Click here to switch to the map view.

The map label for this gene is ampC [C]

Identifier: 119869700

GI number: 119869700

Start: 3868353

End: 3869546

Strand: Direct

Name: ampC [C]

Synonym: Mkms_3668

Alternate gene names: 119869700

Gene position: 3868353-3869546 (Clockwise)

Preceding gene: 119869697

Following gene: 119869701

Centisome position: 67.43

GC content: 70.1

Gene sequence:

>1194_bases
TTGATCTGCTCGACGGCGCCACTCATCTCGGGGTGCTGCGCCGACGAGTTCACCGGCGTCCGCGAGGCATTCGCCCGCAA
CTTCACCGATCGCGCCGAGGTCGGTGCCGCCGTCGCGGTCTGGGTCGACGGCGAACTGGTGGTCGACCTGTGGGGCGGGT
CGGCCGACGGCAGCGGCACGCGGCCGTGGCGCCGTGACACCCTCGCCAGCATCTACTCCGGCTCCAAAGGTCTCACCAGC
ACCTGTGTGCACCTCTTGGCCGAGCGCGGGGACATCGACCTCTACGCCCCGGTCGCCCGGTACTGGCCGGAGTTCGGGCG
GGCGGGGAAAGAGGACATCACCCTCGCGATGGTGATGTCACACCGCTCAGGTGTGATCGGGCCGCGGAGCCGGCTGCACT
GGTCGCAGGCGACGGACTGGGATGCGGTGTGCGCCCACATCGCGGCCGCCGAACCGTGGTGGGCGCCCGGCACCGCGCAG
GGCTACCACATGGTGACCTTCGGGTTCATCCTCGGTGAGGTGGTGCGCCGGGTGACCGGCCGCACCATCGGGCAGTACCT
GCGCACGGAGATCTCCGAACCACTCGGTGCCGACGTCCACATCGGGCTGCCCGCCGCCGAACACCACCGCTGCGCCGAGA
TGGTCGGCAAACCGCACATCCGTGACGTGCTGGCCGCGGGCACGGCGCCGGACCATCCACACTCCCTGACCGAGCACCCG
ATGGCGGGCCTCGCGGTGGCGATGGGCTTCGTCCCGGACGACGAACTCGGTTCGAACGCGCTGGACGCATGGCGCGAAGC
GGAGTTCCCCGCGACCAACGCCCACGTCTCCGCGCTGGGCATGGCCACGTTCTACAACGCGCTCGCGCAGGAGAAGCTGC
TCTCACGTCGGCACATGGAAACGGTGCGGGTCTGCCAGGGCGGGTTCGACACCGACATGGTGCTCGGTCCGCGCGTCGCC
GACCACGGCTGGGGTCTGGGCTACATGCTCAACCAGCGCGGCGTCGCGGGCCCGAACCGGCGCACCTTCGGCCACGGCGG
CTCGGGCGGTTCGTTCGCCTTCGTCGACCTCGAACACCGCATCGGCTACGCGTACGTGATGAACCATTTCGACGCCACGA
AGTGCAACGCCGACCCCCGCACCGTCGCTCTGTCCGACGAGGTCTACCGCGTCCTCGGCGTGCGGGTCCGCTGA

Upstream 100 bases:

>100_bases
CTGTGACCGAACCTCCCCCGGACCGTGATCGGCTCGCGGTGGTACTCGATGTGGGCCCGTCGTTAGGCTTTTCACTTCGA
CCCGATCCGCAGGAGGAGTG

Downstream 100 bases:

>100_bases
TTTTTCGCGCAGCGCGAACGCCGAGGTCGCGTCGGTAGGCTGGACGCATGAACGGCGTCCTGCTCGTCCTGATCATCGTG
GTCGTCGCCGCGCTCGCGCT

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: Esterase; Carboxylesterase; Beta-Lactamase Class C; Esterase A; Esterase/Lipase LipP; Beta-Lactamase Protein; Lactone Hydrolase; Lipase LipE; Esterase/Lipase/Beta-Lactamase; Esterase LipL; Secreted Protein; Lipase LipD; Lipase/Esterase/Beta-Lactamase; Beta-Lactamase Family Protein; Hydrolase; Esterase/Lipase; Carboxylesterase EstC; Serine Hydrolase; D-Alanyl-D-Alanine Carboxypeptidease; Beta-Lactamase Family; Fusion Of Enoyl-CoA Hydratase; Beta-Lactamase-Like Protein

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MICSTAPLISGCCADEFTGVREAFARNFTDRAEVGAAVAVWVDGELVVDLWGGSADGSGTRPWRRDTLASIYSGSKGLTS
TCVHLLAERGDIDLYAPVARYWPEFGRAGKEDITLAMVMSHRSGVIGPRSRLHWSQATDWDAVCAHIAAAEPWWAPGTAQ
GYHMVTFGFILGEVVRRVTGRTIGQYLRTEISEPLGADVHIGLPAAEHHRCAEMVGKPHIRDVLAAGTAPDHPHSLTEHP
MAGLAVAMGFVPDDELGSNALDAWREAEFPATNAHVSALGMATFYNALAQEKLLSRRHMETVRVCQGGFDTDMVLGPRVA
DHGWGLGYMLNQRGVAGPNRRTFGHGGSGGSFAFVDLEHRIGYAYVMNHFDATKCNADPRTVALSDEVYRVLGVRVR

