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The map label for this gene is fabR [H]

Identifier: 119867324

GI number: 119867324

Start: 1363955

End: 1364629

Strand: Reverse

Name: fabR [H]

Synonym: Mkms_1274

Alternate gene names: 119867324

Gene position: 1364629-1363955 (Counterclockwise)

Preceding gene: 119867327

Following gene: 119867323

Centisome position: 23.79

GC content: 67.26

Gene sequence:

>675_bases
GTGAACAGTCGTACACCCAGTTCACGCACAAGCCGGTCCGGATCGCGTTCCCGGAGTTCCGCCTCGTCGCGCGAGGAGAA
GAAGGAAGCCACCCGCAGGGCGATCGTCACCGCCGCGCTGTCGCTGCTGGAGGACCGCAGCTTCGCGGCGCTGAGCCTGC
GTGAGGTCACCCGCGAGGCGGGCATCTCCCCCGCGGCGTTCTACCGGCACTTCGATTCGATGGAGGCGCTCGGACTGGTC
TTGATCGACGAGTCCTTCCGTGTCCTGCGCGATCTGCTGCGCGGCGCCCGCGCGGGCAAGCTGGATCCGACACGGGTCAT
CGAATCGTCGGTCGACATGCTCATCGAGGGTGTCAACCAGCGCCGCGAGTACTGGCGCTTCATCGGCCGGGAGCGGTCGA
GCGGGGTGACCGTGCTGCGCTATGCGATCCGCACCGAGATCCGGCTGATCACCTCCGAGCTCGCGATCGACCTGGCCCGC
TTCCCCGGGCTGAACACCTGGAGCGCCGAAGACCTCAACATCCTGGCCAGTCTGATCGTCAACGCGATGATCTCGATCGC
CGAGGCCATCGAGGATGCGACGGACGCGGCCGCCCTCGCCGACATCAAGCGCACCGCCGTCAAACAGCTGCGGATGATCA
CCGTCGGCGTCAGTGGATGGCGCAGCGCGGGCTGA

Upstream 100 bases:

>100_bases
CAGGCTCCGTGTGCGCGTTTCAGTGAACATATGTATACCATCCGCGGTTACGGTGGATGCCGTCAAGGTTATCGACCCAG
CTTGTGGTAGGTTTCACATC

Downstream 100 bases:

>100_bases
TCGTCCCCCTCCCCGCTACCCTGAATCGGTGAGCAGCCCGGCATCGGTTTCCCCTGTGTGGCTTACCGCCGCCCGACTAT
TCGCGATCCTCACCCTGGTC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNSRTPSSRTSRSGSRSRSSASSREEKKEATRRAIVTAALSLLEDRSFAALSLREVTREAGISPAAFYRHFDSMEALGLV
LIDESFRVLRDLLRGARAGKLDPTRVIESSVDMLIEGVNQRREYWRFIGRERSSGVTVLRYAIRTEIRLITSELAIDLAR
FPGLNTWSAEDLNILASLIVNAMISIAEAIEDATDAAALADIKRTAVKQLRMITVGVSGWRSAG

Sequences:

>Translated_224_residues
MNSRTPSSRTSRSGSRSRSSASSREEKKEATRRAIVTAALSLLEDRSFAALSLREVTREAGISPAAFYRHFDSMEALGLV
LIDESFRVLRDLLRGARAGKLDPTRVIESSVDMLIEGVNQRREYWRFIGRERSSGVTVLRYAIRTEIRLITSELAIDLAR
FPGLNTWSAEDLNILASLIVNAMISIAEAIEDATDAAALADIKRTAVKQLRMITVGVSGWRSAG
>Mature_224_residues
MNSRTPSSRTSRSGSRSRSSASSREEKKEATRRAIVTAALSLLEDRSFAALSLREVTREAGISPAAFYRHFDSMEALGLV
LIDESFRVLRDLLRGARAGKLDPTRVIESSVDMLIEGVNQRREYWRFIGRERSSGVTVLRYAIRTEIRLITSELAIDLAR
FPGLNTWSAEDLNILASLIVNAMISIAEAIEDATDAAALADIKRTAVKQLRMITVGVSGWRSAG

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=201, Percent_Identity=37.3134328358209, Blast_Score=106, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24745; Mature: 24745

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRTPSSRTSRSGSRSRSSASSREEKKEATRRAIVTAALSLLEDRSFAALSLREVTREA
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GISPAAFYRHFDSMEALGLVLIDESFRVLRDLLRGARAGKLDPTRVIESSVDMLIEGVNQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RREYWRFIGRERSSGVTVLRYAIRTEIRLITSELAIDLARFPGLNTWSAEDLNILASLIV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NAMISIAEAIEDATDAAALADIKRTAVKQLRMITVGVSGWRSAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNSRTPSSRTSRSGSRSRSSASSREEKKEATRRAIVTAALSLLEDRSFAALSLREVTREA
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GISPAAFYRHFDSMEALGLVLIDESFRVLRDLLRGARAGKLDPTRVIESSVDMLIEGVNQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
RREYWRFIGRERSSGVTVLRYAIRTEIRLITSELAIDLARFPGLNTWSAEDLNILASLIV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NAMISIAEAIEDATDAAALADIKRTAVKQLRMITVGVSGWRSAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA