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The map label for this gene is adh [H]

Identifier: 119869500

GI number: 119869500

Start: 3638326

End: 3639369

Strand: Direct

Name: adh [H]

Synonym: Mkms_3468

Alternate gene names: 119869500

Gene position: 3638326-3639369 (Clockwise)

Preceding gene: 119869496

Following gene: 119869501

Centisome position: 63.42

GC content: 72.03

Gene sequence:

>1044_bases
ATGAAGGCAATGCAGCTCTCCGCCTGGCAGACGCCGCCGGAGATCCGGGAGGTTCCGGAACCCGAGCCCGGACCCGGTGA
GGTGGTCATCCGCGTCGCGGGCGCGGGCGCCTGCCACTCGGATCTGCACCTGCTCCACGATTTCGCGCCAGGGATGATGC
CGTGGAATCCGCCGTTCACGCTCGGCCACGAGAACGCGGGGTGGGTGCACACCCTCGGCGCCGGGGTGAGCGGTTTCAGC
GTCGGTGAACCCGTCGCGGTGTACGGACCGTGGGGATGCGGACGCTGCAAACGGTGCCAGGTGGGCATGGAGAACTACTG
CGAGCGCGCGGCCGATCAGCCGGCGGCCGGCGGTGGGCTCGGCTACGACGGCGGCATGGCGGAATACATGCTGGTGCCCG
CCGCCCGCCTGCTCGTCCCGCTCGGTGACCTGGACCCGGTCGAGGCCGCCCCGCTGACCGACGCGGCGCTGACGCCGTAT
CACGCGATCAAGCGGTCCCTTCCGCTGCTCACGCCGGGGGCGACCGCGGTGGCCATCGGCATCGGCGGGCTGGGTCATCT
GGGCGTGCAGATCCTGCGCGCGTTGACCGCCGCGCGGATCATCGCCGTCGACAACCGGCCCGAGGCGTTGCGCCTGGCCG
AGCGCAGCGGCGCCGACCACGCGGTGCGCGCGGGCGACGACGCGGCCGGCGAGATCCGCGACCTCACCGAGGGCCTCGGC
GCCGACGTGGTCGTCGACTTCGTCGGGGTCGACGCCACCCTGGCGCTGGCCACCGCGGTCGCCCGGCCACGCTCGGACAT
CACGGTGGTCGGCATCGGCGGCGGCACTGTGCCGTTCGGCTTCTTCTCGGTGCCCTACGAGGCCAGTCTCGCGACGACCT
ACTGGGGCTCCCGCCCGGAGCTGATGGAGGTGCTCGAACTGGCCCGCCACGGACGGATCAAGACAGAGGTGCACCGGTTC
CCGCTCGAGGAGGGACCGCAGGTCTACGAACGTCTCGCCGCGGGCGAGTTCACCGGACGCGCGGTCATCACCCCGAACTC
ATGA

Upstream 100 bases:

>100_bases
GGTTGAGATGGGCTCTCGATAATGAGGTTTGCCGTGATACTTCTGTGATAAACGTGAAATTTGTGACCAATGTGACAGAT
GATTCGAATTGAGGTCCACG

Downstream 100 bases:

>100_bases
GCCCAAAGCCCCGAGTCCGCATTCGTGTGACTTCCGACCCTGGCTCGACCACACCGGACCGTGGCACGTTTGCATTCGTC
ACGCAACGAGAGGACAGATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKAMQLSAWQTPPEIREVPEPEPGPGEVVIRVAGAGACHSDLHLLHDFAPGMMPWNPPFTLGHENAGWVHTLGAGVSGFS
VGEPVAVYGPWGCGRCKRCQVGMENYCERAADQPAAGGGLGYDGGMAEYMLVPAARLLVPLGDLDPVEAAPLTDAALTPY
HAIKRSLPLLTPGATAVAIGIGGLGHLGVQILRALTAARIIAVDNRPEALRLAERSGADHAVRAGDDAAGEIRDLTEGLG
ADVVVDFVGVDATLALATAVARPRSDITVVGIGGGTVPFGFFSVPYEASLATTYWGSRPELMEVLELARHGRIKTEVHRF
PLEEGPQVYERLAAGEFTGRAVITPNS

Sequences:

>Translated_347_residues
MKAMQLSAWQTPPEIREVPEPEPGPGEVVIRVAGAGACHSDLHLLHDFAPGMMPWNPPFTLGHENAGWVHTLGAGVSGFS
VGEPVAVYGPWGCGRCKRCQVGMENYCERAADQPAAGGGLGYDGGMAEYMLVPAARLLVPLGDLDPVEAAPLTDAALTPY
HAIKRSLPLLTPGATAVAIGIGGLGHLGVQILRALTAARIIAVDNRPEALRLAERSGADHAVRAGDDAAGEIRDLTEGLG
ADVVVDFVGVDATLALATAVARPRSDITVVGIGGGTVPFGFFSVPYEASLATTYWGSRPELMEVLELARHGRIKTEVHRF
PLEEGPQVYERLAAGEFTGRAVITPNS
>Mature_347_residues
MKAMQLSAWQTPPEIREVPEPEPGPGEVVIRVAGAGACHSDLHLLHDFAPGMMPWNPPFTLGHENAGWVHTLGAGVSGFS
VGEPVAVYGPWGCGRCKRCQVGMENYCERAADQPAAGGGLGYDGGMAEYMLVPAARLLVPLGDLDPVEAAPLTDAALTPY
HAIKRSLPLLTPGATAVAIGIGGLGHLGVQILRALTAARIIAVDNRPEALRLAERSGADHAVRAGDDAAGEIRDLTEGLG
ADVVVDFVGVDATLALATAVARPRSDITVVGIGGGTVPFGFFSVPYEASLATTYWGSRPELMEVLELARHGRIKTEVHRF
PLEEGPQVYERLAAGEFTGRAVITPNS

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=25.748502994012, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=277, Percent_Identity=26.3537906137184, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156523966, Length=277, Percent_Identity=26.3537906137184, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=23.8605898123324, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=27.0161290322581, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262073058, Length=264, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI71743840, Length=264, Percent_Identity=25, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788073, Length=318, Percent_Identity=27.9874213836478, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082125, Length=367, Percent_Identity=28.8828337874659, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081918, Length=333, Percent_Identity=30.6306306306306, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787863, Length=264, Percent_Identity=31.8181818181818, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=246, Percent_Identity=28.4552845528455, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786518, Length=360, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790045, Length=356, Percent_Identity=21.6292134831461, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=26.2755102040816, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788075, Length=332, Percent_Identity=25.9036144578313, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790718, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=26.9972451790634, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=355, Percent_Identity=28.169014084507, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=348, Percent_Identity=29.0229885057471, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71988145, Length=350, Percent_Identity=26, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=333, Percent_Identity=25.8258258258258, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=326, Percent_Identity=24.2331288343558, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=29.2263610315186, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=29.5522388059701, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=351, Percent_Identity=28.4900284900285, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=28.4023668639053, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=371, Percent_Identity=25.3369272237197, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323099, Length=325, Percent_Identity=24, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=24.5901639344262, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=24.773413897281, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=24.773413897281, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=367, Percent_Identity=26.9754768392371, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=362, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=26.1455525606469, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137530, Length=255, Percent_Identity=28.2352941176471, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17737897, Length=252, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36371; Mature: 36371

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMQLSAWQTPPEIREVPEPEPGPGEVVIRVAGAGACHSDLHLLHDFAPGMMPWNPPFT
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEE
LGHENAGWVHTLGAGVSGFSVGEPVAVYGPWGCGRCKRCQVGMENYCERAADQPAAGGGL
CCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCCCCCCCC
GYDGGMAEYMLVPAARLLVPLGDLDPVEAAPLTDAALTPYHAIKRSLPLLTPGATAVAIG
CCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCEEEEE
IGGLGHLGVQILRALTAARIIAVDNRPEALRLAERSGADHAVRAGDDAAGEIRDLTEGLG
CCCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCC
ADVVVDFVGVDATLALATAVARPRSDITVVGIGGGTVPFGFFSVPYEASLATTYWGSRPE
CCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCEEEECCCCCHH
LMEVLELARHGRIKTEVHRFPLEEGPQVYERLAAGEFTGRAVITPNS
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCCC
>Mature Secondary Structure
MKAMQLSAWQTPPEIREVPEPEPGPGEVVIRVAGAGACHSDLHLLHDFAPGMMPWNPPFT
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEE
LGHENAGWVHTLGAGVSGFSVGEPVAVYGPWGCGRCKRCQVGMENYCERAADQPAAGGGL
CCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCCCCCCCC
GYDGGMAEYMLVPAARLLVPLGDLDPVEAAPLTDAALTPYHAIKRSLPLLTPGATAVAIG
CCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCEEEEE
IGGLGHLGVQILRALTAARIIAVDNRPEALRLAERSGADHAVRAGDDAAGEIRDLTEGLG
CCCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCC
ADVVVDFVGVDATLALATAVARPRSDITVVGIGGGTVPFGFFSVPYEASLATTYWGSRPE
CCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEECCCCCCEEEECCCCCHH
LMEVLELARHGRIKTEVHRFPLEEGPQVYERLAAGEFTGRAVITPNS
HHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]