Click here to switch to the map view.

The map label for this gene is ksdD [H]

Identifier: 119869893

GI number: 119869893

Start: 4078348

End: 4079949

Strand: Direct

Name: ksdD [H]

Synonym: Mkms_3862

Alternate gene names: 119869893

Gene position: 4078348-4079949 (Clockwise)

Preceding gene: 119869892

Following gene: 119869898

Centisome position: 71.09

GC content: 70.97

Gene sequence:

>1602_bases
GTGAGCGCTTGGGACCATGAGACCGATGTCGTCGTGCTGGGCAGCGGCGGCGCCGGACTGGCCGCGGCTCTGACCGCCGC
CGTACACGGCGCCGCGGTCGAGGTGTACGAGAAGGCGCCGACGGTCGGCGGGACCACGGCGGTCTCCGGCGGGATCGTGT
GGATTCCGTCGCACGACAGGGCCGCCGACGAGTTGACCGTCGAGGACGCGCTGGCCTACCTGCGCGCACAGTCACTGGGG
GTGATGGACGACGACCTGGTGGAGACGTTCGTGCGCACCGGGCCGCAGATGCTCGAGTTCGTCGAGGCACACAGCGGCCT
GCGCTTCTCGGTGGCCGAAGGCTTCCCGGACTACAAACCCGAACTGCCGGGCGGACGCCCCGGCGGCGGCCGCTCACTGT
CGGCGGCGCCCTTCGACCTCGCGCGCCTGGGTCCGTGGCGGGACCGGATCACCTCGTTCCCCGCGGATTTCAGCAACGTG
GGAATCGACGCCGAGACCCGCGCCCGCATCCACGCCTCGGTGGACGAGACGCTCGAGGATCCCTGCGTCGCCGGGACGGC
GCTGATCGCCGGCCTGCTCAAGGGTCTGCTCGACGCCGGCGTCACGCCGCAGACCGAATCCCGCGCCGTCGAGTTGATCG
CCGCCGACGGGCGCATCGTGGGCGTGCGAATCCAGCAGCGCGACAGAGAGATCCGCGTACATGCCCGACGCGCGGTCATC
CTCGGCACGGGCGGGTTCGAATGGGACCGCGCACTGGTCGAGGCGTTCCTGCGTGGGCCGATGCGCGGTCCGGTCTCCCC
ACCGAACAACACCGGCGACGGTCTGCGGATGGCGATGGCGCACGGCGCCGATCTGGCCAACATGGGCGAGGCGTGGTGGG
TGCCGATCGTGCAGATCCCCGGCGACACCATCGACGGACACCCCCGCAGTCGCAGCGTCCGGCTGGAGCGCACCCGGCCG
CGCAGCATCATCGTCAACCGGGCCGGTAAGCGGTTCGTCAACGAGGCCGGTGAGTACAACTCGATGGCCGGGGCGTTCCA
GTACCTCGACCCCAAACACGGCTACGTCAACGATCCGGCCTGGATCGTGTTCGACTCGCTGCACCTCAAGAAGTACGGAT
TCCTCGCGGTGGAACCCGATGGCCCCGCCCCGGACTGGTATTCGAAATCGGGCGACCTCGGCGAACTCGGCGAGAAGACC
GGGATCGACGCCGACGGTCTGGCCCGCACGCTGGCCGACTGGAACCATCACGTCGCCGAGGAGCGCGACCCCGACTTCGG
CAGGGGCGCAAGCGCTTACGACGGCTACTGGGGCGACCCGCAGGCGCCCACGCCTGCGTTGCAGACCCTGGGGCCGATCG
ACACGCCGCCGTACTACGCCGTGCCGGTGGGCATCGGTGCGATGGGCACCAAGGGCGGCCCCCGCACCGACCGCGACGGC
CGGGTGCTGCACGTCAGCGGTGCGCAGATCCCGGGGCTGTTCGCGGCGGGCAACGCCATGGCCGGCGCGACGGGTAAGGC
CTACGGCGGTGCCGGCGGAACGCTGGGTCCGGCAATGGTTTTCGGTTACCGCGCCGGCCGGGCGGCCTCCGGGGCATCCT
GA

