GGCCGCGACGGATGCCGAACGCGCGCACTGGACTCTCGGCGACACGGTGACCCTGCGCGGCCACGACGAGCCGACGACGC
TGGCGCTGCTGGCTGACGCCTAG

Upstream 100 bases:

>100_bases
GTCAACCGGCCGACGTAGTCGACCGTGCACTGGGCGATGACGAGACGCACCCGCACAACATTAGGGTCTGCGGACCCGCG
CAAATTAGGCTGGCGGCACA

Downstream 100 bases:

>100_bases
TTCGCGCGCAGCGTTCCGTCGATGTATTCGGTGCGACAGGCCCGTCGGGCCAGCTTGCCGCTGGTTGTCCGCGGGATGGC
GCCGGCGGGGACGAAACGCA

Product: putative adenylate/guanylate cyclase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MDATTTAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTFLILVTNILGIGVSLLLNAVA
IPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVRSLRWAIEERTPTRADQYNVFRAPWQVARMLLLFWGVGTAL
LTLLYGLQDSAFIPRFLFAVGFPGIVVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGIL
LLAVFSLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERGDFDCQLVVFDGTELGELQRG
FNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGEERHAAVIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDE
VDRHHGLVNKFEGDAVLAVFGAPVALDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGE
PVNEAARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLALLADA

Sequences:

>Translated_540_residues
MDATTTAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTFLILVTNILGIGVSLLLNAVA
IPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVRSLRWAIEERTPTRADQYNVFRAPWQVARMLLLFWGVGTAL
LTLLYGLQDSAFIPRFLFAVGFPGIVVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGIL
LLAVFSLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERGDFDCQLVVFDGTELGELQRG
FNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGEERHAAVIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDE
VDRHHGLVNKFEGDAVLAVFGAPVALDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGE
PVNEAARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLALLADA
>Mature_540_residues
MDATTTAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTFLILVTNILGIGVSLLLNAVA
IPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVRSLRWAIEERTPTRADQYNVFRAPWQVARMLLLFWGVGTAL
LTLLYGLQDSAFIPRFLFAVGFPGIVVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGIL
LLAVFSLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERGDFDCQLVVFDGTELGELQRG
FNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGEERHAAVIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDE
VDRHHGLVNKFEGDAVLAVFGAPVALDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGE
PVNEAARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLALLADA

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: 4.6.1.1

Molecular weight: Translated: 58773; Mature: 58773

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATTTAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LILVTNILGIGVSLLLNAVAIPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVR
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLRWAIEERTPTRADQYNVFRAPWQVARMLLLFWGVGTALLTLLYGLQDSAFIPRFLFAV
HHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GFPGIVVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHH
LLAVFSLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFDCQLVVFDGTELGELQRGFNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGE
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
ERHAAVIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDEVDRHHGLVNKFEGDAVLAVF
CCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEE
GAPVALDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECC
PVNEAARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLALLADA
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCEEECCCEEEEECCCCCCEEEEEECC
>Mature Secondary Structure
MDATTTAKKSVPQRLGLLLEKVTRQSGRLPDTPHYGSWLLGKPEENQQRRRIRIQIILTF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LILVTNILGIGVSLLLNAVAIPVPSVFSDAPAWLTWGVVPAYMLVALLFGTAWITSHIVR
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLRWAIEERTPTRADQYNVFRAPWQVARMLLLFWGVGTALLTLLYGLQDSAFIPRFLFAV
HHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GFPGIVVATACYLVTEFALRPIAAQALEAGRPPRRLAQGVMGRTMTVWLLSSGVPVLGIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHH
LLAVFSLSMQNLSATQFGIAVMIIAVVALLFGLILMWLLSWLIATPVRVVRAALKNVERG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFDCQLVVFDGTELGELQRGFNKMVEGLRERERVRDLFGRHVGREVALAAEKEQIELGGE
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
ERHAAVIFVDIIGSTQMVTSRPASEIVELLNRFFAVIVDEVDRHHGLVNKFEGDAVLAVF
CCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEE
GAPVALDNAAAEALAAARAIAERLTSEVPDCEAGIGVAAGQVVAGNVGAKERFEYTVIGE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECC
PVNEAARLCELAKSVPNRLVASSDTVKAATDAERAHWTLGDTVTLRGHDEPTTLALLADA
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHCEEECCCEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]