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The map label for this gene is panE [C]

Identifier: 119868390

GI number: 119868390

Start: 2467013

End: 2467900

Strand: Reverse

Name: panE [C]

Synonym: Mkms_2354

Alternate gene names: 119868390

Gene position: 2467900-2467013 (Counterclockwise)

Preceding gene: 119868392

Following gene: 119868389

Centisome position: 43.02

GC content: 73.99

Gene sequence:

>888_bases
GTGACCACCCGCATCGCACTCGTCGGGCCCGGCGCCATCGGCGCCACCATGGCGGCCCTGCTCCACGAGGCGGGCCGGCC
GGTGCTGCTGTGCGGTCGCACCGCCCGCAGCTCGCTGGAGGTCCGGCCCGACGACCGGGAGCCGATCGTGATACCGGGTC
CGGTGCACACCGATCCCGCGGATGTCGACGGCCCGGTCGACGTGGTCCTGCTGGCGGTCAAGGACACCCAGAACGAGGCG
GCCGCACCCTGGCTGAGCCGGCTGTGCGGCTCGCGCACGGTGGTGTGCGCACTGCAGAACGGTGTCGAGCAGGTCGAGCG
GGTCGGCCGCTTCTGCCCGGATGCGACGGTGGTGCCCGCCGCGGTGTGGATGTCCGCCGAGACGTCCGGGCCGGGGCAGG
TGCGGTTGCGCACCGACGCCCGGGTGGTGCTGCCCGCCACCGAGGCCGCGGCGATGCTGGCCGACACGCTCGCGACACCG
CATCTGAGCGTCGCGTGCGATCCGGACTTCGCGAGCGCGGCGTGGCGCAAGCTGCTGGTCAACGCCGTGGTCGGCCTGAT
GGTGCTGACCGGCCGCAGGTCGGGGATGTTCCGCCGCGACGACATCGCCGCGCTGGGTCGCCGCTACCTGGCCGAATGCC
TGGCGGTGGCCCGGGCCGACGGGGCTGCGCTCGGCGACGAGGTGGTGGACGAGGTGATCGGGATGCTGGCCGCGGGACCG
CCCGACATCACCACGTCGATGCTCACCGACCGGGAGGCCGGGCGCGCGCTGGAATGGGACATCCGCAACGGGGTGATCGC
CCGCAAGGGCGCCGCGTACGGCATCGCGACGCCGATCAGCGACATCGTGGTGCCACTGTTGGCCGCGGCCGGAGAGGGGC
CCGGCTAG

Upstream 100 bases:

>100_bases
ACTGCGCAGCACAAAAAACTCCTGGGGAATGGGTGGGGCGGGACAACGGCACAGTCTAGTTGGGGGCCGTGGCGCGTCCC
CGGCGGTAGCTTGGGCGATC

Downstream 100 bases:

>100_bases
ACAGCTTGGGCTACCGTGTATGGCCATGCACTCCTGCGAGCGCGTCGACCTGTCCTTCGTCGACTCTGCGCCGTACCGCT
TCGTCAGCACCGTCGATCTG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHTDPADVDGPVDVVLLAVKDTQNEA
AAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADTLATP
HLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVARADGAALGDEVVDEVIGMLAAGP
PDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG

Sequences:

>Translated_295_residues
MTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHTDPADVDGPVDVVLLAVKDTQNEA
AAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADTLATP
HLSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVARADGAALGDEVVDEVIGMLAAGP
PDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG
>Mature_294_residues
TTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHTDPADVDGPVDVVLLAVKDTQNEAA
APWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPAAVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADTLATPH
LSVACDPDFASAAWRKLLVNAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVARADGAALGDEVVDEVIGMLAAGPP
DITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 30677; Mature: 30545

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHTDPA
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCCCCCEEECCCCCCCCC
DVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPA
CCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHH
AVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADTLATPHLSVACDPDFASAAWRKLLV
HHEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
NAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVARADGAALGDEVVDEVIGMLAAGP
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
PDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG
CCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTRIALVGPGAIGATMAALLHEAGRPVLLCGRTARSSLEVRPDDREPIVIPGPVHTDPA
CCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCCCCCCEEECCCCCCCCC
DVDGPVDVVLLAVKDTQNEAAAPWLSRLCGSRTVVCALQNGVEQVERVGRFCPDATVVPA
CCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHH
AVWMSAETSGPGQVRLRTDARVVLPATEAAAMLADTLATPHLSVACDPDFASAAWRKLLV
HHEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
NAVVGLMVLTGRRSGMFRRDDIAALGRRYLAECLAVARADGAALGDEVVDEVIGMLAAGP
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
PDITTSMLTDREAGRALEWDIRNGVIARKGAAYGIATPISDIVVPLLAAAGEGPG
CCHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]