| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is yqhE [C]
Identifier: 119868021
GI number: 119868021
Start: 2103761
End: 2104612
Strand: Reverse
Name: yqhE [C]
Synonym: Mkms_1984
Alternate gene names: 119868021
Gene position: 2104612-2103761 (Counterclockwise)
Preceding gene: 119868022
Following gene: 119868017
Centisome position: 36.68
GC content: 67.72
Gene sequence:
>852_bases ATGACGTCAACGCGCGGTGAGGCAGCCGGCATCCCCTCCGTCTCCCTCAACGACGGACACTCGATCCCGGTCCTCGGACT CGGCGTCGGTGAGCTCTCCGAGGCCGAGGCAGAACGGTCGGTGGCCGCCGCGCTCGAGGCGGGTTACCGGCTGATCGACA CGGCCGCGGTCTACGGCAACGAGGCAGCGGTGGGCCGGGCGGTCAACGCCTCGGGCATCCCGCGCGAGGAGATCTACGTG ACGACCAAGCTGGCCGTCGCGGATCAGGGTTTCGGGACATCGCAGGACGCCGCACGCGCCAGCCTCGAACGCCTCGGCCT CGACTACGTCGACCTGTACCTCATCCACTGGCCCGCCGGCGACCACGGCAAGTACATCGACAGCTGGGGCGGGCTGATGA AGGCGAAACAGGATGGCGTCGCCCGCTCGATCGGTGTCTGCAACTTCAACGCCGAGCACCTGTCGAACATCATCGACCTG TCGTTCTTCACCCCGGCCATCAACCAGATCGAGTTGCATCCGCTGCTCAATCAGGCCGAACTGCGTGAGGTCAACGCCGG CTACGGCATCGTGACCGAGGCGTACGGCCCGCTGGGTGTGGGCCGGCTGCTCGATCACGCGGCGGTGACCGGTGTGGCCC AGGCCCACGGCAAGACGCCGGCGCAGGTGCTGCTGCGCTGGAGCATCCAGCTGGGCAACGTGGTGATCGCACGCTCGGCC AACCCGGACCGGATCACGTCCAATCTCGAGGTGTTCGACTTCGAGCTGACCGACGATGAGATGGCCACCCTCAACGGCCT CGACGAGGGCACCCGCTTCCGCCCCGACCCGGAGACCTACACCGGGCCGTAG
Upstream 100 bases:
>100_bases TCGAGTTGAGCGAGCAGGACATGGCGTCCATCTCGTCTCTCGAGGACGGCTCCCGCCTGGGTCCCGACCCCAAAACATTC AACTTCACAGGGTAGGTGAC
Downstream 100 bases:
>100_bases GGCTCAGCACTCTTCTCGTGAATCGGCCGCCGCCCTGCGCCGGCCGATTCTGTTTCGCCTGTGCGGGGGGTCAGCCTCTC GGGCAGGAGTCCGCCGCCCG
Product: 2,5-didehydrogluconate reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 283; Mature: 282
Protein sequence:
>283_residues MTSTRGEAAGIPSVSLNDGHSIPVLGLGVGELSEAEAERSVAAALEAGYRLIDTAAVYGNEAAVGRAVNASGIPREEIYV TTKLAVADQGFGTSQDAARASLERLGLDYVDLYLIHWPAGDHGKYIDSWGGLMKAKQDGVARSIGVCNFNAEHLSNIIDL SFFTPAINQIELHPLLNQAELREVNAGYGIVTEAYGPLGVGRLLDHAAVTGVAQAHGKTPAQVLLRWSIQLGNVVIARSA NPDRITSNLEVFDFELTDDEMATLNGLDEGTRFRPDPETYTGP
Sequences:
>Translated_283_residues MTSTRGEAAGIPSVSLNDGHSIPVLGLGVGELSEAEAERSVAAALEAGYRLIDTAAVYGNEAAVGRAVNASGIPREEIYV TTKLAVADQGFGTSQDAARASLERLGLDYVDLYLIHWPAGDHGKYIDSWGGLMKAKQDGVARSIGVCNFNAEHLSNIIDL SFFTPAINQIELHPLLNQAELREVNAGYGIVTEAYGPLGVGRLLDHAAVTGVAQAHGKTPAQVLLRWSIQLGNVVIARSA NPDRITSNLEVFDFELTDDEMATLNGLDEGTRFRPDPETYTGP >Mature_282_residues TSTRGEAAGIPSVSLNDGHSIPVLGLGVGELSEAEAERSVAAALEAGYRLIDTAAVYGNEAAVGRAVNASGIPREEIYVT TKLAVADQGFGTSQDAARASLERLGLDYVDLYLIHWPAGDHGKYIDSWGGLMKAKQDGVARSIGVCNFNAEHLSNIIDLS FFTPAINQIELHPLLNQAELREVNAGYGIVTEAYGPLGVGRLLDHAAVTGVAQAHGKTPAQVLLRWSIQLGNVVIARSAN PDRITSNLEVFDFELTDDEMATLNGLDEGTRFRPDPETYTGP
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=37.248322147651, Blast_Score=189, Evalue=2e-48, Organism=Homo sapiens, GI5453543, Length=299, Percent_Identity=36.4548494983278, Blast_Score=188, Evalue=4e-48, Organism=Homo sapiens, GI24497577, Length=294, Percent_Identity=33.6734693877551, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI5174391, Length=294, Percent_Identity=33.6734693877551, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI310109922, Length=281, Percent_Identity=38.0782918149466, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI45446745, Length=299, Percent_Identity=36.7892976588629, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI4503285, Length=299, Percent_Identity=36.7892976588629, Blast_Score=187, Evalue=1e-47, Organism=Homo sapiens, GI310109920, Length=299, Percent_Identity=36.4548494983278, Blast_Score=186, Evalue=2e-47, Organism=Homo sapiens, GI24497583, Length=299, Percent_Identity=35.7859531772575, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=32.4232081911263, Blast_Score=167, Evalue=7e-42, Organism=Homo sapiens, GI5174695, Length=303, Percent_Identity=33.6633663366337, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=32.1311475409836, Blast_Score=162, Evalue=3e-40, Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=35.7388316151203, Blast_Score=159, Evalue=2e-39, Organism=Homo sapiens, GI291291012, Length=306, Percent_Identity=30.718954248366, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI300116273, Length=281, Percent_Identity=33.0960854092527, Blast_Score=138, Evalue=6e-33, Organism=Homo sapiens, GI300116271, Length=287, Percent_Identity=32.7526132404181, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI310109924, Length=153, Percent_Identity=37.9084967320261, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI207028673, Length=115, Percent_Identity=42.6086956521739, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI310109926, Length=115, Percent_Identity=41.7391304347826, Blast_Score=87, Evalue=1e-17, Organism=Escherichia coli, GI87082198, Length=271, Percent_Identity=43.9114391143911, Blast_Score=249, Evalue=1e-67, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=36.078431372549, Blast_Score=159, Evalue=3e-40, Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=30.9701492537313, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1788070, Length=200, Percent_Identity=30.5, Blast_Score=64, Evalue=9e-12, Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=36.271186440678, Blast_Score=187, Evalue=4e-48, Organism=Caenorhabditis elegans, GI17537075, Length=301, Percent_Identity=35.5481727574751, Blast_Score=183, Evalue=9e-47, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=35.0746268656716, Blast_Score=181, Evalue=5e-46, Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=35, Blast_Score=171, Evalue=6e-43, Organism=Caenorhabditis elegans, GI17566692, Length=300, Percent_Identity=34, Blast_Score=165, Evalue=3e-41, Organism=Caenorhabditis elegans, GI17550248, Length=298, Percent_Identity=34.8993288590604, Blast_Score=160, Evalue=6e-40, Organism=Caenorhabditis elegans, GI17562292, Length=281, Percent_Identity=32.0284697508897, Blast_Score=148, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=29.9319727891156, Blast_Score=148, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=30.9090909090909, Blast_Score=144, Evalue=5e-35, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=32.3529411764706, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17561298, Length=288, Percent_Identity=29.5138888888889, Blast_Score=137, Evalue=4e-33, Organism=Caenorhabditis elegans, GI17538386, Length=284, Percent_Identity=33.0985915492958, Blast_Score=136, Evalue=1e-32, Organism=Saccharomyces cerevisiae, GI6320576, Length=296, Percent_Identity=40.5405405405405, Blast_Score=206, Evalue=3e-54, Organism=Saccharomyces cerevisiae, GI6324694, Length=290, Percent_Identity=38.2758620689655, Blast_Score=192, Evalue=4e-50, Organism=Saccharomyces cerevisiae, GI6322556, Length=263, Percent_Identity=31.9391634980989, Blast_Score=159, Evalue=5e-40, Organism=Saccharomyces cerevisiae, GI6319625, Length=303, Percent_Identity=35.973597359736, Blast_Score=148, Evalue=1e-36, Organism=Saccharomyces cerevisiae, GI6321896, Length=315, Percent_Identity=30.7936507936508, Blast_Score=141, Evalue=9e-35, Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=29.5373665480427, Blast_Score=118, Evalue=1e-27, Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=38.1270903010033, Blast_Score=194, Evalue=4e-50, Organism=Drosophila melanogaster, GI20129731, Length=291, Percent_Identity=39.5189003436426, Blast_Score=193, Evalue=1e-49, Organism=Drosophila melanogaster, GI24657054, Length=287, Percent_Identity=39.0243902439024, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI221378297, Length=319, Percent_Identity=35.423197492163, Blast_Score=186, Evalue=2e-47, Organism=Drosophila melanogaster, GI24663317, Length=295, Percent_Identity=35.9322033898305, Blast_Score=185, Evalue=3e-47, Organism=Drosophila melanogaster, GI21356425, Length=299, Percent_Identity=35.7859531772575, Blast_Score=183, Evalue=1e-46, Organism=Drosophila melanogaster, GI45553081, Length=292, Percent_Identity=34.2465753424658, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI24662789, Length=307, Percent_Identity=31.2703583061889, Blast_Score=163, Evalue=1e-40, Organism=Drosophila melanogaster, GI24662785, Length=304, Percent_Identity=35.1973684210526, Blast_Score=158, Evalue=5e-39, Organism=Drosophila melanogaster, GI24662781, Length=306, Percent_Identity=34.3137254901961, Blast_Score=158, Evalue=5e-39, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=32.9411764705882, Blast_Score=140, Evalue=8e-34,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 30113; Mature: 29982
Theoretical pI: Translated: 4.45; Mature: 4.45
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 1.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTSTRGEAAGIPSVSLNDGHSIPVLGLGVGELSEAEAERSVAAALEAGYRLIDTAAVYGN CCCCCCCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCC EAAVGRAVNASGIPREEIYVTTKLAVADQGFGTSQDAARASLERLGLDYVDLYLIHWPAG CHHHCCCCCCCCCCHHHEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCC DHGKYIDSWGGLMKAKQDGVARSIGVCNFNAEHLSNIIDLSFFTPAINQIELHPLLNQAE CCCCCHHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHH LREVNAGYGIVTEAYGPLGVGRLLDHAAVTGVAQAHGKTPAQVLLRWSIQLGNVVIARSA HHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCEEEEECC NPDRITSNLEVFDFELTDDEMATLNGLDEGTRFRPDPETYTGP CHHHHCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure TSTRGEAAGIPSVSLNDGHSIPVLGLGVGELSEAEAERSVAAALEAGYRLIDTAAVYGN CCCCCCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEHHHHCCC EAAVGRAVNASGIPREEIYVTTKLAVADQGFGTSQDAARASLERLGLDYVDLYLIHWPAG CHHHCCCCCCCCCCHHHEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCC DHGKYIDSWGGLMKAKQDGVARSIGVCNFNAEHLSNIIDLSFFTPAINQIELHPLLNQAE CCCCCHHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHH LREVNAGYGIVTEAYGPLGVGRLLDHAAVTGVAQAHGKTPAQVLLRWSIQLGNVVIARSA HHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEEEEECCEEEEECC NPDRITSNLEVFDFELTDDEMATLNGLDEGTRFRPDPETYTGP CHHHHCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA