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The map label for this gene is yrkH [H]

Identifier: 119855137

GI number: 119855137

Start: 261014

End: 262393

Strand: Reverse

Name: yrkH [H]

Synonym: Mkms_5751

Alternate gene names: 119855137

Gene position: 262393-261014 (Counterclockwise)

Preceding gene: 119855140

Following gene: 119855136

Centisome position: 86.86

GC content: 66.38

Gene sequence:

>1380_bases
ATGATTCTCGAGCAGTACTACATCGAGTGCCTGTCACACGCGTCATATCTGATAGGTGACGAAACCAGCGGGCGCGCAGT
CGTTGTCGACCCGCGCCGCGACATCACCGAATACCTCGACGCCGCCGCCAAACACGGATTGACGATCGAAGGCGTGATCA
ACACCCACTTTCACGCCGACTTCGTCTCCGGGCACCTGGAACTGGTGGAGGCGACCGGGGCGTGGATCGGCTTCGGCGCG
GCCGCCCAGACCGACTACCCGATCCGCCGGCTGGCCGATGGAGAACACCTGTCGCTGGGCGGGGTCGACCTGGAGATCCT
GTCGACACCCGGCCACACCTGGGAATCGATCAGCGTGGTGGTGCGTGACCATCACGGTGCCGAGTCGGTGGCGGTGCTGA
CCGGGGACGCGCTGTTCATCGGCGATGTGGGCCGACCGGATCTGGCCAACCTTGGTGACGGCTCGACATCTGACCTGGCT
CGGGCGATGTACCGAACCATCCACCACACGCTGCTCACGCTGGCCGATCACGTCACGGTGCTGCCCGCCCACGGCGCCGG
GTCGTCGTGCGGCAAGAACCTGTCGGCCGAGCTGACCTCGACGATCGGCGAGCAGCGCCGCACCAACCCGTCAGTGCAGC
CGATGACCGAGGCTGAGTTCGTCGCCATGATCACCGACGGCCAGCCCGCTGCGCCCGCCTATTTCTCGGTCGACGCGGCG
ATGAACAAACGCGTTCACCCGCTGTTGGATCAGCGCCGCAGCATTCCCGAAATGACGGCGTCGCAGCTGCGGGCCGCGCT
GGAGGCCGGCATCCGGGTGGTGGATGCCCGGTCGGTGGACGACTTCGCCGCCGGTCATCTACGTGGATCGGTCAACGTCG
GTTTCGACGGCCGCTTCGCCGAAACCGCCGGCATGGTCGCCGAGGTGGGCGAGACACTCGTACTGATCACCGACGCCGGC
GACGAGCAGGCCGCGGCCATGCGGCTGGCACGCATCGGCTCAGACAACGTCATCGGCTATCTGGCCGTGGACGGTGAGGG
TAGCTTTCCGGTCGAGCTGGCCGATCTCGTGCAATCAGCATCGCGCGTCAGCGTCGCTGAACTGGACCGGCTCACCGCCG
AGAATGCGGTGACGCTGATCGACATCCGGAATTCCGGCGAACGCGAACTCGGGACGATCCCGGGCGCGGTGCACATACCG
CTAGCTCAGTTGCGCGCACGGTTGGCGCACCTTCCCAGTGACAGGCCGATCGTGGTGCACTGCGCCGGTGGCTGGCGCTC
TAGTGTGGCCGCATCATTGATGCGCGCCGACGGACTGGGCAACGTGAGTGATCTGATCGGCGGGTACAACGCCTGGGCGC
ACACCCACGCCGCAGCGTGA

Upstream 100 bases:

>100_bases
ATCTACTATTTCGGGAATACTATACCCCTGGGGGTATTGTTGTTCCGAGCGATAGGCCGCGATCCGAACCGCGGGCGGCC
CACGGAGAGAAAGAAGAACC

Downstream 100 bases:

>100_bases
CGGCAACCCACTGAGGCGAGGGGTATGTTCGTTAGGCAATCCTCACCTTGCAGAAAGGGCGGCCGATGTCAGCCCGTCGG
AGTCGTTGGAGTCGAATCAC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MILEQYYIECLSHASYLIGDETSGRAVVVDPRRDITEYLDAAAKHGLTIEGVINTHFHADFVSGHLELVEATGAWIGFGA
AAQTDYPIRRLADGEHLSLGGVDLEILSTPGHTWESISVVVRDHHGAESVAVLTGDALFIGDVGRPDLANLGDGSTSDLA
RAMYRTIHHTLLTLADHVTVLPAHGAGSSCGKNLSAELTSTIGEQRRTNPSVQPMTEAEFVAMITDGQPAAPAYFSVDAA
MNKRVHPLLDQRRSIPEMTASQLRAALEAGIRVVDARSVDDFAAGHLRGSVNVGFDGRFAETAGMVAEVGETLVLITDAG
DEQAAAMRLARIGSDNVIGYLAVDGEGSFPVELADLVQSASRVSVAELDRLTAENAVTLIDIRNSGERELGTIPGAVHIP
LAQLRARLAHLPSDRPIVVHCAGGWRSSVAASLMRADGLGNVSDLIGGYNAWAHTHAAA

Sequences:

>Translated_459_residues
MILEQYYIECLSHASYLIGDETSGRAVVVDPRRDITEYLDAAAKHGLTIEGVINTHFHADFVSGHLELVEATGAWIGFGA
AAQTDYPIRRLADGEHLSLGGVDLEILSTPGHTWESISVVVRDHHGAESVAVLTGDALFIGDVGRPDLANLGDGSTSDLA
RAMYRTIHHTLLTLADHVTVLPAHGAGSSCGKNLSAELTSTIGEQRRTNPSVQPMTEAEFVAMITDGQPAAPAYFSVDAA
MNKRVHPLLDQRRSIPEMTASQLRAALEAGIRVVDARSVDDFAAGHLRGSVNVGFDGRFAETAGMVAEVGETLVLITDAG
DEQAAAMRLARIGSDNVIGYLAVDGEGSFPVELADLVQSASRVSVAELDRLTAENAVTLIDIRNSGERELGTIPGAVHIP
LAQLRARLAHLPSDRPIVVHCAGGWRSSVAASLMRADGLGNVSDLIGGYNAWAHTHAAA
>Mature_459_residues
MILEQYYIECLSHASYLIGDETSGRAVVVDPRRDITEYLDAAAKHGLTIEGVINTHFHADFVSGHLELVEATGAWIGFGA
AAQTDYPIRRLADGEHLSLGGVDLEILSTPGHTWESISVVVRDHHGAESVAVLTGDALFIGDVGRPDLANLGDGSTSDLA
RAMYRTIHHTLLTLADHVTVLPAHGAGSSCGKNLSAELTSTIGEQRRTNPSVQPMTEAEFVAMITDGQPAAPAYFSVDAA
MNKRVHPLLDQRRSIPEMTASQLRAALEAGIRVVDARSVDDFAAGHLRGSVNVGFDGRFAETAGMVAEVGETLVLITDAG
DEQAAAMRLARIGSDNVIGYLAVDGEGSFPVELADLVQSASRVSVAELDRLTAENAVTLIDIRNSGERELGTIPGAVHIP
LAQLRARLAHLPSDRPIVVHCAGGWRSSVAASLMRADGLGNVSDLIGGYNAWAHTHAAA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=250, Percent_Identity=28.8, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI94538320, Length=148, Percent_Identity=29.0540540540541, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI94538322, Length=152, Percent_Identity=28.2894736842105, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI14150041, Length=239, Percent_Identity=27.6150627615063, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787158, Length=227, Percent_Identity=28.1938325991189, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538952, Length=235, Percent_Identity=27.6595744680851, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330176, Length=237, Percent_Identity=29.1139240506329, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 48558; Mature: 48558

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEQYYIECLSHASYLIGDETSGRAVVVDPRRDITEYLDAAAKHGLTIEGVINTHFHAD
CCHHHHHHHHHHCCCEEECCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEEECCEEHH
FVSGHLELVEATGAWIGFGAAAQTDYPIRRLADGEHLSLGGVDLEILSTPGHTWESISVV
HHHCCEEEEEECCCEEECCCCCCCCCCHHHHCCCCEEEECCEEEEEEECCCCCCCEEEEE
VRDHHGAESVAVLTGDALFIGDVGRPDLANLGDGSTSDLARAMYRTIHHTLLTLADHVTV
EECCCCCCEEEEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
LPAHGAGSSCGKNLSAELTSTIGEQRRTNPSVQPMTEAEFVAMITDGQPAAPAYFSVDAA
EECCCCCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEHHH
MNKRVHPLLDQRRSIPEMTASQLRAALEAGIRVVDARSVDDFAAGHLRGSVNVGFDGRFA
HCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHCCCCEEECCCCCHH
ETAGMVAEVGETLVLITDAGDEQAAAMRLARIGSDNVIGYLAVDGEGSFPVELADLVQSA
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHH
SRVSVAELDRLTAENAVTLIDIRNSGERELGTIPGAVHIPLAQLRARLAHLPSDRPIVVH
HCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEE
CAGGWRSSVAASLMRADGLGNVSDLIGGYNAWAHTHAAA
ECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCC
>Mature Secondary Structure
MILEQYYIECLSHASYLIGDETSGRAVVVDPRRDITEYLDAAAKHGLTIEGVINTHFHAD
CCHHHHHHHHHHCCCEEECCCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEEECCEEHH
FVSGHLELVEATGAWIGFGAAAQTDYPIRRLADGEHLSLGGVDLEILSTPGHTWESISVV
HHHCCEEEEEECCCEEECCCCCCCCCCHHHHCCCCEEEECCEEEEEEECCCCCCCEEEEE
VRDHHGAESVAVLTGDALFIGDVGRPDLANLGDGSTSDLARAMYRTIHHTLLTLADHVTV
EECCCCCCEEEEEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
LPAHGAGSSCGKNLSAELTSTIGEQRRTNPSVQPMTEAEFVAMITDGQPAAPAYFSVDAA
EECCCCCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEHHH
MNKRVHPLLDQRRSIPEMTASQLRAALEAGIRVVDARSVDDFAAGHLRGSVNVGFDGRFA
HCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHCCCCEEECCCCCHH
ETAGMVAEVGETLVLITDAGDEQAAAMRLARIGSDNVIGYLAVDGEGSFPVELADLVQSA
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHH
SRVSVAELDRLTAENAVTLIDIRNSGERELGTIPGAVHIPLAQLRARLAHLPSDRPIVVH
HCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCEEEE
CAGGWRSSVAASLMRADGLGNVSDLIGGYNAWAHTHAAA
ECCCCHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]