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The map label for this gene is pgl [H]

Identifier: 119868491

GI number: 119868491

Start: 2577674

End: 2578411

Strand: Reverse

Name: pgl [H]

Synonym: Mkms_2456

Alternate gene names: 119868491

Gene position: 2578411-2577674 (Counterclockwise)

Preceding gene: 119868492

Following gene: 119868490

Centisome position: 44.94

GC content: 71.0

Gene sequence:

>738_bases
ATGACGGTTTCAGTGCGCCGGTACCCGGACGGCGATGCGCTGGTCACGGCGGTCGGTGACCGGCTCGCCGACGAGATCGT
GTCGGCCGTCGAGTTCCGCGGGCGGGCGAACATCGTGTTGACCGGCGGCGGCACCGGCATCAAGCTCCTTGCCCGCCTCG
GCACCCACGACGATCGCATCGACTGGTCGAAGGTGCATGTGTTCTTCGGCGACGAGCGGTACGTGCCCGAGGCGGACGAC
GAACGCAACGACAAACAGGCCCGCGAGGCCCTGCTGGACCACATCGACATCCCGACGGCCAATGTCCACGCGATGCCCGC
GGCCGACGGTGAGTTCGGGGACGACCTCGACGCCGCCGCGCTGGCCTACGAGCAGGTGCTGGCGGGGCAGGCCGAACAGG
ACGAACCGACGCCGGTGTTCGACGTGCACCTACTCGGGATGGGCCCCGAGGGACATGTCAACTCGCTGTTCCCGCATACC
CAGGCGGTGCGCGAGACCGCCCGCATGGTGGTCGGCGTGACGGACTCCCCCAAACCGCCGCCCCAGCGGATCACGTTGAC
GCTGCCCGCGGTTCAACGTTCCCGCGAGGTGTGGCTGGTGGTGTCGGGTGACGGTAAGGCCGAGGCGGTCGCCGCCGCCG
TCGGCGGCGCCGACCCCGACGACTGGCCGGCCGCCGGCGCCGTCGGACGCGAGGCGACGGTGTGGTTCCTCGACGAGGGC
GCCGCCTCGCGGCTCTGA

Upstream 100 bases:

>100_bases
GGCGCGAGGCGCGGGATTGTCTGGCGGAGGATCTGCGCCGCCTCGACGCGGACGAGATCTACCACGAGGCGCTGCAGGGT
ATCGACAAGGTGGTGTACGC

Downstream 100 bases:

>100_bases
CCCGCTACTCCTCGCCGACCCGCTGGGCCTGGGCGTCGTTCTGTGCGGCGGCGTAGCCGGCGGTGTAGTCGGCGATGCGG
CGCAGCACGTCGCCGGTGCC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MTVSVRRYPDGDALVTAVGDRLADEIVSAVEFRGRANIVLTGGGTGIKLLARLGTHDDRIDWSKVHVFFGDERYVPEADD
ERNDKQAREALLDHIDIPTANVHAMPAADGEFGDDLDAAALAYEQVLAGQAEQDEPTPVFDVHLLGMGPEGHVNSLFPHT
QAVRETARMVVGVTDSPKPPPQRITLTLPAVQRSREVWLVVSGDGKAEAVAAAVGGADPDDWPAAGAVGREATVWFLDEG
AASRL

Sequences:

>Translated_245_residues
MTVSVRRYPDGDALVTAVGDRLADEIVSAVEFRGRANIVLTGGGTGIKLLARLGTHDDRIDWSKVHVFFGDERYVPEADD
ERNDKQAREALLDHIDIPTANVHAMPAADGEFGDDLDAAALAYEQVLAGQAEQDEPTPVFDVHLLGMGPEGHVNSLFPHT
QAVRETARMVVGVTDSPKPPPQRITLTLPAVQRSREVWLVVSGDGKAEAVAAAVGGADPDDWPAAGAVGREATVWFLDEG
AASRL
>Mature_244_residues
TVSVRRYPDGDALVTAVGDRLADEIVSAVEFRGRANIVLTGGGTGIKLLARLGTHDDRIDWSKVHVFFGDERYVPEADDE
RNDKQAREALLDHIDIPTANVHAMPAADGEFGDDLDAAALAYEQVLAGQAEQDEPTPVFDVHLLGMGPEGHVNSLFPHTQ
AVRETARMVVGVTDSPKPPPQRITLTLPAVQRSREVWLVVSGDGKAEAVAAAVGGADPDDWPAAGAVGREATVWFLDEGA
ASRL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=233, Percent_Identity=30.9012875536481, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI6912586, Length=240, Percent_Identity=35, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI115533058, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115533060, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=205, Percent_Identity=33.6585365853659, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319918, Length=215, Percent_Identity=34.4186046511628, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321957, Length=251, Percent_Identity=28.6852589641434, Blast_Score=101, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6321687, Length=254, Percent_Identity=28.3464566929134, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641119, Length=215, Percent_Identity=35.3488372093023, Blast_Score=107, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26175; Mature: 26044

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSVRRYPDGDALVTAVGDRLADEIVSAVEFRGRANIVLTGGGTGIKLLARLGTHDDRI
CEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCC
DWSKVHVFFGDERYVPEADDERNDKQAREALLDHIDIPTANVHAMPAADGEFGDDLDAAA
CEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHH
LAYEQVLAGQAEQDEPTPVFDVHLLGMGPEGHVNSLFPHTQAVRETARMVVGVTDSPKPP
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCC
PQRITLTLPAVQRSREVWLVVSGDGKAEAVAAAVGGADPDDWPAAGAVGREATVWFLDEG
CCEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC
AASRL
CCCCC
>Mature Secondary Structure 
TVSVRRYPDGDALVTAVGDRLADEIVSAVEFRGRANIVLTGGGTGIKLLARLGTHDDRI
EEEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCC
DWSKVHVFFGDERYVPEADDERNDKQAREALLDHIDIPTANVHAMPAADGEFGDDLDAAA
CEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHHHH
LAYEQVLAGQAEQDEPTPVFDVHLLGMGPEGHVNSLFPHTQAVRETARMVVGVTDSPKPP
HHHHHHHCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCC
PQRITLTLPAVQRSREVWLVVSGDGKAEAVAAAVGGADPDDWPAAGAVGREATVWFLDEG
CCEEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECC
AASRL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]