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The map label for this gene is yngE [H]

Identifier: 119869295

GI number: 119869295

Start: 3421065

End: 3422666

Strand: Direct

Name: yngE [H]

Synonym: Mkms_3263

Alternate gene names: 119869295

Gene position: 3421065-3422666 (Clockwise)

Preceding gene: 119869294

Following gene: 119869296

Centisome position: 59.63

GC content: 65.92

Gene sequence:

>1602_bases
TTGGTACAGGTCCTGCCCGATCGGGTCGACGACACCGCGCCCGGCTATCTCAAGAACCGCGAAGGACTGAGCGCGCAACT
CGACACCATCGCGGAGCAACTGGCGCTGGTCAACGGCGGCGGCGGCGCGAAATACGTTGCGCGCCACCGTAAGCGGGGCA
AGCTGCTTGTCCGCGAGCGCATCGAGCTGATGCTCGACCCCGACACGGCGTTCCTCGAACTATGCCCCTTCGCCGCCTGG
GGCAGTAAGTTCCCCGTCGGCGGTAGCGTGGTGGTAGGCATCGGCGTGGTCGAGGGCATCGAGTCGATGATCATCGCCCA
CGACCCCACCGTCCGCGGCGGCGCATCGAACCCTTATACCTTCCGCAAGGTGTTCCGCGGCATGGCCATCGCGCGGGAGA
ACCGACTGCCCATCATCAACATCGTCGAATCTGGCGGCGCCGACCTGCCCACACAGGCAGAGATCTTCGTGCCCGGCGGA
CAGCTGTTCCACGACTTGACCCAGCACAGCGCAGCGGGGCTGCCGACACTGGCCCTGGTCTTCGGCAACTCGACCGCGGG
AGGTGCGTACGTCCCGGGCATGTGCGACTACGTCGTGATGGTGCGCAACCGTTCCAAGGTGTTCCTCGGCGGTCCGCCGC
TGGTCAAGATGGCCACGGGCGAGGTCTCCGATGACGAGTCGCTCGGCGGCGCCGACATGCACGCCCGCACCTCGGGGCTG
GCCGATTACATGGCCGAGGACGAGCAGGATGCGATCCGCATCGGCCGTCGCATCATGGCGCGGCTCAACTGGCGGAAGAA
CGGCCCCGGACCCACCACGCCGCCGCACCCACCGGTGCACGACCCCGATCAGCTGCTCGGCATCGCGTCGGTCGATCCGA
AGGTGCCCTTCGACCCCCGCGACGTCATCGCCCGAGTGGTCGACGGCTCGGCCTTCGACGAGTTCAAACCTCTCTACGGC
ACGTCACTCGTCACCGGCTGGGCCTCGATCCACGGCTTCCCGGTCGGCATCCTCGCAAACGCACGGGGCATCCTGTTCAG
TGAGGAGGCCGAGAAAGGTTCGCAGTTCATCCAACTGGCAAATCAGATCGACACCCCCCTCATCTTCCTGCAGAACACCA
CCGGTTTCATGGTCGGTGCCGAGTACGAACAGGGCGGCATCATCAAGGACGGCGCCAAGATGATCAACGCCGTATCAAAC
AGCACGGTCCCCCACGTGACCATCACCATGGGTGCGTCCTACGGTGCCGGGAACTACGGCATGTGCGGGCGATCGTACTC
ACCGCGTTTCCTATTCGCTTGGCCTAACTCGAAGTCGGCCGTGATGGGTCCGGCGCAACTGGCCGGAGTGCTGTCCATCG
TGGCGCGCGAGTCCGCCGCCGACCGCGGGCTGCCCTTCGACGAGCAGGCCGACGCCCAGATGCGCGCCGCCGTCGAGGAA
CAGATCGAGCGCGAATCCGTCGCACTGGCCAACAGCGGCCGACTTTACGACGACGGGATCATCGATCCCCGCGATACGCG
GACCGTTCTCGGGTTCTGCCTGTCGGTGATCCACAACGGCGAGGTCCGTGGCCAGCGTGGCTACGGCGTGTTCCGGATGT
GA

Upstream 100 bases:

>100_bases
ACAAATCCGACGCCCGCCTGCGCCGTTGTCACCTGATGTTAATTGCGGCTAACATCAGCGCCTAGTAGATCGACGTCGAT
GCTCGCCCGGAAGGAAAACT

Downstream 100 bases:

>100_bases
TGGCGATGCCCAAGATCCGCAAGGTCCTGGTCGCCAACCGTGGCGAGATCGCGCGGCGGGTGTTCCGCACTTGCCGCGAT
CTCGGGATCGCCACCGTCGC

Product: carboxyl transferase

Products: ADP; H+; Malonyl-CoA; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQLALVNGGGGAKYVARHRKRGKLLVRERIELMLDPDTAFLELCPFAAW
GSKFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYTFRKVFRGMAIARENRLPIINIVESGGADLPTQAEIFVPGG
QLFHDLTQHSAAGLPTLALVFGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGL
ADYMAEDEQDAIRIGRRIMARLNWRKNGPGPTTPPHPPVHDPDQLLGIASVDPKVPFDPRDVIARVVDGSAFDEFKPLYG
TSLVTGWASIHGFPVGILANARGILFSEEAEKGSQFIQLANQIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSN
STVPHVTITMGASYGAGNYGMCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAADRGLPFDEQADAQMRAAVEE
QIERESVALANSGRLYDDGIIDPRDTRTVLGFCLSVIHNGEVRGQRGYGVFRM

Sequences:

>Translated_533_residues
MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQLALVNGGGGAKYVARHRKRGKLLVRERIELMLDPDTAFLELCPFAAW
GSKFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYTFRKVFRGMAIARENRLPIINIVESGGADLPTQAEIFVPGG
QLFHDLTQHSAAGLPTLALVFGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGL
ADYMAEDEQDAIRIGRRIMARLNWRKNGPGPTTPPHPPVHDPDQLLGIASVDPKVPFDPRDVIARVVDGSAFDEFKPLYG
TSLVTGWASIHGFPVGILANARGILFSEEAEKGSQFIQLANQIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSN
STVPHVTITMGASYGAGNYGMCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAADRGLPFDEQADAQMRAAVEE
QIERESVALANSGRLYDDGIIDPRDTRTVLGFCLSVIHNGEVRGQRGYGVFRM
>Mature_533_residues
MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQLALVNGGGGAKYVARHRKRGKLLVRERIELMLDPDTAFLELCPFAAW
GSKFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYTFRKVFRGMAIARENRLPIINIVESGGADLPTQAEIFVPGG
QLFHDLTQHSAAGLPTLALVFGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGL
ADYMAEDEQDAIRIGRRIMARLNWRKNGPGPTTPPHPPVHDPDQLLGIASVDPKVPFDPRDVIARVVDGSAFDEFKPLYG
TSLVTGWASIHGFPVGILANARGILFSEEAEKGSQFIQLANQIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSN
STVPHVTITMGASYGAGNYGMCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAADRGLPFDEQADAQMRAAVEE
QIERESVALANSGRLYDDGIIDPRDTRTVLGFCLSVIHNGEVRGQRGYGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=46.4761904761905, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI119943100, Length=534, Percent_Identity=30.8988764044944, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI295821216, Length=554, Percent_Identity=30.14440433213, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI310133460, Length=133, Percent_Identity=41.3533834586466, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17552936, Length=532, Percent_Identity=44.7368421052632, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI25147359, Length=518, Percent_Identity=30.3088803088803, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147362, Length=518, Percent_Identity=30.3088803088803, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24586065, Length=553, Percent_Identity=44.3037974683544, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.2 [C]

Molecular weight: Translated: 57111; Mature: 57111

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQLALVNGGGGAKYVARHRKRGKLLVRER
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCHHHHHH
IELMLDPDTAFLELCPFAAWGSKFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYT
HHEEECCCHHHHHHCCCHHCCCCCCCCCCEEEEHHHHHHHHHEEEECCCCCCCCCCCCHH
FRKVFRGMAIARENRLPIINIVESGGADLPTQAEIFVPGGQLFHDLTQHSAAGLPTLALV
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEE
FGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGL
ECCCCCCCCCCCCHHEEEEEEECCCEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
ADYMAEDEQDAIRIGRRIMARLNWRKNGPGPTTPPHPPVHDPDQLLGIASVDPKVPFDPR
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCHH
DVIARVVDGSAFDEFKPLYGTSLVTGWASIHGFPVGILANARGILFSEEAEKGSQFIQLA
HHHHHHHCCCCHHHCCCHHCCHHHHHHHHHCCCCEEEEECCCCEEEECHHHHHHHHHHHH
NQIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSNSTVPHVTITMGASYGAGNYG
HHCCCCEEEEECCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
MCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAADRGLPFDEQADAQMRAAVEE
CCCCCCCCCEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QIERESVALANSGRLYDDGIIDPRDTRTVLGFCLSVIHNGEVRGQRGYGVFRM
HHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVQVLPDRVDDTAPGYLKNREGLSAQLDTIAEQLALVNGGGGAKYVARHRKRGKLLVRER
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHCCCHHHHHH
IELMLDPDTAFLELCPFAAWGSKFPVGGSVVVGIGVVEGIESMIIAHDPTVRGGASNPYT
HHEEECCCHHHHHHCCCHHCCCCCCCCCCEEEEHHHHHHHHHEEEECCCCCCCCCCCCHH
FRKVFRGMAIARENRLPIINIVESGGADLPTQAEIFVPGGQLFHDLTQHSAAGLPTLALV
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEEE
FGNSTAGGAYVPGMCDYVVMVRNRSKVFLGGPPLVKMATGEVSDDESLGGADMHARTSGL
ECCCCCCCCCCCCHHEEEEEEECCCEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHH
ADYMAEDEQDAIRIGRRIMARLNWRKNGPGPTTPPHPPVHDPDQLLGIASVDPKVPFDPR
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCCCCCHH
DVIARVVDGSAFDEFKPLYGTSLVTGWASIHGFPVGILANARGILFSEEAEKGSQFIQLA
HHHHHHHCCCCHHHCCCHHCCHHHHHHHHHCCCCEEEEECCCCEEEECHHHHHHHHHHHH
NQIDTPLIFLQNTTGFMVGAEYEQGGIIKDGAKMINAVSNSTVPHVTITMGASYGAGNYG
HHCCCCEEEEECCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
MCGRSYSPRFLFAWPNSKSAVMGPAQLAGVLSIVARESAADRGLPFDEQADAQMRAAVEE
CCCCCCCCCEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
QIERESVALANSGRLYDDGIIDPRDTRTVLGFCLSVIHNGEVRGQRGYGVFRM
HHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; ATP; Bicarbonate [C]

Specific reaction: Acetyl-CoA + ATP + Bicarbonate <==> ADP + H+ + Malonyl-CoA + Phosphate [C]

General reaction: Carboxylation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]