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The map label for this gene is rspB [H]

Identifier: 119868860

GI number: 119868860

Start: 2948297

End: 2949328

Strand: Reverse

Name: rspB [H]

Synonym: Mkms_2828

Alternate gene names: 119868860

Gene position: 2949328-2948297 (Counterclockwise)

Preceding gene: 119868861

Following gene: 119868859

Centisome position: 51.41

GC content: 70.64

Gene sequence:

>1032_bases
GTGGTGACGCGCCGGGTGGTGGTGTCCTCGCTCGACGACGTGGTCGTCGAGACCGAGACCACCGACACCCCGCAGCCCGG
TGAGGTGAGGGTCGGCACGTCGCTGGTCGGCATCTGCGGCTCGGATCTGCACGCCGCGTGCGGCAGACACCCGTTCATCG
ACCTGCCCTACCGCCCCGGGCACGAGGCGGTGGGCGTGGTCGACGCCGTCGGGGCCGGCGTGGACGAATCCTGGCTCGGC
ACACGGGTGACCATCGAACCGAACCTCGCCTGCGGGCACTGCACCCAGTGCCGCGCCGGCCGCTACAACATCTGCCGGGA
ACTGCTGGTGTTCGGCTGCCAGACCGCAGGGGCGCTCGCCGATTCGTTCACGATCCCGGTCGACCGCGTCGTCGCCTTGC
CCGACGAACTCGACGACCGGCACGCGATCCTGATCGAACCGCTCGCCACCCCGGTGCACACCGTGCGGCGGGCGGCCGGA
CTCGTCGGAGACCTTCGCGACCGCGCCGTCGTGGTGATCGGCGCCGGACCCATCGGGCTGTTCACGCTGCTGGCCGCCCG
GCACGCCGGGGCCAGGGTGGTGGTGGCCGATCTGCTGGAGTCCAAGCGGGCGCGGGCCGAACGTCTCGGCGCCGTCGGCA
GTTTCGACCCCACCGGCGACGATGCGGTCGCCACCGCCCAGCGGCTGCTCGGCGGGCCTGCCGCCGTGGTCGTCGACTGT
GTGTCGCGCGAGAGCACCGTGGCGCTGGCGGTGGATCTCGTCGACAAGGGCGGTGCGGTCATGATCGTCGGTGTCGCCGA
AGGGTCCACACCGGTGCCGCTCGGACTGATCCAGGACCGCGAACTCGCCCTGGTCGGCAACCTGATGTACGTGCGGGAGG
ACTTCACCGCCGCGATGGACCTGCTGGCCTCCGGCATCGTCCCGGTCGACGAGATCATCAGCGCCGACTTCGATCTCGAC
CACGCGGCGCAGGCTTTCAGAGCTTCGGCTGATCCGGAGAACGTCAAGGTGCTCGTGACGGTTGGGAGTTGA

Upstream 100 bases:

>100_bases
CGATGCCGGAGGAGATCGCACCCAGCGTGGTGTTCCTGGCCAGCGACGCCGCCTCGTTCATCACCGGTTCGGTGCTGGTC
GCCGACGGTGGGTACACGGC

Downstream 100 bases:

>100_bases
GCGATGGCACAGGCACTACTCGAATGCACTGACATCGAGAAGAGCTTCCACGGGGTGCCGGTCCTCAAGGGGATCACCCT
GAACCTGCAGCCGGGCACGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVTRRVVVSSLDDVVVETETTDTPQPGEVRVGTSLVGICGSDLHAACGRHPFIDLPYRPGHEAVGVVDAVGAGVDESWLG
TRVTIEPNLACGHCTQCRAGRYNICRELLVFGCQTAGALADSFTIPVDRVVALPDELDDRHAILIEPLATPVHTVRRAAG
LVGDLRDRAVVVIGAGPIGLFTLLAARHAGARVVVADLLESKRARAERLGAVGSFDPTGDDAVATAQRLLGGPAAVVVDC
VSRESTVALAVDLVDKGGAVMIVGVAEGSTPVPLGLIQDRELALVGNLMYVREDFTAAMDLLASGIVPVDEIISADFDLD
HAAQAFRASADPENVKVLVTVGS

Sequences:

>Translated_343_residues
MVTRRVVVSSLDDVVVETETTDTPQPGEVRVGTSLVGICGSDLHAACGRHPFIDLPYRPGHEAVGVVDAVGAGVDESWLG
TRVTIEPNLACGHCTQCRAGRYNICRELLVFGCQTAGALADSFTIPVDRVVALPDELDDRHAILIEPLATPVHTVRRAAG
LVGDLRDRAVVVIGAGPIGLFTLLAARHAGARVVVADLLESKRARAERLGAVGSFDPTGDDAVATAQRLLGGPAAVVVDC
VSRESTVALAVDLVDKGGAVMIVGVAEGSTPVPLGLIQDRELALVGNLMYVREDFTAAMDLLASGIVPVDEIISADFDLD
HAAQAFRASADPENVKVLVTVGS
>Mature_343_residues
MVTRRVVVSSLDDVVVETETTDTPQPGEVRVGTSLVGICGSDLHAACGRHPFIDLPYRPGHEAVGVVDAVGAGVDESWLG
TRVTIEPNLACGHCTQCRAGRYNICRELLVFGCQTAGALADSFTIPVDRVVALPDELDDRHAILIEPLATPVHTVRRAAG
LVGDLRDRAVVVIGAGPIGLFTLLAARHAGARVVVADLLESKRARAERLGAVGSFDPTGDDAVATAQRLLGGPAAVVVDC
VSRESTVALAVDLVDKGGAVMIVGVAEGSTPVPLGLIQDRELALVGNLMYVREDFTAAMDLLASGIVPVDEIISADFDLD
HAAQAFRASADPENVKVLVTVGS

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=344, Percent_Identity=31.3953488372093, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI71565154, Length=350, Percent_Identity=23.7142857142857, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1787863, Length=334, Percent_Identity=29.3413173652695, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788073, Length=319, Percent_Identity=33.5423197492163, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=31.1178247734139, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=28.4431137724551, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=28.4023668639053, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790718, Length=338, Percent_Identity=26.6272189349112, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=26.2247838616715, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081918, Length=309, Percent_Identity=28.8025889967638, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082125, Length=348, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786825, Length=381, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=344, Percent_Identity=30.5232558139535, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=30.3206997084548, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562584, Length=303, Percent_Identity=28.0528052805281, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=316, Percent_Identity=26.2658227848101, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=330, Percent_Identity=27.5757575757576, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=31.3432835820896, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=31.044776119403, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323099, Length=326, Percent_Identity=29.7546012269939, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319257, Length=319, Percent_Identity=29.153605015674, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=367, Percent_Identity=26.9754768392371, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=295, Percent_Identity=26.1016949152542, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=289, Percent_Identity=25.2595155709343, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=291, Percent_Identity=25.085910652921, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=290, Percent_Identity=25.1724137931034, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=34.1317365269461, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=33.5329341317365, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI221457811, Length=327, Percent_Identity=25.9938837920489, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45550770, Length=327, Percent_Identity=25.9938837920489, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45551930, Length=327, Percent_Identity=25.9938837920489, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 35743; Mature: 35743

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTRRVVVSSLDDVVVETETTDTPQPGEVRVGTSLVGICGSDLHAACGRHPFIDLPYRPG
CCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCEEEEECCCCHHHHCCCCCEEECCCCCC
HEAVGVVDAVGAGVDESWLGTRVTIEPNLACGHCTQCRAGRYNICRELLVFGCQTAGALA
CCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
DSFTIPVDRVVALPDELDDRHAILIEPLATPVHTVRRAAGLVGDLRDRAVVVIGAGPIGL
CCCCCCHHHEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
FTLLAARHAGARVVVADLLESKRARAERLGAVGSFDPTGDDAVATAQRLLGGPAAVVVDC
HHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEH
VSRESTVALAVDLVDKGGAVMIVGVAEGSTPVPLGLIQDRELALVGNLMYVREDFTAAMD
HCCCCEEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHH
LLASGIVPVDEIISADFDLDHAAQAFRASADPENVKVLVTVGS
HHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVTRRVVVSSLDDVVVETETTDTPQPGEVRVGTSLVGICGSDLHAACGRHPFIDLPYRPG
CCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCEEEEECCCCHHHHCCCCCEEECCCCCC
HEAVGVVDAVGAGVDESWLGTRVTIEPNLACGHCTQCRAGRYNICRELLVFGCQTAGALA
CCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
DSFTIPVDRVVALPDELDDRHAILIEPLATPVHTVRRAAGLVGDLRDRAVVVIGAGPIGL
CCCCCCHHHEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
FTLLAARHAGARVVVADLLESKRARAERLGAVGSFDPTGDDAVATAQRLLGGPAAVVVDC
HHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEH
VSRESTVALAVDLVDKGGAVMIVGVAEGSTPVPLGLIQDRELALVGNLMYVREDFTAAMD
HCCCCEEEEEEEEECCCCEEEEEEECCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHH
LLASGIVPVDEIISADFDLDHAAQAFRASADPENVKVLVTVGS
HHHCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]