Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 119867404

GI number: 119867404

Start: 1447682

End: 1449151

Strand: Direct

Name: ahcY [H]

Synonym: Mkms_1354

Alternate gene names: 119867404

Gene position: 1447682-1449151 (Clockwise)

Preceding gene: 119867403

Following gene: 119867405

Centisome position: 25.23

GC content: 66.05

Gene sequence:

>1470_bases
ATGACCACGACTGAGCAGCGACTGACGGTCGAGAGCCGCAACGGCATCGACTACAAGGTCGCCGACCTGTCCCTGGCCGA
ATTCGGCCGTAAAGAGATCCGCCTGGCCGAGCACGAGATGCCGGGGCTGATGGCGCTGCGGCGCGAGTACGCCGAGGTGG
CGCCGCTCAAGGGCGCCCGTATCTCCGGTTCGCTGCACATGACGGTGCAGACCGCGGTGCTCATCGAGACGCTCGTATCC
CTCGGTGCCGAAGTCCGCTGGGCCAGCTGCAACATCTTCTCCACCCAGGACCACGCGGCCGCCGCGGTCGTCGTCGGCCC
GCACGGCACCCCCGAGGAGCCCAAGGGCACCCCGGTCTTCGCCTGGAAGGGCGAGACGCTGGAGGAGTACTGGTGGGCCG
CGGAGCAGATGCTGACCTGGCCGGGCGAGCCCGCCAACATGATCCTCGACGACGGCGGCGACGCCACGATGCTGGTGCTG
CGCGGTGCGCAGTTCGAGAAGGCCGGCGTGGTCCCGCCCGCCGAGGACGACGACTCCGCCGAGTACAAGGTCTTCCTGAA
CCTGCTGCGGGAGCGGTTCGAGACCGACAAGACCAAGTGGACGAAGATCGCCGAGTCGGTCAAGGGTGTCACCGAGGAGA
CCACCACCGGCGTGCTGCGGCTGTACCAGTTCGAGGCCGCGGGTGAGCTGCCTTTCCCGGCCATCAACGTCAACGACTCG
GTGACCAAGAGCAAGTTCGACAACAAGTACGGCACCCGCCACTCCCTGATCGACGGCATCAACCGCGGCACCGACGTGCT
GATCGGCGGCAAGAAGGTGCTGATCTGCGGCTACGGCGACGTGGGTAAGGGCTGCGCCGAGTCGCTGGCCGGCCAGGGCG
CCCGCGTGCAGGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCGCTGATGGACGGCTTCGACGTGGTGACCGTGGAG
CAGGCGATCGGCAGCGCCGACATCGTCATCACCTCGACGGGCAACAAGGACATCATCACCCTCGACCACATGAAGGCGAT
GAAGGACAAGGCCATCCTCGGCAACATCGGCCACTTCGACAACGAGATCGACATGGCGGCGCTGGAGCGCTCGGGTGCCA
CCCGGATCAACATCAAGCCGCAGGTCGACGAGTGGACCTTCGACGACGGCCACTCGATCGTCCTCCTCTCCGAGGGCCGT
CTGCTGAACCTGGGCAACGCGACGGGCCACCCGTCGTTCGTGATGAGCAACAGCTTCTCCAACCAGGTGATCGCGCAGAT
CGAGCTGTGGACCAAGAACGACGAGTACGACAACGCGGTCTACCGCCTCGCCAAGCACCTCGACGAGAAGGTCGCCCGCA
TCCACGTCGAGGCGCTGGGCGGCACGCTGACCAAGCTCACCAAGGAGCAGGCGGAGTACATCAACGTCGACGTCGAGGGT
CCGTACAAGCCGGAGCACTACCGGTACTGA

Upstream 100 bases:

>100_bases
TGTTATCGAGCAGGATCCGCGGCTGGCGAAGACGCACCGCCCCGATCGCTAATCTGACACTCAGCTAAGTAAATGCGACG
CGCGCACGAGAAGGAAACAC

Downstream 100 bases:

>100_bases
GTTCAATCGCTCCACACCGAAACGCCGCGGCGCAATCGCCGCGGCGTTTCGGCGTCTGTGGGAGGAGGTACACCCGGACC
ATCCATCTGCAACGAAGCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTTTEQRLTVESRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVAPLKGARISGSLHMTVQTAVLIETLVS
LGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVL
RGAQFEKAGVVPPAEDDDSAEYKVFLNLLRERFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDS
VTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVE
QAIGSADIVITSTGNKDIITLDHMKAMKDKAILGNIGHFDNEIDMAALERSGATRINIKPQVDEWTFDDGHSIVLLSEGR
LLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNAVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYINVDVEG
PYKPEHYRY

Sequences:

>Translated_489_residues
MTTTEQRLTVESRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVAPLKGARISGSLHMTVQTAVLIETLVS
LGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVL
RGAQFEKAGVVPPAEDDDSAEYKVFLNLLRERFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDS
VTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVE
QAIGSADIVITSTGNKDIITLDHMKAMKDKAILGNIGHFDNEIDMAALERSGATRINIKPQVDEWTFDDGHSIVLLSEGR
LLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNAVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYINVDVEG
PYKPEHYRY
>Mature_488_residues
TTTEQRLTVESRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVAPLKGARISGSLHMTVQTAVLIETLVSL
GAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLR
GAQFEKAGVVPPAEDDDSAEYKVFLNLLRERFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDSV
TKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTEIDPINALQALMDGFDVVTVEQ
AIGSADIVITSTGNKDIITLDHMKAMKDKAILGNIGHFDNEIDMAALERSGATRINIKPQVDEWTFDDGHSIVLLSEGRL
LNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNAVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYINVDVEGP
YKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=474, Percent_Identity=54.8523206751055, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI239937451, Length=450, Percent_Identity=54.8888888888889, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI24308043, Length=489, Percent_Identity=44.7852760736196, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI298286489, Length=489, Percent_Identity=44.7852760736196, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI195539337, Length=489, Percent_Identity=44.7852760736196, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI195539349, Length=489, Percent_Identity=44.7852760736196, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI21361647, Length=488, Percent_Identity=43.4426229508197, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17506425, Length=476, Percent_Identity=55.672268907563, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6320882, Length=489, Percent_Identity=53.3742331288344, Blast_Score=485, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642172, Length=473, Percent_Identity=57.2938689217759, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=486, Percent_Identity=44.4444444444444, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553387, Length=478, Percent_Identity=45.397489539749, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553385, Length=477, Percent_Identity=45.2830188679245, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 53727; Mature: 53596

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTEQRLTVESRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVAPLKGAR
CCCCCCEEEEECCCCCEEEEECCCHHHCCHHHEEEHHHCCCHHHHHHHHHHHHCCCCCCE
ISGSLHMTVQTAVLIETLVSLGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPKGTPVF
ECCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLRGAQFEKAGVVPPAEDDDSA
EECCCCHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCH
EYKVFLNLLRERFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHEEEEEEECCCCCCCCCEECCCCC
VTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTE
HHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEEE
IDPINALQALMDGFDVVTVEQAIGSADIVITSTGNKDIITLDHMKAMKDKAILGNIGHFD
CCCHHHHHHHHCCCCEEEEHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCC
NEIDMAALERSGATRINIKPQVDEWTFDDGHSIVLLSEGRLLNLGNATGHPSFVMSNSFS
CCHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCEEEECCCC
NQVIAQIELWTKNDEYDNAVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYINVDVEG
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHEEEEECCC
PYKPEHYRY
CCCCCCCCC
>Mature Secondary Structure 
TTTEQRLTVESRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMALRREYAEVAPLKGAR
CCCCCEEEEECCCCCEEEEECCCHHHCCHHHEEEHHHCCCHHHHHHHHHHHHCCCCCCE
ISGSLHMTVQTAVLIETLVSLGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPKGTPVF
ECCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQMLTWPGEPANMILDDGGDATMLVLRGAQFEKAGVVPPAEDDDSA
EECCCCHHHHHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCH
EYKVFLNLLRERFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHEEEEEEECCCCCCCCCEECCCCC
VTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAGQGARVQVTE
HHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHHHCCCCCEEEEEE
IDPINALQALMDGFDVVTVEQAIGSADIVITSTGNKDIITLDHMKAMKDKAILGNIGHFD
CCCHHHHHHHHCCCCEEEEHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHHCCCCCCCC
NEIDMAALERSGATRINIKPQVDEWTFDDGHSIVLLSEGRLLNLGNATGHPSFVMSNSFS
CCHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCEEEECCCC
NQVIAQIELWTKNDEYDNAVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYINVDVEG
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHEEEEECCC
PYKPEHYRY
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA