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The map label for this gene is priA

Identifier: 119869150

GI number: 119869150

Start: 3263628

End: 3264374

Strand: Reverse

Name: priA

Synonym: Mkms_3118

Alternate gene names: 119869150

Gene position: 3264374-3263628 (Counterclockwise)

Preceding gene: 119869151

Following gene: 119869149

Centisome position: 56.9

GC content: 70.28

Gene sequence:

>747_bases
GTGTCCGAGAAAAGACCGTTGATCCTCCTCCCCGCCGTCGATGTCGTCGAAGGCCGTGCCGTGCGCCTGGTACAGGGCAA
GGCCGGCAGTGAAACCGAGTACGGGTCGGCGCTCGACGCCGCGCTCGGCTGGCAGCGCGACGGGGCCGAGTGGATCCATC
TGGTGGATCTCGACGCCGCGTTCGGGCGGGGGTCGAACCGCGAACTGCTCGCCGACGTCGTGGGCCGCCTCGATGTGGCG
GTCGAACTGTCCGGCGGCATCCGTGACGACGAGTCGCTCGAGGCAGCGCTGGCCACCGGATGCGCCCGGGTCAACATCGG
CACCGCCGCGCTGGAGAACCCGCAGTGGTGCGCGAAAGTCGTCGCCGAGTTCGGCGACAAGGTGGCAGTGGGCCTCGACG
TCAAGATCGTCGACGATCAGCACCGCCTGCGCGGACGGGGTTGGGAGACCGACGGCGGGGACCTGTGGGAGGTGCTCGAC
CGCCTCGACTCCGAAGGCTGCTCGCGCTACGTCGTCACCGACGTGACCAAGGACGGCACCCTTCAGGGGCCGAACCTCGA
TCTGCTCGGCCGCGTCGCCGACCGCACCGATGCGCCGGTGATCGCCTCCGGCGGGGTGTCCAGCCTCGACGATCTGCGCG
CGATCGCCACGTTGACCGACCGGGGCGTCGAGGGTGCGATCGTCGGCAAAGCGCTGTACGCCGGGCGCTTCACGCTGCCC
GAGGCGCTGGCAGCGATGGGGCAGTAG

Upstream 100 bases:

>100_bases
CAGTTCCACCCGGAGAAGAGCGGTGACGCGGGCGCGGCACTGCTCCGCAACTGGGTCGAGGAGCTCTGATCTAAGGTTGT
CCGTCGTGCCAGAGAAGTCG

Downstream 100 bases:

>100_bases
GGCGTCGATGGCACTGGACGAGACCGACCTGCAGGGTCTGGTCGACGAGGCCGCGGCGATACTCGACGCCGCGTCCGAAC
CCTTCATCAGCGGGCACCGC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLADVVGRLDVA
VELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLD
RLDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLP
EALAAMGQ

Sequences:

>Translated_248_residues
MSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLADVVGRLDVA
VELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLD
RLDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLP
EALAAMGQ
>Mature_247_residues
SEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAAFGRGSNRELLADVVGRLDVAV
ELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKVVAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLDR
LDSEGCSRYVVTDVTKDGTLQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLPE
ALAAMGQ

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=34.8178137651822, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788336, Length=253, Percent_Identity=22.9249011857708, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_MYCSJ (A3Q127)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071345.1
- ProteinModelPortal:   A3Q127
- SMR:   A3Q127
- STRING:   A3Q127
- EnsemblBacteria:   EBMYCT00000048264
- GeneID:   4878788
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3075
- eggNOG:   COG0106
- GeneTree:   EBGT00050000015857
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- PhylomeDB:   A3Q127
- ProtClustDB:   PRK14024
- BioCyc:   MSP164757:MJLS_3075-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16; =5.3.1.24

Molecular weight: Translated: 26205; Mature: 26074

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: ACT_SITE 14-14 ACT_SITE 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAA
CCCCCCEEEECCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEHHH
FGRGSNRELLADVVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKV
HCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHCCCHHHHHHH
VAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLDRLDSEGCSRYVVTDVTKDGT
HHHCCCEEEEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
LQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLP
CCCCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHH
EALAAMGQ
HHHHHHCC
>Mature Secondary Structure 
SEKRPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAALGWQRDGAEWIHLVDLDAA
CCCCCEEEECCCHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEHHH
FGRGSNRELLADVVGRLDVAVELSGGIRDDESLEAALATGCARVNIGTAALENPQWCAKV
HCCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHCCCEEECCHHHCCCHHHHHHH
VAEFGDKVAVGLDVKIVDDQHRLRGRGWETDGGDLWEVLDRLDSEGCSRYVVTDVTKDGT
HHHCCCEEEEEEEEEEECCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCC
LQGPNLDLLGRVADRTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRFTLP
CCCCCHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHH
EALAAMGQ
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA