| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is fabG [H]
Identifier: 119867575
GI number: 119867575
Start: 1639222
End: 1639998
Strand: Direct
Name: fabG [H]
Synonym: Mkms_1527
Alternate gene names: 119867575
Gene position: 1639222-1639998 (Clockwise)
Preceding gene: 119867574
Following gene: 119867576
Centisome position: 28.57
GC content: 71.17
Gene sequence:
>777_bases ATGTCTGCACTCAAGGGCCGGGTGGCTCTGGTGACCGGGAGCTCCCGAGGGGTGGGCCGCGGTATCGCGCTGCGCCTGGC CGCCGACGGCGCCGCAGTGGCGGTGAACTACCGGCGCGACGCCGAGGCCGCCGACGCGGTTGTCGCCGAAATCGTCTCGG CCGGCGGCGAAGCCAAGGCGTATTCGGCGTCGATCGACGACACCGCGGCCGTCGACGCGATGGTCGACGCGGTGCGCACC GACCTGGGTCCCATCGACCTCGTGGTGAGCAATGCCGGCACGGCGAGCAAGGGACAATCGGTCGGCGACACGCCCGGCGC CGACTTCCAGTCGCTGCTCAACGTGCATGCGCTGGGACCGATCCACCTCATCCAGCGGGTACTGCCGGACATGCGGGCGG CCGGGCGCGGTGACGTGATCATGATCTCGAGCAGCACAGTCGCCGAGGCCCCGGCGTTGTCCGCGCCGTACACGATGGCC AAGGCGGCCATGGAGATGTGCATCCGGACCCTCGCGCAGGAGGAGCGGGTCCACGGCATCCACGCCAACATCGTCGCCCC CGGCCTGGTGGAGACCGAGATGGGCCGTCGGCTGGTGCGGGCGGCCACCGGCGGCGGGACCATGGAGGACATCGCCCAGT CCTATCCGTTCGGGCGCATCTGTACGCCCGCCGACATCGCCGGTGCGGTCGCCTACCTGGTCTCCGCCGACGCGGATTAC GTCACCGGGCAGCGGATCACCGTCGACGGCGGCGGCCGGTCGGTCAGCGTCGTCTAG
Upstream 100 bases:
>100_bases ATCCGATCGCCCGGATGTGGCGCGACGCTCGCATCCAGCGGATCTATGGCGGAGCGAACGAGGTCATGAAGGACCTCGTC GGACGAGCGGTGGTGGGTTG
Downstream 100 bases:
>100_bases TCGCCTCTGAAGGCGCGGAGAGGAATTGCATGATGACGGTGGTGGCAGAGGAGGAGACGTCGATGAGCGACAGCGCATCG GAGTTCCTCACCGAACTCGC
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]
Number of amino acids: Translated: 258; Mature: 257
Protein sequence:
>258_residues MSALKGRVALVTGSSRGVGRGIALRLAADGAAVAVNYRRDAEAADAVVAEIVSAGGEAKAYSASIDDTAAVDAMVDAVRT DLGPIDLVVSNAGTASKGQSVGDTPGADFQSLLNVHALGPIHLIQRVLPDMRAAGRGDVIMISSSTVAEAPALSAPYTMA KAAMEMCIRTLAQEERVHGIHANIVAPGLVETEMGRRLVRAATGGGTMEDIAQSYPFGRICTPADIAGAVAYLVSADADY VTGQRITVDGGGRSVSVV
Sequences:
>Translated_258_residues MSALKGRVALVTGSSRGVGRGIALRLAADGAAVAVNYRRDAEAADAVVAEIVSAGGEAKAYSASIDDTAAVDAMVDAVRT DLGPIDLVVSNAGTASKGQSVGDTPGADFQSLLNVHALGPIHLIQRVLPDMRAAGRGDVIMISSSTVAEAPALSAPYTMA KAAMEMCIRTLAQEERVHGIHANIVAPGLVETEMGRRLVRAATGGGTMEDIAQSYPFGRICTPADIAGAVAYLVSADADY VTGQRITVDGGGRSVSVV >Mature_257_residues SALKGRVALVTGSSRGVGRGIALRLAADGAAVAVNYRRDAEAADAVVAEIVSAGGEAKAYSASIDDTAAVDAMVDAVRTD LGPIDLVVSNAGTASKGQSVGDTPGADFQSLLNVHALGPIHLIQRVLPDMRAAGRGDVIMISSSTVAEAPALSAPYTMAK AAMEMCIRTLAQEERVHGIHANIVAPGLVETEMGRRLVRAATGGGTMEDIAQSYPFGRICTPADIAGAVAYLVSADADYV TGQRITVDGGGRSVSVV
Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=32.1285140562249, Blast_Score=112, Evalue=5e-25, Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=30.8, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=28.968253968254, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.1632653061224, Blast_Score=86, Evalue=4e-17, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.1828793774319, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI19923817, Length=255, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI59889578, Length=187, Percent_Identity=31.0160427807487, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI4504505, Length=211, Percent_Identity=33.175355450237, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI209862901, Length=202, Percent_Identity=29.2079207920792, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI19923983, Length=202, Percent_Identity=29.2079207920792, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=31.1224489795918, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=29.3172690763052, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=32.9317269076305, Blast_Score=110, Evalue=8e-26, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=31.4516129032258, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=32.8, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=29.4820717131474, Blast_Score=103, Evalue=9e-24, Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=29.9610894941634, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=28.2352941176471, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI2367365, Length=252, Percent_Identity=30.952380952381, Blast_Score=93, Evalue=2e-20, Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=29.6747967479675, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=30.078125, Blast_Score=87, Evalue=1e-18, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=1e-14, Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=25.5905511811024, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=30.078125, Blast_Score=67, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=28.6764705882353, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=30.078125, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=29.9610894941634, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=27.0676691729323, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.1666666666667, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17538486, Length=264, Percent_Identity=28.7878787878788, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=30.3370786516854, Blast_Score=95, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=30.4182509505703, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17560332, Length=275, Percent_Identity=30.5454545454545, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=30.4182509505703, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI193204405, Length=269, Percent_Identity=30.1115241635688, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=28.7878787878788, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=28.4090909090909, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.9156626506024, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=28.1368821292776, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71982365, Length=193, Percent_Identity=31.0880829015544, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=26.8199233716475, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=29.3172690763052, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17565030, Length=282, Percent_Identity=28.3687943262411, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=27.3764258555133, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536025, Length=263, Percent_Identity=27.7566539923954, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17568967, Length=210, Percent_Identity=32.8571428571429, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI72000259, Length=279, Percent_Identity=28.3154121863799, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=29.3172690763052, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17561272, Length=265, Percent_Identity=29.4339622641509, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17558628, Length=191, Percent_Identity=33.5078534031414, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI17563726, Length=276, Percent_Identity=26.4492753623188, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17536651, Length=275, Percent_Identity=26.1818181818182, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=23.469387755102, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=26.2745098039216, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=24.6153846153846, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17532725, Length=198, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=6e-11, Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=25.8823529411765, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=30.0518134715026, Blast_Score=77, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6323882, Length=242, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=6e-14, Organism=Saccharomyces cerevisiae, GI6322226, Length=205, Percent_Identity=28.2926829268293, Blast_Score=69, Evalue=8e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=27.2373540856031, Blast_Score=68, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6322227, Length=254, Percent_Identity=25.1968503937008, Blast_Score=66, Evalue=5e-12, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=28.2868525896414, Blast_Score=107, Evalue=8e-24, Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=30, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=29.0196078431373, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI21357673, Length=197, Percent_Identity=31.9796954314721, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=27.3092369477912, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI18859837, Length=191, Percent_Identity=34.0314136125654, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI21356301, Length=212, Percent_Identity=28.7735849056604, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=27.6679841897233, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24649181, Length=197, Percent_Identity=30.4568527918782, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24640492, Length=198, Percent_Identity=24.7474747474747, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=26.1904761904762, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI116007236, Length=206, Percent_Identity=28.1553398058252, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011284 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.100 [H]
Molecular weight: Translated: 26246; Mature: 26115
Theoretical pI: Translated: 5.07; Mature: 5.07
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.5 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSALKGRVALVTGSSRGVGRGIALRLAADGAAVAVNYRRDAEAADAVVAEIVSAGGEAKA CCCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE YSASIDDTAAVDAMVDAVRTDLGPIDLVVSNAGTASKGQSVGDTPGADFQSLLNVHALGP EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCH IHLIQRVLPDMRAAGRGDVIMISSSTVAEAPALSAPYTMAKAAMEMCIRTLAQEERVHGI HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC HANIVAPGLVETEMGRRLVRAATGGGTMEDIAQSYPFGRICTPADIAGAVAYLVSADADY CCCEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCE VTGQRITVDGGGRSVSVV ECCCEEEECCCCCEEEEC >Mature Secondary Structure SALKGRVALVTGSSRGVGRGIALRLAADGAAVAVNYRRDAEAADAVVAEIVSAGGEAKA CCCCCCEEEEECCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCE YSASIDDTAAVDAMVDAVRTDLGPIDLVVSNAGTASKGQSVGDTPGADFQSLLNVHALGP EECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCH IHLIQRVLPDMRAAGRGDVIMISSSTVAEAPALSAPYTMAKAAMEMCIRTLAQEERVHGI HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC HANIVAPGLVETEMGRRLVRAATGGGTMEDIAQSYPFGRICTPADIAGAVAYLVSADADY CCCEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCE VTGQRITVDGGGRSVSVV ECCCEEEECCCCCEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA