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The map label for this gene is fabG [C]

Identifier: 119868615

GI number: 119868615

Start: 2711110

End: 2712084

Strand: Reverse

Name: fabG [C]

Synonym: Mkms_2580

Alternate gene names: 119868615

Gene position: 2712084-2711110 (Counterclockwise)

Preceding gene: 119868616

Following gene: 119868614

Centisome position: 47.27

GC content: 65.54

Gene sequence:

>975_bases
GTGATTGATTTCAAAGACCAGGTGGCGATCGTCACCGGCGCCGGACGCGGGCTCGGCCGGCTCTACGCGCTCGAACTGGC
GCGGCGCGGCGCGGCGGTCGTCGTCAACGACCTGGGCGGCACGATGCACGGAGAGGGATCCGACGCCAGTGTCGCCGACC
AGGTGGTCGAGGAGATCACCCAGGGCGGCGGCCGCGCCGTGGCGTCCTACGATTCGGTCGACAGTCCCGAAGGCGGCCAG
TCCATCGTCGACGCCGCCGTCGACGCCTTCGGCCGCGTCGACGCCGTCGTCAGCAACGCGGGCATCTTCAACAGCATCCC
GTTCGACCAGCTCACCGCCGACGATTGGCGTCGGATGCTCAGCGTCCACCTCGATGGCGGCTTCTACCTCAGCCAGCCCG
CGTTCAAGGTCATGGCGAAGCAGAAATCCGGCCGGTTCGTCTTCATCTCATCGTCGGCAGGCAACTTCGGCCAGCCGATG
GAGGCTCATTACGCCGCGGCCAAGACCGGTCTGGTGGGGCTGTCGAACGTCATCGCCATTGAGGGCGCCGAACACGGCAT
TCTCTCGAACACCGTTCTGCCCACCGGGTTCTCACGAATGGTGACCGAGACGGTCGGCGACGAGAAGTTCCTCGCCGAAT
CCGGCTTCATGCGCGCCATCCGGGCTGAACTCGTCGTTCCGCTCGTGGTTTTCCTCGCAAGTCGCGCGTGTGAATCCACC
CATCGCAACTACTCCGCATGCGCGGGCCGCTACGCGCGAGTCTTCGTCGGGCTCAGCGAAGGTTGGCTGGCCGACGCCGA
GACCCAGCCGACCGCCGACGACATCCTTGCACACCTCGACGCGATATCGGCAACCGAGAAGTTCATCGTGCCTGACTCCA
TCGTCGACGAAGTCCTCGAGGTCTGCGATCGCCGTGGCATCAGCCCCATGCCGGACAACGCCGAGGTCGCTTTCCCGGAA
TCCGCCAAGAAGTAA

Upstream 100 bases:

>100_bases
GTGGGGGCGGCCGGCCGGGGCCCGGCACCTATCTACAACAGCTCGGCGCCGCACTGGCCGCGGCGCATCTTCACCAACGC
CGGTCGGAGGCACACACAGC

Downstream 100 bases:

>100_bases
CTGAGGAGATCGAAATGGATATGAACGACTTCGTCCTCGTGTCGGTCGACGATCACATGGTCGAGCCACCGGATATGTTC
GACGGCCACATCCCGGCCAA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MIDFKDQVAIVTGAGRGLGRLYALELARRGAAVVVNDLGGTMHGEGSDASVADQVVEEITQGGGRAVASYDSVDSPEGGQ
SIVDAAVDAFGRVDAVVSNAGIFNSIPFDQLTADDWRRMLSVHLDGGFYLSQPAFKVMAKQKSGRFVFISSSAGNFGQPM
EAHYAAAKTGLVGLSNVIAIEGAEHGILSNTVLPTGFSRMVTETVGDEKFLAESGFMRAIRAELVVPLVVFLASRACEST
HRNYSACAGRYARVFVGLSEGWLADAETQPTADDILAHLDAISATEKFIVPDSIVDEVLEVCDRRGISPMPDNAEVAFPE
SAKK

Sequences:

>Translated_324_residues
MIDFKDQVAIVTGAGRGLGRLYALELARRGAAVVVNDLGGTMHGEGSDASVADQVVEEITQGGGRAVASYDSVDSPEGGQ
SIVDAAVDAFGRVDAVVSNAGIFNSIPFDQLTADDWRRMLSVHLDGGFYLSQPAFKVMAKQKSGRFVFISSSAGNFGQPM
EAHYAAAKTGLVGLSNVIAIEGAEHGILSNTVLPTGFSRMVTETVGDEKFLAESGFMRAIRAELVVPLVVFLASRACEST
HRNYSACAGRYARVFVGLSEGWLADAETQPTADDILAHLDAISATEKFIVPDSIVDEVLEVCDRRGISPMPDNAEVAFPE
SAKK
>Mature_324_residues
MIDFKDQVAIVTGAGRGLGRLYALELARRGAAVVVNDLGGTMHGEGSDASVADQVVEEITQGGGRAVASYDSVDSPEGGQ
SIVDAAVDAFGRVDAVVSNAGIFNSIPFDQLTADDWRRMLSVHLDGGFYLSQPAFKVMAKQKSGRFVFISSSAGNFGQPM
EAHYAAAKTGLVGLSNVIAIEGAEHGILSNTVLPTGFSRMVTETVGDEKFLAESGFMRAIRAELVVPLVVFLASRACEST
HRNYSACAGRYARVFVGLSEGWLADAETQPTADDILAHLDAISATEKFIVPDSIVDEVLEVCDRRGISPMPDNAEVAFPE
SAKK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=312, Percent_Identity=41.3461538461538, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI15277342, Length=211, Percent_Identity=30.3317535545024, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI19923817, Length=241, Percent_Identity=26.9709543568465, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=28.8702928870293, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI40254992, Length=194, Percent_Identity=30.9278350515464, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI40807363, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=236, Percent_Identity=32.2033898305085, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788459, Length=190, Percent_Identity=36.3157894736842, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790717, Length=204, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082100, Length=194, Percent_Identity=28.3505154639175, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789208, Length=268, Percent_Identity=27.2388059701493, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082160, Length=204, Percent_Identity=30.8823529411765, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787905, Length=147, Percent_Identity=36.734693877551, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=238, Percent_Identity=32.7731092436975, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787526, Length=194, Percent_Identity=28.8659793814433, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789057, Length=192, Percent_Identity=31.7708333333333, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=282, Percent_Identity=44.3262411347518, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=30.2238805970149, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=222, Percent_Identity=30.1801801801802, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=188, Percent_Identity=26.063829787234, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=218, Percent_Identity=28.8990825688073, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=210, Percent_Identity=29.5238095238095, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=237, Percent_Identity=28.2700421940928, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=214, Percent_Identity=27.1028037383178, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997099, Length=207, Percent_Identity=29.951690821256, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=175, Percent_Identity=28, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=304, Percent_Identity=38.8157894736842, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324126, Length=198, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=273, Percent_Identity=40.6593406593407, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24640492, Length=199, Percent_Identity=26.1306532663317, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24639444, Length=235, Percent_Identity=30.2127659574468, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355319, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357041, Length=195, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24649181, Length=213, Percent_Identity=30.0469483568075, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571526, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=171, Percent_Identity=29.8245614035088, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=225, Percent_Identity=28, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 34295; Mature: 34295

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFKDQVAIVTGAGRGLGRLYALELARRGAAVVVNDLGGTMHGEGSDASVADQVVEEIT
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
QGGGRAVASYDSVDSPEGGQSIVDAAVDAFGRVDAVVSNAGIFNSIPFDQLTADDWRRML
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHH
SVHLDGGFYLSQPAFKVMAKQKSGRFVFISSSAGNFGQPMEAHYAAAKTGLVGLSNVIAI
HEECCCCEEECCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCHHCCCCEEEE
EGAEHGILSNTVLPTGFSRMVTETVGDEKFLAESGFMRAIRAELVVPLVVFLASRACEST
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRNYSACAGRYARVFVGLSEGWLADAETQPTADDILAHLDAISATEKFIVPDSIVDEVLE
CCCHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHH
VCDRRGISPMPDNAEVAFPESAKK
HHHHCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MIDFKDQVAIVTGAGRGLGRLYALELARRGAAVVVNDLGGTMHGEGSDASVADQVVEEIT
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
QGGGRAVASYDSVDSPEGGQSIVDAAVDAFGRVDAVVSNAGIFNSIPFDQLTADDWRRML
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHH
SVHLDGGFYLSQPAFKVMAKQKSGRFVFISSSAGNFGQPMEAHYAAAKTGLVGLSNVIAI
HEECCCCEEECCHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCHHCCCCEEEE
EGAEHGILSNTVLPTGFSRMVTETVGDEKFLAESGFMRAIRAELVVPLVVFLASRACEST
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRNYSACAGRYARVFVGLSEGWLADAETQPTADDILAHLDAISATEKFIVPDSIVDEVLE
CCCHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHH
VCDRRGISPMPDNAEVAFPESAKK
HHHHCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]