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The map label for this gene is tdh [H]

Identifier: 119868634

GI number: 119868634

Start: 2733015

End: 2734103

Strand: Direct

Name: tdh [H]

Synonym: Mkms_2599

Alternate gene names: 119868634

Gene position: 2733015-2734103 (Clockwise)

Preceding gene: 119868632

Following gene: 119868635

Centisome position: 47.64

GC content: 64.92

Gene sequence:

>1089_bases
ATGTCCGACCAGATTCCGGAAAAGATGCAGGCAGTGGTCTGTCACGGACCGCGTGACTATCGACTCGAGGAGATCGCCGT
ACCGCAGCGCGGACCCGGCGAAGCGCTGATCAGGGTCGAAGCGGTCGGCATCTGCGCCAGCGATCTGAAGTGCTACCACG
GCGCGGCGAAGTTCTGGGGCGACGAGAACCGCCCCGCGTGGGCCGAGACCATGGTTATCCCCGGACACGAGTTCGTCGGC
ACGGTGGTCGAACTCGACGACGACGCCGCCCAGCGGTGGGGGATCGCCGTCGGTGACCGTGTGGTCTCCGAGCAGATCGT
GCCGTGCTGGGAGTGTCGCTTCTGCAAGCGCGGCCAGTACCACATGTGTCAGCCGCACGACCTCTACGGTTTCAAGCGCC
GCACGCCCGGCGCCATGGCCAGCTACATGGTGTATCCGGCAGAAGCGTTGGTGCACAAGGTGTCCAAAGACATCAAGCCC
CATCATGCCGCCTTCGCCGAACCGCTGTCGTGCTCCCTGCACGCGGTCGAACGCGCCCAGATCACCTTCGAGGACACCGT
CGTCGTCGCGGGGTGCGGACCGATCGGGCTCGGCATGATCGCGGGTGCGCGGGCCAAGAACCCGATGCACGTCATCGCGC
TCGACCTGGCCCCCGACAAGCTCGAACTGGCCGAGAAGTGCGGCGCCGACATCACGATCAACATCGCCGAACAGGATGCG
GTGGCGATCGTCAAGGAGCTCACCGACGGCTACGGCGCCGATGTCTACCTCGAGGGCACCGGCCACACGTCGGCGGTTCC
GCAGGGGCTCAACCTGTTACGCAAGCTCGGCCGCTACGTCGAGTACGGGGTGTTCGGCAGTGACGTCACCGTCGACTGGA
GCATCATCAGCGACGACAAGGAACTCGACGTGCTCGGCGCGCATCTCGGGCCGTACTGCTGGCCGGCCGCCATCAAGATG
ATCGAATCCGGCATCTTGCCGATGGACGAGATCTGCACCCATCAGCTGCCGCTCACCGACTTCCAGAAGGGTCTCGACCT
CGTCGCGAGCGGTAAAGAGTCCGTCAAGGTTTCGTTGATCCCCGCCTGA

Upstream 100 bases:

>100_bases
TGAACGCCTGACGCTGAACAGATTCTCTCTGAACAGATGTTCTGGACAGATGTGCACCGCATTGGTTAGTGTGAGCGCAA
CCACACAGGAGGAGCGCTCG

Downstream 100 bases:

>100_bases
GCGCCGAAGGAACATACCAGATGAGTCGAGATCGGTTCGCGCAGCAACGTCAGCTGTCGCGCCGGAACATGTTGGCCGCC
ATGGGAATCGCCGGAGCGGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSDQIPEKMQAVVCHGPRDYRLEEIAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVG
TVVELDDDAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQYHMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSKDIKP
HHAAFAEPLSCSLHAVERAQITFEDTVVVAGCGPIGLGMIAGARAKNPMHVIALDLAPDKLELAEKCGADITINIAEQDA
VAIVKELTDGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKM
IESGILPMDEICTHQLPLTDFQKGLDLVASGKESVKVSLIPA

Sequences:

>Translated_362_residues
MSDQIPEKMQAVVCHGPRDYRLEEIAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVG
TVVELDDDAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQYHMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSKDIKP
HHAAFAEPLSCSLHAVERAQITFEDTVVVAGCGPIGLGMIAGARAKNPMHVIALDLAPDKLELAEKCGADITINIAEQDA
VAIVKELTDGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKM
IESGILPMDEICTHQLPLTDFQKGLDLVASGKESVKVSLIPA
>Mature_361_residues
SDQIPEKMQAVVCHGPRDYRLEEIAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWGDENRPAWAETMVIPGHEFVGT
VVELDDDAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQYHMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSKDIKPH
HAAFAEPLSCSLHAVERAQITFEDTVVVAGCGPIGLGMIAGARAKNPMHVIALDLAPDKLELAEKCGADITINIAEQDAV
AIVKELTDGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDKELDVLGAHLGPYCWPAAIKMI
ESGILPMDEICTHQLPLTDFQKGLDLVASGKESVKVSLIPA

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=346, Percent_Identity=30.0578034682081, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=31.7647058823529, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788073, Length=332, Percent_Identity=27.4096385542169, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI226510992, Length=354, Percent_Identity=27.1186440677966, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1787863, Length=342, Percent_Identity=26.0233918128655, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790718, Length=357, Percent_Identity=25.2100840336134, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786825, Length=403, Percent_Identity=27.2952853598015, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788407, Length=367, Percent_Identity=26.158038147139, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=24.3697478991597, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=25.561797752809, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=374, Percent_Identity=24.8663101604278, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081918, Length=223, Percent_Identity=30.0448430493274, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=342, Percent_Identity=30.7017543859649, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=326, Percent_Identity=30.3680981595092, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=28.9693593314763, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=29.2957746478873, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=27.9411764705882, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319257, Length=363, Percent_Identity=24.7933884297521, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=374, Percent_Identity=23.7967914438503, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=259, Percent_Identity=30.1158301158301, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=355, Percent_Identity=24.7887323943662, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=258, Percent_Identity=27.1317829457364, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=254, Percent_Identity=25.9842519685039, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137530, Length=346, Percent_Identity=29.1907514450867, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=27.7620396600567, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 39389; Mature: 39257

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQIPEKMQAVVCHGPRDYRLEEIAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWG
CCCCCCHHHHEEEECCCCCCCCCEECCCCCCCCCEEEEEEEEEEEHHHHHHHHCHHHHCC
DENRPAWAETMVIPGHEFVGTVVELDDDAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQY
CCCCCCHHEEEEECCHHHEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCC
HMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSKDIKPHHAAFAEPLSCSLHAVERAQ
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHEEHHHEE
ITFEDTVVVAGCGPIGLGMIAGARAKNPMHVIALDLAPDKLELAEKCGADITINIAEQDA
EEEECEEEEEECCCHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCHH
VAIVKELTDGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDK
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
ELDVLGAHLGPYCWPAAIKMIESGILPMDEICTHQLPLTDFQKGLDLVASGKESVKVSLI
CHHEEHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCHHHHCCCCCCEEEEEE
PA
CC
>Mature Secondary Structure 
SDQIPEKMQAVVCHGPRDYRLEEIAVPQRGPGEALIRVEAVGICASDLKCYHGAAKFWG
CCCCCHHHHEEEECCCCCCCCCEECCCCCCCCCEEEEEEEEEEEHHHHHHHHCHHHHCC
DENRPAWAETMVIPGHEFVGTVVELDDDAAQRWGIAVGDRVVSEQIVPCWECRFCKRGQY
CCCCCCHHEEEEECCHHHEEEEEEECCHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCC
HMCQPHDLYGFKRRTPGAMASYMVYPAEALVHKVSKDIKPHHAAFAEPLSCSLHAVERAQ
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCHHHHHEEHHHEE
ITFEDTVVVAGCGPIGLGMIAGARAKNPMHVIALDLAPDKLELAEKCGADITINIAEQDA
EEEECEEEEEECCCHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCHH
VAIVKELTDGYGADVYLEGTGHTSAVPQGLNLLRKLGRYVEYGVFGSDVTVDWSIISDDK
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCC
ELDVLGAHLGPYCWPAAIKMIESGILPMDEICTHQLPLTDFQKGLDLVASGKESVKVSLI
CHHEEHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHCHHHHCCCCCCEEEEEE
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]