Upstream 100 bases:

>100_bases
GAGGACGTCGTGCTGGACGGGAAGGACGCGGTGATCGCCGCCGCCAAGGAACTCGCCGCCATCCTCTGACCGGGTGTGGC
GCCGACAGGAAGGACCTCGC

Downstream 100 bases:

>100_bases
CGCGGTTCTGCAGGCCGACGGATGTCCTAGGCCGACAGCGCCGCGCCCACGAGATATGTGCCGATCAAGGCGGTTCCGAT
GAGGACGACCCACCCATCGG

Product: fumarate reductase/succinate dehydrogenase flavoprotein domain-containing protein

Products: NA

Alternate protein names: 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MSAWDHETDVVVLGSGGAGLAAALTAAVHGAAVEVYEKAPTVGGTTAVSGGIVWIPSHDRAADELTVEDALAYLRAQSLG
VMDDDLVETFVRTGPQMLEFVEAHSGLRFSVAEGFPDYKPELPGGRPGGGRSLSAAPFDLARLGPWRDRITSFPADFSNV
GIDAETRARIHASVDETLEDPCVAGTALIAGLLKGLLDAGVTPQTESRAVELIAADGRIVGVRIQQRDREIRVHARRAVI
LGTGGFEWDRALVEAFLRGPMRGPVSPPNNTGDGLRMAMAHGADLANMGEAWWVPIVQIPGDTIDGHPRSRSVRLERTRP
RSIIVNRAGKRFVNEAGEYNSMAGAFQYLDPKHGYVNDPAWIVFDSLHLKKYGFLAVEPDGPAPDWYSKSGDLGELGEKT
GIDADGLARTLADWNHHVAEERDPDFGRGASAYDGYWGDPQAPTPALQTLGPIDTPPYYAVPVGIGAMGTKGGPRTDRDG
RVLHVSGAQIPGLFAAGNAMAGATGKAYGGAGGTLGPAMVFGYRAGRAASGAS

Sequences:

>Translated_533_residues
MSAWDHETDVVVLGSGGAGLAAALTAAVHGAAVEVYEKAPTVGGTTAVSGGIVWIPSHDRAADELTVEDALAYLRAQSLG
VMDDDLVETFVRTGPQMLEFVEAHSGLRFSVAEGFPDYKPELPGGRPGGGRSLSAAPFDLARLGPWRDRITSFPADFSNV
GIDAETRARIHASVDETLEDPCVAGTALIAGLLKGLLDAGVTPQTESRAVELIAADGRIVGVRIQQRDREIRVHARRAVI
LGTGGFEWDRALVEAFLRGPMRGPVSPPNNTGDGLRMAMAHGADLANMGEAWWVPIVQIPGDTIDGHPRSRSVRLERTRP
RSIIVNRAGKRFVNEAGEYNSMAGAFQYLDPKHGYVNDPAWIVFDSLHLKKYGFLAVEPDGPAPDWYSKSGDLGELGEKT
GIDADGLARTLADWNHHVAEERDPDFGRGASAYDGYWGDPQAPTPALQTLGPIDTPPYYAVPVGIGAMGTKGGPRTDRDG
RVLHVSGAQIPGLFAAGNAMAGATGKAYGGAGGTLGPAMVFGYRAGRAASGAS
>Mature_532_residues
SAWDHETDVVVLGSGGAGLAAALTAAVHGAAVEVYEKAPTVGGTTAVSGGIVWIPSHDRAADELTVEDALAYLRAQSLGV
MDDDLVETFVRTGPQMLEFVEAHSGLRFSVAEGFPDYKPELPGGRPGGGRSLSAAPFDLARLGPWRDRITSFPADFSNVG
IDAETRARIHASVDETLEDPCVAGTALIAGLLKGLLDAGVTPQTESRAVELIAADGRIVGVRIQQRDREIRVHARRAVIL
GTGGFEWDRALVEAFLRGPMRGPVSPPNNTGDGLRMAMAHGADLANMGEAWWVPIVQIPGDTIDGHPRSRSVRLERTRPR
SIIVNRAGKRFVNEAGEYNSMAGAFQYLDPKHGYVNDPAWIVFDSLHLKKYGFLAVEPDGPAPDWYSKSGDLGELGEKTG
IDADGLARTLADWNHHVAEERDPDFGRGASAYDGYWGDPQAPTPALQTLGPIDTPPYYAVPVGIGAMGTKGGPRTDRDGR
VLHVSGAQIPGLFAAGNAMAGATGKAYGGAGGTLGPAMVFGYRAGRAASGAS

Specific function: Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids. Is also involved in the formation of 1,4- androstadiene-3,17-dione (ADD) from 4-androstene-3,17-dione (AD) to [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. 3-oxosteroid dehydrogenase subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI71986328, Length=338, Percent_Identity=26.0355029585799, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.3.99.4 [H]

Molecular weight: Translated: 56173; Mature: 56041

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAWDHETDVVVLGSGGAGLAAALTAAVHGAAVEVYEKAPTVGGTTAVSGGIVWIPSHDR
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCC
AADELTVEDALAYLRAQSLGVMDDDLVETFVRTGPQMLEFVEAHSGLRFSVAEGFPDYKP
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEHHCCCCCCCC
ELPGGRPGGGRSLSAAPFDLARLGPWRDRITSFPADFSNVGIDAETRARIHASVDETLED
CCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCHHHCCCCCHHHHEEECCHHHHHHC
PCVAGTALIAGLLKGLLDAGVTPQTESRAVELIAADGRIVGVRIQQRDREIRVHARRAVI
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEEECCCCEEEEEEEEEEE
LGTGGFEWDRALVEAFLRGPMRGPVSPPNNTGDGLRMAMAHGADLANMGEAWWVPIVQIP
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEHHHCCCCHHHCCCEEEEEEEECC
GDTIDGHPRSRSVRLERTRPRSIIVNRAGKRFVNEAGEYNSMAGAFQYLDPKHGYVNDPA
CCCCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
WIVFDSLHLKKYGFLAVEPDGPAPDWYSKSGDLGELGEKTGIDADGLARTLADWNHHVAE
EEEEECEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
ERDPDFGRGASAYDGYWGDPQAPTPALQTLGPIDTPPYYAVPVGIGAMGTKGGPRTDRDG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
RVLHVSGAQIPGLFAAGNAMAGATGKAYGGAGGTLGPAMVFGYRAGRAASGAS
CEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SAWDHETDVVVLGSGGAGLAAALTAAVHGAAVEVYEKAPTVGGTTAVSGGIVWIPSHDR
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCC
AADELTVEDALAYLRAQSLGVMDDDLVETFVRTGPQMLEFVEAHSGLRFSVAEGFPDYKP
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEHHCCCCCCCC
ELPGGRPGGGRSLSAAPFDLARLGPWRDRITSFPADFSNVGIDAETRARIHASVDETLED
CCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCHHHCCCCCHHHHEEECCHHHHHHC
PCVAGTALIAGLLKGLLDAGVTPQTESRAVELIAADGRIVGVRIQQRDREIRVHARRAVI
CHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEEEEEECCCCEEEEEEEEEEE
LGTGGFEWDRALVEAFLRGPMRGPVSPPNNTGDGLRMAMAHGADLANMGEAWWVPIVQIP
EECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEEHHHCCCCHHHCCCEEEEEEEECC
GDTIDGHPRSRSVRLERTRPRSIIVNRAGKRFVNEAGEYNSMAGAFQYLDPKHGYVNDPA
CCCCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
WIVFDSLHLKKYGFLAVEPDGPAPDWYSKSGDLGELGEKTGIDADGLARTLADWNHHVAE
EEEEECEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHC
ERDPDFGRGASAYDGYWGDPQAPTPALQTLGPIDTPPYYAVPVGIGAMGTKGGPRTDRDG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
RVLHVSGAQIPGLFAAGNAMAGATGKAYGGAGGTLGPAMVFGYRAGRAASGAS
CEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA