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The map label for this gene is 119867880

Identifier: 119867880

GI number: 119867880

Start: 1954360

End: 1955856

Strand: Reverse

Name: 119867880

Synonym: Mkms_1841

Alternate gene names: NA

Gene position: 1955856-1954360 (Counterclockwise)

Preceding gene: 119867883

Following gene: 119867874

Centisome position: 34.09

GC content: 68.87

Gene sequence:

>1497_bases
ATGACGGACGCGCAGGACTGGAAGGAGACGCTCGAGGACCTCGAGCGCCGCCGTGCGCATACGTACGGGATGGGCGGGCC
GGAGCGCGTCGCCAAACACCACGGCAAGGGCAAGCTCGACGCCAGGGCGCGCATCACACGTCTGCTCGACCCGGATACGT
TCTGCGAGTTCGGCACACTGGTCGGTGGTGACATCGCCGCCGACGGTCTCGTCGCCGGCTCCGGCCGGGTCGGCGGCGTC
CCGGTCATGGTGGGCGCCGAGGATTTCACGACACTCGCAGGCAGTATCGGGCCGGGCGGCAACGCCAAGCGCTACCGGCT
CGCCGAACTGGCGCTGCGCAACAAGATCCCGCTGGTGATGTTGTTGGAGGGCGCGGGTTTCCGGCCCAGCGGCGAACACT
ACGGCCGCACCCCGACCGACCTGATCATCCAGGCGCAGTGCTCGGGAAAGGTGCCCACGGTCGCGGCGGTGCTGGGACCG
TCCGCCGGGCACGGTGCGCTGGTGGCCCCGGTGTGCGATTTCACGATCATGAGTGCCGGCGGGGCGATCTTCACCGCCGG
TCCCCCGGTGGTCAAAGAGTCCACCGGAGAGGACATCTCGAAGGAGGATCTGGGCGGTCCCGAGGTCGCGCTCGCCAGCG
GCGTGATCCACAACTACGGCGAGGACGACGAGACGGTGATCGACGACATCCGTCGGTACCTGTCCTACTTCCCGTCCAGC
GCGTGGTCGTATCCGCCAACCCGGCTCGCCGACGACACCGCCGATCCGCGCCCCACACCCGAACTGCTCGACATCGTCTC
GCGCGACAACCGCCACATCTACGACATGCGCACCGTGCTCGACGTGATCTTCGACCGCCCCGACTGGTTGGAGGTCCAGC
CGCGGTTCGGCCGCGCGGTCATCTGCGCGCTGGCGCATCTGGGCGGTTTCCCCGTCGCGGTGGTGGCGAACCAGCCGGAG
GTGATGGCCGGCTCCATCGACGCCGACGCCGCGGACAAGGCGGCCCACTTCATCACGGTCGCCGATTCGTTCCACCTGCC
CATCGTGTTCCTCGCCGACAACCCGGGCATGCTGCCGGGCAGCCGCTCCGAACGCAGCGGCGTGCTGCGCAGCGGCGCCA
GGATGTTCGCCGCGCAGACCGCCGCGACGACGCTCAAACTGCACGTCACGCTGCGCAAGGCGTTCGGCTTCGGCTCGATG
GTGATGTCGCTGTTGGGCTTCGACGATCAGGTGGCCACGTTCGCGTATCCGGGCGCCACCATGGGGGCGATGAGTGCGGC
GGCGATGAGCCGGGCGACACACGCCGGCGAGGACTACACCGAGGTGCTCAAGAGGATGGAGTTGGAGGCCAGTTACCGCT
CGGCCGGCCACCTCGGCTTCGACGAGCTGATCTCACCGGTGGAGACCCGCGACAGGCTGTTGACGGCGCTGCAGCACGGC
ATCTTCAGCCGTCAGGCGGTCGCCGAACCGGTGGCCCGCACCGTGATCATGCCCTAG

Upstream 100 bases:

>100_bases
TCGGTCCACTTTGAGGCCGGGCACTGCGCCGTCACCCATGGGAGATGACGCTACAGTAAGCAATTCAGTAAGGTCAACGA
CCGTGAGTGAGGACCGACGG

Downstream 100 bases:

>100_bases
CCGGTGATTTCGGCGTGCTCGGTCGCGCTGGGCGCGACCCCGCACGCCGAAATCGCTCACCTGGCGCGGTATTCCTCGAC
GATCGGGGCGAGTTCGTCGG

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: Transcarboxylase 12S subunit [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTDAQDWKETLEDLERRRAHTYGMGGPERVAKHHGKGKLDARARITRLLDPDTFCEFGTLVGGDIAADGLVAGSGRVGGV
PVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKIPLVMLLEGAGFRPSGEHYGRTPTDLIIQAQCSGKVPTVAAVLGP
SAGHGALVAPVCDFTIMSAGGAIFTAGPPVVKESTGEDISKEDLGGPEVALASGVIHNYGEDDETVIDDIRRYLSYFPSS
AWSYPPTRLADDTADPRPTPELLDIVSRDNRHIYDMRTVLDVIFDRPDWLEVQPRFGRAVICALAHLGGFPVAVVANQPE
VMAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPGSRSERSGVLRSGARMFAAQTAATTLKLHVTLRKAFGFGSM
VMSLLGFDDQVATFAYPGATMGAMSAAAMSRATHAGEDYTEVLKRMELEASYRSAGHLGFDELISPVETRDRLLTALQHG
IFSRQAVAEPVARTVIMP

Sequences:

>Translated_498_residues
MTDAQDWKETLEDLERRRAHTYGMGGPERVAKHHGKGKLDARARITRLLDPDTFCEFGTLVGGDIAADGLVAGSGRVGGV
PVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKIPLVMLLEGAGFRPSGEHYGRTPTDLIIQAQCSGKVPTVAAVLGP
SAGHGALVAPVCDFTIMSAGGAIFTAGPPVVKESTGEDISKEDLGGPEVALASGVIHNYGEDDETVIDDIRRYLSYFPSS
AWSYPPTRLADDTADPRPTPELLDIVSRDNRHIYDMRTVLDVIFDRPDWLEVQPRFGRAVICALAHLGGFPVAVVANQPE
VMAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPGSRSERSGVLRSGARMFAAQTAATTLKLHVTLRKAFGFGSM
VMSLLGFDDQVATFAYPGATMGAMSAAAMSRATHAGEDYTEVLKRMELEASYRSAGHLGFDELISPVETRDRLLTALQHG
IFSRQAVAEPVARTVIMP
>Mature_497_residues
TDAQDWKETLEDLERRRAHTYGMGGPERVAKHHGKGKLDARARITRLLDPDTFCEFGTLVGGDIAADGLVAGSGRVGGVP
VMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKIPLVMLLEGAGFRPSGEHYGRTPTDLIIQAQCSGKVPTVAAVLGPS
AGHGALVAPVCDFTIMSAGGAIFTAGPPVVKESTGEDISKEDLGGPEVALASGVIHNYGEDDETVIDDIRRYLSYFPSSA
WSYPPTRLADDTADPRPTPELLDIVSRDNRHIYDMRTVLDVIFDRPDWLEVQPRFGRAVICALAHLGGFPVAVVANQPEV
MAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPGSRSERSGVLRSGARMFAAQTAATTLKLHVTLRKAFGFGSMV
MSLLGFDDQVATFAYPGATMGAMSAAAMSRATHAGEDYTEVLKRMELEASYRSAGHLGFDELISPVETRDRLLTALQHGI
FSRQAVAEPVARTVIMP

Specific function: The 12S subunit specifically catalyzes the transfer of the carboxyl group of methylmalonyl CoA to the biotin of the 1.3S subunit forming propanoyl-CoA and carboxylated 1.3S-biotin [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=510, Percent_Identity=31.1764705882353, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI295821216, Length=530, Percent_Identity=30.188679245283, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=27.4253731343284, Blast_Score=172, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI25147362, Length=479, Percent_Identity=32.3590814196242, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147359, Length=479, Percent_Identity=32.3590814196242, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=27.7669902912621, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71997163, Length=312, Percent_Identity=23.7179487179487, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24586065, Length=527, Percent_Identity=29.2220113851992, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =2.1.3.1 [H]

Molecular weight: Translated: 53143; Mature: 53012

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAQDWKETLEDLERRRAHTYGMGGPERVAKHHGKGKLDARARITRLLDPDTFCEFGTL
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
VGGDIAADGLVAGSGRVGGVPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKIPLVM
CCCCCCCCCEEECCCCCCCEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEE
LLEGAGFRPSGEHYGRTPTDLIIQAQCSGKVPTVAAVLGPSAGHGALVAPVCDFTIMSAG
EEECCCCCCCCCCCCCCCHHEEEEEECCCCCCEEEEEECCCCCCCCEEHHHHCCCEECCC
GAIFTAGPPVVKESTGEDISKEDLGGPEVALASGVIHNYGEDDETVIDDIRRYLSYFPSS
CEEEECCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
AWSYPPTRLADDTADPRPTPELLDIVSRDNRHIYDMRTVLDVIFDRPDWLEVQPRFGRAV
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHH
ICALAHLGGFPVAVVANQPEVMAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPG
HHHHHHCCCCCEEEEECCCCEEECCCCCCCHHCCEEEEEEECCCCCCEEEEECCCCCCCC
SRSERSGVLRSGARMFAAQTAATTLKLHVTLRKAFGFGSMVMSLLGFDDQVATFAYPGAT
CCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHHCHHHHHHHHHCCCCCHHEEECCCCH
MGAMSAAAMSRATHAGEDYTEVLKRMELEASYRSAGHLGFDELISPVETRDRLLTALQHG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
IFSRQAVAEPVARTVIMP
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDAQDWKETLEDLERRRAHTYGMGGPERVAKHHGKGKLDARARITRLLDPDTFCEFGTL
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHH
VGGDIAADGLVAGSGRVGGVPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKIPLVM
CCCCCCCCCEEECCCCCCCEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEE
LLEGAGFRPSGEHYGRTPTDLIIQAQCSGKVPTVAAVLGPSAGHGALVAPVCDFTIMSAG
EEECCCCCCCCCCCCCCCHHEEEEEECCCCCCEEEEEECCCCCCCCEEHHHHCCCEECCC
GAIFTAGPPVVKESTGEDISKEDLGGPEVALASGVIHNYGEDDETVIDDIRRYLSYFPSS
CEEEECCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
AWSYPPTRLADDTADPRPTPELLDIVSRDNRHIYDMRTVLDVIFDRPDWLEVQPRFGRAV
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCHHH
ICALAHLGGFPVAVVANQPEVMAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPG
HHHHHHCCCCCEEEEECCCCEEECCCCCCCHHCCEEEEEEECCCCCCEEEEECCCCCCCC
SRSERSGVLRSGARMFAAQTAATTLKLHVTLRKAFGFGSMVMSLLGFDDQVATFAYPGAT
CCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEHHHHCHHHHHHHHHCCCCCHHEEECCCCH
MGAMSAAAMSRATHAGEDYTEVLKRMELEASYRSAGHLGFDELISPVETRDRLLTALQHG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
IFSRQAVAEPVARTVIMP
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8366018 [H]