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The map label for this gene is prrB [H]

Identifier: 119866231

GI number: 119866231

Start: 188473

End: 189759

Strand: Direct

Name: prrB [H]

Synonym: Mkms_0175

Alternate gene names: 119866231

Gene position: 188473-189759 (Clockwise)

Preceding gene: 119866230

Following gene: 119866234

Centisome position: 3.29

GC content: 72.42

Gene sequence:

>1287_bases
GTGGCGTCGGCGGCCGCCGCGTCGGCCGTCGTGGCGGCGTTCACGATCCTCACCTCGGTGGTGCTGGCCAGCAACGACGA
TGCCCAGCTCGACCGCAGGCTCGACTCCATCGTCGACGCCAGCATGTACCCCGAACAGCTGCAGGACCCCCGCCGCGGGG
TGTTGACCACGGGGCGTGACCGCTCCACCGGGCAGGTGGTGTTCCAGCGCGGGTTCCAGCTGCCGAAGCTGCCGCCGGGC
ACCGAGACCGTCGAGGTCAACGGCGTGGACTACCGGGTGCGGACCCTCGTCGTCGACCAGGAGGGCGGCGTGCTGGTGTC
CATCGGCATCCGCGCCGACAGCATCCTGCTCAGCCGGGGCCGCATCCCCGAGTACGTGCTCGTGGGTCTGGTGACGGTGC
TCATCGCCGGCGGTCTGGGCTGGGTGCTCGCCGGCCCCGCGATCCGGCCGTTGCGCAAGCTCACCGAGCAGACCTCGAAG
CTCAGCACGGGCACCGACGAGATGCCCGAGGTGCGGGGCGCACGGGAGGCCGAGGAACTGTCCGCGGCGATGTCGGCGAT
GCTGCGGCGCCTGGCCGCCGCACAGCAGGCCACGACGAACTCGCTGCAGGCCGCGCAGGACTTCGCCGCCAACGCCGCCC
ACGAGTTGCGCACCCCGCTCACTGCGATGCGCGCCGACCTGGACACGCTGCGCATCCACGATCTGCCCGAGGACGAACGC
GCCGAGGTGGTCGCGGACCTGTCGCGGGCGCAGCGCCGGGTCGAGGCGATCATCACCGCGCTGGGGCAACTGGCGTCCGG
TCAGCTGGCCCAGGCCGCGGACCGCGAACCGATCGACATCACCGACACCCTCGACCGGGTGGCGCGGGAGAACATGCGCT
CGGCGCCGCAGGTCGACATCCAGGTCGACGCGGAGGATCTCGGCACGGTGTGGGGGTTGCCGGACGGGTTGCGCCTCGCC
GTCGACAACCTGGTGCGCAACGCGATCACCCACGGCGGCGCCGGCCGCGTGGTGCTGACCGCGCGGCGCACCGACGGGTG
GCTGACCATCGTCGTCGACGACGACGGACGCGGTCTGCCCGCCGAGGAACACGAGATGGTGCTCGGCCGGTTCCGCCGGG
GCAGCACCGCGGCCCCCGGGGGTTCGGGTCTGGGGCTCGCGCTGGTCGCACAGCAGGCCGAATTGCACGGCGGCACAATC
GAACTGGCCGACAGCCCGCTCGGTGGGTTGCGCGCCACGCTGACGGTATCCACGTCAACCACAGGCGGCGACCCTCAGCT
GCGCTGA

Upstream 100 bases:

>100_bases
CACACCGTGCGCGGGATCGGATACGTGCTGCGGGACGAGCCCTGACGTCGTGTGGTTGCCCCGCCTCTTCCGCTCGACGT
CGTTGCGCACCCGGGTCGCC

Downstream 100 bases:

>100_bases
ATCTGCTTGTGCCGCAGGGCAGTTGCCACACCACGCCATCCGAGCAGCAGCAGCGCGGTGACCAGCGACGCCACGATGAC
GAAGCTGACCGCGACGCCCT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MASAAAASAVVAAFTILTSVVLASNDDAQLDRRLDSIVDASMYPEQLQDPRRGVLTTGRDRSTGQVVFQRGFQLPKLPPG
TETVEVNGVDYRVRTLVVDQEGGVLVSIGIRADSILLSRGRIPEYVLVGLVTVLIAGGLGWVLAGPAIRPLRKLTEQTSK
LSTGTDEMPEVRGAREAEELSAAMSAMLRRLAAAQQATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHDLPEDER
AEVVADLSRAQRRVEAIITALGQLASGQLAQAADREPIDITDTLDRVARENMRSAPQVDIQVDAEDLGTVWGLPDGLRLA
VDNLVRNAITHGGAGRVVLTARRTDGWLTIVVDDDGRGLPAEEHEMVLGRFRRGSTAAPGGSGLGLALVAQQAELHGGTI
ELADSPLGGLRATLTVSTSTTGGDPQLR

