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The map label for this gene is ureC

Identifier: 119899793

GI number: 119899793

Start: 3846323

End: 3848029

Strand: Reverse

Name: ureC

Synonym: azo3504

Alternate gene names: 119899793

Gene position: 3848029-3846323 (Counterclockwise)

Preceding gene: 119899794

Following gene: 119899792

Centisome position: 87.93

GC content: 67.49

Gene sequence:

>1707_bases
ATGGCCAAGATCACCCGCCGCGCCTACGCGGAAATGTTCGGCCCCACCACCGGCGACAAGCTCCGCCTCGCCGACACCGA
ACTCATCATCGAGGTCGAGAAGGACTACACGATCTACGGCGAGGAAGTGAAGTTTGGCGGCGGCAAGGTCATCCGCGACG
GCATGGGCCAGGGCCAGCAGCTCGCCGCCGAGATTGCCGACACGATCATCACCAACGCGCTGATCGTCGACGCGGTGGCC
GGCATCGTGAAGGCCGACGTCGGCCTCAAGGACGGCCGCATCTGGAAGATCGGCAAGGGCGGCAACCCGGACATCCAGCC
GGGCGTCACCATTCCGGTCGGCGCCGGCACGGAGGTCATCGCCGGCGAAGGCATGATCCTCACCGCCGGCGGCATCGACA
GCCACATCCACTGGATCTGCCCGCAGCAGATCGACGAGGCGCTGATGAGCGGCGTCACCACCATGCTGGGCGGCGGCACC
GGTCCGGCCACCGGCACCTACGCCACCACCTGCACGCCGGGGCCGTGGCACATCCACCGCATGCTGGAAGCGGCGGACGC
CTTCCCGATGAACATGGGCTTCTTCGGCAAGGGCAACGCCAGCCTGCCGGGGCCGCTCAAGGAGCAGGTCGAGGCCGGCG
TCATCGGCCTGAAGCTGCACGAAGACTGGGGCACCACTCCGGCAGCCATCGACAACTGCCTGACCGTGGCCGACGAGATG
GACGTGCAGGTCGCCATCCACACCGACACGCTCAACGAATCCGGCTTCGTGGAGACCACGCTGGCCGCCTTCAAGGGCCG
CACCATCCACACCTTCCATACCGAAGGCGCGGGCGGCGGCCATGCGCCGGACATCATCAAGGCGGTGGGGCAGGCCAACG
TGCTGCCGTCCTCCACCAACCCGACCCGGCCCTACACGGTGAACACCATCGACGAGCATCTCGACATGCTGATGGTGTGC
CACCACCTCGACCCCGCGATTGCCGAGGACGTCGCCTTCGCCGAATCGCGCATCCGCCGCGAGACCATCGCCGCCGAGGA
CATCCTGCACGACACCGGCGCGTTCTCGATGATGTCGTCCGACTCGCAGGCAATGGGCCGCGTCGGCGAAGTCGTCATCC
GCACCTGGCAGACCGCGCACAAGATGAAGGTGCAGCGCGGCGCGCTCGCCGAGGATGCCGGCAAGGGCAACGACAACTTC
CGCATCAAGCGCTACATCGCCAAATACACCATCAACCCGGCGATCACCCACGGCATTGCGCACGTGGTCGGCTCGATCGA
GGAGGGCAAGCTCGCCGACCTGGTGCTGTGGAAGCCGGCGTTCTTCGGCGTCAAGCCCAGCCTCATCCTCAAGGGCGGCA
TGATCGCCGCCGCGGCGATGGGCGACGCCAACGCCTCCATCCCGACCCCGCAGCCGGTGCATTACCGGCCGATGTTCGGC
AGCTACGGCAAGGCGCTCAAGACCTCGGTGACCTTCGTGTCGCAGGCCGCGCTCGCCAACCCGGCGGTGGCCGCGCTGCA
GCTGTCCAAGCCGCTGGTGGCGGTGCAGGGCTGCCGCACCGTGCAGAAAGCCGACATGGTGCACAACGGCGCCACCCCGG
CGATCGACGTCGACCCCGAAACCTATGTGGTGCGCGCCGACGGCGAGCTGCTGGTGTGCGAACCGGCCAGCGAGTTGCCG
ATGGCGCAGCGCTATTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
CGCTTCGAGCCGGGGCAGGCGCGCACGGTCGAGCTGGTCGCGCTCGCCGGCGCGCGCAAGGTCTACGGCTTCAACGGCGA
CGTCATGGGAGCGCTCTGAC

Downstream 100 bases:

>100_bases
CGCGGGGGATCATGATGCTCGTGGAACCCTCCGACTCCGCTGCCGCAGACACCCCCATGCTCCTGATCGAATCGTTTTAC
GAAGGCGTGCGTGCCGCCAC

Product: urease subunit alpha

Products: NA

Alternate protein names: Urea amidohydrolase subunit alpha

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MAKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQLAAEIADTIITNALIVDAVA
GIVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVIAGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGT
GPATGTYATTCTPGPWHIHRMLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEM
DVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTNPTRPYTVNTIDEHLDMLMVC
HHLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSSDSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNF
RIKRYIAKYTINPAITHGIAHVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFG
SYGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPETYVVRADGELLVCEPASELP
MAQRYFLF

Sequences:

>Translated_568_residues
MAKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQLAAEIADTIITNALIVDAVA
GIVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVIAGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGT
GPATGTYATTCTPGPWHIHRMLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEM
DVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTNPTRPYTVNTIDEHLDMLMVC
HHLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSSDSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNF
RIKRYIAKYTINPAITHGIAHVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFG
SYGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPETYVVRADGELLVCEPASELP
MAQRYFLF
>Mature_567_residues
AKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQLAAEIADTIITNALIVDAVAG
IVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVIAGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGTG
PATGTYATTCTPGPWHIHRMLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEMD
VQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTNPTRPYTVNTIDEHLDMLMVCH
HLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSSDSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNFR
IKRYIAKYTINPAITHGIAHVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFGS
YGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPETYVVRADGELLVCEPASELPM
AQRYFLF

Specific function: Unknown

COG id: COG0804

COG function: function code E; Urea amidohydrolase (urease) alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 urease domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URE1_AZOSB (A1KBB4)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_935006.1
- ProteinModelPortal:   A1KBB4
- SMR:   A1KBB4
- STRING:   A1KBB4
- MEROPS:   M38.982
- GeneID:   4607979
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3504
- eggNOG:   COG0804
- HOGENOM:   HBG357507
- OMA:   TIHAFHT
- ProtClustDB:   PRK13207
- BioCyc:   ASP62928:AZO3504-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01953
- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR011612
- InterPro:   IPR005848
- InterPro:   IPR017951
- InterPro:   IPR017950
- PRINTS:   PR01752
- TIGRFAMs:   TIGR01792

Pfam domain/function: PF01979 Amidohydro_1; PF00449 Urease_alpha; SSF51338 Metalo_hydrolase

EC number: =3.5.1.5

Molecular weight: Translated: 60296; Mature: 60165

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS01120 UREASE_1; PS00145 UREASE_2; PS51368 UREASE_3

Important sites: ACT_SITE 321-321 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQ
CCCHHHHHHHHHHCCCCCCEEEEECEEEEEEEECCEEEECCEEEECCCEEECCCCCCHHH
LAAEIADTIITNALIVDAVAGIVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEE
AGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGTGPATGTYATTCTPGPWHIHR
ECCCEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
MLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEM
HHHHHCCCCCCCCEECCCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCC
DVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTN
CEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCC
PTRPYTVNTIDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSS
CCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
DSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNFRIKRYIAKYTINPAITHGIA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEEHHEECCHHHHHHHH
HVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFG
HHHCCCCCCCEEEEEEECCHHHCCCHHHEEECCEEEEEEECCCCCCCCCCCCCEECCCCC
SYGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPE
CHHHHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHCCHHHHHHHHHHCCCCCEEECCCC
TYVVRADGELLVCEPASELPMAQRYFLF
EEEEEECCCEEEECCHHHCCCCHHHCCC
>Mature Secondary Structure 
AKITRRAYAEMFGPTTGDKLRLADTELIIEVEKDYTIYGEEVKFGGGKVIRDGMGQGQQ
CCHHHHHHHHHHCCCCCCEEEEECEEEEEEEECCEEEECCEEEECCCEEECCCCCCHHH
LAAEIADTIITNALIVDAVAGIVKADVGLKDGRIWKIGKGGNPDIQPGVTIPVGAGTEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEE
AGEGMILTAGGIDSHIHWICPQQIDEALMSGVTTMLGGGTGPATGTYATTCTPGPWHIHR
ECCCEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
MLEAADAFPMNMGFFGKGNASLPGPLKEQVEAGVIGLKLHEDWGTTPAAIDNCLTVADEM
HHHHHCCCCCCCCEECCCCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHCCC
DVQVAIHTDTLNESGFVETTLAAFKGRTIHTFHTEGAGGGHAPDIIKAVGQANVLPSSTN
CEEEEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCC
PTRPYTVNTIDEHLDMLMVCHHLDPAIAEDVAFAESRIRRETIAAEDILHDTGAFSMMSS
CCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
DSQAMGRVGEVVIRTWQTAHKMKVQRGALAEDAGKGNDNFRIKRYIAKYTINPAITHGIA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEEEEHHEECCHHHHHHHH
HVVGSIEEGKLADLVLWKPAFFGVKPSLILKGGMIAAAAMGDANASIPTPQPVHYRPMFG
HHHCCCCCCCEEEEEEECCHHHCCCHHHEEECCEEEEEEECCCCCCCCCCCCCEECCCCC
SYGKALKTSVTFVSQAALANPAVAALQLSKPLVAVQGCRTVQKADMVHNGATPAIDVDPE
CHHHHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHCCHHHHHHHHHHCCCCCEEECCCC
TYVVRADGELLVCEPASELPMAQRYFLF
EEEEEECCCEEEECCHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA