| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is yqhE [C]
Identifier: 119868022
GI number: 119868022
Start: 2104618
End: 2105448
Strand: Reverse
Name: yqhE [C]
Synonym: Mkms_1985
Alternate gene names: 119868022
Gene position: 2105448-2104618 (Counterclockwise)
Preceding gene: 119868037
Following gene: 119868021
Centisome position: 36.7
GC content: 63.66
Gene sequence:
>831_bases ATGGGAGCTCCTCTGGTCGCGTTGAACGACGGCAATTCGATTCCTCAGGTCGGCCTGGGGGTTTGGCAGACACCACCCGA AGACACCGAACGCGCGGTCGCGGCGGCGCTCGCCGCCGGCTATCGACACGTCGATACGGCCGCAGCGTACGGCAACGAGG AGCAGACCGGCCGGGCGATCGCCCAGTCCGGACTGGACCGTTCGCAGGTGTACCTGGTCACCAAGCTGTGGAACTCCGAA CAGGGCTATGACGCGACGCTGGCGGCCTTCGAGGCGAGTGTGGACCGCCTCGGGGTCGACTACCTCGACCTGTACCTCAT CCACTGGCCGGTCCCCGAGAAGAACCTCTTCGTCGACACCTTCAAAGCGTTCGCCCGGCTACGTGAGGACGGTCGCATCC GGTCCATCGGTGTGAGCAACTTCGAACCCGAACACCTGCGGGTCCTGATCGACTCGACCGGCATCGTGCCCGCGGTCAAC CAGATCGAGTTGCATCCACTGCTGCCTCAGCGGGAACTGCGAGAGCTGCACGCGCAGTTGGGAATCGCCACCGAGGCGTG GAGCCCGCTGGGCCAGGGGTCGCTGCTGGCGCACCCCACGGTGACCGGTGTCGCCGAGTCGCACGGGAAAACCGCAGCAC AGGCACTGATTAGGTGGCATATGCAACTCGGTAATATCGTCATCCCCAAGTCGGTGAACCCACAACGGATTGAGAGCAAC TTCGACGTGTTCGACTTCGAGTTGAGCGAGCAGGACATGGCGTCCATCTCGTCTCTCGAGGACGGCTCCCGCCTGGGTCC CGACCCCAAAACATTCAACTTCACAGGGTAG
Upstream 100 bases:
>100_bases CGTCGCCGCGTTGACGACCGCGTCACGCGTCCGGTTCTTGCCCCGGGGGGCCGGATCCTTGCCGCGGACGGGCGGGGCGG AGGCTGGCAGACTCGGCGGC
Downstream 100 bases:
>100_bases GTGACATGACGTCAACGCGCGGTGAGGCAGCCGGCATCCCCTCCGTCTCCCTCAACGACGGACACTCGATCCCGGTCCTC GGACTCGGCGTCGGTGAGCT
Product: 2,5-didehydrogluconate reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 276; Mature: 275
Protein sequence:
>276_residues MGAPLVALNDGNSIPQVGLGVWQTPPEDTERAVAAALAAGYRHVDTAAAYGNEEQTGRAIAQSGLDRSQVYLVTKLWNSE QGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVLIDSTGIVPAVN QIELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESN FDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG
Sequences:
>Translated_276_residues MGAPLVALNDGNSIPQVGLGVWQTPPEDTERAVAAALAAGYRHVDTAAAYGNEEQTGRAIAQSGLDRSQVYLVTKLWNSE QGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVLIDSTGIVPAVN QIELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESN FDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG >Mature_275_residues GAPLVALNDGNSIPQVGLGVWQTPPEDTERAVAAALAAGYRHVDTAAAYGNEEQTGRAIAQSGLDRSQVYLVTKLWNSEQ GYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDTFKAFARLREDGRIRSIGVSNFEPEHLRVLIDSTGIVPAVNQ IELHPLLPQRELRELHAQLGIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESNF DVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=37.5, Blast_Score=195, Evalue=3e-50, Organism=Homo sapiens, GI24497577, Length=297, Percent_Identity=33.6700336700337, Blast_Score=185, Evalue=3e-47, Organism=Homo sapiens, GI5174391, Length=297, Percent_Identity=33.6700336700337, Blast_Score=185, Evalue=3e-47, Organism=Homo sapiens, GI4502049, Length=292, Percent_Identity=38.6986301369863, Blast_Score=185, Evalue=4e-47, Organism=Homo sapiens, GI93277124, Length=307, Percent_Identity=34.8534201954397, Blast_Score=179, Evalue=4e-45, Organism=Homo sapiens, GI310109922, Length=280, Percent_Identity=34.2857142857143, Blast_Score=171, Evalue=8e-43, Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=34.2281879194631, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=34.2281879194631, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=34.2281879194631, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=34.2281879194631, Blast_Score=166, Evalue=3e-41, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=32.1070234113712, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI291291012, Length=270, Percent_Identity=34.8148148148148, Blast_Score=163, Evalue=2e-40, Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=33.6700336700337, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI24497583, Length=294, Percent_Identity=31.9727891156463, Blast_Score=157, Evalue=9e-39, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=31.7689530685921, Blast_Score=144, Evalue=9e-35, Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=31.1827956989247, Blast_Score=132, Evalue=2e-31, Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=32.8947368421053, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI310109926, Length=117, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI207028673, Length=117, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=1e-17, Organism=Escherichia coli, GI87082198, Length=270, Percent_Identity=47.037037037037, Blast_Score=271, Evalue=3e-74, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=34.9019607843137, Blast_Score=156, Evalue=1e-39, Organism=Escherichia coli, GI1788081, Length=294, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI48994888, Length=170, Percent_Identity=30.5882352941176, Blast_Score=63, Evalue=2e-11, Organism=Escherichia coli, GI1788070, Length=218, Percent_Identity=28.4403669724771, Blast_Score=62, Evalue=4e-11, Organism=Caenorhabditis elegans, GI71998625, Length=267, Percent_Identity=35.9550561797753, Blast_Score=185, Evalue=2e-47, Organism=Caenorhabditis elegans, GI17564128, Length=298, Percent_Identity=35.9060402684564, Blast_Score=181, Evalue=3e-46, Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=35.7859531772575, Blast_Score=180, Evalue=7e-46, Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=35.1535836177474, Blast_Score=179, Evalue=9e-46, Organism=Caenorhabditis elegans, GI17561298, Length=271, Percent_Identity=33.9483394833948, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17566692, Length=295, Percent_Identity=32.8813559322034, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=31.7689530685921, Blast_Score=154, Evalue=5e-38, Organism=Caenorhabditis elegans, GI17537079, Length=301, Percent_Identity=30.2325581395349, Blast_Score=152, Evalue=3e-37, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=33.8235294117647, Blast_Score=150, Evalue=7e-37, Organism=Caenorhabditis elegans, GI17550248, Length=293, Percent_Identity=30.7167235494881, Blast_Score=145, Evalue=3e-35, Organism=Caenorhabditis elegans, GI17561300, Length=270, Percent_Identity=30.7407407407407, Blast_Score=130, Evalue=1e-30, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=29.7101449275362, Blast_Score=126, Evalue=1e-29, Organism=Saccharomyces cerevisiae, GI6320576, Length=284, Percent_Identity=41.5492957746479, Blast_Score=216, Evalue=3e-57, Organism=Saccharomyces cerevisiae, GI6324694, Length=285, Percent_Identity=39.6491228070175, Blast_Score=212, Evalue=6e-56, Organism=Saccharomyces cerevisiae, GI6322556, Length=262, Percent_Identity=33.587786259542, Blast_Score=169, Evalue=5e-43, Organism=Saccharomyces cerevisiae, GI6321896, Length=318, Percent_Identity=31.7610062893082, Blast_Score=158, Evalue=1e-39, Organism=Saccharomyces cerevisiae, GI6319625, Length=275, Percent_Identity=35.6363636363636, Blast_Score=154, Evalue=2e-38, Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=28.1138790035587, Blast_Score=115, Evalue=1e-26, Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=38, Blast_Score=202, Evalue=1e-52, Organism=Drosophila melanogaster, GI24657054, Length=289, Percent_Identity=38.7543252595156, Blast_Score=199, Evalue=1e-51, Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=35.8108108108108, Blast_Score=192, Evalue=1e-49, Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=35.2542372881356, Blast_Score=184, Evalue=5e-47, Organism=Drosophila melanogaster, GI24644950, Length=305, Percent_Identity=36.0655737704918, Blast_Score=184, Evalue=8e-47, Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=36.0824742268041, Blast_Score=180, Evalue=9e-46, Organism=Drosophila melanogaster, GI221378297, Length=325, Percent_Identity=34.1538461538462, Blast_Score=177, Evalue=7e-45, Organism=Drosophila melanogaster, GI24662781, Length=299, Percent_Identity=38.4615384615385, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI45553081, Length=293, Percent_Identity=35.1535836177474, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI24662785, Length=297, Percent_Identity=39.0572390572391, Blast_Score=176, Evalue=2e-44, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=34.375, Blast_Score=149, Evalue=3e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 30161; Mature: 30030
Theoretical pI: Translated: 4.70; Mature: 4.70
Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.1 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 0.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGAPLVALNDGNSIPQVGLGVWQTPPEDTERAVAAALAAGYRHVDTAAAYGNEEQTGRAI CCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH AQSGLDRSQVYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDT HHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHH FKAFARLREDGRIRSIGVSNFEPEHLRVLIDSTGIVPAVNQIELHPLLPQRELRELHAQL HHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHH GIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESN CCCHHHCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHCCC FDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG CCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCC >Mature Secondary Structure GAPLVALNDGNSIPQVGLGVWQTPPEDTERAVAAALAAGYRHVDTAAAYGNEEQTGRAI CCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH AQSGLDRSQVYLVTKLWNSEQGYDATLAAFEASVDRLGVDYLDLYLIHWPVPEKNLFVDT HHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHH FKAFARLREDGRIRSIGVSNFEPEHLRVLIDSTGIVPAVNQIELHPLLPQRELRELHAQL HHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHH GIATEAWSPLGQGSLLAHPTVTGVAESHGKTAAQALIRWHMQLGNIVIPKSVNPQRIESN CCCHHHCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHCCC FDVFDFELSEQDMASISSLEDGSRLGPDPKTFNFTG CCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA