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The map label for this gene is pgm [C]

Identifier: 119867308

GI number: 119867308

Start: 1348011

End: 1349648

Strand: Reverse

Name: pgm [C]

Synonym: Mkms_1258

Alternate gene names: 119867308

Gene position: 1349648-1348011 (Counterclockwise)

Preceding gene: 119867309

Following gene: 119867306

Centisome position: 23.52

GC content: 70.82

Gene sequence:

>1638_bases
ATGACTTCCCCGGCGACCTCGACGACCGTGCAGGAGTGGATTGCTCACGACCCAGACCCGCACACCGCGGCGGAGTTGTC
CGAGTGCAGTCCCGACGAACTCGACGAGCGGTTCTCCCGCTCACTGACATTCGGGACGGCGGGGCTGCGCGGGCCGCTGC
GCGCCGGCCCGAACGGGATGAACCTGGCGGTGGTGCTGCGCACGACGTGGGCGGTCGCCAAGGTGCTCAAGGACCGCGGC
CGGGCGGGTTCGCAGGTCGTCGTGGGCCGTGACGCCCGGCACCGCTCCGACGAATTCGCCCGCGCCGCTGCCGAAGTGCT
CGCCGCACAAGGGTTCGAGGTGCTGCTGCTGCTGGCCGCCGTCCCGACACCGGTGGTGGCGTTCACGGTGCGGCACATGC
ACGCCGCCGCGGGAATCCAGATCACCGCATCGCACAACCCGCCGACCGACAACGGGTACAAGGTGTACTTCGAGGAGGGG
CTGCAGATCATCGGCCCCACCGACACCGACATCGAGGCCGCGATCGCCGAGGCGCCGATGGCCGACGAGATCGCCAGGGC
CGAAGTGGAAACCGGCGGCATGGAGGAGATCGCCCACTACGTCGAACGGGCGGCCAACGTCCGGCACTCGACGGCGCCGG
TGCGGGTGGCGTTCACCCCGATGCACGGGGTGGGCGGTGAGTACGCGATGGACACGTTCGTGCGGGCAGGCATCACCGAC
GTCCACGTCGTCGACAAGCAGTTCGCACCCGACCCCGACTTCCCCACCGTGTCGCTGCCCAACCCGGAGGAACCGGGTGC
GGTCGACGCGCTGCTCGAACTGGCCGCCGACGTCGACGCCGACGTCGCGATCGCGCTCGACCCGGACGCCGACCGGTGCG
CGGTCGGGGTGCCGACACCCGACGGCTGGCGAATGCTCTCGGGGGACGAAACCGGTTGGCTGCTGGGCGATTACATTCTG
GACCAGGTCGAGCCCGGCGAAGTCATGAACGCGACCGTGGTGGCCAGCACCGTGGTGTCGTCGCGGATGCTCGCGGCGAT
CGCCGCCGCGCACGGCGCCCACCACGTCGAAACGCTCACCGGCTTCAAATGGCTCTCCCGCGCCGACGACGACCTGCCCG
GCAAGACCATGGTGTACGCCTACGAGGAGGCCATCGGCCACTGTGTGGATCCGGCCGCGGTTCGCGACAAGGACGGCATC
AGTGCGGCGGTGCTGTTCTGCGACCTCGTCGGCGTGCTGAAGGAGCACGGCCGCACCGTGCTCGACGTCCTCGACGACCT
GGCCCGCCGCCACGGCGTCCACGTCACCGCGGCCGTCAGCCGCCCGGTCGCCGACGCCGACGAAGCCGCCGGGGTGATGG
CCCGACTGCGGGACACCCCGCCCGATCGCCTCGCCGGGCACGAGGTCACCGTCACCGACCTGAGCACCTCACCCGAGCCG
ATGCGCTCGGATGCGCTGATCCTGAGCGGTGGGGATGCCGACACCTCGGTGCGCATGGTCGTGCGACCGTCCGGAACCGA
ACCGAAAGTGAAGTCCTACATCGAGGTTCGACGCGCCTGCGCCGGCGACGTGGGGCGGGCGCGCGCCGAGGCGCAGCGGC
TGCGCGACGAGCTGGTGGCCCTGGCGCAACAGTGGTGA

Upstream 100 bases:

>100_bases
CCGACACGCTGACCGACCTGGAGTTCGACCTGCTGATGCTCGTCGCACCGGTGCTCCGCAAGCTGGCATTAAACGATGCC
AAAGCGGGCACACTTGCTCC

Downstream 100 bases:

>100_bases
GCCTCAGCGCGGACCGAACTGCCGGTCTCCGGCGTCACCGAGTCCGGGCACGATGTAGGCGGCCTCGTCGAGGCATTCGT
CGATCGTCGCGGTGAACAGC

Product: phosphoglucomutase/phosphomannomutase alpha/beta/subunit

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTSPATSTTVQEWIAHDPDPHTAAELSECSPDELDERFSRSLTFGTAGLRGPLRAGPNGMNLAVVLRTTWAVAKVLKDRG
RAGSQVVVGRDARHRSDEFARAAAEVLAAQGFEVLLLLAAVPTPVVAFTVRHMHAAAGIQITASHNPPTDNGYKVYFEEG
LQIIGPTDTDIEAAIAEAPMADEIARAEVETGGMEEIAHYVERAANVRHSTAPVRVAFTPMHGVGGEYAMDTFVRAGITD
VHVVDKQFAPDPDFPTVSLPNPEEPGAVDALLELAADVDADVAIALDPDADRCAVGVPTPDGWRMLSGDETGWLLGDYIL
DQVEPGEVMNATVVASTVVSSRMLAAIAAAHGAHHVETLTGFKWLSRADDDLPGKTMVYAYEEAIGHCVDPAAVRDKDGI
SAAVLFCDLVGVLKEHGRTVLDVLDDLARRHGVHVTAAVSRPVADADEAAGVMARLRDTPPDRLAGHEVTVTDLSTSPEP
MRSDALILSGGDADTSVRMVVRPSGTEPKVKSYIEVRRACAGDVGRARAEAQRLRDELVALAQQW

Sequences:

>Translated_545_residues
MTSPATSTTVQEWIAHDPDPHTAAELSECSPDELDERFSRSLTFGTAGLRGPLRAGPNGMNLAVVLRTTWAVAKVLKDRG
RAGSQVVVGRDARHRSDEFARAAAEVLAAQGFEVLLLLAAVPTPVVAFTVRHMHAAAGIQITASHNPPTDNGYKVYFEEG
LQIIGPTDTDIEAAIAEAPMADEIARAEVETGGMEEIAHYVERAANVRHSTAPVRVAFTPMHGVGGEYAMDTFVRAGITD
VHVVDKQFAPDPDFPTVSLPNPEEPGAVDALLELAADVDADVAIALDPDADRCAVGVPTPDGWRMLSGDETGWLLGDYIL
DQVEPGEVMNATVVASTVVSSRMLAAIAAAHGAHHVETLTGFKWLSRADDDLPGKTMVYAYEEAIGHCVDPAAVRDKDGI
SAAVLFCDLVGVLKEHGRTVLDVLDDLARRHGVHVTAAVSRPVADADEAAGVMARLRDTPPDRLAGHEVTVTDLSTSPEP
MRSDALILSGGDADTSVRMVVRPSGTEPKVKSYIEVRRACAGDVGRARAEAQRLRDELVALAQQW
>Mature_544_residues
TSPATSTTVQEWIAHDPDPHTAAELSECSPDELDERFSRSLTFGTAGLRGPLRAGPNGMNLAVVLRTTWAVAKVLKDRGR
AGSQVVVGRDARHRSDEFARAAAEVLAAQGFEVLLLLAAVPTPVVAFTVRHMHAAAGIQITASHNPPTDNGYKVYFEEGL
QIIGPTDTDIEAAIAEAPMADEIARAEVETGGMEEIAHYVERAANVRHSTAPVRVAFTPMHGVGGEYAMDTFVRAGITDV
HVVDKQFAPDPDFPTVSLPNPEEPGAVDALLELAADVDADVAIALDPDADRCAVGVPTPDGWRMLSGDETGWLLGDYILD
QVEPGEVMNATVVASTVVSSRMLAAIAAAHGAHHVETLTGFKWLSRADDDLPGKTMVYAYEEAIGHCVDPAAVRDKDGIS
AAVLFCDLVGVLKEHGRTVLDVLDDLARRHGVHVTAAVSRPVADADEAAGVMARLRDTPPDRLAGHEVTVTDLSTSPEPM
RSDALILSGGDADTSVRMVVRPSGTEPKVKSYIEVRRACAGDVGRARAEAQRLRDELVALAQQW

