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The map label for this gene is fadR [C]

Identifier: 119868803

GI number: 119868803

Start: 2892956

End: 2893675

Strand: Direct

Name: fadR [C]

Synonym: Mkms_2771

Alternate gene names: 119868803

Gene position: 2892956-2893675 (Clockwise)

Preceding gene: 119868802

Following gene: 119868804

Centisome position: 50.42

GC content: 69.86

Gene sequence:

>720_bases
ATGGCGCTACAACCTGTCAACCGCCGCTCGGTACCCGAGGACGTCTTCGACCAGATCGTCACCGAGGTGCTCAGCGGGCA
GATGCAGCCCGGGCAGACGCTGCCGAGTGAACGGCGGTTGGCCGAGGTGCTCGGGGTGTCGCGGCCGGCGATCCGCGAAG
CGCTCAAACGCCTTGCCGGCGCCGGCCTGATCGAGGTGCGCCAGGGCGATGCGACCACCGTGCGCGACTTCCGGCGCACA
GCCGGCCTCGACCTCCTCCCCCGGCTGCTCATCCGCGGCGGCGAACTCGATCTGACCGTGGTCCGCAGCATTCTCGAGAC
CCGGTTGCACAACGGTCCGAAGGTCGCCGAACTGGCCGCCGAACGCGGCGGTCCCGGCCTCGCGGAGCGGCTGGATGAAA
CCGTGGACGCACTCGAGGCCGAGACCGATCCCGTTGCCGCGCAACAACTTGCGCTCACCTTCTGGGACCACGTCGTGGAC
GGGGCCGATTCGATCGCGTTCCGCCTGATGTACAACACGCTGCGAGCCACATACGAACCGGCCCTGCCTGCGCTGGCCAC
CATGATGGCCGAAGAGGTCGGTCGACCCGACGCCTACCGCGCCGTCACGGCCGCCATCGTGGCGCGTGATCCGGCGGGGG
CGGCCGATGCCGCCAGGCGTCTGCTCGAACCCGCCACCACCGCACTGCTCGACGCACTCGGCGAACTGGAGGCCCGATGA

Upstream 100 bases:

>100_bases
ACCCCACCGGGGCCGCCGAGGCGAAGTACGAGATCACTACGAGGTGCTAACTGGTCAGACCACTTGACCTCTGGCCACTG
ACCCTATCATCCTCGGTGGC

Downstream 100 bases:

>100_bases
CAACCCACCACGCGTCCCGGCCCGCCCGCCGGGCGTTCACGCTGGCCGACGCCGCGCGCGAATTCCGGCGGCACCCCTCG
CCCTGGCTGATCGCGGGCAC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MALQPVNRRSVPEDVFDQIVTEVLSGQMQPGQTLPSERRLAEVLGVSRPAIREALKRLAGAGLIEVRQGDATTVRDFRRT
AGLDLLPRLLIRGGELDLTVVRSILETRLHNGPKVAELAAERGGPGLAERLDETVDALEAETDPVAAQQLALTFWDHVVD
GADSIAFRLMYNTLRATYEPALPALATMMAEEVGRPDAYRAVTAAIVARDPAGAADAARRLLEPATTALLDALGELEAR

Sequences:

>Translated_239_residues
MALQPVNRRSVPEDVFDQIVTEVLSGQMQPGQTLPSERRLAEVLGVSRPAIREALKRLAGAGLIEVRQGDATTVRDFRRT
AGLDLLPRLLIRGGELDLTVVRSILETRLHNGPKVAELAAERGGPGLAERLDETVDALEAETDPVAAQQLALTFWDHVVD
GADSIAFRLMYNTLRATYEPALPALATMMAEEVGRPDAYRAVTAAIVARDPAGAADAARRLLEPATTALLDALGELEAR
>Mature_238_residues
ALQPVNRRSVPEDVFDQIVTEVLSGQMQPGQTLPSERRLAEVLGVSRPAIREALKRLAGAGLIEVRQGDATTVRDFRRTA
GLDLLPRLLIRGGELDLTVVRSILETRLHNGPKVAELAAERGGPGLAERLDETVDALEAETDPVAAQQLALTFWDHVVDG
ADSIAFRLMYNTLRATYEPALPALATMMAEEVGRPDAYRAVTAAIVARDPAGAADAARRLLEPATTALLDALGELEAR

Specific function: Multifunctional Regulator Of Fatty Acid Metabolism. Represses Transcription Of At Least Eight Genes Required For Fatty Acid Transport And Beta-Oxidation Among Which Fada, Fadb, Fadd, Fadl And Fade. Activates Transcription Of At Least Three Genes Required

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=73, Percent_Identity=38.3561643835616, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786303, Length=168, Percent_Identity=32.7380952380952, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25746; Mature: 25615

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQPVNRRSVPEDVFDQIVTEVLSGQMQPGQTLPSERRLAEVLGVSRPAIREALKRLAG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
AGLIEVRQGDATTVRDFRRTAGLDLLPRLLIRGGELDLTVVRSILETRLHNGPKVAELAA
CCEEEEECCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ERGGPGLAERLDETVDALEAETDPVAAQQLALTFWDHVVDGADSIAFRLMYNTLRATYEP
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALPALATMMAEEVGRPDAYRAVTAAIVARDPAGAADAARRLLEPATTALLDALGELEAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALQPVNRRSVPEDVFDQIVTEVLSGQMQPGQTLPSERRLAEVLGVSRPAIREALKRLAG
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
AGLIEVRQGDATTVRDFRRTAGLDLLPRLLIRGGELDLTVVRSILETRLHNGPKVAELAA
CCEEEEECCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
ERGGPGLAERLDETVDALEAETDPVAAQQLALTFWDHVVDGADSIAFRLMYNTLRATYEP
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ALPALATMMAEEVGRPDAYRAVTAAIVARDPAGAADAARRLLEPATTALLDALGELEAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]