| Definition | Mycobacterium sp. KMS chromosome, complete genome. |
|---|---|
| Accession | NC_008705 |
| Length | 5,737,227 |
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The map label for this gene is yqhE [C]
Identifier: 119867428
GI number: 119867428
Start: 1478873
End: 1479721
Strand: Reverse
Name: yqhE [C]
Synonym: Mkms_1378
Alternate gene names: 119867428
Gene position: 1479721-1478873 (Counterclockwise)
Preceding gene: 119867429
Following gene: 119867422
Centisome position: 25.79
GC content: 64.78
Gene sequence:
>849_bases TTGAGCACCGTCCCCACAGTCACCTTGAACGACGGCGCGTCGATCCCGCAGCTCGGGTTCGGCGTCTACCAGGTCAAACC CGATGAGACGGCGAATGCGGTGAAGACGGCGCTCGACATCGGCTATCGCCACATCGACACCGCCGAGATGTACCAGAACG AGCGAGGGGTCGGCGAGGGCATCCGCGACGCCGGCATCGACCGCGCCGAGGTCTTCGTCACCAGCAAGCTCAACAACGGG TTCCACCGGCCCGACGACGCCCGCCGCGCCTTCGACAAGACGTTGAGCGAGTTGGGTTTCGACTACGTCGACCTGTTCCT CATCCACTGGCCACTGCCCACCCTGTACGACGGCGACTTCGTCTCGACGTGGCAGACACTCGAGGAGTTCAAGAAGGACG GCCGCGCGCGCAGCATCGGTGTGTCGAATTTCCAGGTCGACCATCTCGAGCGCCTCGCCCGTGAGACGGAGACGGTGCCC GCGGTCAACCAGATCGAGGTGCATCCGTACTTCACCAACGACGCGGTGCGCGCCTACGGCAGGGAACACGGGATCGCCAC CGAGGCGTGGTCGCCGATCGCGCAGGGTCAGGTGCTCGACGATCCGACGGTCACCCGCATCGCCGAGGCAAGCGGGAAGT CACCCGCGCAGGTGGTGTTGCGCTGGCATGTTCAGCGTGGCGACATCATCTTCCCGAAATCGGTGACGCCCAAGCGCATC GAGGAGAACTTCGACCTGTTCGACTTCGAGTTGGGCGAGGCCGACGTCGATGCGCTGTCCGGTCTCGACAAGGGCGAGCA GGGCCGCATCGGGCCGAATCCGGACACGTTCGACTACATACCCGACTGA
Upstream 100 bases:
>100_bases GAGCTGACAGGCGCGTGACGGAATCGACCCGATGTGTGTGGGGTTGCCCGAACCGGGCACACATCGTATCGATGCAACTA CGCCAGAAGGAGGCTCGACC
Downstream 100 bases:
>100_bases CATCTCCGAACGAAACTGCGGGGAGATCGTCCATCCGATCCGGATGGTGATCTCCCCGCAGTTTCGAGGTATCAGGCTGC GCGCAGCGCGGCCTGTGCAC
Product: 2,5-didehydrogluconate reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 282; Mature: 281
Protein sequence:
>282_residues MSTVPTVTLNDGASIPQLGFGVYQVKPDETANAVKTALDIGYRHIDTAEMYQNERGVGEGIRDAGIDRAEVFVTSKLNNG FHRPDDARRAFDKTLSELGFDYVDLFLIHWPLPTLYDGDFVSTWQTLEEFKKDGRARSIGVSNFQVDHLERLARETETVP AVNQIEVHPYFTNDAVRAYGREHGIATEAWSPIAQGQVLDDPTVTRIAEASGKSPAQVVLRWHVQRGDIIFPKSVTPKRI EENFDLFDFELGEADVDALSGLDKGEQGRIGPNPDTFDYIPD
Sequences:
>Translated_282_residues MSTVPTVTLNDGASIPQLGFGVYQVKPDETANAVKTALDIGYRHIDTAEMYQNERGVGEGIRDAGIDRAEVFVTSKLNNG FHRPDDARRAFDKTLSELGFDYVDLFLIHWPLPTLYDGDFVSTWQTLEEFKKDGRARSIGVSNFQVDHLERLARETETVP AVNQIEVHPYFTNDAVRAYGREHGIATEAWSPIAQGQVLDDPTVTRIAEASGKSPAQVVLRWHVQRGDIIFPKSVTPKRI EENFDLFDFELGEADVDALSGLDKGEQGRIGPNPDTFDYIPD >Mature_281_residues STVPTVTLNDGASIPQLGFGVYQVKPDETANAVKTALDIGYRHIDTAEMYQNERGVGEGIRDAGIDRAEVFVTSKLNNGF HRPDDARRAFDKTLSELGFDYVDLFLIHWPLPTLYDGDFVSTWQTLEEFKKDGRARSIGVSNFQVDHLERLARETETVPA VNQIEVHPYFTNDAVRAYGREHGIATEAWSPIAQGQVLDDPTVTRIAEASGKSPAQVVLRWHVQRGDIIFPKSVTPKRIE ENFDLFDFELGEADVDALSGLDKGEQGRIGPNPDTFDYIPD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=35.8620689655172, Blast_Score=204, Evalue=9e-53, Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=35.8620689655172, Blast_Score=204, Evalue=9e-53, Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=35.1351351351351, Blast_Score=191, Evalue=7e-49, Organism=Homo sapiens, GI223468663, Length=291, Percent_Identity=35.0515463917526, Blast_Score=191, Evalue=9e-49, Organism=Homo sapiens, GI93277124, Length=303, Percent_Identity=33.6633663366337, Blast_Score=190, Evalue=2e-48, Organism=Homo sapiens, GI310109920, Length=300, Percent_Identity=34.3333333333333, Blast_Score=189, Evalue=2e-48, Organism=Homo sapiens, GI5453543, Length=300, Percent_Identity=34.3333333333333, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI45446745, Length=300, Percent_Identity=34.3333333333333, Blast_Score=188, Evalue=6e-48, Organism=Homo sapiens, GI4503285, Length=300, Percent_Identity=34.3333333333333, Blast_Score=188, Evalue=6e-48, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=37.8839590443686, Blast_Score=187, Evalue=8e-48, Organism=Homo sapiens, GI310109922, Length=284, Percent_Identity=34.5070422535211, Blast_Score=182, Evalue=3e-46, Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=34.3434343434343, Blast_Score=181, Evalue=6e-46, Organism=Homo sapiens, GI24497585, Length=295, Percent_Identity=33.8983050847458, Blast_Score=179, Evalue=2e-45, Organism=Homo sapiens, GI291291012, Length=269, Percent_Identity=33.457249070632, Blast_Score=168, Evalue=5e-42, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=34.1726618705036, Blast_Score=166, Evalue=2e-41, Organism=Homo sapiens, GI300116271, Length=279, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI310109926, Length=131, Percent_Identity=41.9847328244275, Blast_Score=103, Evalue=3e-22, Organism=Homo sapiens, GI207028673, Length=131, Percent_Identity=41.9847328244275, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=30.2631578947368, Blast_Score=92, Evalue=4e-19, Organism=Escherichia coli, GI87082198, Length=280, Percent_Identity=44.6428571428571, Blast_Score=265, Evalue=3e-72, Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=38.0392156862745, Blast_Score=176, Evalue=2e-45, Organism=Escherichia coli, GI1788081, Length=275, Percent_Identity=28, Blast_Score=95, Evalue=4e-21, Organism=Escherichia coli, GI1787674, Length=282, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=40.4109589041096, Blast_Score=215, Evalue=2e-56, Organism=Caenorhabditis elegans, GI17537075, Length=308, Percent_Identity=39.2857142857143, Blast_Score=214, Evalue=3e-56, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=35.016835016835, Blast_Score=186, Evalue=1e-47, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=37.3626373626374, Blast_Score=185, Evalue=3e-47, Organism=Caenorhabditis elegans, GI71998625, Length=274, Percent_Identity=33.5766423357664, Blast_Score=172, Evalue=1e-43, Organism=Caenorhabditis elegans, GI17566692, Length=312, Percent_Identity=30.7692307692308, Blast_Score=167, Evalue=7e-42, Organism=Caenorhabditis elegans, GI17538386, Length=273, Percent_Identity=33.6996336996337, Blast_Score=163, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17537079, Length=299, Percent_Identity=31.1036789297659, Blast_Score=160, Evalue=5e-40, Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=32.5259515570934, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17552492, Length=264, Percent_Identity=31.8181818181818, Blast_Score=157, Evalue=8e-39, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.6176470588235, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=29.7101449275362, Blast_Score=143, Evalue=1e-34, Organism=Saccharomyces cerevisiae, GI6324694, Length=303, Percent_Identity=38.6138613861386, Blast_Score=223, Evalue=4e-59, Organism=Saccharomyces cerevisiae, GI6320576, Length=287, Percent_Identity=39.3728222996516, Blast_Score=215, Evalue=7e-57, Organism=Saccharomyces cerevisiae, GI6322556, Length=272, Percent_Identity=34.9264705882353, Blast_Score=166, Evalue=6e-42, Organism=Saccharomyces cerevisiae, GI6319625, Length=275, Percent_Identity=35.2727272727273, Blast_Score=166, Evalue=6e-42, Organism=Saccharomyces cerevisiae, GI6321896, Length=309, Percent_Identity=32.6860841423948, Blast_Score=165, Evalue=6e-42, Organism=Saccharomyces cerevisiae, GI6320079, Length=279, Percent_Identity=32.9749103942652, Blast_Score=141, Evalue=1e-34, Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=38.5135135135135, Blast_Score=205, Evalue=3e-53, Organism=Drosophila melanogaster, GI20129731, Length=287, Percent_Identity=37.6306620209059, Blast_Score=197, Evalue=7e-51, Organism=Drosophila melanogaster, GI24657054, Length=287, Percent_Identity=39.3728222996516, Blast_Score=196, Evalue=2e-50, Organism=Drosophila melanogaster, GI24662789, Length=296, Percent_Identity=36.8243243243243, Blast_Score=195, Evalue=3e-50, Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=35.9322033898305, Blast_Score=191, Evalue=5e-49, Organism=Drosophila melanogaster, GI24662781, Length=278, Percent_Identity=39.9280575539568, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI24662785, Length=277, Percent_Identity=40.072202166065, Blast_Score=187, Evalue=5e-48, Organism=Drosophila melanogaster, GI24644950, Length=303, Percent_Identity=34.3234323432343, Blast_Score=182, Evalue=2e-46, Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=33.2203389830508, Blast_Score=181, Evalue=3e-46, Organism=Drosophila melanogaster, GI221378297, Length=323, Percent_Identity=32.1981424148607, Blast_Score=175, Evalue=3e-44, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=31.640625, Blast_Score=148, Evalue=4e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 31468; Mature: 31337
Theoretical pI: Translated: 4.46; Mature: 4.46
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00687 ALDEHYDE_DEHYDR_GLU
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 0.7 %Met (Translated Protein) 0.7 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 0.4 %Met (Mature Protein) 0.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTVPTVTLNDGASIPQLGFGVYQVKPDETANAVKTALDIGYRHIDTAEMYQNERGVGEG CCCCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCHHCCCHHHHHHCCCCCCCC IRDAGIDRAEVFVTSKLNNGFHRPDDARRAFDKTLSELGFDYVDLFLIHWPLPTLYDGDF HHHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCH VSTWQTLEEFKKDGRARSIGVSNFQVDHLERLARETETVPAVNQIEVHPYFTNDAVRAYG HHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH REHGIATEAWSPIAQGQVLDDPTVTRIAEASGKSPAQVVLRWHVQRGDIIFPKSVTPKRI HHCCCCHHHCCHHHCCCCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCEECCCCCCHHHH EENFDLFDFELGEADVDALSGLDKGEQGRIGPNPDTFDYIPD HCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure STVPTVTLNDGASIPQLGFGVYQVKPDETANAVKTALDIGYRHIDTAEMYQNERGVGEG CCCCEEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCHHCCCHHHHHHCCCCCCCC IRDAGIDRAEVFVTSKLNNGFHRPDDARRAFDKTLSELGFDYVDLFLIHWPLPTLYDGDF HHHCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCH VSTWQTLEEFKKDGRARSIGVSNFQVDHLERLARETETVPAVNQIEVHPYFTNDAVRAYG HHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH REHGIATEAWSPIAQGQVLDDPTVTRIAEASGKSPAQVVLRWHVQRGDIIFPKSVTPKRI HHCCCCHHHCCHHHCCCCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCEECCCCCCHHHH EENFDLFDFELGEADVDALSGLDKGEQGRIGPNPDTFDYIPD HCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA