BacMap

Definition	Mycobacterium sp. KMS chromosome, complete genome.
Accession	NC_008705
Length	5,737,227

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The map label for this gene is kduD [C]

Identifier: 119867604

GI number: 119867604

Start: 1674555

End: 1675382

Strand: Reverse

Name: kduD [C]

Synonym: Mkms_1557

Alternate gene names: 119867604

Gene position: 1675382-1674555 (Counterclockwise)

Preceding gene: 119867608

Following gene: 119867592

Centisome position: 29.2

GC content: 67.75

Gene sequence:

>828_bases
ATGCCACGTCTATCGAACAGGGTCGCCCTCGTCACGGGTGCGACCGCCGTGGAACCCGGCGGCCTCAACATCGGCGGTGC
CGCAGCCACCGAGGTGGTGGCCGAAGGCGCCCGCGTGGTGCTCGCCGACATCAACATCGAGGGCGCTTCGGCTCTCGCCG
AGCAACTCAACCAGAAGTACGGCCCGGACGTCGCGATCGCGGTCCAGACCGACCTCCGCGACGAGGATGCGATTCAACGG
CTCGTGGCCACCACGGTCTCCACCTTCGGCAAAATCGATGTGCTGTTCAACATCGCCGGCGTCTTCCCCGCCGGTGACGG
TGACGTCGCCACCATGCCGATCGAGGTCTGGGACGACGTGATGGCGGTCAACGTGCGCAGTGCCATGCTCACCACCAAAC
ACGCTCTGCCGCATCTTCGCGTCGAGGGCGGGTCGATCGTCAACACCGCGTCCACCCATGCGTTCGCCGGCGACACCAGC
CTCACCGGCTACGGTGCGACCAAGGCGGCGTTGCTGGCCCTGACCAAGTACACCGCCACGCAGTACGGGCGGGAACGGGT
GCGGTGCAACGCCATCTGCCCGGGCACCACCACGACACCACCGGCCCAGCAGTTGCCGGAGGCCGTCAAGGACATCTACC
GCCGCCATACGCCCGCACCGGACCTCAACGGCCCCGCCGATCTGGCCAAGGTGTATGCCTTCCTGGCATCCGATGACTCT
CGCGGGATCAACGGCGAGACCATCCGGGTCGACGGCGGGCTGCTGGCCCACCAGCCCTTCGTCCCGGACATGGACTCACT
GGGCGCCGCGACGGCCACGTCCCAGTAG

Upstream 100 bases:

>100_bases
AGAGCATGGTTGACCCACGGTTTTGTTGAAGTTAGCCTTCACAGTGTGGGCTGCACTACAGGCCGACGCGGAGCTCCGAC
GACCAACAGTGAGGAACGAG

Downstream 100 bases:

>100_bases
CGCAGTCACCCGATTGGCGCACCGGCAGTCAGCTGTCGGTGCGCCGATTGTTTTCGAGCGGTGACTCAGTCCGGGCGGCC
GTACACCGCGACGACGACGG

Product: short-chain dehydrogenase/reductase SDR

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPRLSNRVALVTGATAVEPGGLNIGGAAATEVVAEGARVVLADINIEGASALAEQLNQKYGPDVAIAVQTDLRDEDAIQR
LVATTVSTFGKIDVLFNIAGVFPAGDGDVATMPIEVWDDVMAVNVRSAMLTTKHALPHLRVEGGSIVNTASTHAFAGDTS
LTGYGATKAALLALTKYTATQYGRERVRCNAICPGTTTTPPAQQLPEAVKDIYRRHTPAPDLNGPADLAKVYAFLASDDS
RGINGETIRVDGGLLAHQPFVPDMDSLGAATATSQ

Sequences:

>Translated_275_residues
MPRLSNRVALVTGATAVEPGGLNIGGAAATEVVAEGARVVLADINIEGASALAEQLNQKYGPDVAIAVQTDLRDEDAIQR
LVATTVSTFGKIDVLFNIAGVFPAGDGDVATMPIEVWDDVMAVNVRSAMLTTKHALPHLRVEGGSIVNTASTHAFAGDTS
LTGYGATKAALLALTKYTATQYGRERVRCNAICPGTTTTPPAQQLPEAVKDIYRRHTPAPDLNGPADLAKVYAFLASDDS
RGINGETIRVDGGLLAHQPFVPDMDSLGAATATSQ
>Mature_274_residues
PRLSNRVALVTGATAVEPGGLNIGGAAATEVVAEGARVVLADINIEGASALAEQLNQKYGPDVAIAVQTDLRDEDAIQRL
VATTVSTFGKIDVLFNIAGVFPAGDGDVATMPIEVWDDVMAVNVRSAMLTTKHALPHLRVEGGSIVNTASTHAFAGDTSL
TGYGATKAALLALTKYTATQYGRERVRCNAICPGTTTTPPAQQLPEAVKDIYRRHTPAPDLNGPADLAKVYAFLASDDSR
GINGETIRVDGGLLAHQPFVPDMDSLGAATATSQ

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=34.4827586206897, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=33.852140077821, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI66933014, Length=227, Percent_Identity=31.7180616740088, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=30.2788844621514, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI19923817, Length=277, Percent_Identity=28.5198555956679, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI59889578, Length=212, Percent_Identity=30.6603773584906, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=27.8008298755187, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=29.7297297297297, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=31.6326530612245, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4504505, Length=225, Percent_Identity=30.2222222222222, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI31542939, Length=203, Percent_Identity=28.0788177339901, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=29.7709923664122, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI83715985, Length=260, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=32.1052631578947, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI10190704, Length=278, Percent_Identity=26.2589928057554, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224922801, Length=181, Percent_Identity=26.5193370165746, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4503301, Length=225, Percent_Identity=26.2222222222222, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=33.0769230769231, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=31.1787072243346, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789378, Length=266, Percent_Identity=30.8270676691729, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=27.9527559055118, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=255, Percent_Identity=29.4117647058824, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=29.1338582677165, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=28.515625, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787526, Length=253, Percent_Identity=31.6205533596838, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786812, Length=267, Percent_Identity=29.9625468164794, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788459, Length=232, Percent_Identity=28.8793103448276, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789057, Length=262, Percent_Identity=24.0458015267176, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=34.2307692307692, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=34.6456692913386, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=32.9411764705882, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560676, Length=261, Percent_Identity=31.4176245210728, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=32.2097378277154, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=32.967032967033, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=267, Percent_Identity=31.0861423220974, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562906, Length=270, Percent_Identity=31.8518518518519, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17544670, Length=274, Percent_Identity=29.9270072992701, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=30.7407407407407, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=192, Percent_Identity=34.8958333333333, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=32.1033210332103, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=30.9963099630996, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=28.8461538461538, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=30.2583025830258, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=30.5970149253731, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=28.0769230769231, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=29.4776119402985, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=31.0861423220974, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=30.3370786516854, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=28.996282527881, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=226, Percent_Identity=28.7610619469027, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=276, Percent_Identity=27.8985507246377, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=29.5620437956204, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=28.4132841328413, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=29.520295202952, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=213, Percent_Identity=26.7605633802817, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=210, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=32.5490196078431, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=33.976833976834, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=32.5670498084291, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=29.0566037735849, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=29.811320754717, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644339, Length=262, Percent_Identity=29.3893129770992, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=29.5454545454545, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24644337, Length=225, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643142, Length=263, Percent_Identity=29.277566539924, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 28607; Mature: 28475

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLSNRVALVTGATAVEPGGLNIGGAAATEVVAEGARVVLADINIEGASALAEQLNQKY
CCCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHC
GPDVAIAVQTDLRDEDAIQRLVATTVSTFGKIDVLFNIAGVFPAGDGDVATMPIEVWDDV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEHHHHHHH
MAVNVRSAMLTTKHALPHLRVEGGSIVNTASTHAFAGDTSLTGYGATKAALLALTKYTAT
HHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
QYGRERVRCNAICPGTTTTPPAQQLPEAVKDIYRRHTPAPDLNGPADLAKVYAFLASDDS
HHCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
RGINGETIRVDGGLLAHQPFVPDMDSLGAATATSQ
CCCCCCEEEECCCEEECCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
PRLSNRVALVTGATAVEPGGLNIGGAAATEVVAEGARVVLADINIEGASALAEQLNQKY
CCCCCCEEEEECCCEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHC
GPDVAIAVQTDLRDEDAIQRLVATTVSTFGKIDVLFNIAGVFPAGDGDVATMPIEVWDDV
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEHHHHHHH
MAVNVRSAMLTTKHALPHLRVEGGSIVNTASTHAFAGDTSLTGYGATKAALLALTKYTAT
HHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
QYGRERVRCNAICPGTTTTPPAQQLPEAVKDIYRRHTPAPDLNGPADLAKVYAFLASDDS
HHCHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
RGINGETIRVDGGLLAHQPFVPDMDSLGAATATSQ
CCCCCCEEEECCCEEECCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]