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The map label for this gene is alsR [H]

Identifier: 119867545

GI number: 119867545

Start: 1610763

End: 1611671

Strand: Reverse

Name: alsR [H]

Synonym: Mkms_1497

Alternate gene names: 119867545

Gene position: 1611671-1610763 (Counterclockwise)

Preceding gene: 119867550

Following gene: 119867544

Centisome position: 28.09

GC content: 70.08

Gene sequence:

>909_bases
GTGAACCTGCGCCAGTACGAATACGCCCTGGCCGTCGCCGAGGAGGGCTCCATGACGGCGGCAGCAGAACGTCTGCGAAT
CACTCAACCGTCTCTGTCGCAGCAGATCGGCGCTCTGGAGAAGCACCTCGGGGTGCAGCTGTTCACCCGCACTCCGAGCG
GGGTGACGGTGACAATGGCCGGGCGGGCCTTCCTCGCGGAGGCGAAGATCGCGACGACCGCATCCCGGCGTGCCATCGCG
GCGGCCCGCGCCGCCGACGGGGAACTGGCCGGCGAGCTCATCATCGCCGTCCACATGGGCTTGGGAGCGCGCCAGCTGCC
CCAGGCGCTGGGGCAGCTGCGCAACCGCCACCCGAAGCTCCAGGTCACACTCCACGAGGAGCCCGATCCCGCGGACATGG
AACGACTGGCCCGCCAGGGCACCCTCGACATGGTCCTCGTCCACCGCATCCCCGCCGGGTGCACCTTCGACACCCACCGG
CTGGGCGAGGAAGCCTATGTCGCTGTCCTGCCGAAAGGGCACCCGCGCCTCTCGGACGGCGCGGCCCTGCGCCTGGAAGA
CCTGGCGTCAGAGGGGTGGATCCGATTCCGGCGCGCCAGCCTGCTCGACGACTACCTCGCCCGCACGCTCGCGGACGCCG
GCCTCAGCCCGCAGACGGTAGCCCGAGCGTCACAGATCTCCACCGCGGTGCGGCTCGTGTCTCAGGGGTTGGGCGTCACC
GTGGTCCCGGCCTCGGCCATCCCCGAGGGGTTCGAAGAACTCGCCTGCCCTCTGGTGCCCGCTCTGACCGAGCCCGTCCT
CGTCGGGATGCGACGCAATCCGGGCTCGGCAGAGACGGCCATGCTCGACCATCTCAACCAGCAGAACTGGTGCGGCACAG
GCCTCCTCTGTCAGCCCGCAACCGCTTGA

Upstream 100 bases:

>100_bases
GTGGGCACCACGGTAGGACTTACTCCGACATAGAAGCAAATAGTGCCAAAGTATGCTTTGCATTGATCTTCTCTATACCC
CGGCACGAAGGTGAATCCGT

Downstream 100 bases:

>100_bases
GCATGAAAACGGCCCCCGGCGTGATCTCCGGGGGCCGTTTTACCTGGTAGCGGGGACAGGATTCGAACCTGCGACCTCTG
GGTTATGAGCCGGCCGGTTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNLRQYEYALAVAEEGSMTAAAERLRITQPSLSQQIGALEKHLGVQLFTRTPSGVTVTMAGRAFLAEAKIATTASRRAIA
AARAADGELAGELIIAVHMGLGARQLPQALGQLRNRHPKLQVTLHEEPDPADMERLARQGTLDMVLVHRIPAGCTFDTHR
LGEEAYVAVLPKGHPRLSDGAALRLEDLASEGWIRFRRASLLDDYLARTLADAGLSPQTVARASQISTAVRLVSQGLGVT
VVPASAIPEGFEELACPLVPALTEPVLVGMRRNPGSAETAMLDHLNQQNWCGTGLLCQPATA

Sequences:

>Translated_302_residues
MNLRQYEYALAVAEEGSMTAAAERLRITQPSLSQQIGALEKHLGVQLFTRTPSGVTVTMAGRAFLAEAKIATTASRRAIA
AARAADGELAGELIIAVHMGLGARQLPQALGQLRNRHPKLQVTLHEEPDPADMERLARQGTLDMVLVHRIPAGCTFDTHR
LGEEAYVAVLPKGHPRLSDGAALRLEDLASEGWIRFRRASLLDDYLARTLADAGLSPQTVARASQISTAVRLVSQGLGVT
VVPASAIPEGFEELACPLVPALTEPVLVGMRRNPGSAETAMLDHLNQQNWCGTGLLCQPATA
>Mature_302_residues
MNLRQYEYALAVAEEGSMTAAAERLRITQPSLSQQIGALEKHLGVQLFTRTPSGVTVTMAGRAFLAEAKIATTASRRAIA
AARAADGELAGELIIAVHMGLGARQLPQALGQLRNRHPKLQVTLHEEPDPADMERLARQGTLDMVLVHRIPAGCTFDTHR
LGEEAYVAVLPKGHPRLSDGAALRLEDLASEGWIRFRRASLLDDYLARTLADAGLSPQTVARASQISTAVRLVSQGLGVT
VVPASAIPEGFEELACPLVPALTEPVLVGMRRNPGSAETAMLDHLNQQNWCGTGLLCQPATA

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=34, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790399, Length=281, Percent_Identity=29.1814946619217, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788748, Length=283, Percent_Identity=26.8551236749117, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787601, Length=258, Percent_Identity=26.3565891472868, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=29.8387096774194, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788887, Length=255, Percent_Identity=30.5882352941176, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693105, Length=258, Percent_Identity=27.5193798449612, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=28.8537549407115, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789204, Length=249, Percent_Identity=28.1124497991968, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI157672245, Length=292, Percent_Identity=30.1369863013699, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789506, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787530, Length=260, Percent_Identity=26.1538461538462, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32298; Mature: 32298

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRQYEYALAVAEEGSMTAAAERLRITQPSLSQQIGALEKHLGVQLFTRTPSGVTVTMA
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEEEEC
GRAFLAEAKIATTASRRAIAAARAADGELAGELIIAVHMGLGARQLPQALGQLRNRHPKL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCCE
QVTLHEEPDPADMERLARQGTLDMVLVHRIPAGCTFDTHRLGEEAYVAVLPKGHPRLSDG
EEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEECCCCCCCCCC
AALRLEDLASEGWIRFRRASLLDDYLARTLADAGLSPQTVARASQISTAVRLVSQGLGVT
CEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VVPASAIPEGFEELACPLVPALTEPVLVGMRRNPGSAETAMLDHLNQQNWCGTGLLCQPA
EEEHHHCCCCHHHHHCCHHHHHCCHHEEEECCCCCCHHHHHHHHCCCCCCCCCCCEECCC
TA
CC
>Mature Secondary Structure
MNLRQYEYALAVAEEGSMTAAAERLRITQPSLSQQIGALEKHLGVQLFTRTPSGVTVTMA
CCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEEEEC
GRAFLAEAKIATTASRRAIAAARAADGELAGELIIAVHMGLGARQLPQALGQLRNRHPKL
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCCE
QVTLHEEPDPADMERLARQGTLDMVLVHRIPAGCTFDTHRLGEEAYVAVLPKGHPRLSDG
EEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEECCCCCCCCCC
AALRLEDLASEGWIRFRRASLLDDYLARTLADAGLSPQTVARASQISTAVRLVSQGLGVT
CEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VVPASAIPEGFEELACPLVPALTEPVLVGMRRNPGSAETAMLDHLNQQNWCGTGLLCQPA
EEEHHHCCCCHHHHHCCHHHHHCCHHEEEECCCCCCHHHHHHHHCCCCCCCCCCCEECCC
TA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]