Sequences:

>Translated_397_residues
MICSTAPLISGCCADEFTGVREAFARNFTDRAEVGAAVAVWVDGELVVDLWGGSADGSGTRPWRRDTLASIYSGSKGLTS
TCVHLLAERGDIDLYAPVARYWPEFGRAGKEDITLAMVMSHRSGVIGPRSRLHWSQATDWDAVCAHIAAAEPWWAPGTAQ
GYHMVTFGFILGEVVRRVTGRTIGQYLRTEISEPLGADVHIGLPAAEHHRCAEMVGKPHIRDVLAAGTAPDHPHSLTEHP
MAGLAVAMGFVPDDELGSNALDAWREAEFPATNAHVSALGMATFYNALAQEKLLSRRHMETVRVCQGGFDTDMVLGPRVA
DHGWGLGYMLNQRGVAGPNRRTFGHGGSGGSFAFVDLEHRIGYAYVMNHFDATKCNADPRTVALSDEVYRVLGVRVR
>Mature_397_residues
MICSTAPLISGCCADEFTGVREAFARNFTDRAEVGAAVAVWVDGELVVDLWGGSADGSGTRPWRRDTLASIYSGSKGLTS
TCVHLLAERGDIDLYAPVARYWPEFGRAGKEDITLAMVMSHRSGVIGPRSRLHWSQATDWDAVCAHIAAAEPWWAPGTAQ
GYHMVTFGFILGEVVRRVTGRTIGQYLRTEISEPLGADVHIGLPAAEHHRCAEMVGKPHIRDVLAAGTAPDHPHSLTEHP
MAGLAVAMGFVPDDELGSNALDAWREAEFPATNAHVSALGMATFYNALAQEKLLSRRHMETVRVCQGGFDTDMVLGPRVA
DHGWGLGYMLNQRGVAGPNRRTFGHGGSGGSFAFVDLEHRIGYAYVMNHFDATKCNADPRTVALSDEVYRVLGVRVR

Specific function: This Protein Is A Serine Beta-Lactamase With A Substrate Specificity For Cephalosporins. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI71983659, Length=401, Percent_Identity=31.6708229426434, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17535191, Length=371, Percent_Identity=32.8840970350404, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17538001, Length=381, Percent_Identity=31.2335958005249, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71983666, Length=215, Percent_Identity=39.0697674418605, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17538474, Length=405, Percent_Identity=29.3827160493827, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17535177, Length=373, Percent_Identity=27.3458445040214, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71990590, Length=398, Percent_Identity=24.8743718592965, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 43010; Mature: 43010

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICSTAPLISGCCADEFTGVREAFARNFTDRAEVGAAVAVWVDGELVVDLWGGSADGSGT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCEEEEEEECCCCCCCCC
RPWRRDTLASIYSGSKGLTSTCVHLLAERGDIDLYAPVARYWPEFGRAGKEDITLAMVMS
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCEEEEEEEC
HRSGVIGPRSRLHWSQATDWDAVCAHIAAAEPWWAPGTAQGYHMVTFGFILGEVVRRVTG
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RTIGQYLRTEISEPLGADVHIGLPAAEHHRCAEMVGKPHIRDVLAAGTAPDHPHSLTEHP
HHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCC
MAGLAVAMGFVPDDELGSNALDAWREAEFPATNAHVSALGMATFYNALAQEKLLSRRHME
HHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVRVCQGGFDTDMVLGPRVADHGWGLGYMLNQRGVAGPNRRTFGHGGSGGSFAFVDLEHR
HHHHHCCCCCCCEEECCEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
IGYAYVMNHFDATKCNADPRTVALSDEVYRVLGVRVR
CCCHHHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCCC
>Mature Secondary Structure
MICSTAPLISGCCADEFTGVREAFARNFTDRAEVGAAVAVWVDGELVVDLWGGSADGSGT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCEEEEEEECCCCCCCCC
RPWRRDTLASIYSGSKGLTSTCVHLLAERGDIDLYAPVARYWPEFGRAGKEDITLAMVMS
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCCCCCEEEEEEEC
HRSGVIGPRSRLHWSQATDWDAVCAHIAAAEPWWAPGTAQGYHMVTFGFILGEVVRRVTG
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RTIGQYLRTEISEPLGADVHIGLPAAEHHRCAEMVGKPHIRDVLAAGTAPDHPHSLTEHP
HHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCC
MAGLAVAMGFVPDDELGSNALDAWREAEFPATNAHVSALGMATFYNALAQEKLLSRRHME
HHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TVRVCQGGFDTDMVLGPRVADHGWGLGYMLNQRGVAGPNRRTFGHGGSGGSFAFVDLEHR
HHHHHCCCCCCCEEECCEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHH
IGYAYVMNHFDATKCNADPRTVALSDEVYRVLGVRVR
CCCHHHHHCCCCCCCCCCCCEEEEHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA