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The map label for this gene is idsA [H]

Identifier: 119868335

GI number: 119868335

Start: 2405718

End: 2406974

Strand: Reverse

Name: idsA [H]

Synonym: Mkms_2299

Alternate gene names: 119868335

Gene position: 2406974-2405718 (Counterclockwise)

Preceding gene: 119868344

Following gene: 119868322

Centisome position: 41.95

GC content: 71.76

Gene sequence:

>1257_bases
ATGTCGGACGACCAAGTGCGGTTCGGACGCACAGTCGCCGGGTTCGCGACTGTAGGGATCTACAACGTTGCCGCCGCGGG
CGGACGCGCGGTGTGCCGGCAGGCGAGCATCACCCCATACACTCGCGGCGCCACCCCATCAGGAAGTGAGGATGTCGTGC
CCGACATCGACCAGACGGAGTTCCTGTCCGACCTCGAGGAGCACCTGCACGCGGTCGTCCGCGACACCGTCGCCGAACCG
CTGCGGTCGATCGACGAGAACCTGGGGACCGTCGCGGCGCTCTGCCAGTCCGCGGTGCAGTCCGGCGGCAAACGCCTGCG
CCCCCGGTTCGCCTACTGGGCGTGGCGGGTGGGCGCACCGGCGGACGCCGCGCCGCAACCCCTGATCCGCCTGGCCGCCG
CCCTGGAACTGCTGCACGCGGCGATCCTGGTCCACGACGACGTGATCGACGCCTCCGAGGTGCGGCGTGGGCAGCCGTCG
GTGCGCGCGGCGCTGACCGCCGGCCACCGCCGCGACGCCGGATGGGGTGACGCCACGGACTTCGGCGACAACATGGCCCT
GCTGGTCGGGGATCTGTTGTGGTCGGCCGCCCACGACACGTTCGACGATGCGGTGGCGGGCCTTCCGGCCGGCATCGCCC
AGCGCACGTCGCGCGCGTTCCGGACCATGCGGGTGGAGGTGCTGGCCGGCCAACTGTTGGAGCTGCGGGCCCAGGCCGGG
CGCGACTATCACGCCGACACGGCGGAGAAGATCCTGCGCTACAAGACCAGCGCGTACACCGTCGAACGGCCCGTCGAACT
CGGCCTGGAACTGGCCGGATCCGCGTCGCCGGCCACGGCGCAGACACTGCGCGACTACGCCGGCGCCGTCGGGCAGGCGT
TCCAGCTGCGCGACGACCTCGCCGACCTGTTCGGCACCACGAAGACCAGCGGCAAACGGACCGGTGACGACATCCGGGCG
GGTAAACCCACCGAGTTACTCGGCGCCGCTTACGAGTTGGCGGACGACCTGGACCGCAGCCTGTTGGCCACCATCGTCGG
CGACGCTACGGCCGACCAGGCGGCGATCGCGGAAGTGCAGACGGTCGTGCTGCAGTGCGGGGCCGCTGACCGCGTCGGAC
GGCGCATCGCCGATCTGGTCGCCACCGCCCGGCGGGCGATCGCCGACCTGTCGGCTTCGGCGGACCCGACCGCGCTGGCC
GGGCTCTCGGACATGCTCGCCGAGTGCACCGAGCTGTCGTTCCTGCCGGCGGAGTAG

Upstream 100 bases:

>100_bases
TTCGGTTGGCGCCGAACCTGTTTGCGCATTGGACGTCATCTGGTCTCCCTTTCGCTGCCCCAAGGACACGCAAGTATGGG
CACGCTGCGGGGAGGCCGTC

Downstream 100 bases:

>100_bases
GGGCTACTCCTCGAGCTGGGCGAGGATCTCGTCGGGGATGTCGGCGTTGGTGTACACGTCCTGCACGTCGTCGCTGTCCT
CGAGGGCGTCGACGAGCTTC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSDDQVRFGRTVAGFATVGIYNVAAAGGRAVCRQASITPYTRGATPSGSEDVVPDIDQTEFLSDLEEHLHAVVRDTVAEP
LRSIDENLGTVAALCQSAVQSGGKRLRPRFAYWAWRVGAPADAAPQPLIRLAAALELLHAAILVHDDVIDASEVRRGQPS
VRAALTAGHRRDAGWGDATDFGDNMALLVGDLLWSAAHDTFDDAVAGLPAGIAQRTSRAFRTMRVEVLAGQLLELRAQAG
RDYHADTAEKILRYKTSAYTVERPVELGLELAGSASPATAQTLRDYAGAVGQAFQLRDDLADLFGTTKTSGKRTGDDIRA
GKPTELLGAAYELADDLDRSLLATIVGDATADQAAIAEVQTVVLQCGAADRVGRRIADLVATARRAIADLSASADPTALA
GLSDMLAECTELSFLPAE

Sequences:

>Translated_418_residues
MSDDQVRFGRTVAGFATVGIYNVAAAGGRAVCRQASITPYTRGATPSGSEDVVPDIDQTEFLSDLEEHLHAVVRDTVAEP
LRSIDENLGTVAALCQSAVQSGGKRLRPRFAYWAWRVGAPADAAPQPLIRLAAALELLHAAILVHDDVIDASEVRRGQPS
VRAALTAGHRRDAGWGDATDFGDNMALLVGDLLWSAAHDTFDDAVAGLPAGIAQRTSRAFRTMRVEVLAGQLLELRAQAG
RDYHADTAEKILRYKTSAYTVERPVELGLELAGSASPATAQTLRDYAGAVGQAFQLRDDLADLFGTTKTSGKRTGDDIRA
GKPTELLGAAYELADDLDRSLLATIVGDATADQAAIAEVQTVVLQCGAADRVGRRIADLVATARRAIADLSASADPTALA
GLSDMLAECTELSFLPAE
>Mature_417_residues
SDDQVRFGRTVAGFATVGIYNVAAAGGRAVCRQASITPYTRGATPSGSEDVVPDIDQTEFLSDLEEHLHAVVRDTVAEPL
RSIDENLGTVAALCQSAVQSGGKRLRPRFAYWAWRVGAPADAAPQPLIRLAAALELLHAAILVHDDVIDASEVRRGQPSV
RAALTAGHRRDAGWGDATDFGDNMALLVGDLLWSAAHDTFDDAVAGLPAGIAQRTSRAFRTMRVEVLAGQLLELRAQAGR
DYHADTAEKILRYKTSAYTVERPVELGLELAGSASPATAQTLRDYAGAVGQAFQLRDDLADLFGTTKTSGKRTGDDIRAG
KPTELLGAAYELADDLDRSLLATIVGDATADQAAIAEVQTVVLQCGAADRVGRRIADLVATARRAIADLSASADPTALAG
LSDMLAECTELSFLPAE

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789578, Length=246, Percent_Identity=31.3008130081301, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786623, Length=256, Percent_Identity=33.203125, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508563, Length=203, Percent_Identity=30.5418719211823, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 44160; Mature: 44029

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDDQVRFGRTVAGFATVGIYNVAAAGGRAVCRQASITPYTRGATPSGSEDVVPDIDQTE
CCCCCHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHH
FLSDLEEHLHAVVRDTVAEPLRSIDENLGTVAALCQSAVQSGGKRLRPRFAYWAWRVGAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHEEECCCC
ADAAPQPLIRLAAALELLHAAILVHDDVIDASEVRRGQPSVRAALTAGHRRDAGWGDATD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
FGDNMALLVGDLLWSAAHDTFDDAVAGLPAGIAQRTSRAFRTMRVEVLAGQLLELRAQAG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RDYHADTAEKILRYKTSAYTVERPVELGLELAGSASPATAQTLRDYAGAVGQAFQLRDDL
CCCCHHHHHHHHHHHHHHHEEHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ADLFGTTKTSGKRTGDDIRAGKPTELLGAAYELADDLDRSLLATIVGDATADQAAIAEVQ
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TVVLQCGAADRVGRRIADLVATARRAIADLSASADPTALAGLSDMLAECTELSFLPAE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7979381 [H]