Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 119868201

GI number: 119868201

Start: 2285330

End: 2286160

Strand: Reverse

Name: fabG [C]

Synonym: Mkms_2165

Alternate gene names: 119868201

Gene position: 2286160-2285330 (Counterclockwise)

Preceding gene: 119868202

Following gene: 119868193

Centisome position: 39.85

GC content: 70.64

Gene sequence:

>831_bases
GTGCGCCCCCTGGAGGGCAAGGTCGCCTTCATCACCGGCGCGGCCCGCGGCCAGGGCCGAGCCCATGCCGTGCGGTTGGC
GTCCGACGGCGCCGACATCATCGCGGTGGACCTGTGCGATCAGATCGCCTCGGTGCCGTATCCGCTGGCGACTCCGGACG
ACCTGGCGGCCACGGTCAAGCTCGTCGAGGAGACCGGGGGGCGGATCGTCGCCTCGCAGGCCGACGTTCGGGACCGTGCC
GCGCTCAAGACCGCACTGATGGACGGGGTGGAACGGCTCGGCGGGCGGCTCGACGTCGTCGTCGCCAACGCCGGGATCGC
GCCGATGGCCGGCGAGGACGCCTGGCAGGACGTCATCGACGTCAACCTCACCGGGGTCTTCCACACGGTCGACGTCGCGA
TGCGGCCGATGATCAAGGCGGGCAACGGCGGATCGATCGTGTTGACCAGTTCGGTCGCCGGCCTCGTCGGCCTCGCGTCG
CCGATGGCCGGGTCGATCGGCTACGCCGCCGCCAAACACGGCATCGTCGGGATCATGCGCGTGTACGCGAACATCCTTGC
CACCCACAGCATCCGGGTGAACTCGGTGCACCCCGCGGGGGTCAACACCCCGATGATCGACAACGAGTTCACCCGCAGCT
GGCTCGAGGGGCTCGCGCAGGAGACCCGGGGCAGGGGCGAGATGGCGCCGAACATGACGAACGCCCTGCCGGTGCAGGCC
CTCGAGGTCGAGGACATCGCCGCCGCCGTCGCCTTCCTGGCGTCCGACGAGGCGCGCTACATCACCGGCGTCACGCTGCC
GGTGGACGCGGGCTTCGTCAACAAGCGCTGA

Upstream 100 bases:

>100_bases
GTGAGCACCTCGACGGCGCCCCCGACATCAAGATGCTGGAACCGGTCCCGGCCGGCGACCCGGCCAAGGGCCGGCTGCGG
CCCTGACGGTGACGACACCG

Downstream 100 bases:

>100_bases
TCAGTCCGGTCACCTCGTCAGAGGTGATCCATCAAGCGGGACATCGTCGAGGTCTCGAAGTACGCACACCGGCGCGGGTA
GTAGTGCGAACGGCTCTCCG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MRPLEGKVAFITGAARGQGRAHAVRLASDGADIIAVDLCDQIASVPYPLATPDDLAATVKLVEETGGRIVASQADVRDRA
ALKTALMDGVERLGGRLDVVVANAGIAPMAGEDAWQDVIDVNLTGVFHTVDVAMRPMIKAGNGGSIVLTSSVAGLVGLAS
PMAGSIGYAAAKHGIVGIMRVYANILATHSIRVNSVHPAGVNTPMIDNEFTRSWLEGLAQETRGRGEMAPNMTNALPVQA
LEVEDIAAAVAFLASDEARYITGVTLPVDAGFVNKR

Sequences:

>Translated_276_residues
MRPLEGKVAFITGAARGQGRAHAVRLASDGADIIAVDLCDQIASVPYPLATPDDLAATVKLVEETGGRIVASQADVRDRA
ALKTALMDGVERLGGRLDVVVANAGIAPMAGEDAWQDVIDVNLTGVFHTVDVAMRPMIKAGNGGSIVLTSSVAGLVGLAS
PMAGSIGYAAAKHGIVGIMRVYANILATHSIRVNSVHPAGVNTPMIDNEFTRSWLEGLAQETRGRGEMAPNMTNALPVQA
LEVEDIAAAVAFLASDEARYITGVTLPVDAGFVNKR
>Mature_276_residues
MRPLEGKVAFITGAARGQGRAHAVRLASDGADIIAVDLCDQIASVPYPLATPDDLAATVKLVEETGGRIVASQADVRDRA
ALKTALMDGVERLGGRLDVVVANAGIAPMAGEDAWQDVIDVNLTGVFHTVDVAMRPMIKAGNGGSIVLTSSVAGLVGLAS
PMAGSIGYAAAKHGIVGIMRVYANILATHSIRVNSVHPAGVNTPMIDNEFTRSWLEGLAQETRGRGEMAPNMTNALPVQA
LEVEDIAAAVAFLASDEARYITGVTLPVDAGFVNKR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=283, Percent_Identity=34.2756183745583, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI32483357, Length=277, Percent_Identity=31.4079422382672, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=34.6368715083799, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=275, Percent_Identity=29.8181818181818, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI19923817, Length=280, Percent_Identity=26.0714285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504505, Length=205, Percent_Identity=35.1219512195122, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4758504, Length=222, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40254992, Length=274, Percent_Identity=30.6569343065693, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI126723191, Length=201, Percent_Identity=30.8457711442786, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503301, Length=276, Percent_Identity=26.8115942028986, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI223718074, Length=212, Percent_Identity=30.6603773584906, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=276, Percent_Identity=35.8695652173913, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=282, Percent_Identity=33.6879432624113, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789208, Length=277, Percent_Identity=29.2418772563177, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082160, Length=276, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788459, Length=273, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI2367175, Length=273, Percent_Identity=27.4725274725275, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786812, Length=275, Percent_Identity=28.3636363636364, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790717, Length=285, Percent_Identity=27.3684210526316, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI2367365, Length=279, Percent_Identity=29.7491039426523, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789378, Length=267, Percent_Identity=26.5917602996255, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787905, Length=281, Percent_Identity=27.4021352313167, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.7992277992278, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=279, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=281, Percent_Identity=30.6049822064057, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=281, Percent_Identity=28.1138790035587, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=276, Percent_Identity=27.8985507246377, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=288, Percent_Identity=28.4722222222222, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=278, Percent_Identity=29.4964028776978, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=285, Percent_Identity=27.719298245614, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=286, Percent_Identity=26.5734265734266, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=201, Percent_Identity=29.8507462686567, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=26.7676767676768, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=287, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=32.5, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324126, Length=282, Percent_Identity=29.0780141843972, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639444, Length=279, Percent_Identity=30.4659498207885, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24644339, Length=276, Percent_Identity=31.8840579710145, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI23397609, Length=279, Percent_Identity=30.4659498207885, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355319, Length=273, Percent_Identity=28.2051282051282, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=279, Percent_Identity=30.1075268817204, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=276, Percent_Identity=28.9855072463768, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17737361, Length=231, Percent_Identity=30.7359307359307, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859837, Length=200, Percent_Identity=32, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=243, Percent_Identity=26.7489711934156, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644337, Length=191, Percent_Identity=30.3664921465969, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281364892, Length=211, Percent_Identity=27.9620853080569, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28660; Mature: 28660

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00061 ADH_SHORT ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLEGKVAFITGAARGQGRAHAVRLASDGADIIAVDLCDQIASVPYPLATPDDLAATVK
CCCCCCEEEEEEECCCCCCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHHH
LVEETGGRIVASQADVRDRAALKTALMDGVERLGGRLDVVVANAGIAPMAGEDAWQDVID
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHE
VNLTGVFHTVDVAMRPMIKAGNGGSIVLTSSVAGLVGLASPMAGSIGYAAAKHGIVGIMR
EEEEEHHHHHHHHHHHHEECCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VYANILATHSIRVNSVHPAGVNTPMIDNEFTRSWLEGLAQETRGRGEMAPNMTNALPVQA
HHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LEVEDIAAAVAFLASDEARYITGVTLPVDAGFVNKR
ECHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MRPLEGKVAFITGAARGQGRAHAVRLASDGADIIAVDLCDQIASVPYPLATPDDLAATVK
CCCCCCEEEEEEECCCCCCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHHH
LVEETGGRIVASQADVRDRAALKTALMDGVERLGGRLDVVVANAGIAPMAGEDAWQDVID
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHE
VNLTGVFHTVDVAMRPMIKAGNGGSIVLTSSVAGLVGLASPMAGSIGYAAAKHGIVGIMR
EEEEEHHHHHHHHHHHHEECCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VYANILATHSIRVNSVHPAGVNTPMIDNEFTRSWLEGLAQETRGRGEMAPNMTNALPVQA
HHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LEVEDIAAAVAFLASDEARYITGVTLPVDAGFVNKR
ECHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA