Click here to switch to the map view.

The map label for this gene is aroA [H]

Identifier: 119867430

GI number: 119867430

Start: 1480841

End: 1482157

Strand: Reverse

Name: aroA [H]

Synonym: Mkms_1380

Alternate gene names: 119867430

Gene position: 1482157-1480841 (Counterclockwise)

Preceding gene: 119867433

Following gene: 119867429

Centisome position: 25.83

GC content: 73.2

Gene sequence:

>1317_bases
ATGGACGGCGTGAGCAATTGGCCGGCCCCCTCGACGCCGACCCCCGTGCACGCCACGCTGACGATCCCGGGTTCGAAGTC
CCAGACCAACCGGGCACTCGTGCTCGCCGCGCTGGCCACCCCGCAGGGCACGTCCACGATCAGCGGCGCGCTGCGCAGCC
GCGACACCGACCTGATGATCGGGGCCCTGCAGACCCTCGGATTCGACGTCGAATCCGCCGGCACCGACAGCGACCTGCGC
GTCGGCGGAGGCCTGGGCCCCGCCGCCGGCGCCCGGGTCGACTGCGGGCTCGCGGGTACGGTCCTGCGGTTCCTGCCGCC
CGTGGCGGCGCTGAGCACCGAGACCGTCGAATTCGACGGTGACGAGCAGGCCCGCGCCCGCCCGATCGCGCCGCTGCTGG
CGGGGCTGCAGGCGCTCGGCGTGCGCATCGACGGCGACGGTCTGCCCTTCCGGGTGCGCGGTGAGGGTTCGGTGGCCGGC
GGCACCGTCGAGATCGACGCCTCGGCGTCATCGCAGTTCGTCTCCGGGCTCATGCTGTCCGGCGCCTTGTTCCGCGACGG
GCTGACCATCGTGCACACCGGCGAATCGGTCCCGTCGGCGCCGCACGTGGCGATGACCGTCAGCATGCTGCGCGACGCCG
GCGTCGAGGTCGACGACACCAAGACCAACCGGTGGACCGTGCGGCCCGGTCCCGTGGCGGCGCGCCACTGGACCATCGAA
CCGGACCTGTCCAATGCGGTGCCGTTCCTGTCCGCAGGCGTGGTCAGCGGCGGTGCCGTCAGGATCACCGGCTGGCCGGC
CGTGAGCACCCAACCGGCCGGGGCGATCATGGCGATCCTCGAGAAGGTCGGTGCGGTGGTGCGCCAGACCGAGTCGTACC
TCGAGGTCCAGGGCACCCGGCAGTACCAGGGGTTCGACGTGGACCTGCACGACGTCGGGGAGCTCACCCCCGCGGTGGCG
GCGCTCGCGGCCGTGGCCACCCCGGGTGCGGTGTCCCGGTTGCGCGGCGTCGCACACCTGCGCGGCCACGAGACCGACCG
GCTCGCCGCGCTGAGCGCCGAGATCAACGGCCTGGGCGGGCAGTGCGAGGAGACCGACGACGGACTGGTGATCACCGCCG
CGCCGCTGCACGGCGGCGTCTGGCACTCCTACGCCGACCACCGGATGGCGATGGCCGGCGCCATCGTCGGGTTGCGCACC
CCCGGTGTCGAGATCGAGGACATCGCCACCACCGCGAAGACGCTGCCCGAGTTCCCGCAGATGTGGGCGGACATGCTGGC
GGGGCAGACGGCCACCGACCCCGAGGCAGGCGCTTGA

Upstream 100 bases:

>100_bases
CGATCGCCTTGATCTTCTCGGCCAGCAGGGCCGGGTCGGTGGTGACTGCGAAACGTCCACACATACCTCCGATACTGGCA
CGCCGAACGGACAAGGCAGG

Downstream 100 bases:

>100_bases
GCCCTCGCGAATACGACGAGTCCGACGTCCGGGTGCGGCCGGGTCGGGGCTCGCGTCCGCGGACGAAGACCCGGCCCGAG
CACGCCGACGCGCGCAGCGC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMIGALQTLGFDVESAGTDSDLR
VGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDGDEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAG
GTVEIDASASSQFVSGLMLSGALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIE
PDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTRQYQGFDVDLHDVGELTPAVA
ALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGGQCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRT
PGVEIEDIATTAKTLPEFPQMWADMLAGQTATDPEAGA

Sequences:

>Translated_438_residues
MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMIGALQTLGFDVESAGTDSDLR
VGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDGDEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAG
GTVEIDASASSQFVSGLMLSGALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIE
PDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTRQYQGFDVDLHDVGELTPAVA
ALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGGQCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRT
PGVEIEDIATTAKTLPEFPQMWADMLAGQTATDPEAGA
>Mature_438_residues
MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMIGALQTLGFDVESAGTDSDLR
VGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDGDEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAG
GTVEIDASASSQFVSGLMLSGALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIE
PDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTRQYQGFDVDLHDVGELTPAVA
ALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGGQCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRT
PGVEIEDIATTAKTLPEFPQMWADMLAGQTATDPEAGA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=420, Percent_Identity=31.6666666666667, Blast_Score=166, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320332, Length=449, Percent_Identity=27.3942093541203, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 44971; Mature: 44971

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMI
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHH
GALQTLGFDVESAGTDSDLRVGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDG
HHHHHHCCCHHCCCCCCCEEECCCCCCCCCCEECCCHHHHHHHHHCCHHHCCCCEEEECC
DEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAGGTVEIDASASSQFVSGLMLS
CCHHCCCCHHHHHHHHHHHCEEECCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
GALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIE
HHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEEEECCCCCEEEEEEEC
PDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTR
CCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCC
QYQGFDVDLHDVGELTPAVAALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGG
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEEEEHHHCCCCC
QCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRTPGVEIEDIATTAKTLPEFPQ
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
MWADMLAGQTATDPEAGA
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDGVSNWPAPSTPTPVHATLTIPGSKSQTNRALVLAALATPQGTSTISGALRSRDTDLMI
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHH
GALQTLGFDVESAGTDSDLRVGGGLGPAAGARVDCGLAGTVLRFLPPVAALSTETVEFDG
HHHHHHCCCHHCCCCCCCEEECCCCCCCCCCEECCCHHHHHHHHHCCHHHCCCCEEEECC
DEQARARPIAPLLAGLQALGVRIDGDGLPFRVRGEGSVAGGTVEIDASASSQFVSGLMLS
CCHHCCCCHHHHHHHHHHHCEEECCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
GALFRDGLTIVHTGESVPSAPHVAMTVSMLRDAGVEVDDTKTNRWTVRPGPVAARHWTIE
HHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEEEECCCCCEEEEEEEC
PDLSNAVPFLSAGVVSGGAVRITGWPAVSTQPAGAIMAILEKVGAVVRQTESYLEVQGTR
CCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCC
QYQGFDVDLHDVGELTPAVAALAAVATPGAVSRLRGVAHLRGHETDRLAALSAEINGLGG
EECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEEEEHHHCCCCC
QCEETDDGLVITAAPLHGGVWHSYADHRMAMAGAIVGLRTPGVEIEDIATTAKTLPEFPQ
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
MWADMLAGQTATDPEAGA
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA