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The map label for this gene is rcsC [H]

Identifier: 119900235

GI number: 119900235

Start: 4325235

End: 4325588

Strand: Direct

Name: rcsC [H]

Synonym: azo3946

Alternate gene names: 119900235

Gene position: 4325235-4325588 (Clockwise)

Preceding gene: 119900226

Following gene: 119900244

Centisome position: 98.84

GC content: 64.97

Gene sequence:

>354_bases
ATGAAAAAGGTCCTGGTCGTTGACGACGTGCCCGTCAACCGCAAACTCGCCCTCGCCATGCTGAAGAAGCGCGGCTGGCA
GGCCGAAGAGGTGGACAACGGCGCAGCCGCGCTCGAACGGTTGAGCGCAGGCGGCTTCGACGGCGTGCTGCTCGACATCA
GCATGCCGGGCATGGACGGCGAAGAGGTGTGCCGGCGCATCCGCGCCGACGGCCGCTTCGCGGGGCTGAGAATCGTCGCT
TACACGGCGCATGCGATGGAGTTCGAGAAGGAGCGCATTCTCAGCGCCGGGTTCGACAGCATCATGATCAAGCCGATCAC
GATGAGCGCCCTTCAGTCGGCGCTGCCGGACTGA

Upstream 100 bases:

>100_bases
TTCATGGCCTGGCCTCCGCGCGCGTGCCGGGGCGCAGCTTCTGCGGGCCCACCTTCTGGTGTATAAGGGGCGCTCGAATT
CCCCCCGCTTGCCGCTGCCG

Downstream 100 bases:

>100_bases
CGAGCGGAATCCAGAATTCGAAGTAGGCGCCCTCGCCCGGCGCCGACTCCAGCCGCACCGCCCCACCCATCAGCGCCACC
ACCTCGCGCACCAGCGCGAG

Product: putative two component transcriptional regulator

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MKKVLVVDDVPVNRKLALAMLKKRGWQAEEVDNGAAALERLSAGGFDGVLLDISMPGMDGEEVCRRIRADGRFAGLRIVA
YTAHAMEFEKERILSAGFDSIMIKPITMSALQSALPD

Sequences:

>Translated_117_residues
MKKVLVVDDVPVNRKLALAMLKKRGWQAEEVDNGAAALERLSAGGFDGVLLDISMPGMDGEEVCRRIRADGRFAGLRIVA
YTAHAMEFEKERILSAGFDSIMIKPITMSALQSALPD
>Mature_117_residues
MKKVLVVDDVPVNRKLALAMLKKRGWQAEEVDNGAAALERLSAGGFDGVLLDISMPGMDGEEVCRRIRADGRFAGLRIVA
YTAHAMEFEKERILSAGFDSIMIKPITMSALQSALPD

Specific function: Member of the two-component regulatory system rcsC/rcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with rcsF, rcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=112, Percent_Identity=40.1785714285714, Blast_Score=85, Evalue=1e-18,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=39.3162393162393, Blast_Score=77, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=112, Percent_Identity=39.2857142857143, Blast_Score=75, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=112, Percent_Identity=34.8214285714286, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=110, Percent_Identity=35.4545454545455, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 12763; Mature: 12763

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLVVDDVPVNRKLALAMLKKRGWQAEEVDNGAAALERLSAGGFDGVLLDISMPGMDG
CCCEEEECCCCCCHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCH
EEVCRRIRADGRFAGLRIVAYTAHAMEFEKERILSAGFDSIMIKPITMSALQSALPD
HHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVLVVDDVPVNRKLALAMLKKRGWQAEEVDNGAAALERLSAGGFDGVLLDISMPGMDG
CCCEEEECCCCCCHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCH
EEVCRRIRADGRFAGLRIVAYTAHAMEFEKERILSAGFDSIMIKPITMSALQSALPD
HHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504; 8626298 [H]