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The map label for this gene is prrB [H]

Identifier: 119869071

GI number: 119869071

Start: 3181209

End: 3182564

Strand: Direct

Name: prrB [H]

Synonym: Mkms_3039

Alternate gene names: 119869071

Gene position: 3181209-3182564 (Clockwise)

Preceding gene: 119869069

Following gene: 119869072

Centisome position: 55.45

GC content: 67.48

Gene sequence:

>1356_bases
GTGCGCGTCGACGAGCGGCTACGGCGCGTCATGCCGATGCCGATCGTGTCTCTGCGCACGATCGTGATCGTGGCTGCGCT
ATCGGTCGTCGTGCTGGTGCTCACACTCGGCACGTGGGTGTGGATCGGCGTGACGAACGAGCAGTACAGCCAGTTGGACC
GGCAACTCGACTCGGTGACCAGCCTCGGGGATTTCGGGACGTTGTTGAACGCGGCGAGCACCGGTGACGATCCGGCTGAT
CCGCCCGTCGACCGGACGTTGGTGCGGACGGCACGCATCGGCGGTGTGACCGTGTCGGTGCCCAAGGACATCGTGCTGCC
GCAACTGGACATCGGGTACGCCAACACCACGATCGACGGAGTCGAGTACCGGGTGCGCACGTTCGCCGCGGGGCCCGCCA
CCATCGCGCTGGGCTCACCGCTGTCGGAGACGCAGCGCCGGATCGATCAGTTGCATCTGCGGGTCGTGCTGATCTGCGGC
GGCGTCATCGCGGGCACCGTGGTCGTGGGTTGGGTGATGTGGCTGATCATGATCAATCCGTTCCGGTTGTTGGCGCAGCA
GGCCCGCGCCATCAACGCGCAGTCCAAACCCGAAGAGGTGCAGGTCGGCGGCGTCTGGGAGGCGGCCGAGATCGCCGAGG
CGGTCGAGGGCATGCTGGCGCGCATCGGCGAGGAGCAACAGCGGACGAAGGCGGCGCTGGAGTCGGCACGGGATTTCGCC
GCGGTGGCATCCCACGAGTTGCGGACACCGTTGACGGCGATGCGCACCAACCTCGAGGTGTTGTCGACGCTCGACATGAC
CGACGAGCAGCGCAAAGAGGTCATCAACGACGTGGTGCGCACGCAGACCCGGATCGAGGCGACGCTGACCGCGCTCGAAC
GGTTGGCGCAGGGGGAACTGACCACCGCCGAGGACCACGTCCCGGTCGACATCACCGAACTGTTGGACCGCGCCGCGCAC
GACGCGCTGCGGAGCTACCCCGGCCTGGACGTGTCCCTGGTGCCCTCGGCGCCGGTGCGCATCCTCGGCCTGCCCGCCGG
GCTACGCCTGGTCATCGACAACGCCATCGCGAATGCGGTCAAGCACGGCGATGCCACGCAGATCCGATTGAGCGCGATCC
GGTCCGGTGAGGACGTAGAGATAGCAGTCGACGACAACGGCAGCGGTGTGCCCGAGCAGGAGCGCAAGCTGGTCTTCGAG
CGTTTCTCCCGCGGGTCGACCGCATCGCGCTCCGGTTCGGGGCTCGGTCTGGCGCTTGTCGCGCAACAGGCCGAATTGCA
CGGTGGGACAGCGTCTTTGGAGACCAGCCCGATGGGCGGAGCGCGGCTGTTGTTGCGGCTTCCCGCGACACGTTGA

Upstream 100 bases:

>100_bases
GACGCCGCGGCGTCCCGCCGCACCGGTCAGGCAAGATGAGCGTCGTGGACAGCGCTGCGACATCTCCGCGCCCGCCGGGC
GTCGTGCGGCCAGCCCGATA

Downstream 100 bases:

>100_bases
ACGCGTCGGGCCCGGCGTGCTCACGCCGGGCCCGATCACTGCGTTCGCCCTAGGGCAGGGTCACCAATCGCGACGGTCCG
AGACCGGGCTGGCCGGTGCC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRVDERLRRVMPMPIVSLRTIVIVAALSVVVLVLTLGTWVWIGVTNEQYSQLDRQLDSVTSLGDFGTLLNAASTGDDPAD
PPVDRTLVRTARIGGVTVSVPKDIVLPQLDIGYANTTIDGVEYRVRTFAAGPATIALGSPLSETQRRIDQLHLRVVLICG
GVIAGTVVVGWVMWLIMINPFRLLAQQARAINAQSKPEEVQVGGVWEAAEIAEAVEGMLARIGEEQQRTKAALESARDFA
AVASHELRTPLTAMRTNLEVLSTLDMTDEQRKEVINDVVRTQTRIEATLTALERLAQGELTTAEDHVPVDITELLDRAAH
DALRSYPGLDVSLVPSAPVRILGLPAGLRLVIDNAIANAVKHGDATQIRLSAIRSGEDVEIAVDDNGSGVPEQERKLVFE
RFSRGSTASRSGSGLGLALVAQQAELHGGTASLETSPMGGARLLLRLPATR

Sequences:

>Translated_451_residues
MRVDERLRRVMPMPIVSLRTIVIVAALSVVVLVLTLGTWVWIGVTNEQYSQLDRQLDSVTSLGDFGTLLNAASTGDDPAD
PPVDRTLVRTARIGGVTVSVPKDIVLPQLDIGYANTTIDGVEYRVRTFAAGPATIALGSPLSETQRRIDQLHLRVVLICG
GVIAGTVVVGWVMWLIMINPFRLLAQQARAINAQSKPEEVQVGGVWEAAEIAEAVEGMLARIGEEQQRTKAALESARDFA
AVASHELRTPLTAMRTNLEVLSTLDMTDEQRKEVINDVVRTQTRIEATLTALERLAQGELTTAEDHVPVDITELLDRAAH
DALRSYPGLDVSLVPSAPVRILGLPAGLRLVIDNAIANAVKHGDATQIRLSAIRSGEDVEIAVDDNGSGVPEQERKLVFE
RFSRGSTASRSGSGLGLALVAQQAELHGGTASLETSPMGGARLLLRLPATR
>Mature_451_residues
MRVDERLRRVMPMPIVSLRTIVIVAALSVVVLVLTLGTWVWIGVTNEQYSQLDRQLDSVTSLGDFGTLLNAASTGDDPAD
PPVDRTLVRTARIGGVTVSVPKDIVLPQLDIGYANTTIDGVEYRVRTFAAGPATIALGSPLSETQRRIDQLHLRVVLICG
GVIAGTVVVGWVMWLIMINPFRLLAQQARAINAQSKPEEVQVGGVWEAAEIAEAVEGMLARIGEEQQRTKAALESARDFA
AVASHELRTPLTAMRTNLEVLSTLDMTDEQRKEVINDVVRTQTRIEATLTALERLAQGELTTAEDHVPVDITELLDRAAH
DALRSYPGLDVSLVPSAPVRILGLPAGLRLVIDNAIANAVKHGDATQIRLSAIRSGEDVEIAVDDNGSGVPEQERKLVFE
RFSRGSTASRSGSGLGLALVAQQAELHGGTASLETSPMGGARLLLRLPATR

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=258, Percent_Identity=32.5581395348837, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=208, Percent_Identity=29.8076923076923, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787894, Length=220, Percent_Identity=33.1818181818182, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=28.0487804878049, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=29.7619047619048, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=29.7777777777778, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=274, Percent_Identity=26.2773722627737, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=24.8945147679325, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789403, Length=261, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=222, Percent_Identity=28.8288288288288, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790861, Length=356, Percent_Identity=25.561797752809, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=199, Percent_Identity=32.1608040201005, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=25.3846153846154, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=278, Percent_Identity=25.5395683453237, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=28.6307053941909, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786783, Length=361, Percent_Identity=20.7756232686981, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=330, Percent_Identity=22.7272727272727, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48501; Mature: 48501

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDERLRRVMPMPIVSLRTIVIVAALSVVVLVLTLGTWVWIGVTNEQYSQLDRQLDSVT
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHH
SLGDFGTLLNAASTGDDPADPPVDRTLVRTARIGGVTVSVPKDIVLPQLDIGYANTTIDG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEECC
VEYRVRTFAAGPATIALGSPLSETQRRIDQLHLRVVLICGGVIAGTVVVGWVMWLIMINP
HHEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRLLAQQARAINAQSKPEEVQVGGVWEAAEIAEAVEGMLARIGEEQQRTKAALESARDFA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AVASHELRTPLTAMRTNLEVLSTLDMTDEQRKEVINDVVRTQTRIEATLTALERLAQGEL
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTAEDHVPVDITELLDRAAHDALRSYPGLDVSLVPSAPVRILGLPAGLRLVIDNAIANAV
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHH
KHGDATQIRLSAIRSGEDVEIAVDDNGSGVPEQERKLVFERFSRGSTASRSGSGLGLALV
HCCCCCEEEHEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AQQAELHGGTASLETSPMGGARLLLRLPATR
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MRVDERLRRVMPMPIVSLRTIVIVAALSVVVLVLTLGTWVWIGVTNEQYSQLDRQLDSVT
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHH
SLGDFGTLLNAASTGDDPADPPVDRTLVRTARIGGVTVSVPKDIVLPQLDIGYANTTIDG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEECC
VEYRVRTFAAGPATIALGSPLSETQRRIDQLHLRVVLICGGVIAGTVVVGWVMWLIMINP
HHEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRLLAQQARAINAQSKPEEVQVGGVWEAAEIAEAVEGMLARIGEEQQRTKAALESARDFA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AVASHELRTPLTAMRTNLEVLSTLDMTDEQRKEVINDVVRTQTRIEATLTALERLAQGEL
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTAEDHVPVDITELLDRAAHDALRSYPGLDVSLVPSAPVRILGLPAGLRLVIDNAIANAV
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHH
KHGDATQIRLSAIRSGEDVEIAVDDNGSGVPEQERKLVFERFSRGSTASRSGSGLGLALV
HCCCCCEEEHEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
AQQAELHGGTASLETSPMGGARLLLRLPATR
HHHHHHCCCCCCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]