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The map label for this gene is lon [H]

Identifier: 119868851

GI number: 119868851

Start: 2938631

End: 2940982

Strand: Direct

Name: lon [H]

Synonym: Mkms_2819

Alternate gene names: 119868851

Gene position: 2938631-2940982 (Clockwise)

Preceding gene: 119868850

Following gene: 119868852

Centisome position: 51.22

GC content: 70.28

Gene sequence:

>2352_bases
ATGGCTCAAGCCACATCTGTGCCGGTGTTGTTCTCGAACGAGACGATCGTGCTGCCCGGCATGGTCGTGCCGATCGAACT
GGACGACGCCGCCCGCGCCGCCGTGGAAGCAGCGAAGGTCGCTGCCGCCCCCGGTGAGTCCGGTGAACTGCTCATCGCCC
CCCGACTGGACGACCGCTACCCCACCTACGGTGTCCTGGCGACGATCGTGCAGATCGGCCGCATCCCCAGCGGCGCCGCG
GCGGTCGTCCGCGGAACCAGGCGGGCCCACATCGGCGCCGGCGTCGACGGCCCCGGCACGGCGATGTGGGTCTCGGTCGA
CGAGGTGCCCGAACCCGAGATCACCGACCAGACCCGCGCCCTCGCCGCGGACTACAAGAAGCTCCTGCTGGCGATGCTGC
AGCGCCGCGAGGCCTGGCAGATCATCGACTTCGTCAACCAGCTGACCGATCCGTCGGCGCTGGCGGACACCGCCGGGTAC
GCGTCGTACCTGACGCCGGTGCAGAAGCGCCAGCTGCTCGAGACGCCTGACGTCGAAGAGCGGCTGCGCGCGCTCATCGA
CTGGACGGGCGACCACCTGGCCGAGGTCGAGGTCACCGACAAGATCGCCGAGGACGTGCGGTCCGGTATGGAGAAGCAGC
AGAAGGAGTTCCTGCTGCGCCAGCAACTCGCCGCGATCCGCAAGGAACTCGGCGAACTCGGGCCCGATGGCGAAGAGGGC
TCCGACGACTACCGGTCCCGCATCGAGGCCGCCGACCTGCCCGAGAAGGTGCGCGAGGCGGCGCTGCGCGAAGCCGGCAA
GCTGGAACGCGCCAGCGACCAGAGCCCGGAGGGCGGCTGGATCCGCACCTGGCTCGACACCGTGCTGGACCTGCCGTGGA
ACGTGCGGACCGAGGACTCGACCGATCTGACGGCGGCGCGGGAGATCCTCGACGCCGATCATCACGGTCTCGAGGACGTC
AAGGACCGCATCGTCGAATACCTGGCCGTACGGGCGCGCCGCGCCCAGCGCGGGCTGCAGGTCGTCGGCGGCCGCGGATC
CGGTGCGGTGATGGTGCTGGCCGGGCCGCCCGGCGTCGGCAAGACCTCGCTCGGTGAATCCGTGGCGCGGGCCCTGGGCC
GCGAGTTCGTGCGGGTCGCCCTGGGCGGTGTGCGCGACGAGGCGGAGATCCGCGGACACCGGCGGACCTACGTCGGCGCC
CTGCCGGGCCGCATCGTGCGCGCCATCGCAGAGGCGGGTTCGATGAACCCCGTCGTGCTGCTCGACGAGATCGACAAGGT
CGGCAGCGACTACCGTGGCGATCCGGCCGCGGCACTGCTCGAGGTGCTCGACCCGGCGCAGAACCACACGTTCCGCGACC
ACTACCTCGACCTCGATCTCGACCTGTCCGATGTGGTGTTCCTGGCCACGGCCAACGTGATCGAGAACATCCCGCAGGCC
CTGCTGGACCGGATGGAACTGGTGCAGATCGACGGTTACACCTCCGACGACAAGGTGGCCATCGCCCGCGACTTCCTGCT
GCCGCGGCAGCGCGAGCGCGCGGCGCTGACCACGGATGAAGTCGAGGTGACCGATGCGGCGCTGCGCAAGATCGCCGCGG
ATTACACCCGCGAACCGGGTGTGCGCCAGTTCGAGAGGCTGCTGGCAAAGGCGATGCGCAAGGCGACCACGAAGTTGGCC
ACCAGCGACGAGCCGATCACGATCGACGAGCCCGATCTCGTGGAGTACCTGGGCCGTCCGCGCTTCATGCCGGAGTCGGC
CGAGCGCACCGCGGTGCCGGGCGTGGCGACCGGGCTGGCGGTGACCGGACTGGGCGGTGACGTGCTCTACATCGAAGCCG
GTGCCACCGATGGCGAACCGGGCCTGCAGCTGACGGGTCAGCTGGGCGACGTGATGAAGGAGTCCGCGCAGATCGCGCTG
TCCTACGTGCGCGCCCACGCCGCCGAACTCGGCGTCGACCCGAAGGCGCTGGACCGCCGCATCCACGTGCACGTTCCCGC
GGGTGCCGTGCCGAAGGACGGTCCGTCGGCCGGCGTCACGATGGTCACCGCGCTGGTGTCCATGGCGACGGGACGGCAGG
TGCGCTCCGACGTCGGGATGACCGGCGAGGTGACGCTCAACGGCCGCGTCCTGCCGATCGGCGGGGTCAAGCAGAAGCTG
CTGGCCGCGCAGCGTGCGGGGTTGTCGACGGTGTTCATCCCACAGCGCAACGAGCCGGATCTGGATGACGTGCCCGCCGA
AGTCCTGGCGGAGCTCGAGGTTCGTCCGATGACCGATGTCGCCGACATCGTCGCGCAGGCGCTCGAACCGGCGGCGCAAG
AGTCGACGCCGGCCGTCACGCGCGCCGCGTGA

Upstream 100 bases:

>100_bases
GTCCCGGGCCGTCCCGGATGACCGGCGAGCGGTGACACCTCGGGGAACAAACCACCCGCGGCCAAGGTTGAGTCGATCTG
ACTGAACTTTGGAGGATCAC

Downstream 100 bases:

>100_bases
ACAGTGCACTCAGGGTCGTGATTCCGTGCGGGTCACGACCCTGAGTGCATTCTGCGCGCTACCGTCACGACGTGGCCTAC
GACGCCGACCTCGCCGACCG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 783; Mature: 782

Protein sequence:

>783_residues
MAQATSVPVLFSNETIVLPGMVVPIELDDAARAAVEAAKVAAAPGESGELLIAPRLDDRYPTYGVLATIVQIGRIPSGAA
AVVRGTRRAHIGAGVDGPGTAMWVSVDEVPEPEITDQTRALAADYKKLLLAMLQRREAWQIIDFVNQLTDPSALADTAGY
ASYLTPVQKRQLLETPDVEERLRALIDWTGDHLAEVEVTDKIAEDVRSGMEKQQKEFLLRQQLAAIRKELGELGPDGEEG
SDDYRSRIEAADLPEKVREAALREAGKLERASDQSPEGGWIRTWLDTVLDLPWNVRTEDSTDLTAAREILDADHHGLEDV
KDRIVEYLAVRARRAQRGLQVVGGRGSGAVMVLAGPPGVGKTSLGESVARALGREFVRVALGGVRDEAEIRGHRRTYVGA
LPGRIVRAIAEAGSMNPVVLLDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVVFLATANVIENIPQA
LLDRMELVQIDGYTSDDKVAIARDFLLPRQRERAALTTDEVEVTDAALRKIAADYTREPGVRQFERLLAKAMRKATTKLA
TSDEPITIDEPDLVEYLGRPRFMPESAERTAVPGVATGLAVTGLGGDVLYIEAGATDGEPGLQLTGQLGDVMKESAQIAL
SYVRAHAAELGVDPKALDRRIHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKL
LAAQRAGLSTVFIPQRNEPDLDDVPAEVLAELEVRPMTDVADIVAQALEPAAQESTPAVTRAA

Sequences:

>Translated_783_residues
MAQATSVPVLFSNETIVLPGMVVPIELDDAARAAVEAAKVAAAPGESGELLIAPRLDDRYPTYGVLATIVQIGRIPSGAA
AVVRGTRRAHIGAGVDGPGTAMWVSVDEVPEPEITDQTRALAADYKKLLLAMLQRREAWQIIDFVNQLTDPSALADTAGY
ASYLTPVQKRQLLETPDVEERLRALIDWTGDHLAEVEVTDKIAEDVRSGMEKQQKEFLLRQQLAAIRKELGELGPDGEEG
SDDYRSRIEAADLPEKVREAALREAGKLERASDQSPEGGWIRTWLDTVLDLPWNVRTEDSTDLTAAREILDADHHGLEDV
KDRIVEYLAVRARRAQRGLQVVGGRGSGAVMVLAGPPGVGKTSLGESVARALGREFVRVALGGVRDEAEIRGHRRTYVGA
LPGRIVRAIAEAGSMNPVVLLDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVVFLATANVIENIPQA
LLDRMELVQIDGYTSDDKVAIARDFLLPRQRERAALTTDEVEVTDAALRKIAADYTREPGVRQFERLLAKAMRKATTKLA
TSDEPITIDEPDLVEYLGRPRFMPESAERTAVPGVATGLAVTGLGGDVLYIEAGATDGEPGLQLTGQLGDVMKESAQIAL
SYVRAHAAELGVDPKALDRRIHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKL
LAAQRAGLSTVFIPQRNEPDLDDVPAEVLAELEVRPMTDVADIVAQALEPAAQESTPAVTRAA
>Mature_782_residues
AQATSVPVLFSNETIVLPGMVVPIELDDAARAAVEAAKVAAAPGESGELLIAPRLDDRYPTYGVLATIVQIGRIPSGAAA
VVRGTRRAHIGAGVDGPGTAMWVSVDEVPEPEITDQTRALAADYKKLLLAMLQRREAWQIIDFVNQLTDPSALADTAGYA
SYLTPVQKRQLLETPDVEERLRALIDWTGDHLAEVEVTDKIAEDVRSGMEKQQKEFLLRQQLAAIRKELGELGPDGEEGS
DDYRSRIEAADLPEKVREAALREAGKLERASDQSPEGGWIRTWLDTVLDLPWNVRTEDSTDLTAAREILDADHHGLEDVK
DRIVEYLAVRARRAQRGLQVVGGRGSGAVMVLAGPPGVGKTSLGESVARALGREFVRVALGGVRDEAEIRGHRRTYVGAL
PGRIVRAIAEAGSMNPVVLLDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVVFLATANVIENIPQAL
LDRMELVQIDGYTSDDKVAIARDFLLPRQRERAALTTDEVEVTDAALRKIAADYTREPGVRQFERLLAKAMRKATTKLAT
SDEPITIDEPDLVEYLGRPRFMPESAERTAVPGVATGLAVTGLGGDVLYIEAGATDGEPGLQLTGQLGDVMKESAQIALS
YVRAHAAELGVDPKALDRRIHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKLL
AAQRAGLSTVFIPQRNEPDLDDVPAEVLAELEVRPMTDVADIVAQALEPAAQESTPAVTRAA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=570, Percent_Identity=45.0877192982456, Blast_Score=491, Evalue=1e-138,
Organism=Homo sapiens, GI21396489, Length=703, Percent_Identity=36.5576102418208, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1786643, Length=796, Percent_Identity=43.5929648241206, Blast_Score=599, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17505831, Length=631, Percent_Identity=37.4009508716323, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17556486, Length=553, Percent_Identity=39.2405063291139, Blast_Score=408, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=672, Percent_Identity=37.9464285714286, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI221513036, Length=699, Percent_Identity=38.483547925608, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666867, Length=699, Percent_Identity=38.483547925608, Blast_Score=500, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 84265; Mature: 84133

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQATSVPVLFSNETIVLPGMVVPIELDDAARAAVEAAKVAAAPGESGELLIAPRLDDRY
CCCCCCCCEEECCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PTYGVLATIVQIGRIPSGAAAVVRGTRRAHIGAGVDGPGTAMWVSVDEVPEPEITDQTRA
CHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
LAADYKKLLLAMLQRREAWQIIDFVNQLTDPSALADTAGYASYLTPVQKRQLLETPDVEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCCCHHH
RLRALIDWTGDHLAEVEVTDKIAEDVRSGMEKQQKEFLLRQQLAAIRKELGELGPDGEEG
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SDDYRSRIEAADLPEKVREAALREAGKLERASDQSPEGGWIRTWLDTVLDLPWNVRTEDS
CHHHHHHCCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
TDLTAAREILDADHHGLEDVKDRIVEYLAVRARRAQRGLQVVGGRGSGAVMVLAGPPGVG
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCC
KTSLGESVARALGREFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIAEAGSMNPVVL
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHCCCCCCEEE
LDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVVFLATANVIENIPQA
EECHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHH
LLDRMELVQIDGYTSDDKVAIARDFLLPRQRERAALTTDEVEVTDAALRKIAADYTREPG
HHHHHHEEEECCCCCCCCCHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
VRQFERLLAKAMRKATTKLATSDEPITIDEPDLVEYLGRPRFMPESAERTAVPGVATGLA
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCE
VTGLGGDVLYIEAGATDGEPGLQLTGQLGDVMKESAQIALSYVRAHAAELGVDPKALDRR
EECCCCCEEEEECCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCE
IHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKL
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCEEEECCCHHHHH
LAAQRAGLSTVFIPQRNEPDLDDVPAEVLAELEVRPMTDVADIVAQALEPAAQESTPAVT
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCHHHHCCCCCHH
RAA
CCC
>Mature Secondary Structure 
AQATSVPVLFSNETIVLPGMVVPIELDDAARAAVEAAKVAAAPGESGELLIAPRLDDRY
CCCCCCCEEECCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
PTYGVLATIVQIGRIPSGAAAVVRGTRRAHIGAGVDGPGTAMWVSVDEVPEPEITDQTRA
CHHHHHHHHHHHCCCCCCHHHHHHCCHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHH
LAADYKKLLLAMLQRREAWQIIDFVNQLTDPSALADTAGYASYLTPVQKRQLLETPDVEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHCCCCCHHH
RLRALIDWTGDHLAEVEVTDKIAEDVRSGMEKQQKEFLLRQQLAAIRKELGELGPDGEEG
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SDDYRSRIEAADLPEKVREAALREAGKLERASDQSPEGGWIRTWLDTVLDLPWNVRTEDS
CHHHHHHCCCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
TDLTAAREILDADHHGLEDVKDRIVEYLAVRARRAQRGLQVVGGRGSGAVMVLAGPPGVG
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCC
KTSLGESVARALGREFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIAEAGSMNPVVL
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHEECCCHHHHHHHHHHCCCCCCEEE
LDEIDKVGSDYRGDPAAALLEVLDPAQNHTFRDHYLDLDLDLSDVVFLATANVIENIPQA
EECHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHH
LLDRMELVQIDGYTSDDKVAIARDFLLPRQRERAALTTDEVEVTDAALRKIAADYTREPG
HHHHHHEEEECCCCCCCCCHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
VRQFERLLAKAMRKATTKLATSDEPITIDEPDLVEYLGRPRFMPESAERTAVPGVATGLA
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCHHHCCE
VTGLGGDVLYIEAGATDGEPGLQLTGQLGDVMKESAQIALSYVRAHAAELGVDPKALDRR
EECCCCCEEEEECCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCE
IHVHVPAGAVPKDGPSAGVTMVTALVSMATGRQVRSDVGMTGEVTLNGRVLPIGGVKQKL
EEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCEEEECCCHHHHH
LAAQRAGLSTVFIPQRNEPDLDDVPAEVLAELEVRPMTDVADIVAQALEPAAQESTPAVT
HHHHHCCCCEEEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCHHHHCCCCCHH
RAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9425059 [H]