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The map label for this gene is idsA [H]

Identifier: 119868395

GI number: 119868395

Start: 2474811

End: 2475971

Strand: Reverse

Name: idsA [H]

Synonym: Mkms_2359

Alternate gene names: 119868395

Gene position: 2475971-2474811 (Counterclockwise)

Preceding gene: 119868396

Following gene: 119868394

Centisome position: 43.16

GC content: 69.34

Gene sequence:

>1161_bases
ATGACGTCGACCGTTCCCGATACCGACCGCGCAGTGGACCCGCTCGAGGACTACCTCGCGCTGTGCAAGGAGACCTGCGA
CCGCGAGATCGAGCGGCTCTATTCGTCCGGGCGGCCCGGGTCGGGCTTCGAGGCACTGCTCCTCGACTATCCCCGCCGCG
GCGGCAAGGCGCTGCGGCCGGCGCTGAGCATCGCGGTCTGCCTCGGTCTGGGCGGTCAGCTGGATGCGATCCTGCCGACC
GCGGCAACGCTCGAGCTGTACCACAACGCCTTCCTCATCCACGACGACATCGAGGACGAATCCTGGTGGCGCCGCGGCAA
ACCCACGATGCACATCGACCATGGCATCCCGATCGCCGTCAACGTCGGTGACGCCATGCTCTCGCTGTCGTTGCAGCCGC
TGTTGGACAACGTCGAACGCATCGGGCTCGGGCCGGCACTGCGCATCCTGCGCGCCGTCGCCCACATGACCCGCAGGACC
GTGGAGGGTCAGGCGATCGAGCTCGAATGGGTCAGGTCCAACGCCTGGCGGCTCGACGACGCCGACTACCTCACGATGGT
CGAGCTGAAGACCAGCTGGTACTCGTTCATCACACCGCTGCAGGCGGGGGCGATCGCCGCCGGTGTCGACCCGGACCGGC
TGGAGCCGCTGGAGTCGCTCGGCCGGCACCTCGGGGCGGCCTTCCAGATCACCGACGACCTGCTCAACCTGCGGGCGGAC
CCCGAGGAGTACGGCAAAGAGATCGGCGGCGACCTCTGGGAGGGCAAACGGACCCTGATGCTGTTGCACACACTGCGCAC
GGCACAACCCCAGGACCGGATACGCGCCCTGCAGATACTGGCCCGGCGCCGCCCGGCCGGCCTGGAAGCCGGGCTCGCCG
GGTTACTCGACCGGCTGACCGCCCGCGGCGAACTGTCGCCGACGGGCCGCGCCGAGATTGCGGCCCGCTTCGACACCGCG
GAGGCCAAGAGCCTCGATGACATCCAGTGGTTGTACGAGCTGATGCACGACGTCGGATCGCTCGGGCACGCCCGGGAGGT
GGCCGCCCGGCACGCGCAGCAGGCCGCGGCCGTGCTGGCCGGTCTGGACTGGTTTCCGCCCAGTCGGCACCGTGAGGCGT
TGACCCACCTCGTCGACTATGTGCACGGGCGGACCCGATGA

Upstream 100 bases:

>100_bases
GCGAGGTCGACGACGCCAAAGTCCGCGTCGGGGTGCGGGTTCGCTTCGCGACGCGGGTGAAGGACAAGAACGGCATCGCA
GGAATCGTCGACGAAGCGCC

Downstream 100 bases:

>100_bases
CCCCGGAAGCCCTGGTCGGCATGCTGGCCGAACTCGAACGCATCCGCACACTGACCCTCGATCTCGTCGAACGTGCCGCC
CCGTCACTGCATCCCGAACC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTSTVPDTDRAVDPLEDYLALCKETCDREIERLYSSGRPGSGFEALLLDYPRRGGKALRPALSIAVCLGLGGQLDAILPT
AATLELYHNAFLIHDDIEDESWWRRGKPTMHIDHGIPIAVNVGDAMLSLSLQPLLDNVERIGLGPALRILRAVAHMTRRT
VEGQAIELEWVRSNAWRLDDADYLTMVELKTSWYSFITPLQAGAIAAGVDPDRLEPLESLGRHLGAAFQITDDLLNLRAD
PEEYGKEIGGDLWEGKRTLMLLHTLRTAQPQDRIRALQILARRRPAGLEAGLAGLLDRLTARGELSPTGRAEIAARFDTA
EAKSLDDIQWLYELMHDVGSLGHAREVAARHAQQAAAVLAGLDWFPPSRHREALTHLVDYVHGRTR

Sequences:

>Translated_386_residues
MTSTVPDTDRAVDPLEDYLALCKETCDREIERLYSSGRPGSGFEALLLDYPRRGGKALRPALSIAVCLGLGGQLDAILPT
AATLELYHNAFLIHDDIEDESWWRRGKPTMHIDHGIPIAVNVGDAMLSLSLQPLLDNVERIGLGPALRILRAVAHMTRRT
VEGQAIELEWVRSNAWRLDDADYLTMVELKTSWYSFITPLQAGAIAAGVDPDRLEPLESLGRHLGAAFQITDDLLNLRAD
PEEYGKEIGGDLWEGKRTLMLLHTLRTAQPQDRIRALQILARRRPAGLEAGLAGLLDRLTARGELSPTGRAEIAARFDTA
EAKSLDDIQWLYELMHDVGSLGHAREVAARHAQQAAAVLAGLDWFPPSRHREALTHLVDYVHGRTR
>Mature_385_residues
TSTVPDTDRAVDPLEDYLALCKETCDREIERLYSSGRPGSGFEALLLDYPRRGGKALRPALSIAVCLGLGGQLDAILPTA
ATLELYHNAFLIHDDIEDESWWRRGKPTMHIDHGIPIAVNVGDAMLSLSLQPLLDNVERIGLGPALRILRAVAHMTRRTV
EGQAIELEWVRSNAWRLDDADYLTMVELKTSWYSFITPLQAGAIAAGVDPDRLEPLESLGRHLGAAFQITDDLLNLRADP
EEYGKEIGGDLWEGKRTLMLLHTLRTAQPQDRIRALQILARRRPAGLEAGLAGLLDRLTARGELSPTGRAEIAARFDTAE
AKSLDDIQWLYELMHDVGSLGHAREVAARHAQQAAAVLAGLDWFPPSRHREALTHLVDYVHGRTR

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=228, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI83700220, Length=228, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1789578, Length=218, Percent_Identity=35.3211009174312, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786623, Length=230, Percent_Identity=29.5652173913043, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508563, Length=260, Percent_Identity=28.0769230769231, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365769, Length=232, Percent_Identity=28.8793103448276, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24660002, Length=232, Percent_Identity=28.8793103448276, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 42766; Mature: 42635

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTVPDTDRAVDPLEDYLALCKETCDREIERLYSSGRPGSGFEALLLDYPRRGGKALRP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHH
ALSIAVCLGLGGQLDAILPTAATLELYHNAFLIHDDIEDESWWRRGKPTMHIDHGIPIAV
HHHHHHHHCCCCCCHHHHCHHHHHHHHHCEEEEECCCCCHHHHHCCCCCEEECCCCEEEE
NVGDAMLSLSLQPLLDNVERIGLGPALRILRAVAHMTRRTVEGQAIELEWVRSNAWRLDD
ECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
ADYLTMVELKTSWYSFITPLQAGAIAAGVDPDRLEPLESLGRHLGAAFQITDDLLNLRAD
CCCEEEEEHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHCCCC
PEEYGKEIGGDLWEGKRTLMLLHTLRTAQPQDRIRALQILARRRPAGLEAGLAGLLDRLT
HHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ARGELSPTGRAEIAARFDTAEAKSLDDIQWLYELMHDVGSLGHAREVAARHAQQAAAVLA
CCCCCCCCCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLDWFPPSRHREALTHLVDYVHGRTR
CCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSTVPDTDRAVDPLEDYLALCKETCDREIERLYSSGRPGSGFEALLLDYPRRGGKALRP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHH
ALSIAVCLGLGGQLDAILPTAATLELYHNAFLIHDDIEDESWWRRGKPTMHIDHGIPIAV
HHHHHHHHCCCCCCHHHHCHHHHHHHHHCEEEEECCCCCHHHHHCCCCCEEECCCCEEEE
NVGDAMLSLSLQPLLDNVERIGLGPALRILRAVAHMTRRTVEGQAIELEWVRSNAWRLDD
ECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCC
ADYLTMVELKTSWYSFITPLQAGAIAAGVDPDRLEPLESLGRHLGAAFQITDDLLNLRAD
CCCEEEEEHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCHHEEHHHHHHCCCC
PEEYGKEIGGDLWEGKRTLMLLHTLRTAQPQDRIRALQILARRRPAGLEAGLAGLLDRLT
HHHHHHHHCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ARGELSPTGRAEIAARFDTAEAKSLDDIQWLYELMHDVGSLGHAREVAARHAQQAAAVLA
CCCCCCCCCCHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GLDWFPPSRHREALTHLVDYVHGRTR
CCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]