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The map label for this gene is rnd [H]

Identifier: 119868292

GI number: 119868292

Start: 2368076

End: 2369362

Strand: Reverse

Name: rnd [H]

Synonym: Mkms_2256

Alternate gene names: 119868292

Gene position: 2369362-2368076 (Counterclockwise)

Preceding gene: 119868293

Following gene: 119868291

Centisome position: 41.3

GC content: 72.73

Gene sequence:

>1287_bases
ATGAGCGAGACACCCGACACGGACCCCGAGGGCCCAGACACCGACATCGACGCCGAGGCCGGCACCGACACGGGGGCTGT
CCCGCTGCTCACCCCCGCCGACGGGGTGCCCGACCTCGCGGTGACCACCGACGAGATCCTCGCCGCCGCCGAACTGCTCG
CCGGGGGCCACGGTCCGTTCGCGATCGACGCCGAACGCGCCTCGGGGTTCCGGTACTCCAACCGGGCCTACCTGGTGCAG
ATCCGGCGCGAAGGCGCGGGCACCGTGCTGATCGACCCGGTCAACCACGGCGAGGACCCGACGATGGTGATGGCTCCGGT
GGCCGATGTCCTCGACACCGACGAATGGGTGCTGCACGCCGCCGATCAGGATCTGCCGTGCCTGGCCGAGCTGGGCATGC
GGCCGCCGAAGCTATACGACACCGAACTCGCCGGCCGGCTGGCCGGCCTTGCGCGGGTGAACCTCGCGACGATGGTCTCC
GAACTGCTCGGACTGCAGCTGATGAAGGGCCACGGCGCCGCCGACTGGTCCAAGCGACCGCTGCCCGACGATTGGCTCAA
CTACGCCGCGCTCGACGTCGAAGTGCTGCTCGAACTGCGCGACGCCGTCGCCGCGGTGCTGGACGATCAGGGCAAGACCG
ATTGGGCCATACAGGAATTCGAACACCTGCGCACCTACGAGGCGGCCCCCACCCGCCGCGACCGGTGGCGGCGCACCTCC
GGAATCCACAAGGTGCGCAACCCCCGGGCGCTGGCGGCCGTGCGCGAACTGTGGACCACGCGCGACCACATCGCCCGCAG
GCGCGACATCGCGCCGGGCCGCATCCTGCCCGACGCCGCGATCATCAACGCCGCCACCGCCGATCCCGACAGCGTCGAGA
AGCTCACCGCACTGCCGGTGTTCGGCGGCACCCGGCAGCGCCGCAGCGCCCAGGTGTGGCTCGACGCGCTCGACCGGGCG
CGCCACAACACCGATCCGCCCGACTCGGCCGAACCGCCCAACGGTCCGCCGCCGCCGTCGCGGTGGGCGCGGCGCAAACC
CGAGGCGGCCGCACGCCTGGAAGCCGCCCGCGCCGGCCTGTCCGCGCTGTCGGAGCGGGTGGCGGTGCCCTCGGAGAACC
TCGTCACCCCGGAGGTGGTGCGTCGGCTGTGCTGGGACTGGCAGCCGGTCACCGACATCGCCGCCGCGGTCGAGGAGTTC
CTGGTGGCCGCAGGCGTGCGCCCGTGGCAACGCGATCTGGTGGTGCCGGTGCTGACCGCCGCGCTCGCCCCCTCGACCGC
CGAATGA

Upstream 100 bases:

>100_bases
CTCGGTCCCCACGTGGAGGCCTTCTGCGAAGTGCTCGAGCACGCCGCGGGACTGCCTCCCATCGGGGTGACCGACCTCGG
TTCCCGCACCCGCGCATGAG

Downstream 100 bases:

>100_bases
CCGCATCGCGTTTGGATAATTGACCAACAGGGAACCGCCGAGGGGTGAGTACCACCGGAACGCCGACCGACTCCCCCGAC
GAGACGACGCCACTGGTTCT

Product: 3'-5' exonuclease

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSETPDTDPEGPDTDIDAEAGTDTGAVPLLTPADGVPDLAVTTDEILAAAELLAGGHGPFAIDAERASGFRYSNRAYLVQ
IRREGAGTVLIDPVNHGEDPTMVMAPVADVLDTDEWVLHAADQDLPCLAELGMRPPKLYDTELAGRLAGLARVNLATMVS
ELLGLQLMKGHGAADWSKRPLPDDWLNYAALDVEVLLELRDAVAAVLDDQGKTDWAIQEFEHLRTYEAAPTRRDRWRRTS
GIHKVRNPRALAAVRELWTTRDHIARRRDIAPGRILPDAAIINAATADPDSVEKLTALPVFGGTRQRRSAQVWLDALDRA
RHNTDPPDSAEPPNGPPPPSRWARRKPEAAARLEAARAGLSALSERVAVPSENLVTPEVVRRLCWDWQPVTDIAAAVEEF
LVAAGVRPWQRDLVVPVLTAALAPSTAE

Sequences:

>Translated_428_residues
MSETPDTDPEGPDTDIDAEAGTDTGAVPLLTPADGVPDLAVTTDEILAAAELLAGGHGPFAIDAERASGFRYSNRAYLVQ
IRREGAGTVLIDPVNHGEDPTMVMAPVADVLDTDEWVLHAADQDLPCLAELGMRPPKLYDTELAGRLAGLARVNLATMVS
ELLGLQLMKGHGAADWSKRPLPDDWLNYAALDVEVLLELRDAVAAVLDDQGKTDWAIQEFEHLRTYEAAPTRRDRWRRTS
GIHKVRNPRALAAVRELWTTRDHIARRRDIAPGRILPDAAIINAATADPDSVEKLTALPVFGGTRQRRSAQVWLDALDRA
RHNTDPPDSAEPPNGPPPPSRWARRKPEAAARLEAARAGLSALSERVAVPSENLVTPEVVRRLCWDWQPVTDIAAAVEEF
LVAAGVRPWQRDLVVPVLTAALAPSTAE
>Mature_427_residues
SETPDTDPEGPDTDIDAEAGTDTGAVPLLTPADGVPDLAVTTDEILAAAELLAGGHGPFAIDAERASGFRYSNRAYLVQI
RREGAGTVLIDPVNHGEDPTMVMAPVADVLDTDEWVLHAADQDLPCLAELGMRPPKLYDTELAGRLAGLARVNLATMVSE
LLGLQLMKGHGAADWSKRPLPDDWLNYAALDVEVLLELRDAVAAVLDDQGKTDWAIQEFEHLRTYEAAPTRRDRWRRTSG
IHKVRNPRALAAVRELWTTRDHIARRRDIAPGRILPDAAIINAATADPDSVEKLTALPVFGGTRQRRSAQVWLDALDRAR
HNTDPPDSAEPPNGPPPPSRWARRKPEAAARLEAARAGLSALSERVAVPSENLVTPEVVRRLCWDWQPVTDIAAAVEEFL
VAAGVRPWQRDLVVPVLTAALAPSTAE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Escherichia coli, GI1788105, Length=354, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 46492; Mature: 46361

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPDTDPEGPDTDIDAEAGTDTGAVPLLTPADGVPDLAVTTDEILAAAELLAGGHGPF
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
AIDAERASGFRYSNRAYLVQIRREGAGTVLIDPVNHGEDPTMVMAPVADVLDTDEWVLHA
EEEHHHCCCCEECCCEEEEEEEECCCCEEEECCCCCCCCCCEEEHHHHHHHCCCCCEEEE
ADQDLPCLAELGMRPPKLYDTELAGRLAGLARVNLATMVSELLGLQLMKGHGAADWSKRP
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPDDWLNYAALDVEVLLELRDAVAAVLDDQGKTDWAIQEFEHLRTYEAAPTRRDRWRRTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
GIHKVRNPRALAAVRELWTTRDHIARRRDIAPGRILPDAAIINAATADPDSVEKLTALPV
CHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHCCC
FGGTRQRRSAQVWLDALDRARHNTDPPDSAEPPNGPPPPSRWARRKPEAAARLEAARAGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
SALSERVAVPSENLVTPEVVRRLCWDWQPVTDIAAAVEEFLVAAGVRPWQRDLVVPVLTA
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALAPSTAE
HHCCCCCC
>Mature Secondary Structure 
SETPDTDPEGPDTDIDAEAGTDTGAVPLLTPADGVPDLAVTTDEILAAAELLAGGHGPF
CCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
AIDAERASGFRYSNRAYLVQIRREGAGTVLIDPVNHGEDPTMVMAPVADVLDTDEWVLHA
EEEHHHCCCCEECCCEEEEEEEECCCCEEEECCCCCCCCCCEEEHHHHHHHCCCCCEEEE
ADQDLPCLAELGMRPPKLYDTELAGRLAGLARVNLATMVSELLGLQLMKGHGAADWSKRP
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPDDWLNYAALDVEVLLELRDAVAAVLDDQGKTDWAIQEFEHLRTYEAAPTRRDRWRRTS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
GIHKVRNPRALAAVRELWTTRDHIARRRDIAPGRILPDAAIINAATADPDSVEKLTALPV
CHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHCCC
FGGTRQRRSAQVWLDALDRARHNTDPPDSAEPPNGPPPPSRWARRKPEAAARLEAARAGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHH
SALSERVAVPSENLVTPEVVRRLCWDWQPVTDIAAAVEEFLVAAGVRPWQRDLVVPVLTA
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALAPSTAE
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]