Specific function: This Enzyme Participates In Both The Breakdown And Synthesis Of Glucose. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=581, Percent_Identity=33.5628227194492, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI31377548, Length=601, Percent_Identity=33.1114808652246, Blast_Score=255, Evalue=7e-68,
Organism=Escherichia coli, GI1788361, Length=339, Percent_Identity=25.9587020648968, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789566, Length=265, Percent_Identity=30.188679245283, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=578, Percent_Identity=32.3529411764706, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71993878, Length=307, Percent_Identity=34.2019543973941, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323934, Length=593, Percent_Identity=33.5581787521079, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI20129809, Length=581, Percent_Identity=33.3907056798623, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24651977, Length=558, Percent_Identity=32.078853046595, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24653722, Length=574, Percent_Identity=28.7456445993031, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17864244, Length=429, Percent_Identity=25.8741258741259, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 58012; Mature: 57881

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPATSTTVQEWIAHDPDPHTAAELSECSPDELDERFSRSLTFGTAGLRGPLRAGPNGM
CCCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCCC
NLAVVLRTTWAVAKVLKDRGRAGSQVVVGRDARHRSDEFARAAAEVLAAQGFEVLLLLAA
EEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
VPTPVVAFTVRHMHAAAGIQITASHNPPTDNGYKVYFEEGLQIIGPTDTDIEAAIAEAPM
CCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHCCCC
ADEIARAEVETGGMEEIAHYVERAANVRHSTAPVRVAFTPMHGVGGEYAMDTFVRAGITD
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCE
VHVVDKQFAPDPDFPTVSLPNPEEPGAVDALLELAADVDADVAIALDPDADRCAVGVPTP
EEEECHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCC
DGWRMLSGDETGWLLGDYILDQVEPGEVMNATVVASTVVSSRMLAAIAAAHGAHHVETLT
CCCEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GFKWLSRADDDLPGKTMVYAYEEAIGHCVDPAAVRDKDGISAAVLFCDLVGVLKEHGRTV
HHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCHH
LDVLDDLARRHGVHVTAAVSRPVADADEAAGVMARLRDTPPDRLAGHEVTVTDLSTSPEP
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEECCCCCCC
MRSDALILSGGDADTSVRMVVRPSGTEPKVKSYIEVRRACAGDVGRARAEAQRLRDELVA
CCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LAQQW
HHHCC
>Mature Secondary Structure 
TSPATSTTVQEWIAHDPDPHTAAELSECSPDELDERFSRSLTFGTAGLRGPLRAGPNGM
CCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCCC
NLAVVLRTTWAVAKVLKDRGRAGSQVVVGRDARHRSDEFARAAAEVLAAQGFEVLLLLAA
EEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
VPTPVVAFTVRHMHAAAGIQITASHNPPTDNGYKVYFEEGLQIIGPTDTDIEAAIAEAPM
CCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHCCCC
ADEIARAEVETGGMEEIAHYVERAANVRHSTAPVRVAFTPMHGVGGEYAMDTFVRAGITD
HHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCE
VHVVDKQFAPDPDFPTVSLPNPEEPGAVDALLELAADVDADVAIALDPDADRCAVGVPTP
EEEECHHCCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEECCCCC
DGWRMLSGDETGWLLGDYILDQVEPGEVMNATVVASTVVSSRMLAAIAAAHGAHHVETLT
CCCEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GFKWLSRADDDLPGKTMVYAYEEAIGHCVDPAAVRDKDGISAAVLFCDLVGVLKEHGRTV
HHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCHH
LDVLDDLARRHGVHVTAAVSRPVADADEAAGVMARLRDTPPDRLAGHEVTVTDLSTSPEP
HHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEECCCCCCC
MRSDALILSGGDADTSVRMVVRPSGTEPKVKSYIEVRRACAGDVGRARAEAQRLRDELVA
CCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LAQQW
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]