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The map label for this gene is adhP [C]

Identifier: 119867798

GI number: 119867798

Start: 1869346

End: 1870353

Strand: Reverse

Name: adhP [C]

Synonym: Mkms_1759

Alternate gene names: 119867798

Gene position: 1870353-1869346 (Counterclockwise)

Preceding gene: 119867801

Following gene: 119867795

Centisome position: 32.6

GC content: 74.4

Gene sequence:

>1008_bases
GTGGATGTCCGGTCGGTGGCCGACCCGTCGCCGCCGCCCGGCGGCGTGGTCGTCGAGGTGCACGCCACCGGCCTGTGCCG
GAGCGACTGGCACGGGTGGGCCGGCCACGACCGCGGCATCACGCTCCCCCACGTACCCGGCCACGAACTGGTCGGCGTCG
TGGCGGAGGTCGGTGCCGGCGTCGAGAAATGGCGGGTCGGCGACCGTGTCACCACACCGTTCGTCTGCGGGTGCGGCCGC
TGCCAATGGTGCCTCGAGGGGCAGGCGCAGGTGTGTCCGGACCAGACCCAGCCGGGCTTCACGCACTGGGGTTCGTACGC
CGAGTACGTGGCCCTGCACGCCGCCGACGCCAACCTGGTCGCGGTCCCGGACGCCGTCGGCGACGCCGCCGCGGCGGGAC
TGGGCTGCCGATTCGCCACCGCCTACCGGGCGCTGAGCGCACGCGCCCGGATCCGCCCCGGCGAGTGGGTGACGGTCGTC
GGGGCCGGCGGGGTAGGACTGAGCAGCGTGCAGATCGCCGTCGCCTTCGGCGCCAGGGTGATCGCGGTCGACCGGGAGCC
GGCGGCGCTCGCGCTGGCGAGCCGACTGGGCGCGGAGCACACCGTGCACGCTGACGGCGCCGACGTCGCGGGCCGGGTCC
ACGACCTCACCGGCGGGGGCAGCCATGTCGCCGTGGACGCGGTCGGTTCTGCGGCGACGTGCGCGGATGCCATCCACAGC
CTGCGACGCCGCGGACGTCACCTCCAGGTCGGCCTGCTGCCCGATGTCACCGGGCATCCGGCGGTGCCGATGGACCGGGT
CATCGCGTGGGAACTCGACGTCCTGGGCAGCCACGGCATGGCCAGCGGGGACTACCCCGGAATGATGCGGCTGATCGAGG
CGGGAACGTTGCGCCCGCAGGCAATCGTCGAGCGCGTCGTCGGGCTCACCGAAGGCGCCACGCTCCTGTCGTCGCTGAGC
GTCGCGACCCCGGCAGGGGTCACGCTGATCGACCCGCGGCTCGGCTGA

Upstream 100 bases:

>100_bases
GATCATCTCAGCCGGGCCCGGCGTCACACCGATCCGCGGTGGCCCGTGTCGGCAGACTGTTCTCGTGCGCGCCATGATCT
TCGAAGAGTTCGGTGGTCCG

Downstream 100 bases:

>100_bases
CGCCGGTCAGCGCCGCACCCGCCTGCTGCACACCGGCCAGGCGCCCCAGCCCTGCCCGGCCTGTGTCAGTTCGGCGATCG
CGATCTGCTCTTCGCGGGTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MDVRSVADPSPPPGGVVVEVHATGLCRSDWHGWAGHDRGITLPHVPGHELVGVVAEVGAGVEKWRVGDRVTTPFVCGCGR
CQWCLEGQAQVCPDQTQPGFTHWGSYAEYVALHAADANLVAVPDAVGDAAAAGLGCRFATAYRALSARARIRPGEWVTVV
GAGGVGLSSVQIAVAFGARVIAVDREPAALALASRLGAEHTVHADGADVAGRVHDLTGGGSHVAVDAVGSAATCADAIHS
LRRRGRHLQVGLLPDVTGHPAVPMDRVIAWELDVLGSHGMASGDYPGMMRLIEAGTLRPQAIVERVVGLTEGATLLSSLS
VATPAGVTLIDPRLG

Sequences:

>Translated_335_residues
MDVRSVADPSPPPGGVVVEVHATGLCRSDWHGWAGHDRGITLPHVPGHELVGVVAEVGAGVEKWRVGDRVTTPFVCGCGR
CQWCLEGQAQVCPDQTQPGFTHWGSYAEYVALHAADANLVAVPDAVGDAAAAGLGCRFATAYRALSARARIRPGEWVTVV
GAGGVGLSSVQIAVAFGARVIAVDREPAALALASRLGAEHTVHADGADVAGRVHDLTGGGSHVAVDAVGSAATCADAIHS
LRRRGRHLQVGLLPDVTGHPAVPMDRVIAWELDVLGSHGMASGDYPGMMRLIEAGTLRPQAIVERVVGLTEGATLLSSLS
VATPAGVTLIDPRLG
>Mature_335_residues
MDVRSVADPSPPPGGVVVEVHATGLCRSDWHGWAGHDRGITLPHVPGHELVGVVAEVGAGVEKWRVGDRVTTPFVCGCGR
CQWCLEGQAQVCPDQTQPGFTHWGSYAEYVALHAADANLVAVPDAVGDAAAAGLGCRFATAYRALSARARIRPGEWVTVV
GAGGVGLSSVQIAVAFGARVIAVDREPAALALASRLGAEHTVHADGADVAGRVHDLTGGGSHVAVDAVGSAATCADAIHS
LRRRGRHLQVGLLPDVTGHPAVPMDRVIAWELDVLGSHGMASGDYPGMMRLIEAGTLRPQAIVERVVGLTEGATLLSSLS
VATPAGVTLIDPRLG

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=347, Percent_Identity=27.9538904899135, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI156523966, Length=276, Percent_Identity=28.9855072463768, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501939, Length=276, Percent_Identity=28.9855072463768, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI71565152, Length=256, Percent_Identity=28.125, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4501929, Length=347, Percent_Identity=27.3775216138329, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71743840, Length=338, Percent_Identity=25.4437869822485, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=346, Percent_Identity=27.4566473988439, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=338, Percent_Identity=25.4437869822485, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565154, Length=268, Percent_Identity=25.7462686567164, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI194239674, Length=184, Percent_Identity=32.6086956521739, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI13236495, Length=184, Percent_Identity=32.6086956521739, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI194239676, Length=184, Percent_Identity=32.6086956521739, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI156627571, Length=282, Percent_Identity=25.886524822695, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=30.1492537313433, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788073, Length=326, Percent_Identity=27.6073619631902, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082125, Length=263, Percent_Identity=32.319391634981, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788075, Length=323, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787863, Length=312, Percent_Identity=27.2435897435897, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786825, Length=275, Percent_Identity=29.8181818181818, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI226510992, Length=291, Percent_Identity=27.4914089347079, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786552, Length=261, Percent_Identity=30.2681992337165, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790045, Length=308, Percent_Identity=26.6233766233766, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786518, Length=209, Percent_Identity=34.4497607655502, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788407, Length=293, Percent_Identity=26.6211604095563, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=283, Percent_Identity=32.5088339222615, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=258, Percent_Identity=29.8449612403101, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17562582, Length=259, Percent_Identity=31.2741312741313, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17562876, Length=310, Percent_Identity=30.3225806451613, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=300, Percent_Identity=29.6666666666667, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=271, Percent_Identity=23.9852398523985, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=257, Percent_Identity=24.9027237354086, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=271, Percent_Identity=24.3542435424354, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=256, Percent_Identity=34.765625, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=29.3375394321767, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=28.4457478005865, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=256, Percent_Identity=30.859375, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=272, Percent_Identity=27.9411764705882, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=317, Percent_Identity=29.0220820189274, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=317, Percent_Identity=29.0220820189274, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=322, Percent_Identity=27.3291925465839, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=209, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=206, Percent_Identity=30.5825242718447, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=259, Percent_Identity=27.027027027027, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=28.0120481927711, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737897, Length=341, Percent_Identity=27.8592375366569, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34484; Mature: 34484

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVRSVADPSPPPGGVVVEVHATGLCRSDWHGWAGHDRGITLPHVPGHELVGVVAEVGAG
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCC
VEKWRVGDRVTTPFVCGCGRCQWCLEGQAQVCPDQTQPGFTHWGSYAEYVALHAADANLV
HHHEECCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHEEEEEECCCCEE
AVPDAVGDAAAAGLGCRFATAYRALSARARIRPGEWVTVVGAGGVGLSSVQIAVAFGARV
ECCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCEE
IAVDREPAALALASRLGAEHTVHADGADVAGRVHDLTGGGSHVAVDAVGSAATCADAIHS
EEECCCCHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHH
LRRRGRHLQVGLLPDVTGHPAVPMDRVIAWELDVLGSHGMASGDYPGMMRLIEAGTLRPQ
HHHCCCEEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCHH
AIVERVVGLTEGATLLSSLSVATPAGVTLIDPRLG
HHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCC
>Mature Secondary Structure
MDVRSVADPSPPPGGVVVEVHATGLCRSDWHGWAGHDRGITLPHVPGHELVGVVAEVGAG
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHCCC
VEKWRVGDRVTTPFVCGCGRCQWCLEGQAQVCPDQTQPGFTHWGSYAEYVALHAADANLV
HHHEECCCCCCCCEEECCCCCEEEECCCCCCCCCCCCCCCHHHCCHHHEEEEEECCCCEE
AVPDAVGDAAAAGLGCRFATAYRALSARARIRPGEWVTVVGAGGVGLSSVQIAVAFGARV
ECCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCEE
IAVDREPAALALASRLGAEHTVHADGADVAGRVHDLTGGGSHVAVDAVGSAATCADAIHS
EEECCCCHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCEEEEECCCCHHHHHHHHHH
LRRRGRHLQVGLLPDVTGHPAVPMDRVIAWELDVLGSHGMASGDYPGMMRLIEAGTLRPQ
HHHCCCEEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHCCCCHH
AIVERVVGLTEGATLLSSLSVATPAGVTLIDPRLG
HHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]