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The map label for this gene is zwf [H]

Identifier: 119868493

GI number: 119868493

Start: 2579316

End: 2580887

Strand: Reverse

Name: zwf [H]

Synonym: Mkms_2458

Alternate gene names: 119868493

Gene position: 2580887-2579316 (Counterclockwise)

Preceding gene: 119868494

Following gene: 119868492

Centisome position: 44.98

GC content: 66.98

Gene sequence:

>1572_bases
ATGGTGGCGGTGAACCGGCCGGTCCCCGGAGTGCCGACTCCCGCCCCGGCGGGTTGGCGGAATCCGCTGCGTGACAAACG
CGATAAACGCATGCCCCGGATCGCCGGGCCGTGCGGTGTGGTCATCTTCGGGGTCACCGGCGATCTGTCCCGCAAGAAGC
TGATGCCGGCGATCTACGACCTGGCCAACCGGGGGCTGCTGCCCGCGTCGTTCTCGCTCGTCGGGTTCGCCCGAAGGGAC
TGGGCCGACGAGGATTTCGGGCAGGTCGTCTATGAGGCGGTCAAGAAGCACGCCCGCACCCCGTTCCGCCAGGAGGTGTG
GGACCGGCTGGCCGAGGGAATCCGGTTCGTCCAGGGCACATTCGACGATGAAGCCGCCTTCGCCACTCTCGCCGAAACCC
TGGAGAAGCTCGACGTCGAACGCGGCACCGGCGGCAATCACGCGTTCTACCTGTCGATCCCGCCGAAGGCGTTCCCGGTG
GTCTGCGAACAGCTGCGTAGATCCGGGCTGGCGCGTCCCCAGGAGGGCCGCTGGAGCCGGGTGGTGATCGAGAAGCCGTT
CGGCCACGACCTCGAGAGCGCGGTCGAACTCAACTCGGTGGTGAACAGCGTGTTCCCCGAGGAGTCGGTGTTCCGCATCG
ACCACTACCTCGGCAAGGAGACCGTGCAGAACATCCTGGCGCTGCGGTTCGCCAATGAACTGTACGAGCCGGTCTGGAAC
AACAACTACGTCGACCACGTCCAGATCACGATGGCCGAGGACATCGGATTGGGCGGGCGCGCAGGCTATTACGACGGCAT
CGGCGCCGCCCGCGACGTGATCCAGAACCACCTGCTGCAACTGTTGGCGCTGACGGCGATGGAGGAACCGGTCAGCTTCC
ATCCCCACGAGCTGCAGGCCGAGAAGATCAAGGTGCTCTCCGCGGTGCGGTTGGCTCAACCCCTCGACCAGACCACCTCC
CGCGGTCAGTACACCGGCGGGTGGCAGGGCGGTGAGAAGGTGGTCGGCCTGCACGACGAGGAGGGGTTCTCCAAGACGTC
GACGACCGAGACGTTCGCCGCGATCACCCTCGACATCGACACCCGCCGCTGGGCCGGGGTGCCGTTCTATCTGCGCACCG
GAAAACGGCTGGGCCGCAGGGTCACCGAGATCGCGCTGGTGTTCCGCCGGGCGCCGCACCTGCCGTTCGACGCGACGATG
ACCGAGGAACTGGGCCAGAACGCGCTGGTGATCCGGGTGCAGCCCGACGAGGGCATCACGCTGCGGTTCGGCTCCAAGGT
GCCGGGCAGCGCGATGGAGGTCCGCGACGTCAACATGGACTTCTCCTACGGGTCGGCGTTCGCCGAGGATTCCCCCGAGG
CCTACGAGCGGTTGATCCTCGACGTGCTGCTCGGTGAACCGTCGCTGTTCCCGGTCAACGCCGAGGTCGAACTGTCCTGG
AACATCCTGGATCCGGTGCTGGACTACTGGGCTTCGCACGGCAAGCCGGATCCGTACGAGTCGGGCACGTGGGGGCCGGA
GTCGGCGTTCGAGATGCTGCGGCGAGACGGCCGCGAATGGAGGCGGCCGTGA

Upstream 100 bases:

>100_bases
GTGCTGGAAACCGAGGGCGTCGAGAAGTTCGAGAAGTCGTGGCAGGAGTTGCTCGAGGCCACGCAGGGCCAGCTCGACGA
GAAGAAATCCTGAGTCGCGC

Downstream 100 bases:

>100_bases
TTGTCGACCTGCCCGACACCACCACCAACGATCTGAACAAGAAGATCACGTCGCTGCGTGAGGAGGGCGGCGCGATCACG
CTGGGCCGGGTGCTCACCCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MVAVNRPVPGVPTPAPAGWRNPLRDKRDKRMPRIAGPCGVVIFGVTGDLSRKKLMPAIYDLANRGLLPASFSLVGFARRD
WADEDFGQVVYEAVKKHARTPFRQEVWDRLAEGIRFVQGTFDDEAAFATLAETLEKLDVERGTGGNHAFYLSIPPKAFPV
VCEQLRRSGLARPQEGRWSRVVIEKPFGHDLESAVELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWN
NNYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPHELQAEKIKVLSAVRLAQPLDQTTS
RGQYTGGWQGGEKVVGLHDEEGFSKTSTTETFAAITLDIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATM
TEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSW
NILDPVLDYWASHGKPDPYESGTWGPESAFEMLRRDGREWRRP

Sequences:

>Translated_523_residues
MVAVNRPVPGVPTPAPAGWRNPLRDKRDKRMPRIAGPCGVVIFGVTGDLSRKKLMPAIYDLANRGLLPASFSLVGFARRD
WADEDFGQVVYEAVKKHARTPFRQEVWDRLAEGIRFVQGTFDDEAAFATLAETLEKLDVERGTGGNHAFYLSIPPKAFPV
VCEQLRRSGLARPQEGRWSRVVIEKPFGHDLESAVELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWN
NNYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPHELQAEKIKVLSAVRLAQPLDQTTS
RGQYTGGWQGGEKVVGLHDEEGFSKTSTTETFAAITLDIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATM
TEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSW
NILDPVLDYWASHGKPDPYESGTWGPESAFEMLRRDGREWRRP
>Mature_523_residues
MVAVNRPVPGVPTPAPAGWRNPLRDKRDKRMPRIAGPCGVVIFGVTGDLSRKKLMPAIYDLANRGLLPASFSLVGFARRD
WADEDFGQVVYEAVKKHARTPFRQEVWDRLAEGIRFVQGTFDDEAAFATLAETLEKLDVERGTGGNHAFYLSIPPKAFPV
VCEQLRRSGLARPQEGRWSRVVIEKPFGHDLESAVELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWN
NNYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPHELQAEKIKVLSAVRLAQPLDQTTS
RGQYTGGWQGGEKVVGLHDEEGFSKTSTTETFAAITLDIDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATM
TEELGQNALVIRVQPDEGITLRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSW
NILDPVLDYWASHGKPDPYESGTWGPESAFEMLRRDGREWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=483, Percent_Identity=37.888198757764, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI109389365, Length=483, Percent_Identity=37.888198757764, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI52145310, Length=501, Percent_Identity=30.3393213572854, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=41.851106639839, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17538218, Length=495, Percent_Identity=35.7575757575758, Blast_Score=331, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=37.7593360995851, Blast_Score=309, Evalue=9e-85,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=36.9519832985386, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=36.9519832985386, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=28.2786885245902, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58559; Mature: 58559

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVNRPVPGVPTPAPAGWRNPLRDKRDKRMPRIAGPCGVVIFGVTGDLSRKKLMPAIYD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
LANRGLLPASFSLVGFARRDWADEDFGQVVYEAVKKHARTPFRQEVWDRLAEGIRFVQGT
HHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
FDDEAAFATLAETLEKLDVERGTGGNHAFYLSIPPKAFPVVCEQLRRSGLARPQEGRWSR
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCE
VVIEKPFGHDLESAVELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWN
EEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
NNYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPHELQA
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
EKIKVLSAVRLAQPLDQTTSRGQYTGGWQGGEKVVGLHDEEGFSKTSTTETFAAITLDID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEC
TRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTEELGQNALVIRVQPDEGIT
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCEE
LRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSW
EEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEC
NILDPVLDYWASHGKPDPYESGTWGPESAFEMLRRDGREWRRP
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MVAVNRPVPGVPTPAPAGWRNPLRDKRDKRMPRIAGPCGVVIFGVTGDLSRKKLMPAIYD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
LANRGLLPASFSLVGFARRDWADEDFGQVVYEAVKKHARTPFRQEVWDRLAEGIRFVQGT
HHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
FDDEAAFATLAETLEKLDVERGTGGNHAFYLSIPPKAFPVVCEQLRRSGLARPQEGRWSR
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCE
VVIEKPFGHDLESAVELNSVVNSVFPEESVFRIDHYLGKETVQNILALRFANELYEPVWN
EEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCC
NNYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPVSFHPHELQA
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
EKIKVLSAVRLAQPLDQTTSRGQYTGGWQGGEKVVGLHDEEGFSKTSTTETFAAITLDID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEEEEC
TRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTEELGQNALVIRVQPDEGIT
CCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCEE
LRFGSKVPGSAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELSW
EEECCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEC
NILDPVLDYWASHGKPDPYESGTWGPESAFEMLRRDGREWRRP
CHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]