Sequences:

>Translated_428_residues
MASAAAASAVVAAFTILTSVVLASNDDAQLDRRLDSIVDASMYPEQLQDPRRGVLTTGRDRSTGQVVFQRGFQLPKLPPG
TETVEVNGVDYRVRTLVVDQEGGVLVSIGIRADSILLSRGRIPEYVLVGLVTVLIAGGLGWVLAGPAIRPLRKLTEQTSK
LSTGTDEMPEVRGAREAEELSAAMSAMLRRLAAAQQATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHDLPEDER
AEVVADLSRAQRRVEAIITALGQLASGQLAQAADREPIDITDTLDRVARENMRSAPQVDIQVDAEDLGTVWGLPDGLRLA
VDNLVRNAITHGGAGRVVLTARRTDGWLTIVVDDDGRGLPAEEHEMVLGRFRRGSTAAPGGSGLGLALVAQQAELHGGTI
ELADSPLGGLRATLTVSTSTTGGDPQLR
>Mature_427_residues
ASAAAASAVVAAFTILTSVVLASNDDAQLDRRLDSIVDASMYPEQLQDPRRGVLTTGRDRSTGQVVFQRGFQLPKLPPGT
ETVEVNGVDYRVRTLVVDQEGGVLVSIGIRADSILLSRGRIPEYVLVGLVTVLIAGGLGWVLAGPAIRPLRKLTEQTSKL
STGTDEMPEVRGAREAEELSAAMSAMLRRLAAAQQATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHDLPEDERA
EVVADLSRAQRRVEAIITALGQLASGQLAQAADREPIDITDTLDRVARENMRSAPQVDIQVDAEDLGTVWGLPDGLRLAV
DNLVRNAITHGGAGRVVLTARRTDGWLTIVVDDDGRGLPAEEHEMVLGRFRRGSTAAPGGSGLGLALVAQQAELHGGTIE
LADSPLGGLRATLTVSTSTTGGDPQLR

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=297, Percent_Identity=29.96632996633, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=29.0909090909091, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=28.310502283105, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787374, Length=299, Percent_Identity=24.7491638795987, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789403, Length=305, Percent_Identity=29.8360655737705, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=29.9180327868852, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45366; Mature: 45235

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAAAASAVVAAFTILTSVVLASNDDAQLDRRLDSIVDASMYPEQLQDPRRGVLTTGRD
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCC
RSTGQVVFQRGFQLPKLPPGTETVEVNGVDYRVRTLVVDQEGGVLVSIGIRADSILLSRG
CCHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEEEEEECCCCEEEEEECCCCEEEECCC
RIPEYVLVGLVTVLIAGGLGWVLAGPAIRPLRKLTEQTSKLSTGTDEMPEVRGAREAEEL
CCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
SAAMSAMLRRLAAAQQATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHDLPEDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHH
AEVVADLSRAQRRVEAIITALGQLASGQLAQAADREPIDITDTLDRVARENMRSAPQVDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEE
QVDAEDLGTVWGLPDGLRLAVDNLVRNAITHGGAGRVVLTARRTDGWLTIVVDDDGRGLP
EECHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
AEEHEMVLGRFRRGSTAAPGGSGLGLALVAQQAELHGGTIELADSPLGGLRATLTVSTST
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECC
TGGDPQLR
CCCCCCCC
>Mature Secondary Structure 
ASAAAASAVVAAFTILTSVVLASNDDAQLDRRLDSIVDASMYPEQLQDPRRGVLTTGRD
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCEECCCC
RSTGQVVFQRGFQLPKLPPGTETVEVNGVDYRVRTLVVDQEGGVLVSIGIRADSILLSRG
CCHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEEEEEECCCCEEEEEECCCCEEEECCC
RIPEYVLVGLVTVLIAGGLGWVLAGPAIRPLRKLTEQTSKLSTGTDEMPEVRGAREAEEL
CCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
SAAMSAMLRRLAAAQQATTNSLQAAQDFAANAAHELRTPLTAMRADLDTLRIHDLPEDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHH
AEVVADLSRAQRRVEAIITALGQLASGQLAQAADREPIDITDTLDRVARENMRSAPQVDI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEE
QVDAEDLGTVWGLPDGLRLAVDNLVRNAITHGGAGRVVLTARRTDGWLTIVVDDDGRGLP
EECHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCC
AEEHEMVLGRFRRGSTAAPGGSGLGLALVAQQAELHGGTIELADSPLGGLRATLTVSTST
CHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECC
TGGDPQLR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]