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The map label for this gene is arpA [H]

Identifier: 119867831

GI number: 119867831

Start: 1900022

End: 1900672

Strand: Reverse

Name: arpA [H]

Synonym: Mkms_1792

Alternate gene names: 119867831

Gene position: 1900672-1900022 (Counterclockwise)

Preceding gene: 119867832

Following gene: 119867829

Centisome position: 33.13

GC content: 66.97

Gene sequence:

>651_bases
ATGATTCGCCAAGCACGATCCGAGGCGACCAGGCGCAGGATCATCGAGGCGGCTGTCGACCTGTTCAGTGAACGGGGTTA
TCCCGGAACAGGACTCGGCGACATCATCGAGCGTGCCCAGATGACCAAGGGTGCGCTCTACTACCATTTCGACTCGAAGG
AAGCCCTTGCCGCGGAGATCGTCTCCGAGGGCAGCGCCCGGTTGCTGGCCACCTTCGACGCCATCAGTGAATCGTCGTCG
CCCGCGCTGGAGAGCATCATCCACGGGACTTTCCTCGTCGTGGACCAGCTCGGCAGCGACAAGGTGGCCCGCGTGGGGAT
CGTGCTGATGCGCGTCTTCGCGGGGTTCAGTGAGTCCGCGGGAGGCACCTACAGCGGCTGGCTCTCGGCGATGGTCACGG
ATGTCGCCCGGGCCCGCGACGAGGGCGACGTCCGCGACGACGTCGACATCGTCGCGGTCGCCGAGACGTTCGTCGGCGCC
TTCGTCGGCGGGAGCCTGCTCTCCGACGCCGCCTCGGGTGGGACGGATCTACGCGAGCGCGTCACGCGCCTGTTCGGACT
CGTCCTGCCCGCAATCGTCACCGACGAGTCCCGGGAGTACTTCACCGAGTTCCTGGCGCGCGAGACACGTCGGGGCCCCA
CCGGTGACTGA

Upstream 100 bases:

>100_bases
CCTTGGCGATCAAGAAGGCGCGACCGTTGTCCACCGATACCCTGTGACCGCGGGCCGCGTCACATGGCGACGGTCTCGGT
GCGGAGGTGGGTGACAGCAC

Downstream 100 bases:

>100_bases
CCCGGTTCACATCCCTTCCGCCCACAGCCGCTCGGTGAGATCGGTGAACGTCGCCAGCGCCACCGGATCGTCGCCGCGCA
CCAGCGCGGATTTGCTCATC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: A-factor-binding protein [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MIRQARSEATRRRIIEAAVDLFSERGYPGTGLGDIIERAQMTKGALYYHFDSKEALAAEIVSEGSARLLATFDAISESSS
PALESIIHGTFLVVDQLGSDKVARVGIVLMRVFAGFSESAGGTYSGWLSAMVTDVARARDEGDVRDDVDIVAVAETFVGA
FVGGSLLSDAASGGTDLRERVTRLFGLVLPAIVTDESREYFTEFLARETRRGPTGD

Sequences:

>Translated_216_residues
MIRQARSEATRRRIIEAAVDLFSERGYPGTGLGDIIERAQMTKGALYYHFDSKEALAAEIVSEGSARLLATFDAISESSS
PALESIIHGTFLVVDQLGSDKVARVGIVLMRVFAGFSESAGGTYSGWLSAMVTDVARARDEGDVRDDVDIVAVAETFVGA
FVGGSLLSDAASGGTDLRERVTRLFGLVLPAIVTDESREYFTEFLARETRRGPTGD
>Mature_216_residues
MIRQARSEATRRRIIEAAVDLFSERGYPGTGLGDIIERAQMTKGALYYHFDSKEALAAEIVSEGSARLLATFDAISESSS
PALESIIHGTFLVVDQLGSDKVARVGIVLMRVFAGFSESAGGTYSGWLSAMVTDVARARDEGDVRDDVDIVAVAETFVGA
FVGGSLLSDAASGGTDLRERVTRLFGLVLPAIVTDESREYFTEFLARETRRGPTGD

Specific function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23207; Mature: 23207

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQARSEATRRRIIEAAVDLFSERGYPGTGLGDIIERAQMTKGALYYHFDSKEALAAEI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
VSEGSARLLATFDAISESSSPALESIIHGTFLVVDQLGSDKVARVGIVLMRVFAGFSESA
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
GGTYSGWLSAMVTDVARARDEGDVRDDVDIVAVAETFVGAFVGGSLLSDAASGGTDLRER
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VTRLFGLVLPAIVTDESREYFTEFLARETRRGPTGD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIRQARSEATRRRIIEAAVDLFSERGYPGTGLGDIIERAQMTKGALYYHFDSKEALAAEI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
VSEGSARLLATFDAISESSSPALESIIHGTFLVVDQLGSDKVARVGIVLMRVFAGFSESA
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
GGTYSGWLSAMVTDVARARDEGDVRDDVDIVAVAETFVGAFVGGSLLSDAASGGTDLRER
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VTRLFGLVLPAIVTDESREYFTEFLARETRRGPTGD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592371; 9813285; 2502536; 2111804; 9220006; 10540289; 9098075 [H]