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The map label for this gene is birA [C]

Identifier: 119867371

GI number: 119867371

Start: 1414222

End: 1415034

Strand: Reverse

Name: birA [C]

Synonym: Mkms_1321

Alternate gene names: 119867371

Gene position: 1415034-1414222 (Counterclockwise)

Preceding gene: 119867372

Following gene: 119867370

Centisome position: 24.66

GC content: 72.69

Gene sequence:

>813_bases
GTGAACACCGAGCATCGCCCGCCACTGGACGTCACCCGCCTGCGGGCCTCCCTCGGCGAGGGCTGGCGGACCCTCGATGT
CGTCGACGAAACGGGGTCCACGAACGCCGACCTCCTCGCCCGCGCGGCCGCCGGGGAAGACGTGGCGGGCAGTGTCCTGC
TCACGGAATTTCAAAGTGCCGGCCGCGGCAGGCACGGCCGCCAGTGGACGGCTCCCCCGCGCTCACAGGTGGCGATGTCG
GTCGCCGTCGACGCCGGCGGTGTGCGGCCCGACGCCTGGGGGTGGTTGCCGCTGTTGACCGGGGTGGCGGTACGCGACGC
CGTAGCGGAAGTGTCAGCTGTCGAGGCCGGCCTCAAGTGGCCCAACGACGTACTCGTCGGCGAAGGCAAGCTGGCCGGCA
TCCTCGCCGAGGTCGCCGCCCCGCAGCACGTGGTGATCGTGGGCATCGGTCTCAATGTGACGTTGAGCGCGGCCGAGGCA
CCCGATCCGCGCGCGACCTCGTTGACCATGCTCGGCGCCCGGAATCACGACCGCACCGCGCTCGCCGCGGCGCTCCTGCG
CAACCTCGGCACCCGGATCGCCCGGTGGCGCCGCGCCGCAGGCGCCGACGAGGGCCTCATCGCCGACTACCGCAGGCACA
GCCTGACCCTGGGGCGGGAGGTGACCGCCACCCTGCCCGGCGATCGACGCCTGGATGGGACGGCGACCGACATCGACGAC
CTCGGCAGGCTGACCATCACCACCGGACGGGATTCGGTCACGGTCGCCGCCGGTGACATCACCCATCTGCGCCCCGGGCC
CACCCGCGCGTAA

Upstream 100 bases:

>100_bases
ATCCTCGGCACCGTCGCCGTCGCGGTCGGCCTCTGGCGCATCCGGATCCCGGCGGATACGGAATCGGGGGTCACCGCCCG
CGGGACCTAGGCTCGACCGG

Downstream 100 bases:

>100_bases
CCTGGTGCGACTTTGCTGCGAATCGCATCACGATGTGCGGTAAGCGGACATACCCCTGTCGACCCGAATACCCGGCCGGA
TTCCGCAGCCGATCGCCAGG

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNTEHRPPLDVTRLRASLGEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSAGRGRHGRQWTAPPRSQVAMS
VAVDAGGVRPDAWGWLPLLTGVAVRDAVAEVSAVEAGLKWPNDVLVGEGKLAGILAEVAAPQHVVIVGIGLNVTLSAAEA
PDPRATSLTMLGARNHDRTALAAALLRNLGTRIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDD
LGRLTITTGRDSVTVAAGDITHLRPGPTRA

Sequences:

>Translated_270_residues
MNTEHRPPLDVTRLRASLGEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSAGRGRHGRQWTAPPRSQVAMS
VAVDAGGVRPDAWGWLPLLTGVAVRDAVAEVSAVEAGLKWPNDVLVGEGKLAGILAEVAAPQHVVIVGIGLNVTLSAAEA
PDPRATSLTMLGARNHDRTALAAALLRNLGTRIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDD
LGRLTITTGRDSVTVAAGDITHLRPGPTRA
>Mature_270_residues
MNTEHRPPLDVTRLRASLGEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSAGRGRHGRQWTAPPRSQVAMS
VAVDAGGVRPDAWGWLPLLTGVAVRDAVAEVSAVEAGLKWPNDVLVGEGKLAGILAEVAAPQHVVIVGIGLNVTLSAAEA
PDPRATSLTMLGARNHDRTALAAALLRNLGTRIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDD
LGRLTITTGRDSVTVAAGDITHLRPGPTRA

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=232, Percent_Identity=30.1724137931034, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 28348; Mature: 28348

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEHRPPLDVTRLRASLGEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSA
CCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
GRGRHGRQWTAPPRSQVAMSVAVDAGGVRPDAWGWLPLLTGVAVRDAVAEVSAVEAGLKW
CCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNDVLVGEGKLAGILAEVAAPQHVVIVGIGLNVTLSAAEAPDPRATSLTMLGARNHDRTA
CCCEEEECCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCCHHH
LAAALLRNLGTRIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCHHH
LGRLTITTGRDSVTVAAGDITHLRPGPTRA
CCCEEEEECCCEEEEEECCEEECCCCCCCC
>Mature Secondary Structure
MNTEHRPPLDVTRLRASLGEGWRTLDVVDETGSTNADLLARAAAGEDVAGSVLLTEFQSA
CCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH
GRGRHGRQWTAPPRSQVAMSVAVDAGGVRPDAWGWLPLLTGVAVRDAVAEVSAVEAGLKW
CCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNDVLVGEGKLAGILAEVAAPQHVVIVGIGLNVTLSAAEAPDPRATSLTMLGARNHDRTA
CCCEEEECCHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCCHHH
LAAALLRNLGTRIARWRRAAGADEGLIADYRRHSLTLGREVTATLPGDRRLDGTATDIDD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCEEEEECCCCCCCCCCCCCHHH
LGRLTITTGRDSVTVAAGDITHLRPGPTRA
CCCEEEEECCCEEEEEECCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]