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The map label for this gene is ptpA [H]

Identifier: 119869441

GI number: 119869441

Start: 3575042

End: 3575539

Strand: Direct

Name: ptpA [H]

Synonym: Mkms_3409

Alternate gene names: 119869441

Gene position: 3575042-3575539 (Clockwise)

Preceding gene: 119869440

Following gene: 119869442

Centisome position: 62.31

GC content: 68.88

Gene sequence:

>498_bases
GTGTCTGAAACGCCGTTGCACATCACGTTCGTCTGCTCGGGCAACATCTGCCGCTCGCCCATGGCCGAGAAGATGTTCGC
CCACCAGATCGCCGAACGCGGGCTGTCCGGGGCGGTCCGGGTCAGCAGTGCGGGCACCGGAGGCTGGCATGCGGGTGATC
CCGCCGACCGGCGGGCGATCCACGTGCTGCGCGCGCACGGTTACCCGAGCGGGCACGAGGCCGCCCAGGTCGACGACGAC
CACCTGGCCGCCGATCTGGTGGTCGCGCTGGGCCGCAACCACGTCCGGATGCTGACCGAACTGGGTGTACCGCCCGGGCG
GCTGCGCATGCTGCGCTCGTTCGATCCGCGTTCGGCAGCACATCCCCTCGACGTGGAGGATCCCTACTACGGCACCCAGG
ACGATTTCGAGGACGTGTTCCGGGTGATCGAGGCGGCACTGCCCGGGCTGCACGACTGGGTCGACGAACAGCTCACCATC
CGGGGTATCGCGAGCTGA

Upstream 100 bases:

>100_bases
GTGGTCGGCTGGGGCTACGGCCGCGCCGACTTCGCCGAGCCCACCTCGGTGCCGGCGTTCGCGCACGTGGACAGCGTGGC
CGACCTGCGGGAGGTGCTGG

Downstream 100 bases:

>100_bases
TGAAGCGTTGGGCGTTCCTTCTGCGGCCGGCGTGGCTGGCGCTGTTCGTGGTGGTGCTCGCGTTCGCCTACCTGTGCTTC
ACCGTGCTGGCGCCCTGGCA

Product: protein tyrosine phosphatase

Products: NA

Alternate protein names: PTPase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSETPLHITFVCSGNICRSPMAEKMFAHQIAERGLSGAVRVSSAGTGGWHAGDPADRRAIHVLRAHGYPSGHEAAQVDDD
HLAADLVVALGRNHVRMLTELGVPPGRLRMLRSFDPRSAAHPLDVEDPYYGTQDDFEDVFRVIEAALPGLHDWVDEQLTI
RGIAS

Sequences:

>Translated_165_residues
MSETPLHITFVCSGNICRSPMAEKMFAHQIAERGLSGAVRVSSAGTGGWHAGDPADRRAIHVLRAHGYPSGHEAAQVDDD
HLAADLVVALGRNHVRMLTELGVPPGRLRMLRSFDPRSAAHPLDVEDPYYGTQDDFEDVFRVIEAALPGLHDWVDEQLTI
RGIAS
>Mature_164_residues
SETPLHITFVCSGNICRSPMAEKMFAHQIAERGLSGAVRVSSAGTGGWHAGDPADRRAIHVLRAHGYPSGHEAAQVDDDH
LAADLVVALGRNHVRMLTELGVPPGRLRMLRSFDPRSAAHPLDVEDPYYGTQDDFEDVFRVIEAALPGLHDWVDEQLTIR
GIAS

Specific function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=153, Percent_Identity=34.640522875817, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI6005988, Length=153, Percent_Identity=32.6797385620915, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI96304457, Length=70, Percent_Identity=44.2857142857143, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=147, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78706770, Length=139, Percent_Identity=33.0935251798561, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706772, Length=139, Percent_Identity=33.0935251798561, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706766, Length=125, Percent_Identity=32.8, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78706768, Length=125, Percent_Identity=32.8, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78706764, Length=125, Percent_Identity=32.8, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17998; Mature: 17867

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPLHITFVCSGNICRSPMAEKMFAHQIAERGLSGAVRVSSAGTGGWHAGDPADRRAI
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHH
HVLRAHGYPSGHEAAQVDDDHLAADLVVALGRNHVRMLTELGVPPGRLRMLRSFDPRSAA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCC
HPLDVEDPYYGTQDDFEDVFRVIEAALPGLHDWVDEQLTIRGIAS
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCEEEEECCC
>Mature Secondary Structure 
SETPLHITFVCSGNICRSPMAEKMFAHQIAERGLSGAVRVSSAGTGGWHAGDPADRRAI
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHH
HVLRAHGYPSGHEAAQVDDDHLAADLVVALGRNHVRMLTELGVPPGRLRMLRSFDPRSAA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCC
HPLDVEDPYYGTQDDFEDVFRVIEAALPGLHDWVDEQLTIRGIAS
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]