Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 119868495

GI number: 119868495

Start: 2582041

End: 2584134

Strand: Reverse

Name: tkt [H]

Synonym: Mkms_2460

Alternate gene names: 119868495

Gene position: 2584134-2582041 (Counterclockwise)

Preceding gene: 119868497

Following gene: 119868494

Centisome position: 45.04

GC content: 67.91

Gene sequence:

>2094_bases
GTGACCACCGTCGACGACATCGCGACGCTGACCCAACCCCACCACCCCGACGACTGGTCCGAGTTGGACTCCGTCGCGGT
CGACACCGTGCGGGTGCTGGCGGCGGATGCCGTGCAGAAGGTCGGCAACGGCCATCCCGGTACGGCGATGAGCCTGGCGC
CCCTGGCGTACACGCTGTTCCAGCGGACCATGCGGCACGACCCCAGCGATGTGCACTGGCTGGGCCGGGACCGGTTCGTC
CTGTCCTGCGGTCATTCGAGCCTGACGCTCTACATCCAGCTCTACCTGGGCGGGTTCGGTCTCGAGCTCGAGGACATCCA
GGCGCTGCGGACCTTCAAGTCGAAGACCCCGGGCCATCCCGAGTTCCGGCACACCAAGGGTGTGGAGATCACCACCGGCC
CGCTCGGTCAGGGCCTCGCCTCGGCCGTGGGTATGGCGATGGCGGCGCGCTACGAGCGCGGGCTGTTCGACCCGGACGCC
GCGCCGGGCACCAGCCCGTTCGACCACCACATCTACGTGATCGCCTCCGACGGCGACATCGAAGAGGGTGTGACCAGCGA
GGCGTCGTCGCTGGCGGGTACCCAGCAGCTGGGCAACCTCATCGTCTTCTACGACCAGAACCAGATCTCCATCGAGCACG
ACACGAACATCGCGCTGTCGGAGAATGTCGCCGACCGCTACCGCGCCTACGGCTGGCACGTCCAGGAGGTCGAGGGCGGC
GAGAACGTCGTCGGAATCGAAGAAGCCATCGAGGCCGCCAAGGCGGTCACGGACCGCCCGTCCTTCATCGCGGTGCGCAC
GATCATCGGCTATCCGGCGCCGAACAAGATGAACACCGGCGGCGTGCACGGCTCGGCGCTCGGTGACGACGAGGTCGCGG
CGGTCAAGGAGGTTCTCGGCTTCGATCCGGACAAGACGTTCGAGGTGCGCGACGAGGTCATCGAGCACACCCGCAAGCTC
GTCCAGCGGGGCCGCGAAGCCCACGAGAAGTGGCAGCCCGAGTTCGACGCCTGGGCCGAGCGCGAACCCGAGCGCAAGAA
GCTGCTCGACCGGCTGCTCGCCCAGGAGCTGCCGGACGGCTGGGACGCCGATCTGACGTACTGGGAGCCGGGCAGCAAGG
CGGTCGCCACCCGCGCCGCGTTCGGCCAGGTGCTCAACGACGTCGCGCCGAAGCTGCCCGAATTGTGGGGCGGTTCGGCC
GATTTGGCCGGTAGCAACAACACGACCATCAAGGGCGTGAAATCGTTCGGCCCGCCGTCGATCTCGACCGACGACTTCAC
CGCCGACTGGTACGGCCGGGTGCTGCACTTCGGTATCCGCGAACACGCGATGGGCTCGATCCTGTCGGGCATCGTGCTGC
ACGGCCCGACGCGCGCCTTCGGCGGGACGTTCCTGCAGTTCTCCGACTACATGCGGCCGGCGGTGCGGTTGGCCTCGCTG
ATGGACATCGACACCATCTACATCTGGACCCACGATTCGATCGGTCTCGGCGAGGACGGCCCCACGCACCAGCCGATCGA
ACATCTCGCCGCGCTGCGGGCGATCCCTAACCTGTCGGTGGTCCGGCCGGGTGACCCGAACGAGACGGCCTACGCCTGGC
GCAGCATCCTGGCCCGCGGCAACGGCAGCGGCCCGGTCGGTTTCATCCTGACCCGACAGGGCATCCCGGTGCTGGAGGGC
ACCGACTCCGACGGCGTCGCCCGCGGCGGATACGTCCTCGGCGGCGGGAATCCCTCCGATGACGCCGACGTCATCATCAT
CGCGACCGGATCCGAACTCCAGCTCGCGGTGGAGGCGAAGAAGCTCCTCGCCGAGAAGGACCTCACCGCATACGTGGTGT
CCATGCCGTGCGTGGAGTGGTTCGAGTCGCAGCCGAAGGAATACCGCGACAGCGTGCTGCCTCCCAACGTCTCCGCGCGC
GTCGCAGTGGAGGCCGCCGTCGCCCAGAGCTGGTACAAGCTCGTCGGCGACACCGGCGAGATCGTCTCCATCGAGCACTA
CGGGGAGTCCGCCGACGACAAGACGTTGTTCCGCGAGTTCGGCTTCACCGCCGAGGCCGTGGCCGCCGCCGCGGAGCGCA
CCATAAACAACTAA

Upstream 100 bases:

>100_bases
GCACCATGCGGCGCCGCAGCCGGGAGCACTAGGGTTGGAGGCGCGGTCCGAAAGGTTGTGTGCGGCCGCTGACCGAACAT
TGCCACCAAGGAGCGAGCCA

Downstream 100 bases:

>100_bases
CCGACAAAGCAAGGGCAGGTATAGACGATGACTCAGAATTCGAACCTCGCGGCGCTCAGCGCCGCCGGGGTGTCCGTATG
GCTCGACGATCTGTCCCGTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 697; Mature: 696

Protein sequence:

>697_residues
MTTVDDIATLTQPHHPDDWSELDSVAVDTVRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDVHWLGRDRFV
LSCGHSSLTLYIQLYLGGFGLELEDIQALRTFKSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDA
APGTSPFDHHIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVFYDQNQISIEHDTNIALSENVADRYRAYGWHVQEVEGG
ENVVGIEEAIEAAKAVTDRPSFIAVRTIIGYPAPNKMNTGGVHGSALGDDEVAAVKEVLGFDPDKTFEVRDEVIEHTRKL
VQRGREAHEKWQPEFDAWAEREPERKKLLDRLLAQELPDGWDADLTYWEPGSKAVATRAAFGQVLNDVAPKLPELWGGSA
DLAGSNNTTIKGVKSFGPPSISTDDFTADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMRPAVRLASL
MDIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVRPGDPNETAYAWRSILARGNGSGPVGFILTRQGIPVLEG
TDSDGVARGGYVLGGGNPSDDADVIIIATGSELQLAVEAKKLLAEKDLTAYVVSMPCVEWFESQPKEYRDSVLPPNVSAR
VAVEAAVAQSWYKLVGDTGEIVSIEHYGESADDKTLFREFGFTAEAVAAAAERTINN

Sequences:

>Translated_697_residues
MTTVDDIATLTQPHHPDDWSELDSVAVDTVRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDVHWLGRDRFV
LSCGHSSLTLYIQLYLGGFGLELEDIQALRTFKSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDA
APGTSPFDHHIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVFYDQNQISIEHDTNIALSENVADRYRAYGWHVQEVEGG
ENVVGIEEAIEAAKAVTDRPSFIAVRTIIGYPAPNKMNTGGVHGSALGDDEVAAVKEVLGFDPDKTFEVRDEVIEHTRKL
VQRGREAHEKWQPEFDAWAEREPERKKLLDRLLAQELPDGWDADLTYWEPGSKAVATRAAFGQVLNDVAPKLPELWGGSA
DLAGSNNTTIKGVKSFGPPSISTDDFTADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMRPAVRLASL
MDIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVRPGDPNETAYAWRSILARGNGSGPVGFILTRQGIPVLEG
TDSDGVARGGYVLGGGNPSDDADVIIIATGSELQLAVEAKKLLAEKDLTAYVVSMPCVEWFESQPKEYRDSVLPPNVSAR
VAVEAAVAQSWYKLVGDTGEIVSIEHYGESADDKTLFREFGFTAEAVAAAAERTINN
>Mature_696_residues
TTVDDIATLTQPHHPDDWSELDSVAVDTVRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDVHWLGRDRFVL
SCGHSSLTLYIQLYLGGFGLELEDIQALRTFKSKTPGHPEFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDAA
PGTSPFDHHIYVIASDGDIEEGVTSEASSLAGTQQLGNLIVFYDQNQISIEHDTNIALSENVADRYRAYGWHVQEVEGGE
NVVGIEEAIEAAKAVTDRPSFIAVRTIIGYPAPNKMNTGGVHGSALGDDEVAAVKEVLGFDPDKTFEVRDEVIEHTRKLV
QRGREAHEKWQPEFDAWAEREPERKKLLDRLLAQELPDGWDADLTYWEPGSKAVATRAAFGQVLNDVAPKLPELWGGSAD
LAGSNNTTIKGVKSFGPPSISTDDFTADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMRPAVRLASLM
DIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVRPGDPNETAYAWRSILARGNGSGPVGFILTRQGIPVLEGT
DSDGVARGGYVLGGGNPSDDADVIIIATGSELQLAVEAKKLLAEKDLTAYVVSMPCVEWFESQPKEYRDSVLPPNVSARV
AVEAAVAQSWYKLVGDTGEIVSIEHYGESADDKTLFREFGFTAEAVAAAAERTINN

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=612, Percent_Identity=25.1633986928105, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI4507521, Length=612, Percent_Identity=25.1633986928105, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI133778974, Length=674, Percent_Identity=24.4807121661721, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788808, Length=676, Percent_Identity=43.7869822485207, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI48994911, Length=676, Percent_Identity=42.7514792899408, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17539652, Length=534, Percent_Identity=25.8426966292135, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6325331, Length=681, Percent_Identity=44.640234948605, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319593, Length=682, Percent_Identity=43.841642228739, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45551847, Length=589, Percent_Identity=25.2971137521222, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45550715, Length=589, Percent_Identity=25.2971137521222, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24645119, Length=569, Percent_Identity=25.1318101933216, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24666278, Length=584, Percent_Identity=25, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 75590; Mature: 75459

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVDDIATLTQPHHPDDWSELDSVAVDTVRVLAADAVQKVGNGHPGTAMSLAPLAYTLF
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QRTMRHDPSDVHWLGRDRFVLSCGHSSLTLYIQLYLGGFGLELEDIQALRTFKSKTPGHP
HHHHCCCCCCEEECCCCCEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
EFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDAAPGTSPFDHHIYVIASDGDI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
EEGVTSEASSLAGTQQLGNLIVFYDQNQISIEHDTNIALSENVADRYRAYGWHVQEVEGG
CCCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCEEECCCHHHHHHHCCCEEEEECCC
ENVVGIEEAIEAAKAVTDRPSFIAVRTIIGYPAPNKMNTGGVHGSALGDDEVAAVKEVLG
CCEECHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
FDPDKTFEVRDEVIEHTRKLVQRGREAHEKWQPEFDAWAEREPERKKLLDRLLAQELPDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCC
WDADLTYWEPGSKAVATRAAFGQVLNDVAPKLPELWGGSADLAGSNNTTIKGVKSFGPPS
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCC
ISTDDFTADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMRPAVRLASL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHH
MDIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVRPGDPNETAYAWRSILARG
HCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCC
NGSGPVGFILTRQGIPVLEGTDSDGVARGGYVLGGGNPSDDADVIIIATGSELQLAVEAK
CCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCEEEHHHHH
KLLAEKDLTAYVVSMPCVEWFESQPKEYRDSVLPPNVSARVAVEAAVAQSWYKLVGDTGE
HHHHHCCCCEEEHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
IVSIEHYGESADDKTLFREFGFTAEAVAAAAERTINN
EEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTVDDIATLTQPHHPDDWSELDSVAVDTVRVLAADAVQKVGNGHPGTAMSLAPLAYTLF
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QRTMRHDPSDVHWLGRDRFVLSCGHSSLTLYIQLYLGGFGLELEDIQALRTFKSKTPGHP
HHHHCCCCCCEEECCCCCEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
EFRHTKGVEITTGPLGQGLASAVGMAMAARYERGLFDPDAAPGTSPFDHHIYVIASDGDI
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
EEGVTSEASSLAGTQQLGNLIVFYDQNQISIEHDTNIALSENVADRYRAYGWHVQEVEGG
CCCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCCCEEECCCHHHHHHHCCCEEEEECCC
ENVVGIEEAIEAAKAVTDRPSFIAVRTIIGYPAPNKMNTGGVHGSALGDDEVAAVKEVLG
CCEECHHHHHHHHHHHCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
FDPDKTFEVRDEVIEHTRKLVQRGREAHEKWQPEFDAWAEREPERKKLLDRLLAQELPDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCC
WDADLTYWEPGSKAVATRAAFGQVLNDVAPKLPELWGGSADLAGSNNTTIKGVKSFGPPS
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCC
ISTDDFTADWYGRVLHFGIREHAMGSILSGIVLHGPTRAFGGTFLQFSDYMRPAVRLASL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHH
MDIDTIYIWTHDSIGLGEDGPTHQPIEHLAALRAIPNLSVVRPGDPNETAYAWRSILARG
HCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCC
NGSGPVGFILTRQGIPVLEGTDSDGVARGGYVLGGGNPSDDADVIIIATGSELQLAVEAK
CCCCCEEEEEECCCCCEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCEEEHHHHH
KLLAEKDLTAYVVSMPCVEWFESQPKEYRDSVLPPNVSARVAVEAAVAQSWYKLVGDTGE
HHHHHCCCCEEEHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
IVSIEHYGESADDKTLFREFGFTAEAVAAAAERTINN
EEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]