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The map label for this gene is guaB [H]

Identifier: 119867234

GI number: 119867234

Start: 1266535

End: 1268088

Strand: Direct

Name: guaB [H]

Synonym: Mkms_1184

Alternate gene names: 119867234

Gene position: 1266535-1268088 (Clockwise)

Preceding gene: 119867232

Following gene: 119867235

Centisome position: 22.08

GC content: 69.69

Gene sequence:

>1554_bases
ATGTCGATCGCTGAACGCAGCGTTCCCATCGCCGTACCGGTGCCGACCGGCGGCGACGATCCGACGAAGGTGGCCATGCT
CGGGCTGACCTTCGACGACGTCCTGCTGCTGCCCGCCGCCTCCGACGTCATACCCGCGACGGCCGACACCTCGAGCCAGC
TGACCAAGCGCATCCGGCTGCGGGTGCCGCTGGTCAGCTCGGCGATGGACACGGTCACCGAATCCCGGATGGCCATCGCG
ATGGCCCGGGCCGGCGGCATGGGTGTGCTGCACCGCAACCTGCCCGTGGCCGAACAGGCCGGTCAGGTCGAAACCGTCAA
ACGGTCCGAGGCCGGGATGGTCACCGACCCGGTGACCTGCTCACCGGACAACACGCTGGCCGAAGTCGACGCGATGTGCG
CGCGGTTCCGCATCTCCGGGCTGCCGGTCGTGGATGAGCGCGGCTCCCTCGTCGGCATCATCACCAACCGCGACATGCGC
TTCGAGGTCGACCAGTCCAAACCGGTCTCCGAGGTGATGACCAAGGCGCCCTTGATCACGGCGCAGGAAGGTGTGTCGGC
CGAGGCCGCGCTCGGCCTGCTGCGCCGGCACAAGATCGAGAAGCTGCCGATCGTCGACGGGCACGGCAAGCTCACCGGGC
TGATCACCGTCAAGGACTTCGTCAAGACCGAACAGTTCCCGCTGGCGACCAAGGATTCCGACGGCAGGCTGCTCGTCGGC
GCCGCGGTCGGCGTCGGCGACGACGCGTGGAACCGCGCGATGACGCTGGCCGACGCCGGCGTCGACGTGCTGATCGTCGA
CACCGCCCACGCCCACAACCGGTCGGTGCTCGAGATGGTGCACCGCATCAAGACCGTGCTCGGTGACCGCGTCGAGGTCG
TCGGCGGCAACGTCGCCACCCGCGCCGGGGCCGCCGCACTCGTCGAAGCCGGCGCGGACGCGGTGAAGGTCGGTGTCGGC
CCGGGGTCGATCTGCACCACGCGGGTCGTCGCGGGCGTCGGGGCGCCACAGATCACCGCGATCCTCGAATCGGTCGCCGC
GTGCGCCCCGGCCGGTGTGCCGGTGATCGCCGACGGCGGCCTGCAGTACTCGGGGGACATCGCCAAGGCGCTGGCCGCGG
GCGCGTCGACGGCCATGCTGGGTTCGCTGCTCGCGGGCACCGCAGAGGCGCCGGGCGAGCTGATCTTCGTCAACGGCAAG
CAGTTCAAGAGCTACCGCGGCATGGGATCGCTCGGTGCGATGCAGGGCCGCGGCGCGACAGGCAACCTCCGGGGCTCCTT
CTCGAAGGACCGCTACTTCCAGGACGACGTGCTCTCCGAGGACAAGCTGGTACCCGAGGGCATCGAGGGCCGGGTGCCGT
TCCGCGGTCCGCTGGCGCAGGTGATCCACCAGCTCACCGGCGGTCTGCGCGCGGCCATGGGTTACACCGGTTCACCCTCC
ATCGAGGCGTTGCAGCAGGCGCAATTGGTGCAGATCACCGCGGCGGGGCTGAAGGAAAGCCACCCGCACGACATCACGAT
GACCGTCGAAGCGCCCAACTACTACGCCCGCTGA

Upstream 100 bases:

>100_bases
AGCCGTCGCCGGTGTGGCGACGTGGTGTGCGGGGCCGAGCGACCACGGCCGCAACCGATAGGATTGTGTATCCGCCCAAG
TACCTATGGAGGGCCCGCCC

Downstream 100 bases:

>100_bases
CGGACTGGGATACAGCACTGTGCGAGACATGGTCGAAATCGGTATGGGCCGCACCGCCCGCCGCACCTACGAACTCCACG
ACATCAACATCGTGCCGTCG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIA
MARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMR
FEVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVG
PGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGK
QFKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
IEALQQAQLVQITAAGLKESHPHDITMTVEAPNYYAR

Sequences:

>Translated_517_residues
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIA
MARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMR
FEVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVG
PGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGK
QFKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
IEALQQAQLVQITAAGLKESHPHDITMTVEAPNYYAR
>Mature_516_residues
SIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRLRVPLVSSAMDTVTESRMAIAM
ARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTCSPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRF
EVDQSKPVSEVMTKAPLITAQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVGA
AVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVATRAGAAALVEAGADAVKVGVGP
GSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQ
FKSYRGMGSLGAMQGRGATGNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPSI
EALQQAQLVQITAAGLKESHPHDITMTVEAPNYYAR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=42.7038626609442, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=42.7038626609442, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=42.7038626609442, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=42.7038626609442, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=42.9501084598698, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI217035152, Length=461, Percent_Identity=42.5162689804772, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=42.0600858369099, Blast_Score=325, Evalue=9e-89,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=40.5579399141631, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI50541956, Length=277, Percent_Identity=31.7689530685921, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI50541954, Length=277, Percent_Identity=31.7689530685921, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI50541952, Length=277, Percent_Identity=31.7689530685921, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI50541948, Length=277, Percent_Identity=31.7689530685921, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI156104880, Length=270, Percent_Identity=30.7407407407407, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1788855, Length=494, Percent_Identity=53.6437246963563, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1786293, Length=278, Percent_Identity=30.2158273381295, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=35.0622406639004, Blast_Score=268, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=434, Percent_Identity=36.6359447004608, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=269, Percent_Identity=33.457249070632, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323585, Length=463, Percent_Identity=41.9006479481641, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=463, Percent_Identity=41.2526997840173, Blast_Score=329, Evalue=8e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=463, Percent_Identity=39.7408207343413, Blast_Score=326, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=339, Percent_Identity=38.3480825958702, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=42.5, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641071, Length=463, Percent_Identity=41.6846652267819, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI24641073, Length=463, Percent_Identity=41.6846652267819, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI28571163, Length=422, Percent_Identity=40.7582938388626, Blast_Score=288, Evalue=6e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53673; Mature: 53542

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRL
CCCCCCCCCEEEECCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCHHHHHHHHEE
RVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTC
ECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCHHHHHHCCCCCEECCEEC
SPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRFEVDQSKPVSEVMTKAPLIT
CCCCHHHHHHHHHHHHEECCCCEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCEE
AQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
ECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEHHHHCCCCCCCEECCCCCCEEEE
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVAT
EEECCCCHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHH
RAGAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGG
HHCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCC
LQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGAT
CEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCC
GNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCH
IEALQQAQLVQITAAGLKESHPHDITMTVEAPNYYAR
HHHHHHHHHEEEEHHCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SIAERSVPIAVPVPTGGDDPTKVAMLGLTFDDVLLLPAASDVIPATADTSSQLTKRIRL
CCCCCCCCEEEECCCCCCCCCEEEEEECCHHHEEEECCCCCCCCCCCCCHHHHHHHHEE
RVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVETVKRSEAGMVTDPVTC
ECCHHHHHHHHHHHHHHHEEECCCCCCEEEECCCCCHHHCCCHHHHHHCCCCCEECCEEC
SPDNTLAEVDAMCARFRISGLPVVDERGSLVGIITNRDMRFEVDQSKPVSEVMTKAPLIT
CCCCHHHHHHHHHHHHEECCCCEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHCCCEE
AQEGVSAEAALGLLRRHKIEKLPIVDGHGKLTGLITVKDFVKTEQFPLATKDSDGRLLVG
ECCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEHHHHCCCCCCCEECCCCCCEEEE
AAVGVGDDAWNRAMTLADAGVDVLIVDTAHAHNRSVLEMVHRIKTVLGDRVEVVGGNVAT
EEECCCCHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHH
RAGAAALVEAGADAVKVGVGPGSICTTRVVAGVGAPQITAILESVAACAPAGVPVIADGG
HHCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCC
LQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQFKSYRGMGSLGAMQGRGAT
CEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCCCC
GNLRGSFSKDRYFQDDVLSEDKLVPEGIEGRVPFRGPLAQVIHQLTGGLRAAMGYTGSPS
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCH
IEALQQAQLVQITAAGLKESHPHDITMTVEAPNYYAR
HHHHHHHHHEEEEHHCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]